The DOI matches its Crossref record.
Regulation of the Gene Encoding Tumor Necrosis Factor Alpha (TNF-α) in the Rat Brain and Pituitary in Response to Different Models of Systemic Immune Challenge
Abstract
Tumor necrosis factor (TNF)-alpha is usually referred to as a proinflammatory cytokine that plays a central role in initiating the cascade of other cytokines and factors for an appropriate immune response to infection. Like systemic phagocytes, recent studies have reported that specific cellular populations of the CNS have the ability to express and release the proinflammatory cytokine in response to peripheral administration of the bacterial endotoxin lipopolysaccharide (LPS). Whether such phenomenon represents a general mechanism of systemic immunogenic stimuli and how the severity of the challenge may influence TNF-alpha transcription in the brain has yet to be defined. Adult male rats were sacrificed 1, 3, 6, 12, 24 and 48 hours (h) after intraperitoneal (IP) injection of LPS (25-250 microg/100 g) or intramuscular (IM) injection of turpentine. Brains and pituitary glands were removed, cut, and TNF-alpha mRNA assayed by in situ hybridization using a full-length rat cRNA probe. The results show no positive signal under basal conditions or following sterile inflammation into the left hind limb. Systemic LPS caused a profound increase in the expression of the gene encoding TNF-alpha in the leptomeninges, choroid plexus (chp) and all sensorial circumventricular organs (CVOs). Interestingly, a migratory-like pattern of TNF-alpha-positive cells became apparent around the sensorial CVOs at 3 h, while a ubiquitous-like positive signal was found throughout the brain 6 h after the injection with the highest dose of LPS. The IP LPS injection also stimulated TNF-alpha transcription in the anterior pituitary lobe; the signal was maximal 1 h after the injection and returned gradually to basal levels at 12 h, whereas the mRNA encoding the cytokine was detected later in the neurohypophysis, i.e. 3 and 6 h post challenge. Dual-labeling procedure provided the evidence of an LPS-dependent induction of TNF-alpha in different phagocytic cellular populations of the brain, including parenchymal microglial cells during severe endotoxemia. The fact that these myeloid-derived cells have the ability to express the LPS receptor CD14 in the brain may well explain the transcriptional activation of the cytokine in response to the bacterial endotoxin, but not to systemic localized inflammation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
LPS administration promotes rapid expression of pro-inflammatory cytokines such as TNFα in all sensory CVOs as well as the meninges and choroid plexus.
“LPS administration is also known to promote rapid expression of pro-inflammatory cytokines such as TNFα in all sensory CVOs as well as the meninges and choroid plexus (102).”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [102]
Citations
Cited by
Sorted by citations
The blood-brain barrier in systemic inflammation
Varatharaj, A., & Galea, I. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.03.010 · Cited by 1,172
“Receptors for IL-1b, IL-6, and TNF-a are expressed on cerebral endothelium (Ericsson et al., 1995; Vallières and Rivest, 1997; Nadeau and Rivest, 1999), and systemic IL-1b and TNF-a cause cerebral endothelial activation (Skelly et al., 2013).”
Regulation of innate immune responses in the brain
Rivest, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2565 · Cited by 843
Self-citationInnate immunity: the missing link in neuroprotection and neurodegeneration?
Nguyen, M. D., Julien, J., & Rivest, S. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn752 · Cited by 710
Self-citationImmune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection
Silverman, M. N., Pearce, B. D., Biron, C. A., & Miller, A. H. (2005) · Viral Immunology · doi:10.1089/vim.2005.18.41 · Cited by 506
LAFLAMME, N., & RIVEST, S. (2001) · The FASEB Journal · doi:10.1096/fj.00-0339com · Cited by 501
“Microscopic analysis of emulsion-dipped slides revealed that TNFpositive cells spread over the anatomical boundaries of the CVOs in a migratory-like pattern during the course of the endotoxemia ( 14 ).”
BackgroundInfluentialSelf-citationCytokines and brain excitability
Galic, M. A., Riazi, K., & Pittman, Q. J. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.12.002 · Cited by 462
“Receptors for cytokines are also present in the CNS, with localization on vascular endothelial and perivascular cells, microglia, astrocytes and neurons [42,47,53,106].”
