Cited by 165Barrier Structure and Function StudiesDrug Transport and Resistance MechanismsIon Transport and Channel Regulation

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Blood—Brain Barrier Genomics

Open access

Li, Jian Yi, Boado, Ruben J., Pardridge, William M.·2001·Journal of Cerebral Blood Flow & Metabolism

DOI 10.1097/00004647-200101000-00008

Open this paper in CoChat — free account Open PDF

Abstract

The blood–brain barrier (BBB) is formed by the brain microvascular endothelium, and the unique transport properties of the BBB are derived from tissue-specific gene expression within this cell. The current studies developed a gene microarray approach specific for the BBB by purifying the initial mRNA from isolated rat brain capillaries to generate tester cDNA. A polymerase chain reaction–based subtraction cloning method, suppression subtractive hybridization (SSH), was used, and the BBB cDNA was subtracted with driver cDNA produced from mRNA isolated from rat liver and kidney. Screening 5% of the subtracted tester cDNA resulted in identification of 50 gene products and more than 80% of those were selectively expressed at the BBB; these included novel gene sequences not found in existing databases, ESTs, and known genes that were not known to be selectively expressed at the BBB. Genes in the latter category include tissue plasminogen activator, insulin-like growth factor-2, PC-3 gene product, myelin basic protein, regulator of G protein signaling 5, utrophin, IκB, connexin-45, the class I major histocompatibility complex, the rat homologue of the transcription factors hbrm or EZH1, and organic anion transporting polypeptide type 2. Knowledge of tissue-specific gene expression at the BBB could lead to new targets for brain drug delivery and could elucidate mechanisms of brain pathology at the microvascular level.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1097/00004647-200101000-00008

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray
Schena, M., Shalon, D., Davis, R. W., & Brown, P. O. (1995) · Science · doi:10.1126/science.270.5235.467 · Cited by 9,609
Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction
Liang, P., & Pardee, A. B. (1992) · Science · doi:10.1126/science.1354393 · Cited by 4,964
Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries.
Diatchenko, L. B., Lau, Y. C., Campbell, A. P., Chenchik, A. A., Moqadam, F., Huang, B. C. B., Lukyanov, S., Lukyanov, K. A., Gurskaya, N. G., Sverdlov, E. D., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.6025 · Cited by 3,009
Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.
Adams, Kerlavage, A. R., Fleischmann, R. D., Ra, F., Cj, B., Lee, N., Ef, K., Kg, W., Gocayne, J. D., & White, O. R. (1995) · PubMed · Cited by 793
Molecular Cloning of Transferrin Receptor 2
Kawabata, H., Yang, R., Hirama, T., Vuong, P. T., Kawano, S., Gombart, A. F., & Koeffler, H. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.20826 · Cited by 661
Identification of a Novel Gene Family Encoding Human Liver-specific Organic Anion Transporter LST-1
Abe, T., Kakyo, M., Tokui, T., Nakagomi, R., Nishio, T., Nakai, D., Nomura, H., Unno, M., Suzuki, M., Naitoh, T., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17159 · Cited by 543
Selective expression of the large neutral amino acid transporter at the blood–brain barrier
Boado, R. J., Li, J. Y., Nagaya, M., Zhang, C., & Pardridge, W. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12079 · Cited by 482
Self-citation
A Pilot Trial of Cop 1 in Exacerbating–Remitting Multiple Sclerosis
Bornstein, M. B., Miller, A., Slagle, S., Weitzman, M., Crystal, H., Drexler, E. D., Keilson, M. J., Merriam, A. E., Wassertheil-Smoller, S. W., Spada, V., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198708133170703 · Cited by 462
CNS Drug Design Based on Principles of Blood‐Brain Barrier Transport
Pardridge, W. M. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70051781.x · Cited by 460
Self-citation
Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.
Jakeman, L. B., Winer, J., Bennett, G. L., Altar, C. A., & Ferrara, N. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115568 · Cited by 433

