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Cited by 106Attention Deficit Hyperactivity DisorderPharmaceutical studies and practicesPharmacology and Obesity Treatment

Comparative Effects of Methylphenidate and Mixed Salts Amphetamine on Height and Weight in Children With Attention-Deficit/Hyperactivity Disorder

PLISZKA, STEVEN R., MATTHEWS, THOMAS L., BRASLOW, KENNETH J., WATSON, MELISSA A.·2006·Journal of the American Academy of Child & Adolescent Psychiatry
DOI 10.1097/01.chi.0000205702.48324.fd
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Abstract

Objective To determine whether methylphenidate (MPH) and mixed salts amphetamine (MSA) have different effects on growth in children with attention-deficit/hyperactivity disorder.Method Patients treated for at least 1 year with MPH or MSA were identified. A linear regression was performed to determine the effect of stimulant type, patient gender, cumulative stimulant dose, and length of time in treatment on change in Z scores for height. A subset of patients was identified who had 3 years of consistent stimulant treatment on either MSA or MPH. Repeated-measures analyses of variance were performed to examine the effects of time and medication type on Z scores for weight, height, and body mass index.Results The linear regression showed no effect of stimulant type, drug holidays, or length of time of treatment on change in height Z score. Cumulative dose of stimulant had a small (-0.26) relationship to change in height Z scores. For patients treated for 3 years, there were no effects of stimulant or time on height Z scores. MSA produced more decrease in weight and body mass index Z scores than MPH; all of the subjects were heavier than average at baseline.Conclusion MSA and MPH did not differ in their effects on height. MSA had more of an effect on weight than MPH, although the effect was modest in magnitude and may be of limited clinical significance.

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Crossref · 10.1097/01.chi.0000205702.48324.fd

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15 of 15 references verified0 citation errors · 0 not checkable

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  • Most studies do not suggest differences in the magnitude of growth deficits between methylphenidate and dexamfetamine.

    “Most studies do not suggest differences in the magnitude of growth deficits between methylphenidate and dexamfetamine [108].”

    From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [108]

  • In two recent studies where drug holidays were allowed but not systematically varied, stimulant-related reductions in growth rates were not documented.

    “In two recent studies (Pliszka et al., 2006;Spencer et al., 2006) in which drug holidays were allowed but were not systematically varied, stimulantrelated reductions in growth rates were not documented.”

    From Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up (2007) · cites this paper as Pliszka et al., 2006

  • Two other recent chart-review studies (Pliszka et al., 2006; Spencer et al., 2006) found no evidence that clinical treatment with stimulant medications reduced growth rates of children with ADHD.

    “In two other recent chart-review studies, no evidence was found to support the hypothesis that clinical treatment with stimulant medications reduced the growth rates of children with ADHD (Pliszka et al., 2006;Spencer et al., 2006).”

    From Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up (2007) · cites this paper as Pliszka et al., 2006

  • The finding of a reduction in growth rate in height that extends up to 3 years is not consistent with two other retrospective reviews (Pliszka et al., 2006; Spencer et al., 2006).

    “but not with two others (Pliszka et al., 2006;Spencer et al., 2006)”

    From Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up (2007) · cites this paper as Pliszka et al., 2006

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Authors
PLISZKA, S. R., MATTHEWS, T. L., BRASLOW, K. J., & WATSON, M. A.
Affiliations
The University of Texas at San Antonio Health Science Center (US)
Corresponding author
PLISZKA, STEVEN R.
ORCID
PLISZKA, STEVEN R.
Venue
Journal of the American Academy of Child & Adolescent Psychiatry
Publisher
Elsevier BV
Published
2006-05
Volume
45
Issue
5
Pages
520-526
ISSN
0890-8567 (ISSN-L)
DOI
10.1097/01.chi.0000205702.48324.fd
OpenAlex
W2078945716
Cited by
106
References
15
Citations by year
2026: 3 · 2025: 1 · 2024: 1 · 2023: 6 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 2 · 2012: 7
FWCI
9.12
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
Keywords
methylphenidate, attention deficit hyperactivity disorder, stimulant medication, child growth, height, weight, body mass index, drug holidays
MeSH terms
Adolescent, Amphetamines, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Body Height, Body Weight, Child, Clinical Trials as Topic, Delayed-Action Preparations, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Humans, Long-Term Care, Male, Methylphenidate, Retrospective Studies, Sex Factors, Body Mass Index, Adverse Drug Reaction Reporting Systems

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