BackgroundUrakubo, A., Jarskog, L. F., Lieberman, J. A., & Gilmore, J. H. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00032-3 · Cited by 405
Choroid plexus and the blood–cerebrospinal fluid barrier in disease
Solár, P., Zamani, A., Kubíčková, L., Dubový, P., & Joukal, M. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-00196-2 · Cited by 365
The anatomy and immunology of vasculature in the central nervous system
Mastorakos, P., & McGavern, D. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav0492 · Cited by 333
“LPS administration is also known to promote rapid expression of pro-inflammatory cytokines such as TNF in all sensory CVOs as well as the meninges and choroid plexus (102).”
Nadeau, S., & Rivest, S. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00225-0 · Cited by 279
Self-citationRivest, S., Lacroix, S., Vallières, L., Nadeau, S., Zhang, J., & Laflamme, N. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22304.x · Cited by 277
Self-citationDevelopment of the choroid plexus
Dzięgielewska, K. M., Ek, C. J., Habgood, M. D., & Saunders, N. R. (2000) · Microscopy Research and Technique · doi:10.1002/1097-0029(20010101)52:1 · Cited by 245
Ageing and neurodegenerative diseases
Hung, C.-W., Chen, Y., Hsieh, W.-L., Chiou, S., & Kao, C.-L. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.006 · Cited by 257
Lacroix, S., Feinstein, D., & Rivest, S. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00189.x · Cited by 223
“kBa mRNA expression in the rat brain (27).”
BackgroundSelf-citationDuan, L., Zhang, X., Miao, W., Sun, Y., Xiong, G., Wu, Q.-Z., Li, G., Yang, P., Yu, H., Li, H., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.030 · Cited by 219
Turrin, N. P., & Rivest, S. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.03.010 · Cited by 213
Self-citationNeural Mechanisms of Inflammation-Induced Fever
Blomqvist, A. G., & Engblom, D. (2018) · The Neuroscientist · doi:10.1177/1073858418760481 · Cited by 197
“…such as interleukin (IL)-1β, IL-6 and tumor necrosis factor alpha (TNFα) (Ericsson and others 1995; Konsman and others 2004; Laflamme and Rivest 2001; Nadeau and Rivest 1999a, 1999b; Vallieres and Rivest 1997), although it seems as if the receptor expressing cells are endothelial cells and not…”
BackgroundRivest, S. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00064-6 · Cited by 195
Self-citationLaflamme, N., & Rivest, S. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730309.x · Cited by 182
“…necrosis factor-a (TNF-a) and IL-1b has recently been found in the brain of LPStreated rats, although a second pattern of small scattered cells became apparent throughout the brain after the challenge (Breder et al., 1994; Buttini and Boddeke, 1995; Quan et al., 1997a; Nadeau and Rivest, 1999).”
BackgroundSelf-citationGilmore, J. H., Jarskog, L. F., & Vadlamudi, S. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.10.008 · Cited by 177
Nadeau, S., & Rivest, S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03456.2000 · Cited by 217
“Of interest is the data that systemic injection of the bacterial endotoxin induced strong expression of CD14 (Lacroix et al., 1998) mRNA in a pattern that was closely related to the induction of tumor necrosis factor a (TNF-a) (Nadeau and Rivest, 1999) transcript with a rapid and delayed response.”
