The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Diet-induced hypercholesterolemia enhances brain Aβ accumulation in transgenic mice
Abstract
Epidemiological data show correlations between hypercholesterolemia and Alzheimer's disease (AD). We test the hypothesis that hypercholesterolemia modulates Abeta deposition in mice overexpressing the human APP695 Swedish mutation (K670N and M671L) (TgAPPsw). Feeding mice a high fat/high cholesterol (HFHC) diet for 7-10 months increased total cholesterol levels by 4-fold. The extent of Abeta immunostained plaque-like deposits were significantly higher for mice fed the HFHC diet as compared with mice fed rodent chow. Extent of deposits correlated inversely with plasma levels of HDL and directly to apolipoprotein E. Overall, plasma lipoproteins may be an important factor in induction of AD-like plaques in mice. The lowering of plasma lipids may be therapeutic for AD patients.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
An inverse relationship has been reported between plasma HDL-cholesterol and cerebral β-amyloid load in Tg2576 mice fed an atherogenic diet.
“An inverse relationship has been reported between plasma HDL-cholesterol and cerebral β-amyloid load in Tg2576 mice fed an atherogenic diet [10], and it has been shown that HDL-cholesterol increases the degradation of Aβ by microglia in vitro [29].”
From ApoB100/LDLR-/- Hypercholesterolaemic Mice as a Model for Mild Cognitive Impairment and Neuronal Damage (2011) · cites this paper as [10]
Hypercholesterolaemia accelerates cerebral Aβ deposition in APP-transgenic mice.
“and the acceleration of cerebral Aβ deposition in APP-transgenic mice [9], [10].”
From ApoB100/LDLR-/- Hypercholesterolaemic Mice as a Model for Mild Cognitive Impairment and Neuronal Damage (2011) · cites this paper as [10]
Citations
Cites
Mato, M., Ookawara, S., Sakamoto, A., Aikawa, E., Ogawa, T., Mitsuhashi, U., Masuzawa, T., Suzuki, H., Honda, M., Yazaki, Y., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3269 · Cited by 187
Flagged first, then by citations
Research works printed but not linked: 23
- Selkoe, 2001, Physiol Rev, 81, 741, 10.1152/physrev.2001.81.2.741 · DOI · Paper page
- Racchi, 1997, Biochem J, 322, 893, 10.1042/bj3220893 · DOI
- Simons, 1998, Proc Natl Acad Sci USA, 95, 6460, 10.1073/pnas.95.11.6460 · DOI
- Puglielli, 2001, Nature Cell Biol, 3, 905, 10.1038/ncb1001-905 · DOI · Paper page
- Giubilei, 1990, Acta Neurol Scand, 81, 84, 10.1111/j.1600-0404.1990.tb00936.x · DOI
- Lehtonen, 1986, Age Ageing, 15, 267, 10.1093/ageing/15.5.267 · DOI
- Kuo, 1998, Biochem Biophys Res Commun, 252, 711, 10.1006/bbrc.1998.9652 · DOI · Paper page
- Caramelli, 1999, Acta Neurol Scand, 100, 61, 10.1111/j.1600-0404.1999.tb00724.x · DOI · Paper page
- Chandra, 1998, Neuroepidemiology, 17, 225, 10.1159/000026175 · DOI
- Fassbender, 2001, Proc Natl Acad Sci USA, 98, 5856, 10.1073/pnas.081620098 · DOI · Paper page
- Wolozin, 2001, Proc Natl Acad Sci USA, 98, 5371, 10.1073/pnas.101123198 · DOI
- Sparks, 1994, Exp Neurol, 126, 88, 10.1006/exnr.1994.1044 · DOI · Paper page
- Refolo, 2000, Neurobiol Dis, 7, 321, 10.1006/nbdi.2000.0304 · DOI · Paper page
- Howland, 1998, J Biol Chem, 273, 16576, 10.1074/jbc.273.26.16576 · DOI
- Hsiao, 1995, Neuron, 15, 1203, 10.1016/0896-6273(95)90107-8 · DOI
- Paigen, 1985, Atherosclerosis, 57, 65, 10.1016/0021-9150(85)90138-8 · DOI