Show all 27 references

Research works printed but not linked: 1

Adams MD, 1995, Nature, 377, 3

Sorted by citations

The blood-brain barrier
Daneman, R., & Prat, A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020412 · Cited by 3,437
Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,312
Tight junctions of the blood-brain barrier: development, composition and regulation.
Wolburg, H., & Lippoldt, A. (2002) · PubMed · doi:10.1016/s1537-1891(02)00200-8 · Cited by 1,236
Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties
Hagenbuch, B., & Meier, P. J. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1168-y · Cited by 1,033
The superfamily of organic anion transporting polypeptides
Hagenbuch, B., & Meier, P. J. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00633-8 · Cited by 862
Blood-brain barrier drug targeting: the future of brain drug development.
Pardridge, W. M. (2003) · Molecular Interventions · doi:10.1124/mi.3.2.90 · Cited by 570
Self-citation
Modelling of the blood–brain barrier in drug discovery and development
Cecchelli, R., Bérézowski, V., Lundquist, S., Culot, M., Renftel, M., Dehouck, M., & Fénart, L. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2368 · Cited by 660
The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells
Daneman, R., Zhou, L., Agalliu, D., Cahoy, J. D., Kaushal, A., & Barres, B. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013741 · Cited by 577
Dynamics of CNS Barriers: Evolution, Differentiation, and Modulation
Abbott, N. J. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-004-1374-y · Cited by 471
Contribution of Carrier-Mediated Transport Systems to the Blood–Brain Barrier as a Supporting and Protecting Interface for the Brain; Importance for CNS Drug Discovery and Development
Ohtsuki, S., & Terasaki, T. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9374-5 · Cited by 476
Strategy for effective brain drug delivery
Alam, M. I., Beg, S., Samad, A., Baboota, S., Kohli, K., Ali, J., Ahuja, A., & Akbar, M. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.05.003 · Cited by 415
Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms
Ahn, S. I., Sei, Y. J., Park, H., Kim, J., Ryu, Y., Choi, J. J., Sung, H., MacDonald, T. J., Levey, A. I., & Kim, Y. (2020) · Nature Communications · doi:10.1038/s41467-019-13896-7 · Cited by 414
Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain
Pardridge, W. M. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00373 · Cited by 405
Self-citation
Pathogenesis and pathophysiology of pneumococcal meningitis
Koedel, U., Scheld, W. M., & Pfister, H. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00450-4 · Cited by 385
Update on connexins and gap junctions in neurons and glia in the mammalian nervous system
Nagy, J. I., Dudek, F. E., & Rash, J. E. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.05.005 · Cited by 375
Functional Characterization of Rat Brain-specific Organic Anion Transporter (Oatp14) at the Blood-Brain Barrier
Sugiyama, D., Kusuhara, H., Taniguchi, H., Ishikawa, S., Nozaki, Y., Aburatani, H., & Sugiyama, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306933200 · Cited by 283
Mediated efflux of IgG molecules from brain to blood across the blood–brain barrier
Zhang, Y., & Pardridge, W. M. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00242-9 · Cited by 272
Self-citation
Expression of the neonatal Fc receptor (FcRn) at the blood–brain barrier
Schlachetzki, F., Zhu, C., & Pardridge, W. M. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00840.x · Cited by 268
Self-citation
Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood − brain barrier using MRI-guided focused ultrasound
Nance, E. A., Timbie, K. F., Miller, G. W., Song, J. S., Louttit, C., Klibanov, A. L., Shih, T.-Y., Swaminathan, G., Tamargo, R. J., Woodworth, G. F., et al. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.031 · Cited by 259
Active efflux across the blood-brain barrier: Role of the solute carrier family
Kusuhara, H., & Sugiyama, Y. (2004) · NeuroRx · doi:10.1602/neurorx.2.1.73 · Cited by 235
Physiology and pharmacological role of the blood-brain barrier.
Bernacki, J., Dobrowolska, A., Nierwińska, K., & Małecki, A. (2008) · PubMed · Cited by 235
