Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer’s disease

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Grundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M., Wisniewski, H. M., & Binder, L. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4913 · Cited by 3,676 · see citing works

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668 · see citing works

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

Boulton, T. G., Nye, S. H., Robbins, D. J., Ip, N. Y., Radzlejewska, E., Morgenbesser, S. D., DePinho, R. A., Panayotatos, N., Cobb, M. H., & Yancopoulos, G. D. (1991) · Cell · doi:10.1016/0092-8674(91)90098-j · Cited by 1,876 · see citing works

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

Grundke, I., Iqbal, K., Quinlan, M., Tung, Y. C., Zaidi, M. S., & Wisniewski, H. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38495-8 · Cited by 1,780 · see citing works

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

Anderson, N. G., Maller, J. L., Tonks, N. K., & Sturgill, T. W. (1990) · Nature · doi:10.1038/343651a0 · Cited by 1,064 · see citing works

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

Braak, F., Braak, H., & Mandelkow, E. (1994) · Acta Neuropathologica · doi:10.1007/bf00293315 · Cited by 769 · see citing works

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase

Hanger, D. P., Hughes, K., Woodgett, J. R., Brion, J.-P., & Anderton, B. H. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90774-2 · Cited by 737 · see citing works

DEFECTIVE BRAIN MICROTUBULE ASSEMBLY IN ALZHEIMER'S DISEASE

Iqbal, K., Zaidi, T., Wen, G. Y., Grundke, I., MERZ, P. A., Shaikh, S., Wisniewski, H., Alafuzoff, I. I., & Winblad, B. G. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92134-3 · Cited by 727 · see citing works

Identification of normal and pathological aging in prospectively studied nondemented elderly humans

Dickson, D. W., Crystal, H. A., Mattiace, L. A., Masur, D. M., Blau, A. D., Davies, P., Yen, S.-H., & Aronson, M. K. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90027-u · Cited by 643 · see citing works

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

Gomez, N. M., & Cohen, P. (1991) · Nature · doi:10.1038/353170a0 · Cited by 580 · see citing works

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer‐like state.

Drewes, G., Lichtenberg‐Kraag, B., Döring, F., Mandelkow, E. M., Biernat, J., Goris, J., Dorée, M., & Mandelkow, E. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05272.x · Cited by 565 · see citing works

Phosphoprotein Phosphatase Activities in Alzheimer Disease Brain

Gong, C., Singh, T. J., Grundke‐Iqbal, I., & Iqbal, K. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03603.x · Cited by 527 · see citing works

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells

Lovestone, S., Reynolds, C. H., Latimer, D. A., Davis, D. R., Anderton, B. H., Gallo, J., Hanger, D. P., Mulot, S., Marquardt, B., Stabel, S., et al. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00246-3 · Cited by 470 · see citing works

Distribution of Active Glycogen Synthase Kinase 3β (GSK-3β) in Brains Staged for Alzheimer Disease Neurofibrillary Changes

Pei, J.-J., Braak, E., Braak, H., Grundke-Iqbal, I., Iqbal, K., Winblad, B., & Cowburn, R. F. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199909000-00011 · Cited by 459 · see citing works

Activation and redistribution of c‐Jun N‐terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease

Zhu, X.-W., Raina, A., Rottkamp, C., Aliev, G., Perry, G., Boux, H., & Smith, M. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00046.x · Cited by 440 · see citing works

Phosphatase Activity Toward Abnormally Phosphorylated τ: Decrease in Alzheimer Disease Brain

Gong, C., Shaikh, S., Wang, J., Zaidi, T., Grundke, I., & Iqbal, K. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65020732.x · Cited by 440 · see citing works

Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques

Braak, H., Braak, E., Grundke-Iqbal, I., & Iqbal, K. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90288-0 · Cited by 432 · see citing works

Silver staining of Alzheimer's neurofibrillary changes by means of physical development.

Gallyas, F. (1971) · PubMed · Cited by 411 · see citing works

New Phosphorylation Sites Identified in Hyperphosphorylated Tau (Paired Helical Filament‐Tau) from Alzheimer's Disease Brain Using Nanoelectrospray Mass Spectrometry

Hanger, D. P., Betts, J. C., Loviny, T. L. F., Blackstock, W. P., & Anderton, B. H. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71062465.x · Cited by 378 · see citing works

Activation of p38 Kinase Links Tau Phosphorylation, Oxidative Stress, and Cell Cycle-Related Events in Alzheimer Disease

Zhu, X., Rottkamp, C. A., Boux, H., Takeda, A., Perry, G., & Smith, M. A. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.10.880 · Cited by 378 · see citing works

Distribution, Levels, and Activity of Glycogen Synthase Kinase-3 in the Alzheimer Disease Brain

PEI, J.-J., TANAKA, T., TUNG, Y.-C., BRAAK, E., IQBAL, K., & GRUNDKE-IQBAL, I. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199701000-00007 · Cited by 371 · see citing works

Phosphorylation of Tau at Both Thr 231 and Ser 262 Is Required for Maximal Inhibition of Its Binding to Microtubules

Sengupta, A., Kabat, J., Novak, M., Wu, Q., Grundke-Iqbal, I., & Iqbal, K. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0813 · Cited by 363 · see citing works

Association of mitogen-activated protein kinase with the microtubule cytoskeleton.

