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Cited by 185Acute Ischemic Stroke ManagementNeuroinflammation and Neurodegeneration MechanismsCell Adhesion Molecules Research

The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.

Antibodies against Adhesion Molecules Reduce Apoptosis after Transient Middle Cerebral Artery Occlusion in Rat Brain

Chopp, Michael, Li, Yi, Jiang, Ning, Zhang, Rui Lan, Prostak, Jonathan·1996·Journal of Cerebral Blood Flow & Metabolism
DOI 10.1097/00004647-199607000-00007
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Abstract

We tested the hypothesis that treatment of transient focal cerebral ischemia in rat with antibodies directed against adhesion molecules reduces apoptosis. Rats (n = 31) were subjected to 2 h of middle cerebral artery (MCA) occlusion induced by intraluminal insertion of a nylon monofilament into the internal carotid artery. Upon reperfusion, animals were treated with monoclonal antibodies directed against intercellular adhesion molecule (ICAM)-1) (n = 8) or integrin CD11b/CD18 (n = 10), or administered IgG1 as a control (n = 13). At 48 h after ischemia, animals were killed and the brains analyzed for ischemic cell damage, using hematoxylin and eosin (H/E); apoptosis, using the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) method; and inflammatory cells, using immunohistochemistry with an anti-myeloperoxidase (MPO) antibody. Data revealed a significant reduction in the volume of infarction (p < 0.01) and a decline in the absolute (p < 0.001), and normalized (to the ischemic areas, p < 0.05) numbers of apoptotic cells in both animals treated with anti-ICAM-1 and anti-CD11b antibodies compared to control animals. The numbers of immunoreactive MPO cells were also reduced in the treatment groups compared to those in the control group (p < 0.05). These data suggest that treatment with anti-adhesion molecule antibodies selectively reduce apoptosis, and that a contributing factor to the beneficial effect of antibody treatment for reducing ischemic cell damage may be a reduction in numbers of apoptotic cells.

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Crossref · 10.1097/00004647-199607000-00007

Cites

76 of 76 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 76 references

Research works printed but not linked: 10

  1. Birdsall HH, 1991, Am J Pathol, 139, 1341
  2. Bowes MP, 1993, Exp Model, 119, 215
  3. Engler RL, 1983, Am J Pathol, 111, 98
  4. Granger DN, 1988, Am J Physiol, 255, H1269
  5. Jiang N, 1994, Neurosci Res Comm, 15, 85
  6. Jiang N, Moyle M, Soule HR, Rote WE, Chopp M (1995) Postischemic administration of the CD11b/CD18 antagonist neutrophil inhibitory factor (NIF) is neuroprotective after transient middle cerebral artery occlusion in rats. Ann Neurol (in press)
  7. Li Y, 1995, Am J Pathol, 146, 1045
  8. Schmid-Schönbein GW, 1986, Am J Cardiovasc Pathol, 1, 15
  9. Schmid-Schönbein GW, 1987, Proc Fed Am Soc Exp Biol, 46, 2397
  10. Tamatani T, 1993, Int Immunol, 2, 166

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Related

Metadata

Authors
Chopp, M., Li, Y., Jiang, N., Zhang, R. L., & Prostak, J.
Affiliations
Henry Ford Health (US)
ORCID
Venue
Journal of Cerebral Blood Flow & Metabolism
Publisher
SAGE Publications
Published
1996-07
Volume
16
Issue
4
Pages
578-584
ISSN
  • 0271-678X (ISSN-L)
  • 1559-7016
DOI
10.1097/00004647-199607000-00007
OpenAlex
W2056824541
Cited by
185
References
76
Citations by year
2025: 1 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 6 · 2012: 3
FWCI
13.52
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Hort Innovation
  • National Institutes of Health (5r01ns034184-04, 5r01ns033627-08)
  • National Institute of Neurological Disorders and Stroke (R01NS-33627, P01NS023393, R01NS-34184)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
adhesion molecules, apoptosis, transient middle cerebral artery occlusion, focal cerebral ischemia, ICAM-1, CD11b/CD18 integrin, infarct size, ischemia-reperfusion injury, neuroprotection
MeSH terms
Animals, Antibodies, Monoclonal, Arterial Occlusive Diseases, Brain, Cell Count, Cerebrovascular Disorders, Male, Peroxidase, Cell Adhesion Molecules, Macrophage-1 Antigen, Apoptosis, Rats

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