Circadian change of dopaminergic neuron activity: effects of constant light and melatonin
Abstract
Twenty-four hour profiles of tuberoinfundibular (TI), nigrostriatal and mesolimbic dopaminergic (DA) neuronal activities were assessed in estrogen-primed ovariectomized rats using DOPAC and DOPA levels in terminal regions of DA neurons. Significant decreases in DOPAC and DOPA levels in the median eminence were observed at 17.00 and 21.00 h, which corresponded with higher serum prolactin levels. DOPAC or DOPA levels in the striatum and nucleus accumbens were, however, significantly higher during the dark (21.00-05.00 h) phase. In rats kept under conditions of continuous light, no late afternoon decline in median eminence DOPA was observed; this decline could be reinstated by repeated injections of melatonin between 18.00 and 01.30 h for 3 days. In summary, circadian rhythms of central DA neurons were shown and melatonin may play an entraining role.
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Major neurotransmitters implicated in mood regulation, including serotonin, norepinephrine, and dopamine, have a circadian rhythm in their levels, release, and synthesis-related enzymes.
“Indeed some of the major neurotransmitters that have been implicated in mood regulation, including serotonin, norepinephrine and dopamine, have a circadian rhythm in their levels, release, and synthesis-related enzymes (Weiner et al., 1992; Shieh et al., 1997; Aston-Jones et al., 2001; Barassin et al., 2002; Khaldy et al., 2002; Castaneda et al., 2004; Weber et al., 2004; Malek et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Shieh et al., 1997
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- Authors
- Shieh, K.-R., Chu, Y.-S., & Pan, J.-T.
- Affiliations
- National Yang Ming University (TW)
- ORCID
- Chu, Yeh-Shiu
- Venue
- Neuroreport
- Published
- 1997-07
- Volume
- 8
- Issue
- 9
- Pages
- 2283-2287
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W1996056872
- Cited by
- 53
- References
- 17
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 3 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 1
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- circadian rhythm, dopaminergic neurons, nigrostriatal dopamine, mesolimbic dopamine system, DOPAC, DOPA, median eminence, striatum, nucleus accumbens, prolactin, melatonin, light entrainment, ovariectomized rats
- MeSH terms
- Animals, Circadian Rhythm, Dihydroxyphenylalanine, Dopamine, Female, Light, Melatonin, Neurons, Prolactin, Time Factors, 3,4-Dihydroxyphenylacetic Acid, Rats, Sprague-Dawley, Rats
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