The role of oxytocin-dopamine interactions in cocaine-induced locomotor hyperactivity
Abstract
Cocaine is a widely used drug of abuse. One of the characteristic effects of this stimulant drug in the CNS of mice is the induction of motor hyperactivity. It was demonstrated that cocaine-induced motor hyperactivity could be blocked by pimozide, a dopamine receptor blocker, suggesting that dopamine was involved in cocaine-induced hyperactivity. Oxytocin, a neurohypophyseal neuropeptide, also partially antagonized cocaine-induced motor hyperactivity. Moreover, oxytocin antagonized the increased utilization of dopamine, elicited by cocaine in the nucleus accumbens. The data suggest that oxytocin may influence the behavioural effects of cocaine by affecting dopaminergic neurotransmission in some regions of the brain.
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Exogenous OT attenuates many immediate behavioral effects of drugs of abuse, including reducing drug consumption, with some effects localized to the NAC.
“Exogenous OT attenuates many of the immediate behavioral effects of drugs of abuse, including reducing drug consumption, and some of the attenuating effects of OT are localized to the NAC (Kovacs et al 1990; Sarnyai et al 1990; Sarnyai et al 1991; Qi et al 2009; Carson et al 2010a; Baracz et al 2012).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Kovacs et al 1990
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- Authors
- Kovàcs, G. L., Sarnyai, Z., Babarczi, E., Szabó, G., & Telegdy, G.
- Affiliations
- University of Szeged (HU)
- ORCID
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 1990-04
- Volume
- 29
- Issue
- 4
- Pages
- 365-368
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2003308034
- Cited by
- 101
- References
- 18
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 6
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- cocaine, locomotor hyperactivity, oxytocin, dopamine, pimozide, dopamine receptor blockade, nucleus accumbens, dopamine signaling
- MeSH terms
- Animals, Cocaine, Dopamine, Dose-Response Relationship, Drug, Male, Methyltyrosines, Mice, Inbred Strains, Motor Activity, Synaptic Transmission, Oxytocin, alpha-Methyltyrosine, Mice
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