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The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Early intraneuronal Aβ deposition in the hippocampus of APP transgenic mice

Shie, Feng-Shiun, LeBoeur, Renée C., Jin, Lee-Way·2003·NeuroReport
DOI 10.1097/00001756-200301200-00023
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Abstract

Increasing evidence suggests that intraneuronal amyloid-beta (Abeta) accumulation may be an early event in Alzheimer's disease (AD) pathogenesis. However direct in vivo evidence regarding initial Abeta seeding is missing. Using an APP transgenic mouse model, our sensitive immunocytochemical procedures revealed a novel intraneuronal Abeta deposition in the somas of hippocampal CA1/subiculum neurons far in advance of the occurrence of extracellular Abetaplaques. These deposits increased exponentially with age and were elevated approximately 4-fold (p < 0.001) by high fat/high cholesterol diet. Abeta40 and Abeta42 were the major constituents of these deposits and were co-localized with lysosomal markers. Our results are consistent with the notion that the earliest Abeta deposition occurs intraneuronally, prior to extracellular amyloid plaque formation.

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Crossref · 10.1097/00001756-200301200-00023

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12 of 12 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 39

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Metadata

Authors
Shie, F.-S., LeBoeur, R. C., & Jin, L.-W.
Venue
NeuroReport
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-01
Volume
14
Issue
1
Pages
123-129
ISSN
0959-4965
DOI
10.1097/00001756-200301200-00023
Cited by
70
References
12
Language
en

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