Hyperkinetic borderline hypertension in Tecumseh, Michigan
Abstract
Of 691 healthy (untreated) villagers of Tecumseh, Michigan (average age 32.6 years), 99 had a clinical blood pressure exceeding 140/90 mmHg. Thirty-seven per cent of these borderline hypertensives had increased heart rate, cardiac index, forearm blood flow and plasma norepinephrine. These subjects had elevated self-determined home blood pressure (average of 14 measurements). The present hyperkinetic borderlines had elevated blood pressure at 5, 8, 21 and 23 years of age and their parents also had higher blood pressure. The prevalence of high blood pressure in Tecumseh, its long history, elevated blood pressure readings outside the physician's office and family background of hypertension, suggests that the hyperkinetic state is a significant clinical condition. Previous studies on hospital-based populations proved that the hyperkinetic state is caused by an excessive autonomic drive. The association of the hyperkinetic state with elevated norepinephrine in this study suggests that a sympathetic hyperactivity is present in a large proportion of unselected subjects with mild blood pressure elevation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Young subjects with hyperkinetic borderline hypertension had increased heart rate frequently associated with an elevation in plasma norepinephrine.
“In classic studies by Julius et al31, young subjects with hyperkinetic borderline hypertension, had increased heart rate which was frequently associated with an elevation in plasma norepinephrine.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [31]
Cited by
Sorted by citations
In utero programming of chronic disease
BARKER, D. J. P. (1998) · Clinical Science · doi:10.1042/cs0950115 · Cited by 1,765 · see citing works
Feasibility of Treating Prehypertension with an Angiotensin-Receptor Blocker
Julius, S., Nesbitt, S. D., Egan, B. M., Weber, M. A., Michelson, E. L., Kaciroti, N., Black, H. R., Grimm, R. H., Messerli, F. H., Oparil, S., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa060838 · Cited by 919 · see citing works
Self-citationOsmond, C., & Barker, D. J. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s3545 · Cited by 656 · see citing works
The Autonomic Nervous System and Hypertension
Mancia, G., & Grassi, G. (2014) · Circulation Research · doi:10.1161/circresaha.114.302524 · Cited by 627 · see citing works
The Sympathetic Nervous System Alterations in Human Hypertension
Grassi, G., Mark, A., & Esler, M. (2015) · Circulation Research · doi:10.1161/circresaha.116.303604 · Cited by 616 · see citing works
Heart rate and the cardiovascular risk
Palatini, P., & Julius, S. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715010-00001 · Cited by 508 · see citing works
Self-citationThe sympathetic nervous system and the metabolic syndrome
Mancia, G., Bousquet, P., Elghozi, J. L., Esler, M., Grassi, G., Julius, S., Reid, J., & Van Zwieten, P. A. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e328048d004 · Cited by 385 · see citing works
Self-citationAssessment of Sympathetic Cardiovascular Drive in Human Hypertension
Grassi, G. M. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.119883 · Cited by 340 · see citing works
Isolated systolic hypertension, obesity, and hyperkinetic hemodynamic states in children
Sorof, J. M., Poffenbarger, T. S., Franco, K., Bernard, L., & Portman, R. J. (2002) · The Journal of Pediatrics · doi:10.1067/mpd.2002.125228 · Cited by 339 · see citing works
McEniery, C. M., Yasmin, Y., Wallace, S. M. L., Maki-Petaja, K. M., McDonnell, B. J., Sharman, J. E., Retallick, C., Franklin, S. S., Brown, M. J., Lloyd, R., et al. (2005) · Hypertension · doi:10.1161/01.hyp.0000165310.84801.e0 · Cited by 284 · see citing works
Autonomic imbalance, hypertension, and cardiovascular risk
Brook, R. H. (2000) · American Journal of Hypertension · doi:10.1016/s0895-7061(00)00228-4 · Cited by 260 · see citing works
Overweight and Hypertension: A 2-Way Street?
Julius, S., Valentini, M., & Palatini, P. (2000) · Hypertension · doi:10.1161/01.hyp.35.3.807 · Cited by 253 · see citing works
Self-citationSympathetic overactivity in hypertension. A moving target
JULIUS, S., & NESBITT, S. (1996) · American Journal of Hypertension · doi:10.1016/0895-7061(96)00287-7 · Cited by 237 · see citing works
Self-citationSympathetic Neural Activity in Hypertension and Related Diseases
Grassi, G. M. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.154 · Cited by 225 · see citing works
Corcoran Lecture. Sympathetic hyperactivity and coronary risk in hypertension.
