The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Mild Cognitive Impairment is Associated With Characteristic Neuropsychiatric Symptoms
Abstract
Mild cognitive impairment (MCI) has emerged as an identifiable condition and in many cases is a transitional state preceding diagnosable Alzheimer disease (AD). Neurobiological and neuroimaging characteristics of amnestic-type MCI have been investigated, but few comprehensive neuropsychiatric studies have been reported. The aim of this preliminary study was to define the neuropsychiatric features of the amnestic-type MCI and compare them with those of mild AD and normal controls. The Neuropsychiatric Inventory (NPI) was used to assess the neuropsychiatric symptoms in three age and education comparable groups, i.e., 28 MCI, 124 mild AD, and 50 normal subjects. Individual subscores of the 10 NPI symptoms and total NPI scores were compared between the MCI patients and the other 2 groups. The results of this preliminary investigation showed that MCI patients frequently manifested neuropsychiatric symptoms. The most common symptoms in the MCI group were dysphoria (39%), apathy (39%), irritability (29%), and anxiety (25%). There were significant differences in apathy, dysphoria, irritability, anxiety, agitation, and aberrant motor behavior between the MCI and control groups; in contrast, only delusions were significantly less common in MCI compared with mild AD. There was a significant difference between the MCI and control groups on total NPI scores (p = 0.001), but not between the MCI and mild AD groups (p = 0.304). Amnestic MCI is associated with significant neuropsychiatric symptoms, especially mood disturbances and apathy. Psychotic symptoms are significantly more common in the early stage of AD than in MCI. These results are derived from a limited clinical sample and require confirmation in longitudinal community-based investigations.
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Cites
Mild Cognitive Impairment: Clinical Characterization and Outcome
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The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
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“The NPI has been shown to be valid and reliable.(23) Normal elderly individuals typically have NPI scores of 2.”
MethodSelf-citationLyketsos, C. G., Lopez, O., Jones, B., Fitzpatrick, A. L., Breitner, J., & DeKosky, S. (2002) · JAMA · doi:10.1001/jama.288.12.1475 · Cited by 2,049
Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment
Jack, C. R., Petersen, R. C., Xu, Y. C., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Waring, S. C., Tangalos, E. G., & Kokmen, E. (1999) · Neurology · doi:10.1212/wnl.52.7.1397 · Cited by 1,404
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Incontinence and Troublesome Behaviors Predict Institutionalization in Dementia
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Cited by
Neuropsychiatric symptoms in Alzheimer's disease
Lyketsos, C. G., Carrillo, M. C., Ryan, J. M., Khachaturian, A. S., Trzepacz, P., Amatniek, J., Cedarbaum, J., Brashear, R., & Miller, D. S. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.05.2410 · Cited by 1,139
Anxiety disorders in older adults: a comprehensive review
Wolitzky-Taylor, K. B., Castriotta, N., Lenze, E. J., Stanley, M. A., & Craske, M. G. (2010) · Depression and Anxiety · doi:10.1002/da.20653 · Cited by 726
Geda, Y. E., Roberts, R. O., Knopman, D. S., Petersen, R. C., Christianson, T. J. H., Pankratz, V. S., Smith, G. E., Boeve, B. F., Ivnik, R. J., Tangalos, E. G., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.10.1193 · Cited by 438
Neuropsychiatric Manifestations in Mild Cognitive Impairment: A Systematic Review of the Literature
Apostolova, L. G., & Cummings, J. L. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000112509 · Cited by 391
Self-citationNeuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future
Geda, Y. E., Schneider, L. S., Gitlin, L. N., Miller, D. S., Smith, G. S., Bell, J., Evans, J., Lee, M., Porsteinsson, A., Lanctôt, K. L., et al. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.12.001 · Cited by 378
Metadata
- Authors
- Hwang, T. J., Masterman, D. L., Ortiz, F., Fairbanks, L. A., & Cummings, J. L.
- Venue
- Alzheimer Disease & Associated Disorders
- Published
- 2004-01
- Volume
- 18
- Issue
- 1
- Pages
- 17-21
- ISSN
- 0893-0341 (ISSN-L)
- OpenAlex
- W2054802697
- Cited by
- 259
- References
- 7
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- closed
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