Cited by 629Posttraumatic Stress Disorder ResearchPsychoanalysis and Psychopathology ResearchPersonality Disorders and Psychopathology

Comorbidity between post-traumatic stress disorder and major depressive disorder: Alternative explanations and treatment considerations

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Flory, Janine D., Yehuda, Rachel·2015·Dialogues in Clinical Neuroscience

Abstract

Approximately half of people with post-traumatic stress disorder (PTSD) also suffer from Major Depressive Disorder (MDD). The current paper examines evidence for two explanations of this comorbidity. First, that the comorbidity reflects overlapping symptoms in the two disorders. Second, that the co-occurrence of PTSD and MDD is not an artifact, but represents a trauma-related phenotype, possibly a subtype of PTSD. Support for the latter explanation is inferred from literature that examines risk and biological correlates of PTSD and MDD, including molecular processes. Treatment implications of the comorbidity are considered.

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Authors
Flory, J. D., & Yehuda, R.
Affiliations
James J. Peters VA Medical Center (US)
Corresponding author
Flory, Janine D.
Venue
Dialogues in Clinical Neuroscience
Published
2015-06-30
Volume
17
Issue
2
Pages
141-150
ISSN
  • 1294-8322 (ISSN-L)
  • 1958-5969
OpenAlex
W2402965079
Cited by
629
References
57
Citations by year
2026: 57 · 2025: 63 · 2024: 82 · 2023: 71 · 2022: 90 · 2021: 68 · 2020: 74 · 2019: 42 · 2018: 43 · 2017: 26 · 2016: 10 · 2015: 2
FWCI
33.94
Type
journal article
Language
en
Open access
Locations
  • Dialogues in Clinical Neuroscience (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
U.S. Department of Veterans Affairs (I01 CX000952)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords
post-traumatic stress disorder, major depressive disorder, comorbidities, symptom overlap, PTSD subtypes, risk factors, biological correlates, molecular processes, therapeutic implications
MeSH terms
Major Depressive Disorder, Depressive Disorder, Major, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Risk Factors, Stress Disorders, Post-Traumatic, Comorbidity, Neuroimaging

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