Julius, S. (1993) · Hypertension · doi:10.1161/01.hyp.21.6.886 · Cited by 216 · see citing works
Self-citationSimms, A. E., Paton, J. F. R., Pickering, A. E., & Allen, A. M. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.165902 · Cited by 211 · see citing works
“In man, measures of sympathetic function, using microneurography or noradrenaline spill-over, have shown increased activity levels in young hypertensive patients and populations at risk of developing hypertension (Julius et al. 1991; Grassi, 1998; Esler, 2000; Schlaich et al. 2004).”
MethodThe role of cardiac autonomic function in hypertension and cardiovascular disease
Palatini, P., & Julius, S. (2009) · Current Hypertension Reports · doi:10.1007/s11906-009-0035-4 · Cited by 195 · see citing works
“In the young general population of the Tecumseh Offspring Study, 37% of those studied were classifi ed by cluster analysis as having a hyperkinetic state and high norepinephrine values [ 4 ].”
BackgroundInfluentialSelf-citationAutonomic impairment in painful neuropathy
Novak, V., Freimer, M. L., Kissel, J. T., Sahenk, Z., Periquet‐Collins, I., Nash, S. M., Collins, M. P., & Mendell, J. R. (2001) · Neurology · doi:10.1212/wnl.56.7.861 · Cited by 177 · see citing works
Sex-specific determinants of increased left ventricular mass in the Tecumseh blood pressure study
Marcus, R., Krause, L., Weder, A. B., Dominguez-Meja, A., Schork, N. J., & Julius, S. (1994) · Circulation · doi:10.1161/01.cir.90.2.928 · Cited by 174 · see citing works
The underlying mechanisms for development of hypertension in the metabolic syndrome
Yanai, H., Tomono, Y., Ito, K., Furutani, N., Yoshida, H., & Tada, N. (2008) · Nutrition Journal · doi:10.1186/1475-2891-7-10 · Cited by 171 · see citing works
“Elevated resting heat rates [20,21], and baroreflex dysfunction have been reported to play an important role in development of hypertension in the metabolic syndrome [22].”
The Interconnection between Sympathetics, Microcirculation, and Insulin Resistance in Hypertension
Julius, S., Gudbrandsson, T., Jamerson, K., & Andersson, O. (1992) · Blood Pressure · doi:10.3109/08037059209065119 · Cited by 153 · see citing works
Self-citationLind, L., & Lithell, H. (1993) · American Heart Journal · doi:10.1016/0002-8703(93)90446-g · Cited by 132 · see citing works
Sympathetic Overdrive and Cardiovascular Risk in the Metabolic Syndrome
Grassi, G. M. (2006) · Hypertension Research · doi:10.1291/hypres.29.839 · Cited by 131 · see citing works
“For example “old” data collected in the Tecumseh Study have shown that young patients with borderline hypertension (and particularly those with a hyperkinetic circulation) display a resting tachycardia associated with increased plasma norepinephrine values (6).”
BackgroundAdverse childhood experiences and the cardiovascular health of children: a cross-sectional study
Pretty, C., O’Leary, D. D., Cairney, J., & Wade, T. J. (2013) · BMC Pediatrics · doi:10.1186/1471-2431-13-208 · Cited by 132 · see citing works
Impaired Autonomic Nervous System-Microbiome Circuit in Hypertension
Zubcevic, J. A., Richards, E. M., Yang, T., Kim, S., Sumners, C., Pepine, C. J., & Raizada, M. K. (2019) · Circulation Research · doi:10.1161/circresaha.119.313965 · Cited by 123 · see citing works
FACCHINI, F., Stoohs, R. A., & Reaven, G. M. (1996) · American Journal of Hypertension · doi:10.1016/0895-7061(96)87747-8 · Cited by 121 · see citing works
Angiotensin-Converting Enzyme Inhibitors
Izzo, J. L., & Weir, M. R. (2011) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2011.00508.x · Cited by 120 · see citing works
The changing face of sympathetic overactivity in hypertension
Julius, S., & Majahalme, S. K. (2000) · Annals of Medicine · doi:10.3109/07853890008995939 · Cited by 113 · see citing works
Self-citationNeuroinflammation and sympathetic overactivity: Mechanisms and implications in hypertension
Haspula, D., & Clark, M. A. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.01.002 · Cited by 111 · see citing works
Fagard, R. H., Pardaens, K., Staessen, J. A., & Thijs, L. (1996) · Hypertension · doi:10.1161/01.hyp.28.1.31 · Cited by 101 · see citing works
Adaptation, allometry, and hypertension.