BackgroundMethodInfluentialSelf-citation(Peri)vascular production and action of pro-inflammatory cytokines in brain pathology
Konsman, J. P., Drukarch, B., & van Dam, A. (2006) · Clinical Science · doi:10.1042/cs20060043 · Cited by 174
The choroid plexus—a multi-role player during infectious diseases of the CNS
Schwerk, C., Tenenbaum, T., Kim, K. S., & Schroten, H. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00080 · Cited by 147
“Challenge with TLR ligands including lipopolysaccharide (LPS), a ligand for TLR4, elicits the up-regulation of cytokines in the CP, as demonstrated by in situ hybridization of brain sections or microarray analyses in animal models (Tarlow et al., 1993; Vallières and Rivest, 1997; Nadeau and Rivest, 1999; Quan et al.,…”
BackgroundSekino, N., Selim, M. H., & Shehadah, A. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02464-4 · Cited by 146
Thibeault, I., Laflamme, N., & Rivest, S. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1187 · Cited by 129
Self-citationWohleb, E. S., & Delpech, J.-C. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.04.013 · Cited by 132
Interleukin-10 inhibits endotoxin-induced pro-inflammatory cytokines in microglial cell cultures
Kremlev, S. G., & Palmer, C. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.01.010 · Cited by 128
Immunomodulatory Strategies in Herpes Simplex Virus Encephalitis
Piret, J., & Boivin, G. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00105-19 · Cited by 136
Marques, F., Sousa, J. C., Coppola, G., Falcão, A. M., Rodrigues, A. J., Geschwind, D. H., Sousa, N., Correia‐Neves, M., & Palha, J. A. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.15 · Cited by 122
“Among these are immune mediators such as interleukin IL-1b and TNF (Nadeau and Rivest, 1999; Quan et al, 1999), enzymes such as prostaglandin D2 synthase (Marques et al, 2007) and bacteriostatic proteins such as lipocalin 2 (LCN2) (Marques et al, 2008).”
BackgroundInfluentialKremlev, S. G., Roberts, R. L., & Palmer, C. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.11.012 · Cited by 117
Mingam, R., Smedt, V. D., Amédée, T., Bluthé, R.-M., Kelley, K. W., Dantzer, R., & Layé, S. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.08.007 · Cited by 110
“The main cellular sources of IL-1β and TNFα in the brain are microglia that are well known to express P2X7R (Buttini and Boddeke, 1995; Ferrari et al., 1997; Nadeau and Rivest, 1999; van Dam et al., 1992).”
BackgroundGilmore, J. H., Jarskog, L. F., & Vadlamudi, S. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00095-x · Cited by 106
Central nervous system recognition of peripheral inflammation: a neural, hormonal collaboration.
Hopkins, S. J. (2007) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · Cited by 102
Thompson, W. L., Karpus, W. J., & Eldik, L. J. V. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-35 · Cited by 107
Connecting cytokines and brain: a review of current issues.
Quan, N., & Herkenham, M. A. (2002) · PubMed · doi:10.14670/hh-17.273 · Cited by 101
Voirin, A.-C., Perek, N., & Roche, F. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146647 · Cited by 99
Immune-To-Brain Signaling: How Important are the Blood–Brain Barrier-independent Pathways?
Quan, N. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8026-z · Cited by 97
“First, peripheral immune challenge induces strong expression of proinflammatory cytokines by cells inside the CVOs [25–29].”
BackgroundNadeau, S., & Rivest, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.3370 · Cited by 94
“This contrasts with the effects of systemic LPS injection that cause transcriptional activation of CD14 (5) and TNF ( 11 ) first within the CVOs and thereafter throughout the brain microglial cells.”
Zhang, J., & Rivest, S. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00080.x · Cited by 92
“Systemic LPS treatment increased TNF-a expression ®rst in the circumventricular organs and thereafter within microglial cells across the brain parenchyma (Nadeau and Rivest 1999, 2000).”
BackgroundMethodInfluentialSelf-citationAudoy-Rémus, J., Richard, J.-F., Soulet, D., Zhou, H., Kubes, P., & Vallières, L. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3510-08.2008 · Cited by 93
“As previously reported (Nadeau and Rivest, 1999; Quan et al., 1999), LPS strongly induced the expression of both cytokines in the brains of wild-type mice, predominantly along the leptomeninges and some blood vessels (Fig.”