Reszka, A. A., Seger, R., Diltz, C. D., Krebs, E. G., & Fischer, E. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8881 · Cited by 357 · see citing works

Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the ‘two hit’ hypothesis

Zhu, X., Castellani, R. J., Takeda, A., Nunomura, A., Atwood, C., Perry, G. L., & Smith, M. A. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00342-6 · Cited by 309 · see citing works

The Endogenous and Cell Cycle-dependent Phosphorylation of tau Protein in Living Cells: Implications for Alzheimer’s Disease

Illenberger, S., Zheng‐Fischhöfer, Q., Preuß, U., Stamer, K., Baumann, K., Trinczek, B., Biernat, J., Godemann, R., Mandelkow, E., & Mandelkow�, E. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.6.1495 · Cited by 300 · see citing works

Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation.

Perry, G., Roder, H., Nunomura, A., Takeda, A., Friedlich, A., Zhu, X.-W., Raina, A., Holbrook, N., Siedlak, S., Harris, P., et al. (1999) · NeuroReport · doi:10.1097/00001756-199908020-00035 · Cited by 296 · see citing works

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A₁ Implications for Alzheimer's disease

Goedert, M., Cohen, E. S., Jakes, R., & Cohen, P. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81418-l · Cited by 272 · see citing works

Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis

Alafuzoff, I. I., Iqbal, K., Fridén, H., Adolfsson, R., & Winblad, B. G. (1987) · Acta Neuropathologica · doi:10.1007/bf00688184 · Cited by 265 · see citing works

Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease.

Iqbal, K., Grundke, I., Smith, A. J., George, L., Tung, Y. C., & Zaidi, T. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.14.5646 · Cited by 260 · see citing works

Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3β and cyclin-dependent kinase 5, a component of TPK II

Yamaguchi, H., Ishiguro, K., Uchida, T., Takashima, A., Lemere, C. A., & Imahori, K. (1996) · Acta Neuropathologica · doi:10.1007/s004010050513 · Cited by 253 · see citing works

Phosphorylated Map Kinase (ERK1, ERK2) Expression is Associated with Early Tau Deposition in Neurones and Glial Cells, but not with Increased Nuclear DNA Vulnerability and Cell Death, in Alzheimer Disease, Pick's Disease, Progressive Supranuclear Palsy and Corticobasal Degeneration

Ferrer, I., Blanco, R., Carmona, M., Ribera, R., Goutan, E., Puig, B., Rey, M. J., Cardozo, A., Viñals, F., & Ribalta, T. (2001) · Brain Pathology · doi:10.1111/j.1750-3639.2001.tb00387.x · Cited by 239 · see citing works

Hyperphosphorylation of tau in PHF.

Morishima-kawashima, M., Hasegawa, M., Takio, K., Suzuki, M., Yoshida, H., Watanabe, A., Titani, K., & Ihara, Y. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00027-c · Cited by 238 · see citing works

Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies

Ferrer, I., Blanco, R. E., Carmona, M., & Puig, B. (2001) · Journal of Neural Transmission · doi:10.1007/s007020100016 · Cited by 207 · see citing works

τ is phosphorylated by GSK‐3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A‐kinase

Wang, J.-Z., Wu, Q., Smith, A., Grundke, I., & Iqbal, K. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01090-4 · Cited by 199 · see citing works

Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease

Ledesma, M. D., Correas, I., Ávila, J., & Díaz‐Nido, J. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81278-t · Cited by 189 · see citing works

Selective Phosphorylation of Adult Tau Isoforms in Mature Hippocampal Neurons Exposed to Fibrillar Aβ

Ferreira, A., Lu, Q., Orecchio, L., & Kosik, K. S. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1997.0615 · Cited by 178 · see citing works

Activation of the JNK/p38 Pathway Occurs in Diseases Characterized by Tau Protein Pathology and Is Related to Tau Phosphorylation But Not to Apoptosis

Atzori, C., Ghetti, B. F., Piva, R., Srinivasan, A., Zolo, P., Delisle, M. B., Mirra, S. S., & Migheli, A. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.12.1190 · Cited by 175 · see citing works

Silver Impregnation of Alzheimer's Neurofibrillary Changes Counterstained for Basophilic Material and Lipofuscin Pigment

Braak, H., Braak, E., Ohm, T. G., & Böhl, J. (1988) · Stain Technology · doi:10.3109/10520298809107184 · Cited by 171 · see citing works

Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration

Pei, J.-J., Braak, E., Braak, H., Grundke-Iqbal, I., Iqbal, K., Winblad, B., & Cowburn, R. F. (2001) · Journal of Alzheimer's Disease · doi:10.3233/jad-2001-3107 · Cited by 165 · see citing works

p42 mitogen-activated protein kinase in brain: Prominent localization in neuronal cell bodies and dendrites

Fiore, R. S., Bayer, V. E., Pelech, S., Posada, J. A., Cooper, J. A., & Baraban, J. M. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90516-i · Cited by 158 · see citing works

Okadaic-Acid-Induced Inhibition of Protein Phosphatase 2A Produces Activation of Mitogen-Activated Protein Kinases ERK1/2, MEK1/2, and p70 S6, Similar to That in Alzheimer's Disease

Pei, J.-J., Gong, C., An, W., Winblad, B. G., Cowburn, R. F., Grundke, I., & Iqbal, K. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63445-1 · Cited by 142 · see citing works

Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease

Arendt, T., Holzer, M., Grossmann, A., Zedlick, D., & Brückner, M. K. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00146-a · Cited by 122 · see citing works

The regulation of phosphorylation of τ in SY5Y neuroblastoma cells: the role of protein phosphatases

Tanaka, T., Zhong, J., Iqbal, K., Trenkner, E., & Grundke, I. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00346-9 · Cited by 113 · see citing works

Brain Protein Kinase PK40erk Converts TAU into a PHF-like Form as Found in Alzheimer′s Disease

Roder, H. M., Eden, P. A., & Ingram, V. M. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1672 · Cited by 110 · see citing works

Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease

Iqbal, K., & Grundke, I. (1991) · Molecular Neurobiology · doi:10.1007/bf02935561 · Cited by 108 · see citing works

Polyethylene glycol embedding: a technique compatible with immunocytochemistry, enzyme histochemistry, histofluorescence and intracellular staining

Smithson, K. G., MacVicar, B. A., & Hatton, G. I. (1983) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(83)90016-x · Cited by 107 · see citing works

A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope.

Ishiguro, K., Omori, A., Sato, K., Tomizawa, K., Imahori, K., & Uchida, T. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90259-v · Cited by 106 · see citing works

Inhibition of PP‐2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356

Bennecib, M., Gong, C., Grundke, I., & Iqbal, K. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02127-5 · Cited by 105 · see citing works

Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration

Gärtner, U., Holzer, M., & Arendt, T. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00059-7 · Cited by 95 · see citing works

Parvalbumin-immunoreactive structures in the hippocampus of the human adult

Braak, E., Strotkamp, B., & Braak, H. (1991) · Cell and Tissue Research · doi:10.1007/bf00305720 · Cited by 94 · see citing works

Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease.

Hyman, B. T., Elvhage, T. E., & Reiter, J. S. (1994) · PubMed Central · Cited by 92 · see citing works

Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites.

Trojanowski, J., Mawal-Dewan, M., Schmidt, M., Martin, J. A., & Lee, V. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91286-2 · Cited by 91 · see citing works

Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals.

Pei, J.-J., Sersen, E., Iqbal, K., & Grundke-Iqbal, I. (1994) · Brain Research · doi:10.1016/0006-8993(94)91598-9 · Cited by 89 · see citing works

p44mpk MAP kinase induces aizheimer type alterations in tau function and in primary hippocampal neurons

Lu, Q., Soria, J., & Wood, J. (1993) · Journal of Neuroscience Research · doi:10.1002/jnr.490350411 · Cited by 60 · see citing works

Demonstration by Fluorescence Resonance Energy Transfer of a Close Association Between Activated MAP Kinase and Neurofibrillary Tangles: Implications for MAP Kinase Activation in Alzheimer Disease

Knowles, R. B., Chin, J., Ruff, C. T., & Hyman, B. T. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199910000-00007 · Cited by 59 · see citing works

Stimulation of MAP kinase by v‐<i>raf</i> transformation of fibroblasts fails to induce hyperphosphorylation of transfected tau

Latimer, D. A., Gallo, J.-M., Lovestone, S., Miller, C. C. J., Hugh Reynolds, C., Marquardt, B., Stabel, S., Woodgett, J. R., & Anderton, B. H. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00434-b · Cited by 48 · see citing works

Tau phosphorylation in brain slices: pharmacological evidence for convergent effects of protein phosphatases on tau and mitogen-activated protein kinase.

Garver, T. D., Oyler, G. A., Harris, K. A., Polavarapu, R., Damuni, Z., Lehman, R. A. W., & Billingsley, M. L. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08622-5 · Cited by 36 · see citing works

Alzheimer abnormally phosphorylated tau is more hyperphosphorylated than the fetal tau and causes the disruption of microtubules

Iqbal, K., & Grundke, I. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00033-b · Cited by 29 · see citing works

Okadaic Acid Induces Hyperphosphorylation of τ Independently of Mitogen‐Activated Protein Kinase Activation

Ho, D. T., Shayan, H., & Murphy, T. H. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68010106.x · Cited by 22 · see citing works

The phosphatase inhibitor okadaic acid induces a phosphorylated paired helical filament tau epitope in human LA-N-5 neuroblastoma cells

Vandermeeren, M., bke, U. L. ⁄., Six, J., & Cras, P. P. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90076-w · Cited by 22 · see citing works

The topography and subcellular distribution ofmitogen-activated protein kinase kinase 1 (MEK1) inadult rat brain and differentiating PC12 cells

Schipper, H. M., Agarwal-Mawal, A., & Paudel, H. K. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00120-7 · Cited by 10 · see citing works

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer’s disease indicate possible resistance to IGF-1 and insulin signalling

Moloney, A. M., Griffin, R. J., Timmons, S., O’Connor, R., Ravid, R., & O’Neill, C. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.04.002 · Cited by 764 · see citing works

Tau protein kinases: Involvement in Alzheimer's disease

Martin, L., Latypova, X., Wilson, C. M., Magnaudeix, A., Perrin, M.-L., Yardin, C., & Terro, F. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.06.003 · Cited by 631 · see citing works

Alzheimer's disease: the two-hit hypothesis.