Weder, A. B., & Schork, N. J. (1994) · Hypertension · doi:10.1161/01.hyp.24.2.145 · Cited by 100 · see citing works
Self-citationVentura, H. O., Taler, S. J., & Strobeck, J. E. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.11.002 · Cited by 95 · see citing works
The Evidence for a Pathophysiologic Significance of the Sympathetic Overactivity in Hypertension
Julius, S. (1996) · Clinical and Experimental Hypertension · doi:10.3109/10641969609088965 · Cited by 89 · see citing works
Self-citationIsolated systolic hypertension in the young
Palatini, P., Rosei, E. A., Avolio, A. P., Bilo, G., Casiglia, E., Ghiadoni, L., Giannattasio, C., Grassi, G. M., Jelakovich, B., Julius, S., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001726 · Cited by 88 · see citing works
“6 years) had prehypertension and 37% of them had hyperkinetic circulation [33,34].”
BackgroundMethodInfluentialSelf-citationPal, G. K., Pal, P., Nanda, N., Amudharaj, D., & Adithan, C. (2012) · Future Cardiology · doi:10.2217/fca.12.80 · Cited by 84 · see citing works
“It was observed that in patients with chronic HTN, vascular resistance remains elevated even after a complete blockade of the ANS suggesting that vascular tone in established HTN is not dependent on autonomic tone for its maintenance [63,64].”
BackgroundHeart Rate, Sympathetic Cardiovascular Influences, and The Metabolic Syndrome
Grassi, G. M., Arenare, F., Quarti‐Trevano, F., Seravalle, G., & Mancia, G. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2009.05.007 · Cited by 79 · see citing works
“This is particularly the case in young borderline hypertensive patients, displaying the so-called hyperkinetic circulation, or in subjects with a severe obese state.(4,13) There is evidence that when pooling together data related to sympathetic markers collected in people with hypertension, obesity, or heart failure (…”
BackgroundThe Autonomic Nervous System and Hypertension: Ethnic Differences and Psychosocial Factors
Hill, L. K., & Thayer, J. F. (2019) · Current Cardiology Reports · doi:10.1007/s11886-019-1100-5 · Cited by 70 · see citing works
Blood Pressure in Pediatric Patients with Cushing Syndrome
Lodish, M. B., Sinaii, N., Patronas, N. J., Batista, D. L., Keil, M. F., Samuel, J., Moran, J., Verma, S., Popovic, J., & Stratakis, C. A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2694 · Cited by 72 · see citing works
Hyperdynamic circulation and the insulin resistance syndrome ("syndrome X").
D, M. P. S. M., Morales, P. A., Haffner, S. M., & Valdez, R. A. (1992) · Hypertension · doi:10.1161/01.hyp.20.6.802 · Cited by 73 · see citing works
Excessive Respiratory Modulation of Blood Pressure Triggers Hypertension
Menuet, C., Le, S., Dempsey, B., Connelly, A. A., Kamar, J., Jancovski, N., Bassi, J. K., Walters, K., Simms, A. E., Hammond, A., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.01.019 · Cited by 72 · see citing works
“This elevated SNA is established during childhood, prior to clinical hypertension, in some humans (Julius et al., 1991).”
BackgroundRostral Ventrolateral Medulla Neurons of Neonatal Wistar-Kyoto and Spontaneously Hypertensive Rats
Matsuura, T., Kumagai, H., Kawai, A., Onimaru, H., Imai, M., Oshima, N., Sakata, K., & Saruta, T. (2002) · Hypertension · doi:10.1161/01.hyp.0000032043.64223.87 · Cited by 70 · see citing works
The autonomic control of heart rate and insulin resistance in young adults.