Molecular Biology of the Blood–Brain Barrier
Pardridge, W. M. (2005) · Molecular Biotechnology · doi:10.1385/mb:30:1:057 · Cited by 220
Self-citation
A Historical Review of Brain Drug Delivery
Pardridge, W. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061283 · Cited by 219
Self-citation
Role of blood–brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain
Ohtsuki, S., Asaba, H., Takanaga, H., Deguchi, T., Hosoya, K., Otagiri, M., & Terasaki, T. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01108.x · Cited by 216
The rat blood-brain barrier transcriptome
Enerson, B. E., & Drewes, L. R. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600249 · Cited by 205
How can we realize the promise of personalized antidepressant medicines?
Holsboer, F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2453 · Cited by 177
Blood–brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery
Pardridge, W. M. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1042364 · Cited by 159
Self-citation
Blood-Brain Barrier Integrity and Glial Support: Mechanisms that can be Targeted for Novel Therapeutic Approaches in Stroke
Ronaldson, P. T., & Davis, T. P. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212802002625 · Cited by 160
Involvement of Multispecific Organic Anion Transporter, Oatp14 (Slc21a14), in the Transport of Thyroxine across the Blood-Brain Barrier
Tohyama, K., Kusuhara, H., & Sugiyama, Y. (2004) · Endocrinology · doi:10.1210/en.2004-0058 · Cited by 155
Blood-brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody
Pardridge, W. M. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.952627 · Cited by 152
Self-citation
Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood–brain barrier delivery in the mouse
Boado, R. J., Zhang, Y., Wang, Y., & Pardridge, W. M. (2008) · Biotechnology and Bioengineering · doi:10.1002/bit.22135 · Cited by 146
Self-citation
Delivery of Biologics Across the Blood–Brain Barrier with Molecular Trojan Horse Technology
Pardridge, W. M. (2017) · BioDrugs · doi:10.1007/s40259-017-0248-z · Cited by 152
Self-citation
Chemokine-dependent mechanisms of leukocyte trafficking across a model of the blood–brain barrier
Eugenín, E. A., & Berman, J. W. (2003) · Methods · doi:10.1016/s1046-2023(02)00359-6 · Cited by 140
An Overview of In Vitro Techniques for Blood-Brain Barrier Studies
Reichel, A., Begley, D. J., & Abbott, N. J. (2003) · Humana Press eBooks · doi:10.1385/1-59259-419-0:307 · Cited by 135
Transporters of the blood–brain and blood–CSF interfaces in development and in the adult
Saunders, N. R., Daneman, R., Dzięgielewska, K. M., & Liddelow, S. A. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.11.006 · Cited by 133
Borrelia burgdorferi, Host-Derived Proteases, and the Blood-Brain Barrier
Grab, D. J., Perides, G., Dumler, J. S., Kim, K. J., Park, J., Kim, Y. V., Nikolskaia, O. V., Choi, K. S., Stins, M. F., & Kim, K. S. (2005) · Infection and Immunity · doi:10.1128/iai.73.2.1014-1022.2005 · Cited by 123
Drug targeting to brain: a systematic approach to study the factors, parameters and approaches for prediction of permeability of drugs across BBB
Nagpal, K., Singh, S. K., & Mishra, D. N. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.762354 · Cited by 119
Modulation of Brain Tumor Capillaries for Enhanced Drug Delivery Selectively to Brain Tumor
Black, K. L., & Ningaraj, N. S. (2004) · Cancer Control · doi:10.1177/107327480401100304 · Cited by 115
Characteristic gene expression profile of primary human cerebral endothelial cells
Kallmann, B.-A., Wagner, S., Hummel, V., Buttmann, M., Bayas, A., Tonn, J. C., & Rieckmann, P. (2002) · The FASEB Journal · doi:10.1096/fj.01-0594fje · Cited by 113
Endothelial cell heterogeneity of blood‐brain barrier gene expression along the cerebral microvasculature
Macdonald, J. A., Murugesan, N., & Pachter, J. S. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22316 · Cited by 111
A Genomic Comparison of in vivo and in vitro Brain Microvascular Endothelial Cells
Calabria, A. R., & Shusta, E. V. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600518 · Cited by 109
Efflux transport systems for organic anions and cations at the blood?CSF barrier