Zhu, X.-W., Raina, A., Perry, G., & Smith, M. A. (2004) · Lancet Neurology · doi:10.1016/s1474-4422(04)00707-0 · Cited by 449 · see citing works

Oxidative stress signalling in Alzheimer's disease

Zhu, X., Raina, A. K., Lee, H., Casadesús, G., Smith, M. A., & Perry, G. L. (2004) · Brain Research · doi:10.1016/j.brainres.2004.01.012 · Cited by 390 · see citing works

Therapeutic approaches to Alzheimer's disease

Klafki, H., Staufenbiel, M., Kornhuber, J., & Wiltfang, J. (2006) · Brain · doi:10.1093/brain/awl280 · Cited by 359 · see citing works

Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain

Li, X., Alafuzoff, I., Soininen, H., Winblad, B., & Pei, J. (2005) · The FEBS Journal · doi:10.1111/j.1742-4658.2005.04833.x · Cited by 324 · see citing works

mTOR signaling in aging and neurodegeneration: at the crossroad between metabolism dysfunction and impairment of autophagy

Perluigi, M., Di Domenico, F., & Butterfield, D. A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.014 · Cited by 339 · see citing works

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

An, W.-L., Cowburn, R. F., Li, L., Braak, H., Alafuzoff, I., Iqbal, K., Iqbal, I.-G., Winblad, B., & Pei, J.-J. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63687-5 · Cited by 312 · see citing works

Oxidative neuronal injury

Chu, C. T., Levinthal, D. J., Kulich, S. M., Chalovich, E. M., & DeFranco, D. B. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04132.x · Cited by 273 · see citing works

Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress

Dagda, R., Zhu, J.-H., Kulich, S., & Chu, C. T. (2008) · Autophagy · doi:10.4161/auto.6458 · Cited by 280 · see citing works

ERK and cell death: ERK1/2 in neuronal death

Subramaniam, S., & Unsicker, K. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07367.x · Cited by 263 · see citing works

Phosphorylation meets nuclear import: a review

Nardozzi, J. D., Lott, K., & Cingolani, G. (2010) · Cell Communication and Signaling · doi:10.1186/1478-811x-8-32 · Cited by 251 · see citing works

Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A

Martin, L., Latypova, X., Wilson, C. M., Magnaudeix, A., Perrin, M.-L., & Terro, F. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.06.008 · Cited by 250 · see citing works

The extracellular signal-regulated kinase 1/2 pathway in neurological diseases: A potential therapeutic target (Review)

Sun, J., & Nan, G. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2962 · Cited by 241 · see citing works

Dysregulation of Insulin Signaling, Glucose Transporters, O-GlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain

Deng, Y., Li, B., Liu, Y. M., Iqbal, K., Grundke, I., & Gong, C. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090157 · Cited by 233 · see citing works

An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice

Corre, S. L., Klafki, H., Plesnila, N., Hübinger, G., Obermeier, A., Sahagún, H., Monse, B., Seneci, P., Lewis, J. M., Eriksen, J. L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602913103 · Cited by 221 · see citing works

Tau Phosphorylation and Sevoflurane Anesthesia: An Association to Postoperative Cognitive Impairment

Le Freche, H., Brouillette, J., Fernandez-Gomez, F.-J., Patin, P., Caillierez, R., Zommer, N., Sergeant, N., Buée-Scherrer, V., Lebuffe, G., Blum, D., et al. (2012) · Anesthesiology · doi:10.1097/aln.0b013e31824be8c7 · Cited by 212 · see citing works

Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer’s Disease

Kirouac, L., Rajic, A. J., Cribbs, D. H., & Padmanabhan, J. (2017) · eneuro · doi:10.1523/eneuro.0149-16.2017 · Cited by 207 · see citing works

Age- and Stage-dependent Accumulation of Advanced Glycation End Products in Intracellular Deposits in Normal and Alzheimer's Disease Brains

Lüth, H. J. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh123 · Cited by 186 · see citing works

Impaired insulin signalling and allostatic load in Alzheimer disease

Felice, F. G. D., Gonçalves, R. A., & Ferreira, S. T. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00558-9 · Cited by 180 · see citing works

Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases

Yu, Y., Run, X., Liang, Z., Li, Y., Liu, F., Liu, Y. M., Iqbal, K., Grundke, I., & Gong, C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05882.x · Cited by 177 · see citing works

MicroRNA Expression Levels Are Altered in the Cerebrospinal Fluid of Patients with Young-Onset Alzheimer’s Disease

McKeever, P. M., Schneider, R., Taghdiri, F., Weichert, A., Multani, N., Brown, R. A., Boxer, A. L., Karydas, A., Miller, B. L., Robertson, J., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1032-x · Cited by 175 · see citing works

Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications

Butterfield, D. A., Marzia Perluigi, A., Reed, T. T., Muharib, T., Hughes, C. P., Robinson, R. A. S., & Rukhsana Sultana, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4109 · Cited by 167 · see citing works

Tau and Tauopathies

Lee, G. S., & Leugers, C. J. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385883-2.00004-7 · Cited by 166 · see citing works

Role of protein kinase B in Alzheimer's neurofibrillary pathology

Pei, J.-J., Khatoon, S., An, W., Nordlinder, M., Tanaka, T., Braak, H., Tsujio, I., Takeda, M., Alafuzoff, I. I., Winblad, B. G., et al. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0657-y · Cited by 165 · see citing works

Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies

Limorenko, G., & Lashuel, H. A. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00127b · Cited by 162 · see citing works

Emerging Role for ERK as a Key Regulator of Neuronal Apoptosis

Cheung, E. C., & Slack, R. S. (2004) · Science s STKE · doi:10.1126/stke.2512004pe45 · Cited by 162 · see citing works

Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model

Wang, X., Zheng, W. H., Xie, J., Wang, T., Wang, S., Teng, W., & Wang, Z. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-46 · Cited by 161 · see citing works

Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain

SWATTON, J. E., Sellers, L. A., Faull, R. L. M., Holland, A. J., Iritani, S., & Bahn, S. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03365.x · Cited by 158 · see citing works

Increased tau Phosphorylation in Apolipoprotein E4 Transgenic Mice Is Associated with Activation of Extracellular Signal-regulated Kinase

Harris, F. M., Brecht, W. J., Xu, Q., Mahley, R. W., & Huang, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408127200 · Cited by 151 · see citing works

ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology

Sakae, N., Liu, C., Shinohara, M., Frisch‐Daiello, J. L., Ma, L., Yamazaki, Y., Tachibana, M., Younkin, L. H., Kurti, A., Carrasquillo, M. M., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3757-15.2016 · Cited by 146 · see citing works

Tau-Based Treatment Strategies in Neurodegenerative Diseases

Schneider, A., & Mandelkow�, E. (2008) · Neurotherapeutics · doi:10.1016/j.nurt.2008.05.006 · Cited by 142 · see citing works

Okadaic-Acid-Induced Inhibition of Protein Phosphatase 2A Produces Activation of Mitogen-Activated Protein Kinases ERK1/2, MEK1/2, and p70 S6, Similar to That in Alzheimer's Disease

Pei, J.-J., Gong, C., An, W., Winblad, B. G., Cowburn, R. F., Grundke, I., & Iqbal, K. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63445-1 · Cited by 142 · see citing works

Reversible oxidation of ERK-directed protein phosphatases drives oxidative toxicity in neurons

Levinthal, D. J., & DeFranco, D. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410771200 · Cited by 126 · see citing works

Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis

Tang, Z., Bereczki, E., Zhang, H., Wang, S., Li, C., Ji, X., Branca, R. M., Lehtiö, J., Guan, Z., Filipčík, P., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.435123 · Cited by 124 · see citing works

Calpain Mediates Calcium-Induced Activation of the Erk1,2 MAPK Pathway and Cytoskeletal Phosphorylation in Neurons

Veeranna, Kaji, T., Boland, B., Odrljin, T. M., Mohan, P. S., Basavarajappa, B. S., Peterhoff, C. M., Cataldo, A. M., Rudnicki, A., Amin, N. D., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63342-1 · Cited by 123 · see citing works

Grape Derived Polyphenols Attenuate Tau Neuropathology in a Mouse Model of Alzheimer's Disease

Wang, J., Santa‐María, I., Ho, L., Ksiȩżak-Reding, H., Ono, K., Teplow, D. B., & Pasinetti, G. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101074 · Cited by 121 · see citing works

Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons

Padmanabhan, J., Levy, M. M., Dickson, D. W., & Potter, H. (2006) · Brain · doi:10.1093/brain/awl255 · Cited by 123 · see citing works

The fate of Nissl-stained dark neurons following traumatic brain injury in rats: difference between neocortex and hippocampus regarding survival rate

Ooigawa, H., Nawashiro, H., Fukui, S., Otani, N., 大角, 篤., Toyooka, T., & Shima, K. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0108-2 · Cited by 121 · see citing works

P70 S6 kinase mediates tau phosphorylation and synthesis

Pei, J.-J., An, W., Zhou, X., Nishimura, T., Norberg, J., Benedikz, E., Götz, J., & Winblad, B. G. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.11.059 · Cited by 119 · see citing works

MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models

Du, Y., Du, Y., Zhang, Y., Huang, Z., Fu, M., Li, J., Pang, Y., Lei, P., Wang, Y. T., Song, W., et al. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0091-4 · Cited by 117 · see citing works

Anesthesia Induces Phosphorylation of Tau

Run, X., Liang, Z., Zhang, L., Iqbal, K., Grundke, I., & Gong, C. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1003 · Cited by 114 · see citing works

Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation

Ambegaokar, S. S., & Jackson, G. R. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr432 · Cited by 113 · see citing works

mTor mediates tau localization and secretion: implication for Alzheimer’s disease

Tang, Z., Ioja, E., Bereczki, E., Hultenby, K., Li, C., Guan, Z., Winblad, B., & Pei, J.-J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.03.003 · Cited by 112 · see citing works

Molecular and Cellular Mechanism of Okadaic Acid (OKA)-Induced Neurotoxicity: A Novel Tool for Alzheimer’s Disease Therapeutic Application

Kamat, P. K., Rai, S., Swarnkar, S., Shukla, R., & Nath, C. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8699-4 · Cited by 112 · see citing works

Multiple pathways of apolipoprotein E signaling in primary neurons

Hoe, H., Harris, D. C., & Rebeck, G. W. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.03007.x · Cited by 111 · see citing works

Dissecting the signaling pathway of nicotine‐mediated neuroprotection in a mouse Alzheimer disease model