BackgroundZimmermann, C., Ginis, I., Furuya, K., Klimanis, D., Ruetzler, C. A., Spatz, M., & Hallenbeck, J. M. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02028-5 · Cited by 92
Wetzel, M. K., Rosenberg, G. A., & Cunningham, L. A. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02838.x · Cited by 91
Signaling the brain in inflammation: the role of endothelial cells
Matsumura, K. (2004) · Frontiers in bioscience · doi:10.2741/1439 · Cited by 87
Rods and cones project to the inner plexiform layer during development
Johnson, P. T., Williams, R. R., Cusato, K., & Reese, B. E. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991108)414:1 · Cited by 56
Segura, M. F., Solé, C., Pascual, M., Moubarak, R. S., Pérez‐García, M. J., Gozzelino, R., Iglesias‐Guimarais, V., Badiola, N., Bayascas, J. R., Llecha, N., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3462-07.2007 · Cited by 79
Old Friends, immunoregulation, and stress resilience
Langgartner, D., Lowry, C. A., & Reber, S. O. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2228-7 · Cited by 76
Lebel, E., Vallières, L., & Rivest, S. (2000) · Endocrinology · doi:10.1210/endo.141.10.7695 · Cited by 31
Self-citationThe choroid plexus response to peripheral inflammatory stimulus
Marques, F., Sousa, J. C., Correia‐Neves, M., Oliveira, P., Sousa, N., & Palha, J. A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.029 · Cited by 67
In-depth conversation: Spectrum and kinetics of neuroimmune afferent pathways
Quan, N. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.02.006 · Cited by 65
“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript IL-1β and TNFα in circulation activate neurons in the subfornical organ, a CVO involved in sensing angiotensin II, to trigger increased blood pressure, heart rate, and renal sympathetic activity (Wei et al., 2013).”
BackgroundInfluentialBerčík, P., Verdu, E. F., Foster, J. A., Lu, J., Scharringa, A., Kean, I. R. L., Wang, L., Blennerhassett, P. A., & Collins, S. M. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90752.2008 · Cited by 62
“Also, increased c-fos mRNA has been detected in the circumventricular organs of rats after intravenous TNF- challenge (21).”
BackgroundStern, E. L., Quan, N., Proescholdt, M. G., & Herkenham, M. A. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00318-0 · Cited by 57
Bette, M., Kaut, O., Schäfer, M. K.-H., & Weihe, E. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10877 · Cited by 56
Peebles, D., Miller, S. L., Newman, J. P., et al. (2003) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2003.02152.x · Cited by 54
Impact of intestinal disorders on central and peripheral nervous system diseases
El-Hakim, Y., Bake, S., Mani, K. K., & Sohrabji, F. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105627 · Cited by 54
Foster, J. A., Quan, N., Stern, E. L., Kristensson, K., & Herkenham, M. A. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00258-8 · Cited by 51
Stridh, L., Ek, C. J., Wang, X., Nilsson, H., & Mallard, C. E. (2013) · Translational Stroke Research · doi:10.1007/s12975-012-0248-8 · Cited by 49
“Others have previously shown, by in situ hybridization, that IL-1β and TNF-α mRNA expression is increased in the choroid plexus and circumventricular organs following peripheral LPS injection in adult rats [40, 41].”
BackgroundVasilache, A. M., Qian, H., & Blomqvist, A. G. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.02.003 · Cited by 49
The complement system is an integrated part of the natural innate immune response in the brain
Nadeau, S., & Rivest, S. (2001) · The FASEB Journal · doi:10.1096/fj.00-0709fje · Cited by 49
“This delay fits quite well with the hypothesis that centrally produced TNF-α is an endogenous prerequisite factor in the activation of cerebral innate immune response.”
BackgroundInfluentialSelf-citationTumor Necrosis Factor-α Activates the Human Prolactin Gene Promoter via Nuclear Factor-κB Signaling
Friedrichsen, S., Harper, C. V., Semprini, S., Wilding, M., Adamson, A. D., Spiller, D. G., Nelson, G., Mullins, J. J., White, M., & Davis, J. R. (2005) · Endocrinology · doi:10.1210/en.2005-0967 · Cited by 49
“TNF-α is expressed in multiple tissues including brain and pituitary (18).”
Kim, J., Ryu, H. J., & Kang, T. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-62 · Cited by 44
“Similar to previous studies [26-29], the present study shows that TNF-a immunoreactivity is readily apparent in hippocampal neurons as well as dentate granule cells in non-SE-induced animals.”
