Inhibition by oxytocin of methamphetamine-induced hyperactivity related to dopamine turnover in the mesolimbic region in mice
Abstract
Accumulated data have shown the neuroactive properties of oxytocin (OT), a neurohypophyseal neuropeptide, and its capability of reducing the abuse potential of drugs. The present study investigated the effect of OT on methamphetamine (MAP)-induced hyperactivity in mice and its possible mechanism of action. Locomotor activity was measured after administered with MAP using an infrared sensor. High-performance liquid chromatography with electrochemical detection (HPLC-ECD) was used to detect the content of monoamines and their metabolites in the striatum and accumbens and prefrontal cortex in mice after the behavioral test. OT (0.1, 0.5, and 2.5 microg/mouse, i.c.v.) had no effect on locomotor activity in naïve mice, but inhibited, in a dose-dependent manner, the hyperactivity induced by acute administration of MAP. Atosiban (Ato) (2.0 microg/mouse, i.c.v.), the selective inhibitor of OT receptor, attenuated the inhibitory effect of OT on MAP. A marked reduction of the ratios of 3, 4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) to dopamine (DA) was observed in the striatum and accumbens of mice after acute administration of MAP. OT (2.5 microg, i.c.v.) significantly inhibited the reduction of DOPAC/DA and HVA/DA ratios. However, Ato decreased the ratio of DOPAC/DA significantly in mice compared with OT (2.5 microg) in combination with MAP. There was no significant change in serotonin (5-HT) metabolism in mice after a single administration of MAP. These results suggested that OT inhibited the MAP-induced hyperactivity by altering the DA turnover in the mesolimbic region of mice.
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Axonal release of oxytocin from the PVN may have effects on hedonic food consumption via dopaminergic mesolimbic neurons in the ventral tegmental area (VTA).
“Axonal release of oxytocin from the PVN may also have effects on hedonic food consumption via dopaminergic mesolimbic neurons in the ventral tegmental area (VTA)(25, 26, 27).”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [27]
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- Authors
- Qi, J., Yang, J.-Y., Song, M., Li, Y., Wang, F., & Wu, C.-F.
- Affiliations
- Shenyang Pharmaceutical University (CN)
- Venue
- Naunyn-Schmiedeberg s Archives of Pharmacology
- Published
- 2007-12-19
- Volume
- 376
- Issue
- 6
- Pages
- 441-448
- ISSN
- 0028-1298 (ISSN-L)
- 1432-1912
- OpenAlex
- W2028244020
- Cited by
- 129
- References
- 66
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 6 · 2019: 9 · 2018: 9 · 2017: 13 · 2016: 12 · 2015: 10 · 2014: 14 · 2013: 16 · 2012: 5
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Naunyn-Schmiedeberg s Archives of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, methamphetamine, locomotor hyperactivity, dopamine turnover, mesolimbic system, DOPAC, homovanillic acid, atosiban, oxytocin receptor, serotonin metabolism, striatum, nucleus accumbens, prefrontal cortex
- MeSH terms
- Central Nervous System Stimulants, Analysis of Variance, Animals, Behavior, Animal, Corpus Striatum, Dopamine, Dose-Response Relationship, Drug, Homovanillic Acid, Male, Methamphetamine, Motor Activity, Nucleus Accumbens, Oxytocin, Serotonin, Vasotocin, 3,4-Dihydroxyphenylacetic Acid, Prefrontal Cortex, Receptors, Oxytocin, Mice, Cerebrum
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