Flanagan, D., Vaile, J., Petley, G., Moore, V., Godsland, I., Cockington, R., Robinson, J., & Phillips, D. (1999) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem.84.4.5592 · Cited by 77 · see citing works
The sympathetic nervous system and baroreflexes in hypertension and hypotension
Izzo, J. L., & Taylor, A. A. (1999) · Current Hypertension Reports · doi:10.1007/s11906-999-0030-9 · Cited by 69 · see citing works
“Subsequent to that review, a prospective cohort follow-up study in Tecumseh, Michigan found that 37% of borderline hypertensives had elevated resting plasma NE, heart rate, cardiac index, and forearm blood flow [ 40 ].”
BackgroundCentral imidazoline (I1) receptors as targets of centrally acting antihypertensives
van Zwieten, P. A. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715020-00001 · Cited by 65 · see citing works
Elevated heart rate in cardiovascular diseases: a target for treatment?
Palatini, P. (2009) · Progress in cardiovascular diseases · doi:10.1016/j.pcad.2009.05.005 · Cited by 68 · see citing works
The impact of elevated blood pressure on exercise capacity in elite athletes
Mazic, S. D., Suzic-Lazić, J., Dekleva, M., Antić, M., Soldatović, I., Djelic, M. N., Nešić, D., Aćimović, T., Lazic, M., Lazović, B., et al. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.11.125 · Cited by 63 · see citing works
Isolated Systolic Hypertension in Young People Is Not Spurious and Should Be Treated
McEniery, C. M., Franklin, S. S., Cockcroft, J. R., & Wilkinson, I. B. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.06547 · Cited by 63 · see citing works
The Role of the Autonomic Nervous System in Hypertension.
Amerena, J., & Julius, S. (1995) · Hypertension Research · doi:10.1291/hypres.18.99 · Cited by 63 · see citing works
Self-citationPalatini, P., Saladini, F., Mos, L., Fania, C., Mazzer, A., Cozzio, S., Zanata, G., Garavelli, G., Biasion, T., Spinella, P., et al. (2019) · Journal of Hypertension · doi:10.1097/hjh.0000000000002074 · Cited by 62 · see citing works
“com as other cohort studies [41,42] and sympathetic predominance has been found to be implicated in the development of hypertensive complications [40,43,44].”
BackgroundReactivity as a Predictor of Subsequent Blood Pressure
Knox, S. S., Hausdorff, J. M., & Markovitz, J. H. (2002) · Hypertension · doi:10.1161/01.hyp.0000041417.94797.57 · Cited by 62 · see citing works
Origins of Primary Hypertension in Children
Litwin, M., & Feber, J. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14586 · Cited by 58 · see citing works
“Increased sympathetic activity seems to be an important step in the development of PH, and there are data showing that PH evolves from a hyperkinetic to a normokinetic state, starting in childhood.(84,85) Although there are no data on direct measurements of sympathetic nervous system activity in children with PH, ther…”
BackgroundSiński, M., Lewandowski, J., Przybylski, J., Zalewski, P., Symonides, B., Abramczyk, P., & Gaciong, Z. A. (2014) · Hypertension Research · doi:10.1038/hr.2014.91 · Cited by 56 · see citing works
Balanos, G. M., Phillips, A. C., Frenneaux, M. P., McIntyre, D. B., Lykidis, C. K., Griffin, H. S., & Carroll, D. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.06.001 · Cited by 57 · see citing works
Ernsberger, P. R., Koletsky, R. J., Collins, L. A., & Bedol, D. (1996) · Cardiovascular Drugs and Therapy · doi:10.1007/bf00120497 · Cited by 55 · see citing works
Consequences of the Increased Autonomic Nervous Drive in Hypertension, Heart Failure and Diabetes
Julius, M. (1998) · Blood Pressure · doi:10.1080/080370598438410-1 · Cited by 55 · see citing works
Seravalle, G., Mancia, G., & Grassi, G. M. (2014) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-014-0056-1 · Cited by 53 · see citing works
“First, in young hypertensive subjects, displaying a very mild blood pressure increase, plasma norepinephrine values are already elevated [16].”