BackgroundResultMurta, V., Farías, M. I., Pitossi, F. J., & Ferrari, C. C. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.11.023 · Cited by 43
“The up-regulation of IL-6 and TNFαwas described in the brain of animals peripherally treated with LPS (Breder et al., 1994; Vallieres and Rivest, 1997; Nadeau and Rivest, 1999), while the acute ip injection of IL-1β protein inmice induces hypothalamic IL-1β and TNFα (but not IL-6) ex-”
BackgroundPiret, J., & Boivin, G. (2015) · Reviews in Medical Virology · doi:10.1002/rmv.1848 · Cited by 44
“This leads to the progressive activation of resident microglial cells and to the production of TNF-α, which acts in autocrine and paracrine manners to activate the immune cells across the brain parenchyma [53].”
BackgroundImmune mechanisms of stress susceptibility and resilience: Lessons from animal models
Tsyglakova, M., McDaniel, D. K., & Hodes, G. E. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100771 · Cited by 46
Sánchez-Lemus, E., Benický, J., Pavel, J., & Saavedra, J. M. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.04.012 · Cited by 43
“Conversely, IL-1b and TNF-a may be produced in macrophage-like cells (Eriksson et al., 2000; Herkenham, 2005; Nadeau and Rivest, 1999; Whiteside et al., 1999).”
Paterson, G., Ohashi, Y., Reynolds, G. P., Pratt, J. A., & MORRIS, B. J. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881106062025 · Cited by 41
“This contrasts with a brain immune type response in which systemic administration of LPS or other inflammatory agents leads to a transient increase in TNF mRNA which is maximal after 1–2h and not detected at 12h (De Simoni et al., 1997; Laflamme and Rivest, 1999; Nadeau and Rivest, 1999).”
BackgroundCautionary notes on the use of NF-κB p65 and p50 antibodies for CNS studies
Herkenham, M. A., Rathore, P., Brown, P., & Listwak, S. J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-141 · Cited by 41
“The lack of neuronal NF- B response observed with the authentic p65 antibodies is a finding consistent with studies employing in situ hybridization histochemistry showing non-neuronal localization of induced I Ba mRNA expression in injury, infection, and pain models [20,54-56] and of known NFB-regulated genes in simil…”
ResultTNF-α Induces Apoptosis of Lactotropes from Female Rats
Candolfi, M., Zaldivar, V., Laurentiis, A. D., Jaita, G., Pisera, D. A., & Seilicovich, A. (2002) · Endocrinology · doi:10.1210/en.2002-220377 · Cited by 41
Schwerk, C., Adam, R., Borkowski, J., Schneider, H., Klenk, M., Zink, S., Quednau, N., Schmidt, N., Stump-Guthier, C., Sagar, A., et al. (2011) · Microbes and Infection · doi:10.1016/j.micinf.2011.05.012 · Cited by 38
Candolfi, M., Jaita, G., Zaldivar, V., Zárate, S., Ferrari, L. C., Pisera, D. A., Castro, M. G., & Seilicovich, A. (2004) · Endocrinology · doi:10.1210/en.2004-1276 · Cited by 39
Fink, K. D., Crane, A. T., Lévêque, X., et al. (2014) · Stem Cells Translational Medicine · doi:10.5966/sctm.2013-0151 · Cited by 38
Xia, Y., & Krukoff, T. L. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00065-1 · Cited by 38
Reyes-Irisarri, E., Pérez-Torres, S., Miró, X., Martı́nez, E., Puigdomènech, P., Palacios, J. M., & Mengod, G. (2007) · Synapse · doi:10.1002/syn.20459 · Cited by 36
“Regulation of the gene encoding tumor necrosis factor alpha (TNF-alpha) in the rat brain and pituitary in response in different models of systemic immune challenge.”
BackgroundInfluentialInhibition of nuclear factor-kappa B prevents staphylococcal enterotoxin A-induced fever
Shao, D.-Z., Lee, J.-J., Huang, W.-T., et al. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000038233.20276.e0 · Cited by 36
Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation
Ma, L.-L., Liu, H., Luo, C., He, Y., Wang, F., Huang, H., Han, L., Yang, M., Xu, R., & Zhang, D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.583279 · Cited by 38
“Brain endothelial cells express IL-1 receptor type 1 (Konsman et al., 2004) and TNF-α receptor p55 (Nadeau and Rivest, 1999).”
