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Cited by 81Attention Deficit Hyperactivity DisorderBehavioral and Psychological StudiesNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Pemoline Effects on Children with ADHD: A Time-Response by Dose-Response Analysis on Classroom Measures

PELHAM, WILLIAM E., SWANSON, JAMES M., FURMAN, MARY BENDER, SCHWINDT, HEIDI·1995·Journal of the American Academy of Child & Adolescent Psychiatry
DOI 10.1097/00004583-199511000-00018
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Abstract

Objective To evaluate the dose-response by time-response characteristics of pemoline (Cylert) on dependent measures of behavior and academic performance in a laboratory classroom.Method After a 2-week baseline, a double-blind crossover design was used to compare placebo, 18.75 mg, 37.5 mg, 75 mg, and 112.5 mg of pemoline, q.a.m., with each dose administered for 1 week. Medication was given at 9:00 A.M., and performance was measured beginning immediately and beginning 2, 4, and 6 hours after ingestion. The dependent measures included number of math problems completed correctly, teacher-recorded rates of on-task behavior and noncompliance, and teacher ratings on an Abbreviated Conners Teacher Rating Scale.Results There were linear effects of medication, with pemoline doses greater than 18.75 mg having an effect beginning 2 hours after ingestion and lasting through the seventh hour after ingestion.Conclusions Results are contrasted with widespread misbeliefs regarding pemoline's time course and efficacy.

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Crossref · 10.1097/00004583-199511000-00018

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Metadata

Authors
PELHAM, W. E., SWANSON, J. M., FURMAN, M. B., & SCHWINDT, H.
Affiliations
  • University of Pittsburgh (US)
  • University of California, Irvine (US)
Corresponding author
PELHAM, WILLIAM E.
ORCID
Venue
Journal of the American Academy of Child & Adolescent Psychiatry
Publisher
Elsevier BV
Published
1995-11
Volume
34
Issue
11
Pages
1504-1513
ISSN
0890-8567 (ISSN-L)
DOI
10.1097/00004583-199511000-00018
OpenAlex
W2016706076
Cited by
81
References
37
Citations by year
2025: 1 · 2020: 1 · 2019: 1 · 2017: 3 · 2015: 1
FWCI
6.30
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Hospital for Sick Children, Toronto, Research Institute and Abbott Laboratories, Canada (AA06267, DA05605, MH40567, MH45576, and MH48157)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
pemoline, attention deficit hyperactivity disorder, dose-response relationship, time course of drug effects, classroom behavior, academic performance, on-task behavior, non-compliance, stimulant medication, children
MeSH terms
Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Child, Preschool, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Pemoline, Placebos, Schools, Time Factors, Cross-Over Studies

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