Kusuhara, H., & Sugiyama, Y. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.07.007 · Cited by 106
Evaluating therapeutic targets for reperfusion‐related brain hemorrhage
Maier, C. M., Hsieh, L. B., Crandall, T., Narasimhan, P., & Chan, P. H. (2006) · Annals of Neurology · doi:10.1002/ana.20850 · Cited by 103
AFRICAN TRYPANOSOME INTERACTIONS WITH AN IN VITRO MODEL OF THE HUMAN BLOOD–BRAIN BARRIER
Grab, D. J., Nikolskaia, O. V., Kim, Y. V., Lonsdale‐Eccles, J. D., Ito, S., Hara, T., Fukuma, T., Nyarko, E., Kim, K. J., Stins, M. F., et al. (2004) · Journal of Parasitology · doi:10.1645/ge-287r · Cited by 104
ABCB1 and ABCG2 Regulation at the Blood-Brain Barrier: Potential New Targets to Improve Brain Drug Delivery
Schulz, J., Hartz, A. M. S., & Bauer, B. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000025 · Cited by 118
Inner Blood-Retinal Barrier Transporters: Role of Retinal Drug Delivery
Hosoya, K., & Tachikawa, M. (2009) · Pharmaceutical Research · doi:10.1007/s11095-009-9930-2 · Cited by 102
Expression Profiling of the Solute Carrier (SLC) Gene Family in the Mouse Brain
Dahlin, A., Royall, J., Hohmann, J., & Wang, J. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.149831 · Cited by 102
Targeting Neurotherapeutic Agents Through the Blood-Brain Barrier
Pardridge, W. M. (2002) · Archives of Neurology · doi:10.1001/archneur.59.1.35 · Cited by 91
Self-citation
MiR-7-5p is frequently downregulated in glioblastoma microvasculature and inhibits vascular endothelial cell proliferation by targeting RAF1
Liu, Z., Liu, Y., Li, L., Xu, Z., Bi, B., Wang, Y., & Li, J. Y. (2014) · Tumor Biology · doi:10.1007/s13277-014-2318-x · Cited by 88
Self-citation
Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC/D3 cell line
Sajja, R. K., Prasad, S., & Cucullo, L. (2014) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-11-8 · Cited by 90
Cloned Blood–Brain Barrier Adenosine Transporter is Identical to the Rat Concentrative Na + Nucleoside Cotransporter CNT2
Li, J. Y., Boado, R. J., & Pardridge, W. M. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200108000-00005 · Cited by 82
Self-citation
The impact of endothelial cell death in the brain and its role after stroke: A systematic review
Zille, M., Ikhsan, M., Jiang, Y., Lampe, J., Wenzel, J., & Schwaninger, M. (2019) · Cell Stress · doi:10.15698/cst2019.11.203 · Cited by 77
The Blood–Brain Barrier: Composition, Properties, and Roles in Brain HealthPreprint
Lacoste, B., Prat, A., Andrade, M. F., & Gu, C. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041422 · Cited by 83
Functionalization strategies of polymeric nanoparticles for drug delivery in Alzheimer’s disease: Current trends and future perspectives
La Barbera, L., Mauri, E., D’Amelio, M., & Gori, M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.939855 · Cited by 74
Treatment of glioma by cisplatin-loaded nanogels conjugated with monoclonal antibodies against Cx43 and BSAT1
Baklaushev, V. P., Nukolova, N. V., Khalansky, A. S., Gurina, O. I., Yusubalieva, G. M., Grinenko, N. P., Gubskiy, I. L., Melnikov, P., Kardashova, K. S., Kabanov, A. V., et al. (2014) · Drug Delivery · doi:10.3109/10717544.2013.876460 · Cited by 72
Efficient In Vivo Delivery of siRNA Into Brain Capillary Endothelial Cells Along With Endogenous Lipoprotein
Kuwahara, H., Nishina, K., Yoshida, K., Nishina, T., Yamamoto, M., Saito, Y., Piao, W., Yoshida, M., Mizusawa, H., & Yokota, T. (2011) · Molecular Therapy · doi:10.1038/mt.2011.186 · Cited by 71
BBB-Genomics: creating new openings for brain-drug targeting
Pardridge, W. M. (2001) · Drug Discovery Today · doi:10.1016/s1359-6446(01)01721-4 · Cited by 70
Self-citation
The molecular, cellular, and morphological components of blood–brain barrier development during embryogenesis
Hagan, N., & Ben‐Zvi, A. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.12.006 · Cited by 70
Current Status and Challenges Associated with CNS-Targeted Gene Delivery across the BBB
Kimura, S., & Harashima, H. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121216 · Cited by 65
Developmental regulation of barrier‐ and non‐barrier blood vessels in the CNS
Ben‐Zvi, A., & Liebner, S. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13263 · Cited by 67
