Cited by 415Barrier Structure and Function StudiesNanoparticle-Based Drug DeliveryDrug Transport and Resistance Mechanisms

Strategy for effective brain drug delivery

Alam, M. Intakhab, Beg, Sarwar, Samad, Abdus, Baboota, Sanjula, Kohli, Kanchan, Ali, Javed, Ahuja, Alka, Akbar, M.·2010·European Journal of Pharmaceutical Sciences

Abstract

Blood-brain barrier (BBB) together with enzymes restricts the entry of substances for maintaining the internal milieu of the brain. Because of the presence of multiple endogenous transporters, BBB allows a selective entry of nutrients and minerals across it and limits the entry of foreign substances like drugs as well as neuropharmaceutical agents. This makes the CNS treatment ineffective. The conventional drug delivery systems which release drug into general circulation fail to deliver drugs effectively to brain and is therefore not very useful in treating certain diseases that affect CNS including Alzheimer's disease, dementia, Parkinson's disease, mood disorder, AIDS, viral and bacterial meningitis. Therefore there is a need to develop and design approaches which specifically target to brain in a better and effective way. The present review enlightens about several novel approaches including nanotechnology based approach like nanoparticles, liposomes, antibody mediated delivery approach and application of genomics in brain drug targeting that would give an insight to the researchers, academia and industrialists.

Integrity signals

Registry

Crossref · 10.1016/j.ejps.2010.05.003

Cites

178 of 178 references verified0 citation errors · 0 not checkable

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  • Nasal administration of drugs using the nose-to-brain pathway allows direct drug targeting into the brain, avoiding the first-pass effect and bypassing the BBB.

    “The nasal administration of drugs using the nose-to-brain pathway allows direct drug targeting into the brain, avoiding the first-pass effect and bypassing the BBB.”

    From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [10]

  • Nose-to-brain drug delivery is a painless, non-invasive administration route that can deliver therapeutic agents into the brain by bypassing the blood-brain barrier.

    “Nose-to-brain drug delivery is a painless, non-invasive administration route that can be used to deliver therapeutic agents into the brain by bypassing the BBB [10,14,15,16,17].”

    From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [10]

  • Because of the direct connection provided by the olfactory and trigeminal nerves between the olfactory epithelium and the brain, drug targeting can be achieved by administering formulations onto the nasal mucosa.

    “Thanks to the direct connection provided by the olfactory and trigeminal nerves present between the olfactory epithelium and the brain, drug targeting can be achieved with the administration of formulations onto nasal mucosa [10,11,12].”

    From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [10]

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Authors
Alam, M. I., Beg, S., Samad, A., Baboota, S., Kohli, K., Ali, J., Ahuja, A., & Akbar, M.
Affiliations
  • Jamia Hamdard (IN)
  • Oman Medical College (OM)
Corresponding author
Baboota, Sanjula
Venue
European Journal of Pharmaceutical Sciences
Publisher
Elsevier BV
Published
2010-08
Volume
40
Issue
5
Pages
385-403
ISSN
0928-0987 (ISSN-L)
OpenAlex
W2016864853
Cited by
415
References
178
Citations by year
2026: 8 · 2025: 23 · 2024: 31 · 2023: 29 · 2022: 31 · 2021: 23 · 2020: 36 · 2019: 28 · 2018: 29 · 2017: 24 · 2016: 28 · 2015: 40 · 2014: 25 · 2013: 16 · 2012: 21
FWCI
1.62
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmaceutical Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
blood-brain barrier, brain drug delivery, central nervous system disorders, nanoparticles, liposomes, neuropharmaceuticals, Alzheimer's disease, Parkinson's disease, meningitis
MeSH terms
Animals, Biological Transport, Blood-Brain Barrier, Brain, Central Nervous System Diseases, Pharmaceutical Preparations, Humans, Proteins, Technology, Pharmaceutical, Drug Design, Drug Delivery Systems, Mice, Rats

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