BackgroundWittmann, G., Szabon, J., Mohácsik, P., Nouriel, S. S., Gereben, B., Fekete, C., & Lechan, R. M. (2015) · Endocrinology · doi:10.1210/en.2014-1830 · Cited by 35
Bruening, S., Oh, E. J., Hetzenauer, A., Escobar-Alvarez, S., Westphalen, R. I., Hemmings, H. C., Singewald, N., Shippenberg, T. S., & Tóth, M. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04129.x · Cited by 35
“The collective influence of modifier genes on a mutant phenotype is referred to as the genetic background (Romeo and McKusick 1994; Nadeau and Rivest 1999; Nadeau 2001; Johnson et al. 2006).”
Background- Self-citation
Lasa, M., Gil-Araujo, B., Palafox, M., & Aranda, A. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0298 · Cited by 32
Lonnemann, N., Hosseini, S., Ohm, M., Geffers, R., Hiller, K., Dinarello, C. A., & Körte, M. (2022) · eLife · doi:10.7554/elife.75889 · Cited by 28
Rafiei, M., Shojaei, A., & Chau, Y. (2025) · Drug Delivery · doi:10.1080/10717544.2025.2465909 · Cited by 32
“…significantly decreased thereafter. this finding is consistent with previous studies that have noted the transient nature of il10’s effects, underscoring the necessity for sustained delivery of anti-inflammatory signals through mRNa-based therapies (Nadeau and Rivest, 1999; Dagvadorj et al., 2008).”
Cytokines and HPA Axis Regulation
Silverman, M. N., Pearce, B. D., & Miller, A. H. (2003) · Neurobiological foundation of aberrant behaviors · doi:10.1007/978-1-4615-0323-1_5 · Cited by 29
Candolfi, M., Jaita, G., Zaldivar, V., Zárate, S., Pisera, D. A., & Seilicovich, A. (2004) · Neuroendocrinology · doi:10.1159/000081313 · Cited by 25
Stern, E. L., Quan, N., Proescholdt, M. G., & Herkenham, M. A. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00194-6 · Cited by 24
Involvement of brain cytokines in zymosan-induced febrile response
Bastos-Pereira, A. L., Fraga, D., Ott, D., Simm, B., Murgott, J., Roth, J., & Zampronio, A. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01278.2013 · Cited by 23
Boivin, N., Menasria, R., Piret, J., Rivest, S., & Boivin, G. (2013) · Antiviral Research · doi:10.1016/j.antiviral.2013.10.007 · Cited by 22
Self-citationHu, J., Ferchmin, P. A., Hemmerle, A. M., Seroogy, K. B., Eterović, V. A., & Hao, J. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00272 · Cited by 22
“…of a variety of inflammatory mediators in brain endothelial cells, such as interleukin-1 (Quan et al., 1998a), tumor necrosis factor (TNF) (Nadeau and Rivest, 1999; Yang et al., 1999), cyclooxygenase-2 (Quan et al., 1998b), inducible nitric oxide synthase (Wong et al., 1996), and the…”
BackgroundTheas, M. S., Pisera, D. A., Duvilanski, B. H., et al. (2000) · Endocrine · doi:10.1385/endo:12:3:249 · Cited by 20
Mapping the areas sensitive to long‐term endotoxin tolerance in the rat brain: a c‐fos mRNA study
Vallès, A., Martı́, O., & Armario, A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03100.x · Cited by 20
Stress and Cognition: Psychological Basis and Support Resources
Llanderal, T. C., Melgarejo-Gutiérrez, M. A., & Hernández-Baltazar, D. (2018) · InTech eBooks · doi:10.5772/intechopen.72566 · Cited by 19
Brain parenchymal TNF-α and IL-1β induction in experimental pneumococcal meningitis
Izadpanah, K., Freyer, D., Weber, J. R., et al. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.08.625 · Cited by 19
“Both glia and neurons have the intrinsic capacity to produce TNF-α and IL-1β in vitro and in vivo in diverse disease models (Freyer et al., 1999; Nadeau and Rivest, 1999; Sairanen et al., 2001; Kiaei et al., 2007).”