BackgroundCardiovascular Phenotype of Elevated Blood Pressure Differs Markedly Between Young Males and Females
Nardin, C., Maki-Petaja, K. M., Miles, K. L., Yasmin, Y., McDonnell, B. J., Cockcroft, J. R., Wilkinson, I. B., McEniery, C. M., on behalf of the Enigma Study Investigators*, Benedict, S., et al. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11975 · Cited by 53 · see citing works
“Previous investigators have described the phenomenon of a hyperdynamic circulation in young males, preceding the development of sustained hypertension, characterized by normal PVR but increased SV and HR.(21) In addition, our previous data from the Enigma study, which focused on the pathogenesis of isolated systolic h…”
InfluentialPalatini, P., Longo, D., Zaetta, V., et al. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000234118.25401.1c · Cited by 53 · see citing works
Heart rate: a strong predictor of mortality in subjects with coronary artery disease
Palatini, P. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi235 · Cited by 53 · see citing works
“Records of subjects with ‘hyperkinetic’ circulation diagnosed at average age of 32 years in the Tecumseh study, show that they had reproducible tachycardia at 6 and 22 years of age.(10) Today, a large body of evidence substantiates the concept that tachycardia is not only a marker of other cardiovascular risk factors…”
BackgroundHeart rate as a cardiovascular risk factor: do women differ from men?
Palatini, P. (2001) · Annals of Medicine · doi:10.3109/07853890108998748 · Cited by 52 · see citing works
Brachial vs. Central Systolic Pressure and Pulse Wave Transmission Indicators: A Critical Analysis
Izzo, J. L. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu135 · Cited by 50 · see citing works
Saladini, F., Fania, C., Mos, L., et al. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09516 · Cited by 46 · see citing works
Akahoshi, M., Hida, A., Imaizumi, M., Soda, M., Maeda, R., Ichimaru, S., Nakashima, E., Seto, S., & Yano, K. (2006) · Hypertension Research · doi:10.1291/hypres.29.1 · Cited by 46 · see citing works
“It is also known that sympathetic hyperactivity is associated with increased HR in borderline hypertension (24, 25).”
BackgroundIs augmented central respiratory–sympathetic coupling involved in the generation of hypertension?
Simms, A. E., Paton, J. F. R., Allen, A. M., & Pickering, A. E. (2010) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2010.07.010 · Cited by 45 · see citing works
Isolated Systolic Hypertension in Young People Is Not Spurious and Should Be Treated
Lurbe, E., & Redón, J. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.06548 · Cited by 45 · see citing works
Vriz, O. (1997) · American Journal of Hypertension · doi:10.1016/s0895-7061(96)00489-x · Cited by 42 · see citing works
Centrally acting antihypertensives
van Zwieten, P. A. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715011-00001 · Cited by 44 · see citing works
Abnormalities of autonomic nervous control in human hypertension
Julius, S. (1994) · Cardiovascular Drugs and Therapy · doi:10.1007/bf00877080 · Cited by 43 · see citing works
“Plasma norepinephrine levels in hyperkinet.ic borderline hypertension are elevated [ 22 ].”
BackgroundResultSelf-citationThe complex interaction between overweight, hypertension, and sympathetic overactivity
Feldstein, C. A., & Julius, S. (2009) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2009.10.001 · Cited by 41 · see citing works
Self-citationDisorders of Blood Pressure Regulation—Role of Catecholamine Biosynthesis, Release, and Metabolism
Currie, G. E., Freel, E. M., Perry, C. G., & Dominiczak, A. F. (2011) · Current Hypertension Reports · doi:10.1007/s11906-011-0239-2 · Cited by 41 · see citing works
Autonomic Nervous Dysfunction in Essential Hypertension
Julius, S. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.249 · Cited by 41 · see citing works
“Thirty-seven percent of all subjects with borderline hypertension investigated in Tecumseh, Michigan, have high cardiac output and elevated plasma norepinephrine levels (52).”
BackgroundSelf-citationUnusual Hypertensive Phenotypes
Franklin, S. S., Wilkinson, I. B., & McEniery, C. M. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.182956 · Cited by 40 · see citing works
Noninvasive hemodynamic profiles in hypertensive subjects
ABDELHAMMED, A., SMITH, R., Levy, P. J., et al. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.11.043 · Cited by 40 · see citing works
“Subjects who are younger or pregnant are more likely to have a high cardiac output as a component of their hypertension.(2,3) In contrast, increased systemic vascular resistance often associated with either normal or reduced cardiac output is the hallmark of hypertensive stages in older subjects.”
BackgroundDo Allelic Variants in α 2A and α 2C Adrenergic Receptors Predispose to Hypertension in Blacks?
