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Cited by 119Attention Deficit Hyperactivity DisorderPharmaceutical studies and practicesPharmacology and Obesity Treatment

The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.

Stimulant Treatment Over 5 Years: Effects on Growth

CHARACH, ALICE, FIGUEROA, MAX, CHEN, SHIRLEY, ICKOWICZ, ABEL, SCHACHAR, RUSSELL·2006·Journal of the American Academy of Child & Adolescent Psychiatry
DOI 10.1097/01.chi.0000199026.91699.20
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Abstract

Objective Long-term effects of psychostimulants on growth in height and in weight are investigated in children with attention-deficit/hyperactivity disorder.Method Participants were 79 children, 6 to 12 years of age, with attention-deficit/hyperactivity disorder, who were followed annually for up to 5 years, between the years 1993 and 1994 and 1998 and 1999. Annual height and weight measurements were standardized by age and gender using the 2000 Centers for Disease Control and Prevention Growth Charts for the United States and reported as z scores. For children taking stimulants throughout the previous school year, dose potency was standardized to methylphenidate in milligrams per kilogram per day. We used hierarchical linear modeling to investigate the influence of dose and duration of stimulant treatment on the rate of growth in height and weight.Results Controlling for time since initiation of treatment, daily dose of stimulant medication was negatively associated with z scores for height (beta = -.11, SE = 0.03, p <.01) and for weight (beta = -.29, SE = 0.04, p <.01). Estimates based on the statistical model suggest that children receiving > or = 1.5 mg/kg/day methylphenidate will show diminished weight gain after 1 year; those receiving > or = 2.5 mg/kg/day methylphenidate will show diminished gains in height after 4 years.Conclusion Long-term use of high doses of stimulants during a period of 1 to 5 years is likely to have measurable effects on the rate of growth in school-age children with attention-deficit/hyperactivity disorder.

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Crossref · 10.1097/01.chi.0000199026.91699.20

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  • Significant effects on weight and height may require average doses of methylphenidate exceeding 1.5 mg/kg per day which are given continuously.

    “Significant effects on weight and height may require average doses of methylphenidate exceeding 1.5 mg/kg per day which are given continuously [28, 132].”

    From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [28]

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Metadata

Authors
CHARACH, A., FIGUEROA, M., CHEN, S., ICKOWICZ, A., & SCHACHAR, R.
Affiliations
Hospital for Sick Children (CA)
Corresponding author
CHARACH, ALICE
ORCID
Venue
Journal of the American Academy of Child & Adolescent Psychiatry
Publisher
Elsevier BV
Published
2006-04
Volume
45
Issue
4
Pages
415-421
ISSN
0890-8567 (ISSN-L)
DOI
10.1097/01.chi.0000199026.91699.20
OpenAlex
W1998722353
Cited by
119
References
22
Citations by year
2025: 2 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 9 · 2019: 6 · 2018: 3 · 2017: 7 · 2016: 2 · 2015: 8 · 2014: 6 · 2013: 3 · 2012: 4
FWCI
8.27
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
  • Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
Keywords
attention deficit hyperactivity disorder, psychostimulants, methylphenidate, long-term drug effects, child growth, height, weight gain, dose-response relationship
MeSH terms
Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Body Height, Child, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Growth, Humans, Male, Methylphenidate

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