Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain
Abstract
Eukaryotic translation factor 4E (eIF4E) plays a key role in regulating protein translation. It was thought that in order to maintain neuronal functions, tau protein is continuously generated to compensate those being hyperphosphorylated and compromised in its ability to promote and maintain microtubule assembly in Alzheimer's disease. If eIF4E is involved in tau mRNA translation, level of eIF4E phosphorylation should be changed. In the current study, we found a dramatic increase of phosphorylated eIF4E in Alzheimer's disease, especially in those cases with late stages of neurofibrillary changes. Level of eIF4E phosphorylation is significantly correlated with total- and Alzheimer hyperphosphorylated taus. These data suggest that the increase of eIF4E phosphorylation is involved in formation of Alzheimer neurofibrillary changes.
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Other studies showed significant increases of P-p70S6K (T389 and T421/S424), P-mTOR (S2481), P-eIF4E and P-4E-BP1 (T70 and S65) in homogenates of the medial temporal cortex in AD patients as compared to control brains.
“Other studies showed significant increases of P-p70S6K (T389 and T421/S424), P-mTOR (S2481), P-eIF4E and P-4E-BP1 (T70 and S65) in homogenates of the medial temporal cortex in AD patients as compared to control brains [92, 93].”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [93]
The levels of the mTOR signalling markers were significantly and positively correlated with total τ and P-t.
“The levels of the mTOR signalling markers were significantly and positively correlated with total τ and P-t[92, 93].”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [93]
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PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease
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- Authors
- Li, X., An, W.-L., Alafuzoff, I., Soininen, H., Winblad, B., & Pei, J.-J.
- Affiliations
- Karolinska Institutet (SE)
- Venue
- NeuroReport
- Published
- 2004-10
- Volume
- 15
- Issue
- 14
- Pages
- 2237-2240
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2086834321
- Cited by
- 84
- References
- 3
- Citations by year
- 2026: 13 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 8 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- eIF4E, eIF4E phosphorylation, Alzheimer's disease, tau hyperphosphorylation, neurofibrillary tangles, mRNA translation
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Female, Humans, Male, Middle Aged, Phosphorylation, Eukaryotic Initiation Factor-4E
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