- Streit, 1997, J Mol Med, 75, 130, 10.1007/s001090050097 · DOI
- Dietschy, 2001, Curr Opin Lipidol, 12, 105, 10.1097/00041433-200104000-00003 · DOI · Paper page
- Dehouck, 1997, J Cell Biol, 138, 877, 10.1083/jcb.138.4.877 · DOI · Paper page
- Oram, 1996, J Lipid Res, 37, 2473, 10.1016/S0022-2275(20)37453-8 · DOI
- Farhangrazi, 1997, Neuroreport, 8, 1127, 10.1097/00001756-199703240-00013 · DOI
- deVries, 1995, Biochem Pharmacol, 50, 271, 10.1016/0006-2952(95)00127-L · DOI
- Koldamova, 2001, Biochemistry, 40, 3553, 10.1021/bi002186k · DOI · Paper page
Cited by
Sorted by citations
Cao, D., Lu, H., Lewis, T. L., & Li, L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703561200 · Cited by 336
Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models
Patel, N. V., Gordon, M. N., Connor, K. E., Good, R. A., Engelman, R. W., Mason, J., Morgan, D. G., Morgan, T. E., & Finch, C. E. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.09.014 · Cited by 329
Ketogenic Diet in Alzheimer’s Disease
Rusek, M., Pluta, R., Ułamek-Kozioł, M., & Czuczwar, S. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163892 · Cited by 319
A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease
Van der Auwera, I., Wera, S., Van Leuven, F., & Henderson, S. T. (2005) · Nutrition & Metabolism · doi:10.1186/1743-7075-2-28 · Cited by 307
Koldamova, R. P., Lefterov, I. M., Staufenbiel, M., Wolfe, D., Huang, S., Glorioso, J. C., Walter, M., Roth, M. G., & Lazo, J. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411420200 · Cited by 279
Associations Between Serum Cholesterol Levels and Cerebral Amyloidosis
Reed, B., Villeneuve, S., Mack, W., DeCarli, C., Chui, H. C., & Jagust, W. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.5390 · Cited by 267
Candela, P., Gosselet, F., Miller, F., Buee-Scherrer, V., Torpier, G., Cecchelli, R., & Fenart, L. (2008) · Endothelium · doi:10.1080/10623320802487759 · Cited by 117
Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice
Cao, D., Fukuchi, K.-I., Wan, H., Kim, H., & Li, L. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.011 · Cited by 106
Lefterov, I., Bookout, A., Wang, Z., Staufenbiel, M., Mangelsdorf, D., & Koldamova, R. (2007) · Molecular Neurodegeneration · doi:10.1186/1750-1326-2-20 · Cited by 89
Hirsch-Reinshagen, V., & Wellington, C. L. (2007) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32813aeabf · Cited by 61
Zhao, X.-S., Wu, Q., Peng, J., Pan, L.-H., Ren, Z., Liu, H.-T., Jiang, Z.-S., Wang, G.-X., Tang, Z.-H., & Liu, L.-S. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2016.6055 · Cited by 46
Li, L., Cao, D., Desmond, R., Rahman, A., Lah, J. J., Levey, A. I., & Zamrini, E. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000164271 · Cited by 45
Abisambra, J. F., Fiorelli, T., Padmanabhan, J., Neame, P., Wefes, I., & Potter, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008556 · Cited by 42
Ramírez, C., Sierra, S., Tercero, I., Vázquez, J. A., Pineda, A., Manrique, T., & Burgos, J. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022712 · Cited by 31
Metadata
- Authors
- Shie, F.-S., Jin, L.-W., Cook, D. G., Leverenz, J. B., & LeBoeuf, R. C.
- Venue
- Neuroreport
- Published
- 2002-03
- Volume
- 13
- Issue
- 4
- Pages
- 455-459
- ISSN
- 0959-4965
- Cited by
- 184
- References
- 1
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