Li, J.-L., Canham, R. M., Vongpatanasin, W., Leonard, D. S., Auchus, R. J., & Victor, R. G. (2006) · Hypertension · doi:10.1161/01.hyp.0000217972.80731.ef · Cited by 39 · see citing works
Autonomic Dysfunction in Diabetes: a Consequence of Cardiovascular Damage
Lefrandt, J. D., Smit, A. J., Zeebregts, C. J., Gans, R. O. B., & Hoogenberg, K. (2010) · Current Diabetes Reviews · doi:10.2174/157339910793499128 · Cited by 38 · see citing works
Julius, S. (1995) · Clinical and Experimental Hypertension · doi:10.3109/10641969509087078 · Cited by 37 · see citing works
Self-citationValentini, M., Julius, S., Palatini, P., Brook, R. D., Bard, R. L., Bisognano, J. D., & Kaciroti, N. (2004) · Journal of Hypertension · doi:10.1097/00004872-200410000-00024 · Cited by 36 · see citing works
Self-citationSynchronization of Adolescent Blood Pressure and Pubertal Somatic Growth
Tu, W., Eckert, G. J., Saha, C., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0997 · Cited by 37 · see citing works
“For children going through puberty, much of the rise in BP is accompanied by an increase in height (9, 10).”
BackgroundMechanisms underlying elevated SBP differ with adiposity in young adults
Middlemiss, J. E., Miles, K. L., McDonnell, B. J., Yasmin, Y., Maki-Petaja, K. M., Cockcroft, J. R., Wilkinson, I. B., & McEniery, C. M. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000798 · Cited by 37 · see citing works
“Previous data in young adults from the Tecumseh study [34] highlighted an adverse metabolic profile in individuals with borderline hypertension compared with those with normal BP.”
BackgroundEssential hypertension and the sympathetic nervous system
Grassi, G. M., Quarti‐Trevano, F., Dell’Oro, R., & Mancia, G. (2008) · Neurological Sciences · doi:10.1007/s10072-008-0882-9 · Cited by 36 · see citing works
“These haemodynamic abnormalities are accompanied (and probably triggered) by a state of adrenergic overdrive, given the evidence that the circulating plasma levels of the main adrenergic neurotransmitter, i.e., norepinephrine, are increased in these young patients [ 2 ].”
BackgroundHering, D., Kára, T., Kucharska, W., Somers, V. K., & Narkiewicz, K. (2015) · Blood Pressure · doi:10.3109/08037051.2015.1121708 · Cited by 35 · see citing works
“documented in this cohort.[13,14] Therapy with cande-”
Arterial mechanics predict cardiovascular risk in hypertension
Safar, M. E., Siche, J. P., Mallion, J.-M., et al. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715120-00061 · Cited by 35 · see citing works
A prediction model for the response to oral labetalol for the treatment of antenatal hypertension
Stott, D., Bolten, M., Salman, M., Paraschiv, D., Douiri, A., & Kametas, N. A. (2016) · Journal of Human Hypertension · doi:10.1038/jhh.2016.50 · Cited by 33 · see citing works
Palatini, P., Reboldi, G., Saladini, F., Angeli, F., Mos, L., Rattazzi, M., Vriz, O., & Verdecchia, P. (2022) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwac020 · Cited by 32 · see citing works
Essential hypertension in adolescents and children: Recent advances in causative mechanisms
Raj, M. (2011) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.86981 · Cited by 31 · see citing works
“[43] Resting tachycardia probably resulting from increased levels of norepinephrine is consistently seen in these young patients.[43] The increased sympathetic activity is probably due to a derangement in the sympathoinhibition exerted by reflexogenic areas (such as the arterial baroreceptors, the cardiopulmonary rece…”
Circulating renalase, catecholamines, and vascular adhesion protein 1 in hypertensive patients
Maciorkowska, D., Zbroch, E., & Małyszko, J. (2015) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2015.08.002 · Cited by 30 · see citing works
The proinflammatory cytokine tumor necrosis factor-α excites subfornical organ neurons
Simpson, N. J., & Ferguson, A. V. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00238.2017 · Cited by 29 · see citing works
Pathogenesis and etiology of essential hypertension: role of dietary carbohydrate
Kopp, W. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.10.009 · Cited by 29 · see citing works
“In some persons, insulin evokes an abnormal muscle sympathetic overactivity, with high NE spillover rates [8] and often a hyperdynamic circulation – characterised by a high cardiac output, a rapid heart rate and a low PVR [3,9].”