The CCL2 synthesis inhibitor bindarit targets cells of the neurovascular unit, and suppresses experimental autoimmune encephalomyelitis
Ge, S., Shrestha, B., Paul, D., Keating, C. E., Cone, R. E., Guglielmotti, A., & Pachter, J. S. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-171 · Cited by 64
Adenosine 5'-triphosphate-sensitive potassium channel-mediated blood-brain tumor barrier permeability increase in a rat brain tumor model.
Ningaraj, N. S., Rao, M. K., & Black, K. L. (2003) · PubMed · Cited by 64
Receptor-mediated drug delivery of bispecific therapeutic antibodies through the blood-brain barrier
Pardridge, W. M. (2023) · Frontiers in Drug Delivery · doi:10.3389/fddev.2023.1227816 · Cited by 62
Self-citation
Targeting blood–brain Barrier Changes During Inflammatory Pain: an Opportunity for Optimizing CNS Drug Delivery
Ronaldson, P. T., & Davis, T. P. (2011) · Therapeutic Delivery · doi:10.4155/tde.11.67 · Cited by 60
Pathomechanisms of Blood-Brain Barrier Disruption in ALS
Kakaroubas, N., Brennan, S. E., Keon, M., & Saksena, N. (2019) · Neuroscience Journal · doi:10.1155/2019/2537698 · Cited by 63
Blood-brain barrier genomics and the use of endogenous transporters to cause drug penetration into the brain.
Pardridge, W. M. (2003) · PubMed · Cited by 61
Self-citation
Brain Drug Targeting and Gene Technologies
Pardridge, W. M. (2001) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.87.97 · Cited by 60
Self-citation
Receptor-Mediated Therapeutic Transport Across the Blood–Brain Barrier
Wang, Y., Lui, P. C. W., & Li, J. Y. (2009) · Immunotherapy · doi:10.2217/imt.09.75 · Cited by 59
Self-citation
Subtractive Expression Cloning Reveals High Expression of CD46 at the Blood-Brain Barrier
Shusta, E. V., Zhu, C., Boado, R. J., & Pardridge, W. M. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.7.597 · Cited by 56
Self-citation
Application of magnetically isolated rat retinal vascular endothelial cells for the determination of transporter gene expression levels at the inner blood–retinal barrier
Tomi, M., & Hosoya, K. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02842.x · Cited by 55
Vascular Genomics of the Human Brain
Shusta, E. V., Boado, R. J., Mathern, G. W., & Pardridge, W. M. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200203000-00001 · Cited by 55
Self-citation
Brain Penetrating Bifunctional Erythropoietin–Transferrin Receptor Antibody Fusion Protein for Alzheimer’s Disease
Chang, R., Maghribi, A. A., Vanderpoel, V., Vasilevko, V., Cribbs, D. H., Boado, R. J., Pardridge, W. M., & Sumbria, R. K. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00594 · Cited by 53
Self-citation
DNA array reveals altered gene expression in response to focal cerebral ischemia
Kim, Y.-D., Sohn, N. W., Kang, C., & Soh, Y. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(02)00823-7 · Cited by 54
Drug Permeability: From the Blood–Brain Barrier to the Peripheral Nerve Barriers
Sun, Y., Zabihi, M., Li, Q., Li, X., Kim, B. J., Ubogu, E. E., Raja, S. N., Wesselmann, U., & Zhao, C. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202200150 · Cited by 59
The Promises and Challenges of Erythropoietin for Treatment of Alzheimer’s Disease
Sun, J., Martin, J. M., Vanderpoel, V., & Sumbria, R. K. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-019-08524-y · Cited by 56
Critical View of Novel Treatment Strategies for Glioblastoma: Failure and Success of Resistance Mechanisms by Glioblastoma Cells
Burster, T., Traut, R., Yermekkyzy, Z., Mayer, K., Westhoff, M., Bischof, J., & Knippschild, U. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.695325 · Cited by 51
Blood–brain barrier genomics and proteomics: elucidating phenotype, identifying disease targets and enabling brain drug delivery
Calabria, A. R., & Shusta, E. V. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.07.006 · Cited by 52
The Isolated Brain Microvessel: A Versatile Experimental Model of the Blood-Brain Barrier
Pardridge, W. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00398 · Cited by 52
Self-citation
Pharmacokinetics and Brain Uptake of an IgG-TNF Decoy Receptor Fusion Protein Following Intravenous, Intraperitoneal, and Subcutaneous Administration in Mice
