Posttraumatic Stress Disorder and Major Depressive Disorder: Investigating the Role of Overlapping Symptoms in Diagnostic Comorbidity

FRANKLIN, C. LAUREL; ZIMMERMAN, MARK

doi:10.1097/00005053-200108000-00008

Cited by 156Posttraumatic Stress Disorder ResearchSleep and related disordersAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Posttraumatic Stress Disorder and Major Depressive Disorder: Investigating the Role of Overlapping Symptoms in Diagnostic Comorbidity

FRANKLIN, C. LAUREL, ZIMMERMAN, MARK·2001·The Journal of Nervous and Mental Disease

DOI 10.1097/00005053-200108000-00008

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Abstract

Studies of posttraumatic stress disorder (PTSD) have found high levels of comorbid major depressive disorder (MDD). One reason suggested for the comorbidity is the symptom overlap (contaminated symptoms) between the disorders. The present study investigated the contribution of contaminated symptoms (anhedonia, concentration, and sleep problems) to the comorbidity of PTSD and MDD. PTSD symptoms were subdivided into two groups: the contaminated symptoms and the 14 unique symptoms. It was speculated that if the contaminated symptoms are responsible for the comorbidity, then they will show less specificity than the unique symptoms, will be less highly correlated with a PTSD symptom total count, and be more frequently endorsed in PTSD patients with than without MDD. These hypotheses were tested in a sample (N = 1300) of psychiatric outpatients, 260 of whom had lifetime PTSD. None of the hypotheses were supported, thereby suggesting that the comorbidity between PTSD and MDD is not an artifact of symptom overlap.

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The symptom dimensions used for a diagnosis may reflect complex sequelae resulting from an overlap in symptom presentation of multiple disorders.
“Similarly, the symptom dimensions used for a diagnosis may reflect complex sequelae resulting from an overlap in symptom presentation of multiple disorders (20).”
From Conditioned fear associated phenotypes as robust, translational indices of trauma-, stressor-, and anxiety-related behaviors (2014) · cites this paper as [20]

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Authors: FRANKLIN, C. L., & ZIMMERMAN, M.
Affiliations: Brown University (US)
ORCID: FRANKLIN, C. LAUREL
Venue: The Journal of Nervous and Mental Disease
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2001-08
Volume: 189
Issue: 8
Pages: 548-551
ISSN: 0022-3018 (ISSN-L)
DOI: 10.1097/00005053-200108000-00008
OpenAlex: W2057466150
Cited by: 156
References: 14
Citations by year: 2026: 2 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 10 · 2019: 7 · 2018: 4 · 2017: 10 · 2016: 7 · 2015: 8 · 2014: 11 · 2013: 4 · 2012: 10
FWCI: 5.76
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Nervous and Mental Disease (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: post-traumatic stress disorder, major depressive disorder, symptom overlap, anhedonia, concentration difficulties, sleep disorders, symptom specificity, psychiatric outpatients
MeSH terms: Adolescent, Adult, Aged, Ambulatory Care, Antibody Specificity, Depressive Disorder, Diagnosis, Differential, Female, Humans, Life Change Events, Male, Middle Aged, Models, Psychological, Psychiatric Status Rating Scales, Psychometrics, Stress Disorders, Post-Traumatic, Reproducibility of Results, Comorbidity, Chi-Square Distribution

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Posttraumatic Stress Disorder and Major Depressive Disorder: Investigating the Role of Overlapping Symptoms in Diagnostic Comorbidity

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