BackgroundZhu, Q., Emanuele, M. A., LaPaglia, N., Kovacs, E. J., & Emanuele, N. (2007) · Endocrine · doi:10.1007/s12020-007-9010-5 · Cited by 19
Loss of class I MHC function alters behavior and stress reactivity
Sankar, A., MacKenzie, R. N., & Foster, J. A. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.12.025 · Cited by 20
“5B), representative of glial cells previously shown to upregulate TNF-α mRNA following immune challenge (Nadeau and Rivest, 1999, 2000; Proescholdt et al., 2002).”
BackgroundClinical and experimental aspects of breathing modulation by inflammation
Peña‐Ortega, F. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.11.002 · Cited by 21
Nitric Oxide Mediates the Inhibitory Effect of Tumor Necrosis Factor-α on Prolactin Release
Theas, M. S., Laurentiis, A. D., Candolfi, M., López, S. L., Carrasco, A. E., Zaldivar, V., & Seilicovich, A. (2001) · Neuroendocrinology · doi:10.1159/000054673 · Cited by 18
“This cytokine is synthesized and released by anterior pituitary cells [”
BackgroundPedchenko, T. V., Bronshteyn, I. G., & LeVine, S. M. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00345-3 · Cited by 18
Emanuele, N., LaPaglia, N., Kovacs, E. J., & Emanuele, M. A. (2005) · Endocrine Research · doi:10.1080/07435800500228930 · Cited by 17
Cytokines, neurophysiology, neuropsychology, and psychiatric symptoms.
Schwarz, M. (2003) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2003.5.2/mschwarz · Cited by 19
“IL-1 appears to act on neurons in hippocampus and amygdala to inhibit long-term poten- B a s i c r e s e a r c h tiation and weaken synaptic strength.116,117 A contrary effect was demonstrated for TNF-α.”
BackgroundGut instincts in neuroimmunity from the eighteenth to twenty-first centuries
Nguyen, M. T., & Palm, N. W. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00948-2 · Cited by 20
“Sylvain Nadeau and Serge Rivest at Laval University found that myeloid-derived cells in the brain express the LPS receptor CD14, indicating that brain-resident myeloid cells may sense peripheral bacterial products [28].”
BackgroundRôle de la réponse immunitaire innée dans le cerveau
Blais, V., & Rivest, S. (2003) · médecine/sciences · doi:10.1051/medsci/20031910981 · Cited by 16
“Le LPS circulant entraîne lui aussi une forte augmentation de l’expression des gènes codant pour le CD14, le TLR2, plusieurs cytokines et chimiokines, ainsi que les protéines du système du complément [17-22] dans les”
BackgroundSelf-citationProposed Toxic and Hypoxic Impairment of a Brainstem Locus in Autism
McGinnis, W. R., AUDHYA, T. K., & Edelson, S. B. (2013) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph10126955 · Cited by 18
Metadata
- Authors
- Nadeau, S., & Rivest, S.
- Affiliations
- Centre hospitalier de l'Université Laval (CA)
- Corresponding author
- Rivest, Serge
- ORCID
- Rivest, Serge
- Venue
- Journal of Neuropathology and Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01
- Volume
- 58
- Issue
- 1
- Pages
- 61-77
- ISSN
- 0022-3069 (ISSN-L)
- OpenAlex
- W2049819816
- Cited by
- 142
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 1
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- TNF-α, TNF-alpha gene expression, lipopolysaccharide, endotoxemia, brain, pituitary gland, choroid plexus, circumventricular organs, microglia, CD14, neuroinflammation, turpentine, neurohypophysis, phagocytes, CNS immune response, rats, in situ hybridization
- MeSH terms
- Animals, Antibody Formation, Brain, Dose-Response Relationship, Drug, Gene Expression Regulation, Genetic Code, Inflammation, Injections, Intramuscular, Lipopolysaccharides, Male, Models, Biological, Pituitary Gland, Tumor Necrosis Factor-alpha, Turpentine, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