Sumbria, R. K., Zhou, Q.-H., Hui, E. K., Lu, J. Z., Boado, R. J., & Pardridge, W. M. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400004a · Cited by 47
Self-citation
The Vasculome of the Mouse Brain
Guo, S., Zhou, Y., Xing, C., Lok, J. M., Som, A. T., Ning, M., Ji, X., & Lo, E. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052665 · Cited by 47
Morphology and Properties of Brain Endothelial Cells
Nag, S. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-938-3_1 · Cited by 54
Recent advances in the brain-to-blood efflux transport across the blood–brain barrier
Hosoya, K., Ohtsuki, S., & Terasaki, T. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00457-x · Cited by 47
Epigenetics in blood–brain barrier disruption
Ihezie, S. A., Mathew, I. E., McBride, D. W., Dienel, A., Blackburn, S., & Pandit, P. K. T. (2021) · Fluids and Barriers of the CNS · doi:10.1186/s12987-021-00250-7 · Cited by 48
Blood-Brain Barrier Genomics
Pardridge, W. M. (2007) · Stroke · doi:10.1161/01.str.0000247887.61831.74 · Cited by 45
Self-citation
New systems for delivery of drugs to the brain in neurological disease
Cornford, E. M., & Cornford, M. E. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00136-9 · Cited by 44
Blood—Brain Barrier Genomics and Cloning of a Novel Organic Anion Transporter
Chu, C., Li, J. Y., Boado, R. J., & Pardridge, W. M. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600538 · Cited by 42
Self-citation
Rat Blood–Brain Barrier Genomics. II
Li, J. Y., Boado, R. J., & Pardridge, W. M. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000040944.89393.0f · Cited by 46
Self-citation
Blood-brain barrier genomics, proteomics, and new transporter discovery
Shusta, E. V. (2004) · NeuroRx · doi:10.1602/neurorx.2.1.151 · Cited by 43
Drug delivery to brain tumours: challenges and progress
Ningaraj, N. S. (2006) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.3.4.499 · Cited by 41
Analysis of mouse brain microvascular endothelium using immuno‐laser capture microdissection coupled to a hybrid linear ion trap with Fourier transform‐mass spectrometry proteomics platform
Lu, Q., Murugesan, N., Macdonald, J. A., Wu, S., Pachter, J. S., & Hancock, W. S. (2008) · Electrophoresis · doi:10.1002/elps.200700936 · Cited by 39
Dissecting gene expression at the blood-brain barrier
Huntley, M. A., Bien‐Ly, N., Daneman, R., & Watts, R. J. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00355 · Cited by 41
Identification and expression profiling of blood–brain barrier membrane proteins
Agarwal, N., Lippmann, E. S., & Shusta, E. V. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06481.x · Cited by 39
The transcriptome of cerebral ischemia
VanGilder, R. L., Huber, J. D., Rosen, C. L., & Barr, T. L. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.02.002 · Cited by 37
Genetic approach for intracerebroventricular delivery
Regev, L., Ezrielev, E., Gershon, E., Gil, S., & Chen, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907059107 · Cited by 35
Tissue Non-specific Alkaline Phosphatase (TNAP) in Vessels of the Brain
Deracinois, B., Lenfant, A., Dehouck, M., & Flahaut, C. (2015) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-017-7197-9_7 · Cited by 37
Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules
Janson, C. G., & During, M. J. (2006) · Springer eBooks · doi:10.1007/0-387-32956-0 · Cited by 35
In Vitro Models of CNS Barriers
Abbott, N. J., Dolman, D. E. M., Yusof, S. R., & Reichel, A. (2013) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4614-9105-7_6 · Cited by 34
Isolation of Cerebral Capillaries from Fresh Human Brain Tissue
Hartz, A. M. S., Schulz, J., Sokola, B. S., Edelmann, S. E., Shen, A. N., Rempe, R. G., Zhong, Y., Seblani, N. E., & Bauer, B. (2018) · Journal of Visualized Experiments · doi:10.3791/57346 · Cited by 33
OspA-CD40 dyad: ligand-receptor interaction in the translocation of neuroinvasive Borrelia across the blood-brain barrier
Pulzová, L., Kováč, A., Mucha, R., Mlynárčik, P., Bencúrová, E., Maďar, M., Novák, M., & Bhide, M. R. (2011) · Scientific Reports · doi:10.1038/srep00086 · Cited by 31
Application of data mining approaches to drug delivery
Ekins, S., Shimada, J., & Chang, C. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.005 · Cited by 31

