Circadian Rhythms, the Mesolimbic Dopaminergic Circuit, and Drug Addiction
Open accessAbstract
Drug addiction is a devastating disease that affects millions of individuals worldwide. Through better understanding of the genetic variations that create a vulnerability for addiction and the molecular mechanisms that underlie the progression of addiction, better treatment options can be created for those that suffer from this condition. Recent studies point to a link between abnormal or disrupted circadian rhythms and the development of addiction. In addition, studies suggest a role for specific genes that make up the molecular clock in the regulation of drug sensitivity, sensitization, and reward. The influence of circadian genes and rhythms on drug-induced behaviors may be mediated through the mesolimbic dopaminergic system. This system has long been implicated in the development of addiction, and recent evidence supports a regulatory role for the brain's central pacemaker and circadian gene expression in the regulation of dopaminergic transmission. This review highlights the association between circadian genes and drug addiction, and the possible role of the mesolimbic dopaminergic system in this association.
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Circadian genes in brain regions outside the SCN contribute locally to the control of neuronal metabolism, neurotransmitter synthesis and activity, and disruption of these functions might contribute to brain disorders.
“circadian genes in other brain regions outside of this central pace-maker also contribute locally to the control of neuronal metabolism, neurotransmitter synthesis and activity, and the disruption of these functions might contribute to brain disorders264,304–315”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [307]
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- Authors
- McClung, C. A.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- McClung, Colleen A.
- ORCID
- McClung, Colleen A.
- Venue
- The Scientific World JOURNAL
- Publisher
- Wiley
- Published
- 2007
- Volume
- 7
- Pages
- 194-202
- ISSN
- 1537-744X (ISSN-L)
- PMC
- PMC5901358
- OpenAlex
- W2100880494
- Cited by
- 99
- References
- 72
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 8 · 2014: 10 · 2013: 2 · 2012: 10
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- The Scientific World JOURNAL (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Drug Abuse
- National Institute of Mental Health
- Brain and Behavior Research Foundation
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- circadian rhythm, drug addiction, mesolimbic dopamine system, circadian genes, molecular clock, dopamine signaling, drug sensitivity, drug sensitization, drug reward, central pacemaker
- MeSH terms
- Animals, Behavior, Behavior, Animal, Circadian Rhythm, Dopamine, Humans, Trans-Activators, Substance-Related Disorders, CLOCK Proteins
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