Liu, Q., Zhang, J., Zhu, H., Qin, C., Chen, Q., & Zhao, B. (2006) · The FASEB Journal · doi:10.1096/fj.06-5841com · Cited by 112 · see citing works

Mechanism of zinc‐induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3β in SH‐SY5Y neuroblastoma cells

An, W., Björkdahl, C., Liu, R., Cowburn, R. F., Winblad, B. G., & Pei, J.-J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02948.x · Cited by 106 · see citing works

Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases

Arrazola Sastre, A., Luque Montoro, M., Gálvez-Martín, P., Lacerda, H. M., Lucia, A., Llavero, F., & Zugaza, J. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176312 · Cited by 103 · see citing works

Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the β-amyloid peptide intracellularly in hippocampal and cortical neurons

Echeverrı́a, V., Ducatenzeiler, A., Dowd, E., Jänne, J., Grant, S. M., Szyf, M., Wandosell, F. G., Ávila, J., Grimm, H. S., Dunnett, S. B., et al. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.036 · Cited by 101 · see citing works

Heat Shock Protein 90 in Alzheimer’s Disease

Ou, J.-R., Tan, M., Xie, A., Yu, J., & Tan, L. (2014) · BioMed Research International · doi:10.1155/2014/796869 · Cited by 99 · see citing works

Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing protein

Waza, M., Adachi, H., Katsuno, M., Minamiyama, M., Tanaka, F., Doyu, M., & Sobue, G. (2006) · Journal of Molecular Medicine · doi:10.1007/s00109-006-0066-0 · Cited by 98 · see citing works

Signal Transduction Cascades Associated with Oxidative Stress in Alzheimer's Disease

Petersen, R. B., Nunomura, A., Lee, H., Casadesús, G., Perry, G. L., Smith, M. A., & Zhu, X. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-11202 · Cited by 99 · see citing works

ERK1/2 is an endogenous negative regulator of the γsecretase activity

Kim, S., Park, H., Hong, H. S., Baik, E. J., Jung, M. W., & Mook‐Jung, I. (2006) · The FASEB Journal · doi:10.1096/fj.05-4055fje · Cited by 92 · see citing works

Phosphorylated Tau: Toxic, Protective, or None of the Above

Castellani, R. J., Nunomura, A., Lee, H., Perry, G. L., & Smith, M. A. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14404 · Cited by 92 · see citing works

Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer's disease subjects

Domenico, F. D., Rukhsana Sultana, A., Barone, E., Marzia Perluigi, A., Cini, C., Mancuso, C., Cai, J., Pierce, W. M. J., & Butterfield, D. A. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.03.033 · Cited by 91 · see citing works

Recent developments of protein kinase inhibitors as potential AD therapeutics

Tell, V., & Hilgeroth, A. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00189 · Cited by 90 · see citing works

The Role of ERK1/2 Pathway in the Pathophysiology of Alzheimer’s Disease: An Overview and Update on New Developments

Khezri, M. R., Yousefi, K., Esmaeili, A., & Ghasemnejad‐Berenji, M. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01191-x · Cited by 92 · see citing works

Aberrant phosphorylation in the pathogenesis of Alzheimer's disease

Chung, S. (2009) · BMB Reports · doi:10.5483/bmbrep.2009.42.8.467 · Cited by 89 · see citing works

Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain

Li, X., An, W.-L., Alafuzoff, I., Soininen, H., Winblad, B., & Pei, J.-J. (2004) · NeuroReport · doi:10.1097/00001756-200410050-00019 · Cited by 84 · see citing works

Extracellular signal-regulated kinase as an inducer of non-apoptotic neuronal death

Subramaniam, S., & Unsicker, K. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.12.013 · Cited by 86 · see citing works

Aberrant protein phosphorylation in Alzheimer disease brain disturbs pro-survival and cell death pathways

Marzia Perluigi, A., Barone, E., Domenico, F. D., & Butterfield, D. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.07.005 · Cited by 85 · see citing works

JNK and ERK1/2 pathways have a dual opposite effect on the expression of BACE1

Tamagno, E., Guglielmotto, M., Giliberto, L., Vitali, A., Borghi, R., Autelli, R., Danni, O., & Tabaton, M. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.015 · Cited by 84 · see citing works

Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices

Shahani, N., Subramaniam, S., Wolf, T., Tackenberg, C., & Brandt, R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4245-05.2006 · Cited by 81 · see citing works

Secreted β-amyloid precursor protein activates microglia via JNK and p38-MAPK

Bodles, A. M., & Barger, S. W. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.022 · Cited by 82 · see citing works

Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi

Du, L., Xie, J., Cheng, X., Li, X.-H., Kong, F., Jiang, X., Ma, Z., Wang, J., Chen, C., & Zhou, X. (2013) · AGE · doi:10.1007/s11357-013-9592-1 · Cited by 83 · see citing works

Caffeine induces beneficial changes in PKA signaling and JNK and ERK activities in the striatum and cortex of Alzheimer's transgenic mice

Zeitlin, R., Patel, S., Burgess, S., Arendash, G. W., & Echeverrı́a, V. (2011) · Brain Research · doi:10.1016/j.brainres.2011.08.036 · Cited by 82 · see citing works

Early Life Stress and Epigenetics in Late-onset Alzheimer’s Dementia: A Systematic Review

Lemche, E. (2018) · Current Genomics · doi:10.2174/1389202919666171229145156 · Cited by 82 · see citing works

Neuroprotective Effects of Limonene (+) against Aβ42-Induced Neurotoxicity in a &lt;i&gt;Drosophila&lt;/i&gt; Model of Alzheimer’s Disease

Shin, M., Liu, Q. F., Choi, B., Shin, C., Lee, B., Yuan, C., Song, Y. J., Yun, H. S., Lee, I.-S., Koo, B.-S., et al. (2020) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00495 · Cited by 80 · see citing works

Location, Location, Location: Altered Transcription Factor Trafficking in Neurodegeneration

Chu, C. T., Plowey, E., Wang, Y., Patel, V., & Jordan-Sciutto, K. (2007) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/nen.0b013e318156a3d7 · Cited by 77 · see citing works

Intracellular and Extracellular Aβ, a Tale of Two Neuropathologies

Cuello, A. C. (2006) · Brain Pathology · doi:10.1111/j.1750-3639.2005.tb00101.x · Cited by 77 · see citing works

Elevated levels of brain-pathologies associated with neurodegenerative diseases in the methionine sulfoxide reductase A knockout mouse

Pal, R., Oien, D. B., Ersen, F. Y., & Moskovitz, J. (2007) · Experimental Brain Research · doi:10.1007/s00221-007-0903-6 · Cited by 76 · see citing works

Flavonoids as an Intervention for Alzheimer’s Disease: Progress and Hurdles Towards Defining a Mechanism of Action

Hole, K. L., & Williams, R. J. (2020) · Brain Plasticity · doi:10.3233/bpl-200098 · Cited by 78 · see citing works

p70 S6 Kinase and Tau in Alzheimer's Disease

Pei, J.-J., Björkdahl, C., Zhang, H., Zhou, X., & Winblad, B. G. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14405 · Cited by 75 · see citing works

Neuronal response in Alzheimer’s and Parkinson’s disease: the effect of toxic proteins on intracellular pathways

Majd, S., Power, J. H. T., & Grantham, H. J. M. (2015) · BMC Neuroscience · doi:10.1186/s12868-015-0211-1 · Cited by 76 · see citing works

Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles

Sonoda, Y., Mukai, H., Matsuo, K., Takahashi, M., Ono, Y., Maeda, K., Akiyama, H., & Kawamata, T. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2009.12.078 · Cited by 74 · see citing works

Oral nicotinamide riboside raises NAD + and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin

Vreones, M. P., Mustapić, M., Moaddel, R., Pucha, K. A., Lovett, J., Seals, D. R., Kapogiannis, D., & Martens, C. R. (2022) · Aging Cell · doi:10.1111/acel.13754 · Cited by 74 · see citing works

The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation

Al‐kuraishy, H. M., Jabir, M. S., Albuhadily, A. K., Al-Gareeb, A. I., & Rafeeq, M. F. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102084 · Cited by 73 · see citing works

Hippocampal metabotropic glutamate receptor long‐term depression in health and disease: focus on mitogen‐activated protein kinase pathways

Sanderson, T. M., Hogg, E. L., Collingridge, G. L., & Corrêa, S. A. L. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13592 · Cited by 70 · see citing works

Manganese Induces Tau Hyperphosphorylation through the Activation of ERK MAPK Pathway in PC12 Cells

Cai, T., Che, H., Yao, T. S., Chen, Y., Huang, C., Zhang, W., Du, K., Zhang, J., Cao, Y., Chen, J., et al. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq308 · Cited by 67 · see citing works

Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase

Qi, H., Prabakaran, S., Cantrelle, F., Chambraud, B., Gunawardena, J., Lippens, G. M., & Landrieu, I. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.700914 · Cited by 67 · see citing works

Assessments of the accumulation severities of amyloid β-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains

Zhou, X., Li, X., Björkdahl, C., Sjögren, M. J. C., Alafuzoff, I. I., Soininen, H. S., Grundke, I., Iqbal, K., Winblad, B. G., & Pei, J.-J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.01.006 · Cited by 65 · see citing works

Transcriptional regulation of homeostatic and disease‐associated‐microglial genes by IRF1, LXRβ, and CEBPα

Gao, T., Jernigan, J. E., Raza, S. A., Dammer, E. B., Xiao, H., Seyfried, N. T., Levey, A. I., & Rangaraju, S. (2019) · Glia · doi:10.1002/glia.23678 · Cited by 64 · see citing works

The Antioxidant Activity of Limonene Counteracts Neurotoxicity Triggered byAβ1-42 Oligomers in Primary Cortical Neurons

Piccialli, I., Tedeschi, V., Caputo, L., Amato, G., De Martino, L., De Feo, V., Secondo, A., & Pannaccione, A. (2021) · Antioxidants · doi:10.3390/antiox10060937 · Cited by 64 · see citing works

Activating transcription factor 2 expression in the adult human brain: Association with both neurodegeneration and neurogenesis

Pearson, A. G., Curtis, M. A., Waldvogel, H. J., Faull, R. L. M., & Dragunow, M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.02.029 · Cited by 63 · see citing works

Extracellular signal-regulated kinase is involved in alpha-synuclein-induced mitochondrial dynamic disorders by regulating dynamin-like protein 1