Authors: Li, J. Y., Boado, R. J., & Pardridge, W. M.
Affiliations: University of California, Los Angeles (US)
Department of Medicine, UCLA School of Medicine, Los Angeles, California, U.S.A.
ORCID: Pardridge, William M.
Venue: Journal of Cerebral Blood Flow & Metabolism
Publisher: SAGE Publications
Published: 2001-01
Volume: 21
Issue: 1
Pages: 61-68
ISSN: 0271-678X (ISSN-L)
1559-7016
DOI: 10.1097/00004647-200101000-00008
OpenAlex: W1972326404
Cited by: 164
References: 27
Citations by year: 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 8 · 2019: 4 · 2018: 7 · 2017: 2 · 2016: 1 · 2015: 6 · 2014: 12 · 2013: 6 · 2012: 8
FWCI: 8.52
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ns038894-04)
National Institute of Neurological Disorders and Stroke (NS-38894)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords: blood-brain barrier, brain microvascular endothelium, tissue-specific gene expression, suppression subtractive hybridization, brain drug delivery, tissue plasminogen activator, insulin-like growth factor II, connexin 45, MHC class I, EZH1
MeSH terms: Animals, Blood-Brain Barrier, Brain, Capillaries, Cerebrovascular Circulation, Cloning, Molecular, Glioma, Kidney, Liver, Molecular Sequence Data, Myocardium, Nerve Tissue Proteins, Organ Specificity, RNA, Messenger, Tumor Cells, Cultured, Polymerase Chain Reaction, In Situ Hybridization, Oligonucleotide Array Sequence Analysis, Genomics, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Blood—Brain Barrier Genomics

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks