Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14
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There is a robust and transient innate immune response in the brain during endotoxemia, which is associated with a cascade of NF-kappaB signaling events and transcriptional activation of genes that encode TNF-alpha and the LPS receptor CD14. The present study investigated whether circulating LPS has the ability to modulate the cerebral innate immune response caused by an intrastriatal (IS) injection of the endotoxin. We also tested the possibility that CD14 plays a role in these effects and male rats received an intracerebroventricular injection with an anti-CD14 before the IS LPS administration. The single LPS bolus into the striatum caused a strong and time-dependent transcriptional activation of TNF-alpha, IkappaBalpha, CD14, and monocyte chemoattractant protein-1 mRNA in microglial cells ipsilateral to the site of injection. Surprisingly, this wave of induced transcripts was essentially abolished by the systemic endotoxin pretreatment. Such anti-inflammatory properties of circulating LPS are mediated via plasma corticosterone, because exogenous corticoids mimicked while glucocorticoid receptor antagonist RU486 prevented the effects of systemic endotoxin challenge. Of interest is the partial involvement of CD14 in LPS-induced neuroinflammation; the anti-CD14 significantly abolished the microglial activity at day 3, but not at times earlier. The inflammatory response provoked by an acute intraparenchymal LPS bolus was not associated with convincing neurodegenerative processes. These data provide compelling evidence that systemic inflammation, through the increase in circulating glucocorticoids, has the ability to prevent the cerebral innate immune reaction triggered by an IS endotoxin injection. This study also further consolidates the existence of such system in the brain, which is finely regulated and its transient activation is not harmful for the neuronal elements.
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The robust inflammatory response induced by an intracerebral injection of LPS could be abolished by a prior systemic administration of the endotoxin.
“Accordingly, Nadeau et al. reported that the robust inflammatory response induced by an intracerebral injection of LPS could be abolished by a prior systemic administration of the endotoxin (137).”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [137]
The immunosuppressive actions of peripheral LPS were mediated by plasma corticosterone and GR activation.
“Further investigation revealed that the immunosuppressive actions of peripheral LPS were mediated by plasma corticosterone and GR activation.”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [137]
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Cites
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777 · see citing works
Schmued, L. C., Albertson, C., & Slikker, W. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01387-x · Cited by 995 · see citing works
Neuroendocrine Regulation of Immunity
Webster, J. I., Tonelli, L., & Sternberg, E. M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.082401.104914 · Cited by 957 · see citing works
Kim, W., Mohney, R. P., Wilson, B. C., Jeohn, G., Liu, B., & Hong, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06309.2000 · Cited by 881 · see citing works
Tlr4: central component of the sole mammalian LPS sensor.
Beutler, B. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00046-1 · Cited by 847 · see citing works
Haziot, A., Ferrero, E., Köntgen, F., Hijiya, N., Yamamoto, S., Silver, J. E., Stewart, C. L., & Goyert, S. M. (1996) · Immunity · doi:10.1016/s1074-7613(00)80254-x · Cited by 732 · see citing works
Innate immunity: the missing link in neuroprotection and neurodegeneration?
Nguyen, M. D., Julien, J., & Rivest, S. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn752 · Cited by 698 · see citing works
The role of microglia and macrophages in the pathophysiology of the CNS
Stollg, G., & Jander, S. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00083-5 · Cited by 683 · see citing works
Toll signaling pathways in the innate immune response.
Anderson, K. V. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00045-x · Cited by 677 · see citing works
LAFLAMME, N., & RIVEST, S. (2001) · The FASEB Journal · doi:10.1096/fj.00-0339com · Cited by 501 · see citing works
Castaño, A., Herrera, A. J., Cano, J., & Machado, A. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70041584.x · Cited by 393 · see citing works
Quan, N., Whiteside, M., & Herkenham, M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00350-3 · Cited by 335 · see citing works
Andersson, P.-B., Perry, V. H., & Gordon†, S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90347-5 · Cited by 324 · see citing works
A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis
Persidsky, Y., Stins, M. F., Way, D., Witte, M., Weinand, M. E., Kim, K. S., Bock, P., Gendelman, H. E., & Fiala, M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.7.3499 · Cited by 316 · see citing works
Toll, A New Piece in the Puzzle of Innate Immunity
Wright, S. D. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.4.605 · Cited by 235 · see citing works
Breder, C. D., Hazuka, C., Ghayur, T., Klug, C., Huginin, M., Yasuda, K., Teng, M., & Saper, C. B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11393 · Cited by 226 · see citing works
Lacroix, S., Feinstein, D., & Rivest, S. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00189.x · Cited by 223 · see citing works
Nadeau, S., & Rivest, S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03456.2000 · Cited by 217 · see citing works
Kitchens, R. L., & Munford, R. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.17.9904 · Cited by 144 · see citing works
Nadeau, S., & Rivest, S. (1999) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199901000-00008 · Cited by 142 · cited 2× · see citing works
“This contrasts with the effects of systemic LPS injection that cause transcriptional activation of CD14 (5) and TNF ( 11 ) first within the CVOs and thereafter throughout the brain microglial cells.”
Haziot, A., Lin, X. Y., Zhang, F., & Goyert, S. (1998) · Journal of Immunology · doi:10.4049/jimmunol.160.6.2570 · Cited by 82 · see citing works
Toll gates for pathogen selection
Ulevitch, R. J. (1999) · Nature · doi:10.1038/44490 · Cited by 69 · see citing works
Haziot, A., Lin, X. Y., Zhang, F., & Goyert, S. M. (1998) · PubMed · Cited by 66 · see citing works
Stern, E. L., Quan, N., Proescholdt, M. G., & Herkenham, M. A. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00318-0 · Cited by 57 · see citing works
Immune regulation and CNS autoimmune disease
Antel, J. P., & Owens, T. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00186-1 · Cited by 55 · see citing works
Stern, E. L., Quan, N., Proescholdt, M. G., & Herkenham, M. A. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00194-6 · Cited by 24 · see citing works
Flagged first, then by citations
1 of the 27 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144 · see citing works
Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265 · see citing works
Regulation of innate immune responses in the brain
Rivest, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2565 · Cited by 843 · see citing works
Self-citationAn inflammatory review of glucocorticoid actions in the CNS
Sorrells, S. F., & Sapolsky, R. M. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.11.006 · Cited by 461 · see citing works
The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain
Bellavance, M.-A., & Rivest, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00136 · Cited by 419 · see citing works
Self-citationMolecular insights on the cerebral innate immune system
Rivest, S. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00055-7 · Cited by 417 · see citing works
Human lupus autoantibodies against NMDA receptors mediate cognitive impairment
Kowal, C., DeGiorgio, L. A., Lee, J. Y., Edgar, M. A., Huerta, P. T., Volpe, B. T., & Diamond, B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608397104 · Cited by 415 · see citing works
Neuroprotective role of the innate immune system by microglia
Glezer, I., Simard, A. R., & Rivest, S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.055 · Cited by 371 · see citing works
Review: Systemic inflammation and<scp>A</scp>lzheimer's disease
Holmes, C. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01307.x · Cited by 356 · see citing works
The Impact of Systemic Inflammation on Alzheimer’s Disease Pathology
Xie, J., Van Hoecke, L., & Vandenbroucke, R. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.796867 · Cited by 324 · see citing works
Sierra, A., Beccari, S., Díaz‐Aparicio, I., Encinas, J. M., Comeau, S., & Tremblay, M. (2014) · Neural Plasticity · doi:10.1155/2014/610343 · Cited by 249 · see citing works
MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation
Fricker, M., Neher, J. J., Zhao, J.-W., Théry, C., Tolkovsky, A. M., & Brown, G. C. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4837-11.2012 · Cited by 218 · see citing works
Turrin, N. P., & Rivest, S. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.03.010 · Cited by 213 · see citing works
Nguyen, M. D., D'Aigle, T., Gowing, G., Julien, J.-P., & Rivest, S. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4786-03.2004 · Cited by 248 · see citing works
Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats
Loram, L. C., Sholar, P. W., Taylor, F. R., Wiesler, J. L., Babb, J. A., Strand, K. A., Berkelhammer, D. L., Day, H. E. W., Maier, S. F., & Watkins, L. R. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.02.018 · Cited by 196 · see citing works
Glucocorticoids Play a Fundamental Role in Protecting the Brain during Innate Immune Response
Nadeau, S., & Rivest, S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05536.2003 · Cited by 190 · see citing works
Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells
Liberman, A. C., Budziñski, M. L., Sokn, C., Gobbini, R. P., Steininger, A., & ARZT, E. S. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00235 · Cited by 185 · see citing works
Inflammation in Parkinson’s disease: role of glucocorticoids
Herrero, M.-T., Estrada, C., Maatouk, L., & Vyas, S. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00032 · Cited by 175 · see citing works
“…through prior challenge with systemic LPS that resulted in rise in systemic corticosterone levels with concomitant and significant reductions in proinflammatory TNF-α , Monocyte chemoattractant protein MCP-1, I κ B α transcripts in lesioned striatal/cortical region (Nadeau and Rivest, 2002).”
Laflamme, N., Echchannaoui, H., Landmann, R. M., & Rivest, S. (2003) · European Journal of Immunology · doi:10.1002/eji.200323821 · Cited by 160 · see citing works
Nayak, D., Huo, Y., Kwang, T. W., Pushparaj, P. N., Srinivasan, D. K., