The DOI matches its Crossref record.
Alzheimerʼs PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide
Abstract
Mutations in the presenilin-1 (PS-1) gene on chromosome 14 are linked to autosomal dominant early-onset Alzheimer's disease. The amino acid sequence of PS-1 predicts an integral membrane protein and immunocytochemical studies indicate that PS-1 is localized to endoplasmic reticulum (ER). We report that expression of PS-1 mutation L286V in cultured PC12 cells exaggerates Ca2+ responses to agonists (carbachol and bradykinin) that induce Ca2+ release from ER. Cells expressing L286V exhibit enhanced elevations of [Ca2+]i following exposure to amyloid beta-peptide (A beta) and increased vulnerability to A beta toxicity. An antagonist of voltage-dependent calcium channels (nifedipine), and a blocker of Ca2+ release from ER (dantrolene), counteract the adverse consequences of the PS-1 mutation. By perturbing Ca2+ homeostasis, PS-1 mutations may sensitize neurons to A beta-induced apoptosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
Bezprozvanny, I., & Mattson, M. P. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.005 · Cited by 938
Self-citationYu, Z., Luo, H., Fu, W., & Mattson, M. P. (1999) · Experimental Neurology · doi:10.1006/exnr.1998.7002 · Cited by 438
Self-citationSheehan, J. P., Swerdlow, R. H., Miller, S. W., Davis, R. E., Parks, J. K., Parker, W. D., & Tuttle, J. B. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04612.1997 · Cited by 249
Presenilin-1 regulates neuronal differentiation during neurogenesis
Handler, M., Yang, X., & Shent, J. (2000) · Development · doi:10.1242/dev.127.12.2593 · Cited by 225
Guo, Q., Sebastian, L., Sopher, B. L., Miller, M. W., Ware, C. B., Martin, G. M., & Mattson, M. P. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0721019.x · Cited by 197
Self-citationGuo, Q., Robinson, N., & Mattson, M. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.20.12341 · Cited by 196
Self-citationCalcium signalling and Alzheimer's disease
Berridge, M. J. (2011) · Neurochemical Research · doi:10.1007/s11064-010-0371-4 · Cited by 167
Pellegrini, L., Passer, B. J., Tabaton, M., Ganjei, J. K., & D'Adamio, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.21011 · Cited by 139
Biology of Aβ Amyloid in Alzheimer's Disease
Wisniewski, T., Ghiso, J., & Frangione, B. (1997) · Neurobiology of Disease · doi:10.1006/nbdi.1997.0147 · Cited by 134
Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease
Hashimoto, S., & Saido, T. C. (2018) · Open Biology · doi:10.1098/rsob.180024 · Cited by 129
Kelliher, M., Fastbom, J., Cowburn, R. F., Bonkale, W., Ohm, T. G., Ravid, R., Sorrentino, V., & O'Neill, C. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00042-1 · Cited by 129
Gluthatione level is altered in lymphoblasts from patients with familial Alzheimer’s disease
Cecchi, C., Latorraca, S., Sorbi, S., Iantomasi, T., Favilli, F., Vincenzini, M. T., & Liguri, G. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00751-x · Cited by 101
Presenilins and Alzheimer's disease
Kim, T.-W., & Tanzi, R. E. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80089-x · Cited by 97
Suen, K.-C., Yu, M.-S., So, K.-F., Chang, R. C.-C., & Hugon, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306503200 · Cited by 95
Arnsten, A. F. T., Datta, D., Leslie, S., Yang, S.-T., Wang, M., & Nairn, A. C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903671116 · Cited by 74
Huang, H.-M., Zhang, H., Xu, H., & Gibson, G. E. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(02)00222-3 · Cited by 61
ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease
Sadleir, K. R., Popovic, J., & Vassar, R. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005769 · Cited by 60
Metadata
- Authors
- Guo, Q., Furukawa, K., Sopher, B. L., Pham, D. G., Xie, J., Robinson, N., Martin, G. M., & Mattson, M. P.
- Venue
- NeuroReport
- Published
- 1996-12
- Volume
- 8
- Issue
- 1
- Pages
- 379-383
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2054499580
- Cited by
- 320
- References
- 0
- FWCI
- 16.04
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