Gui, Y.-X., Wang, X., Kang, W., Zhang, Y., Zhang, Y., Zhou, Y. F., Quinn, T. J., Liu, J., & Chen, S. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.02.001 · Cited by 62 · see citing works

Distribution, levels, and activation of MEK1 in Alzheimer's disease

Zhu, X.-W., Sun, Z., Lee, H.-G., Siedlak, S., Perry, G., & Smith, M. A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01820.x · Cited by 60 · see citing works

Zinc in Cognitive Impairment and Aging

Sun, R., Wang, J., Feng, J., & Cao, B. (2022) · Biomolecules · doi:10.3390/biom12071000 · Cited by 61 · see citing works

PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK‐3

Kerr, F., Rickle, A., Nayeem, N., Brandner, S., Cowburn, R. F., & Lovestone, S. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.04.064 · Cited by 60 · see citing works

Self-assembly hollow manganese Prussian white nanocapsules attenuate Tau-related neuropathology and cognitive decline

Cai, X., Zhang, K., Xie, X., Zhu, X., Feng, J., Jin, Z., Zhang, H., Tian, M., & Chen, H. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119678 · Cited by 59 · see citing works

Melatonin directly binds and inhibits death‐associated protein kinase 1 function in Alzheimer’s disease

Chen, D., Mei, Y., Kim, N., Lan, G., Gan, C., Fan, F., Zhang, T., Xia, Y., Wang, L., Lin, C., et al. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12665 · Cited by 59 · see citing works

Activation of ERK1/2 MAP kinases in Familial Amyloidotic Polyneuropathy

Monteiro, F. A., Sousa, M. M., Cardoso, I., do Amaral, B., Guimarães, A., & Saraiva, M. J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03716.x · Cited by 57 · see citing works

Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes

Ruegsegger, G. N., Manjunatha, S., Summer, P., Gopala, S., Zabeilski, P., Dasari, S., Vanderboom, P. M., Lanza, I. R., Klaus, K. A., & Nair, K. S. (2019) · The FASEB Journal · doi:10.1096/fj.201802043r · Cited by 56 · see citing works

Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling

Li, L., Wu, X., Zhao, X.-J., Xu, L., Pan, C., & Zhang, Z. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01744-1 · Cited by 55 · see citing works

Tau Potentiates Nerve Growth Factor-induced Mitogen-activated Protein Kinase Signaling and Neurite Initiation without a Requirement for Microtubule Binding

Leugers, C. J., & Lee, G. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.105387 · Cited by 51 · see citing works

Activated c-Jun is present in neurofibrillary tangles in Alzheimer's disease brains

Pearson, A. G., Byrne, U. T. E., MacGibbon, G. A., Faull, R. L. M., & Dragunow, M. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.01.031 · Cited by 51 · see citing works

Alleviating Neurodegeneration by an Anticancer Agent

Waza, M., Adachi, H., Katsuno, M., Minamiyama, M., Tanaka, F., & Sobue, G. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1377.012 · Cited by 49 · see citing works

Heat Shock Protein 90 Indirectly Regulates ERK Activity by Affecting Raf Protein Metabolism

Dou, F., Yuan, L.-D., & Zhu, J. (2005) · Acta Biochimica et Biophysica Sinica · doi:10.1111/j.1745-7270.2005.00069.x · Cited by 49 · see citing works

Chronic Arsenic Exposure Increases Aβ(1–42) Production and Receptor for Advanced Glycation End Products Expression in Rat Brain

Niño, S. A., Martel‐Gallegos, G., Castro‐Zavala, A., Ortega-Berlanga, B., Delgado, J. M., Hernández‐Mendoza, H., Romero-Guzmán, E. T., Ríos-Lugo, M. J., Rosales‐Mendoza, S., Jiménez-Capdeville, M. E., et al. (2017) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.7b00215 · Cited by 49 · see citing works

Brain Endothelial Cell-Derived Exosomes Induce Neuroplasticity in Rats with Ischemia/Reperfusion Injury

Gao, B., Zhou, S.-T., Sun, C., Cheng, D., Zhang, Y., Li, X., Zhang, L., Zhao, J., Xu, D., & Bai, Y. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00089 · Cited by 48 · see citing works

Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites.

Trojanowski, J., Mawal-Dewan, M., Schmidt, M., Martin, J. A., & Lee, V. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91286-2 · Cited by 91 · see citing works

Distribution, levels, and activation of MEK1 in Alzheimer's disease

Zhu, X.-W., Sun, Z., Lee, H.-G., Siedlak, S., Perry, G., & Smith, M. A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01820.x · Cited by 60 · see citing works

Phosphorylated Map Kinase (ERK1, ERK2) Expression is Associated with Early Tau Deposition in Neurones and Glial Cells, but not with Increased Nuclear DNA Vulnerability and Cell Death, in Alzheimer Disease, Pick's Disease, Progressive Supranuclear Palsy and Corticobasal Degeneration

Ferrer, I., Blanco, R., Carmona, M., Ribera, R., Goutan, E., Puig, B., Rey, M. J., Cardozo, A., Viñals, F., & Ribalta, T. (2001) · Brain Pathology · doi:10.1111/j.1750-3639.2001.tb00387.x · Cited by 239 · see citing works

P3‐025: Chronic inhibition of the MEK/ERK pathway fails to delay disease progression in a transgenic animal model of tauopathy

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