Aβ42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease

Mochizuki, Akihide; Tamaoka, Akira; Shimohata, Atsushi; Komatsuzaki, Yasuko; Shoji, Shin'ichi

doi:10.1016/s0140-6736(99)04937-5

Cited by 85Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Aβ42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease

Mochizuki, Akihide, Tamaoka, Akira, Shimohata, Atsushi, Komatsuzaki, Yasuko, Shoji, Shin'ichi·2000·The Lancet

DOI 10.1016/s0140-6736(99)04937-5

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Abstract

Immunohistochemistry with end-specific antibodies against C-termini of Abeta40 and Abeta42 in Alzheimer's disease showed that Abeta42 immunoreactivity was localised intracellularly in subpopulations of neurons of patients with Alzheimer's disease.

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Early increases in intracellular amyloid-β levels have been observed in vulnerable neurons of Alzheimer's disease human patients and animal models, preceding the appearance of amyloid-β plaques.
“Apart from extracellular deposition, early increases in intracellular Aβ levels have been observed in vulnerable neurons of AD human patients [41, 78] and animal models [22, 87, 110], preceding the appearance of Aβ plaques.”
From Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology (2023) · cites this paper as [78]
Intraneuronal amyloid-β accumulation in specific Alzheimer's disease-vulnerable neurons precedes the formation of extracellular amyloid-β plaques both in Alzheimer's disease patients and mouse models.
“Additionally, it has been shown that intraneuronal Aβ accumulation in specific AD-vulnerable neurons precedes the formation of extracellular Aβ plaques both in AD patients [41, 78] and mouse models [22, 87, 110].”
From Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology (2023) · cites this paper as [78]
Intraneuronal Aβ accumulation has been found in the brains of patients presenting AD or mild cognitive impairment and is suggested to represent an early step in AD neuropathology.
“Intraneuronal Aβ accumulation has been found in the brains of patients presenting AD or mild cognitive impairment [3, 21, 41, 47, 78], and studies suggest that this phenomenon represents an early step in AD neuropathology [40].”
From Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology (2023) · cites this paper as [78]
Two publications appeared in January 2000 on the intraneuronal accumulation of particularly Aβ42 by light microscopy within neurons of human brain.
“Two publications appeared in January 2000 on the intraneuronal accumulation of particularly Aβ42 by light microscopy within neurons of human brain.”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [123]

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Authors: Mochizuki, A., Tamaoka, A., Shimohata, A., Komatsuzaki, Y., & Shoji, S.
Affiliations: University of Tsukuba (JP)
ORCID: Tamaoka, Akira
Venue: The Lancet
Publisher: Elsevier BV
Published: 2000-01
Volume: 355
Issue: 9197
Pages: 42-43
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(99)04937-5
OpenAlex: W1967168807
Cited by: 85
References: 5
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 1 · 2018: 4 · 2016: 1 · 2014: 3 · 2013: 2 · 2012: 4
FWCI: 4.49
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, amyloid-beta 42, amyloid plaques, non-pyramidal neurons, intracellular amyloid-beta, Aβ40
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Brain, Female, Humans, Male, Middle Aged, Neurons, Case-Control Studies, Amyloid beta-Peptides

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Aβ42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease

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