A role for the circadian genes in drug addiction
Open accessAbstract
Diurnal and circadian rhythms are prominent in nearly all bodily functions. Chronic disruptions in normal sleep wake and social schedules can lead to serious health problems such as those seen in shift worker's syndrome. Moreover, genetic disruptions in normal circadian gene functions have recently been linked to a variety of psychiatric conditions including depression, bipolar disorder, seasonal affective disorder and alcoholism. Recent studies are beginning to determine how these circadian genes and rhythms are involved in the development of drug addiction. Several of these studies suggest an important role for these genes in limbic regions of the brain, outside of the central circadian pacemaker in the suprachiasmatic nucleus (SCN). This review summarizes some of the basic research into the importance of circadian genes in drug addiction.
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Circadian disruptions, such as social jet-lag, during adolescence increase vulnerability to substance use, and conversely, chronic exposure to these substances can lead to long-lasting changes in the circadian and sleep networks.
“Circadian disruptions (such as social jet-lag) during adolescence increase vulnerability to substance use, and conversely, chronic exposure to these substances can lead to long-lasting changes in the circadian and sleep networks154.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [154]
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“…and pre-clinical studies provide strong evidence that circadian rhythms and the genes that make up the molecular clock play a key role in the expression of mood-related symptoms in psychiatric disorders (Falcón and McClung, 2009; Karatsoreos, 2014; Landgraf et al., 2014; Logan et al., 2014).”
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- Authors
- Falcón, E., & McClung, C. A.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- McClung, Colleen A.
- ORCID
- McClung, Colleen A.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 56
- Pages
- 91-96
- ISSN
- 0028-3908 (ISSN-L)
- PMC
- PMC2635341
- OpenAlex
- W2016646738
- Cited by
- 135
- References
- 64
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 9 · 2021: 10 · 2020: 6 · 2019: 4 · 2018: 11 · 2017: 6 · 2016: 6 · 2015: 9 · 2014: 11 · 2013: 18 · 2012: 10
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (K01DA019541)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- circadian genes, drug addiction, circadian rhythm, diurnal cycle, limbic system, suprachiasmatic nucleus, sleep disruption, mental illness, alcoholism
- MeSH terms
- Animals, Circadian Rhythm, Humans, Illicit Drugs, Suprachiasmatic Nucleus, Substance-Related Disorders
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