BackgroundHigh Heart Rate Relates to Clustering of Cardiovascular Risk Factors in a Screened Cohort.
Inoue, T., Oshiro, S., Iseki, K., Tozawa, M., Touma, T., Ikemiya, Y., & Takishita, S. (2001) · Japanese Circulation Journal-english Edition · doi:10.1253/jcj.65.969 · Cited by 28 · see citing works
Park, C. M., Fraser, A., Howe, L. D., Jones, S. H., Smith, G. D., Lawlor, D. A., Chaturvedi, N., & Hughes, A. D. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11925 · Cited by 28 · see citing works
Grassi, G. M., Seravalle, G., Brambilla, G., & Mancia, G. (2012) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2011.11.005 · Cited by 27 · see citing works
P‐Wave dispersion increases in prehypertension
Cagirci, G., Çay, S., Karakurt, Ö., ERYAŞAR, N. E., Açıkel, S., Doğan, M., Yeşilay, A. B., Kılıç, H., & Akdemir, R. (2009) · Blood Pressure · doi:10.1080/08037050902779441 · Cited by 27 · see citing works
Resting Heart Rate as a Cardiovascular Risk Factor in Hypertensive Patients: An Update
Palatini, P. (2020) · American Journal of Hypertension · doi:10.1093/ajh/hpaa187 · Cited by 27 · see citing works
Llabre, M. M., Klein, B., Saab, P. G., McCalla, J. R., & Schneiderman, N. (1998) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm0503_3 · Cited by 27 · see citing works
“Our hypertensive group was rather mild and relatively young, so it may be that their responses are consistent with that initial hyperkinetie state described by Julius (1988) .”
ResultPalatini, P., Majahalme, S. K., Amerena, J. V., Nesbitt, S. D., Vriz, O., Michieletto, M., Krause, L. C., & Julius, S. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018060-00016 · Cited by 27 · see citing works
Self-citationSchäfers, R. F., Nürnberger, J., Rütz, A., et al. (2001) · Pharmacogenetics · doi:10.1097/00008571-200108000-00001 · Cited by 27 · see citing works
Saladini, F., & Palatini, P. (2017) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-017-0199-y · Cited by 26 · see citing works
“One of the first authors who investigated the mechanisms leading to hypertension in young subjects was Stevo Julius in the USA [20].”
BackgroundAllen, A. M. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.12.003 · Cited by 25 · see citing works
Light, K. C., Turner, J. R., Hinderliter, A. L., Girdler, S. S., & Sherwood, A. (1994) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm0103_4 · Cited by 25 · see citing works
Prehypertension: Demographics, pathophysiology, and treatment
Izzo, J. L. (2007) · Current Hypertension Reports · doi:10.1007/s11906-007-0049-8 · Cited by 25 · see citing works
“The pathogenesis of prehypertension and sustained hypertension is thus becoming clearer (Fig. 1). The findings of TROPHY are entirely consistent with the early neurohumoral activation demonstrated in prehypertension in the Tecumseh Study [ 13 ].”
Result
- Authors
- Julius, S., Krause, L., Schork, N. J., Mejia, A. D., Jones, K. A., van de Ven, C., Johnson, E. H., Sekkarie, M. A., Kjeldsen, S. E., Petrin, J., Schmouder, R., Gupta, R., Ferraro, J., Nazzaro, P., & Weissfeld, J.
- Affiliations
- University of Michigan (US)
- ORCID
- Venue
- Journal of Hypertension
- Published
- 1991-01
- Volume
- 9
- Issue
- 1
- Pages
- 77-84
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W2151385266
- Cited by
- 248
- References
- 0
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 6 · 2022: 14 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 13 · 2017: 11 · 2016: 10 · 2015: 7 · 2014: 8 · 2013: 8 · 2012: 3
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r37hl037464-10)
- National Heart, Lung, and Blood Institute (HL-37464)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- borderline hypertension, Tecumseh, Michigan, home blood pressure, norepinephrine, sympathetic hyperactivity, heart rate, cardiac index, forearm blood flow, family history of hypertension, autonomic nervous system, blood pressure prevalence
- MeSH terms
- Adult, Female, Hemodynamics, Humans, Hyperkinesis, Hypertension, Longitudinal Studies, Male, Michigan, Norepinephrine, Population Surveillance, Risk Factors, Sympathetic Nervous System, Echocardiography, Doppler, Prevalence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
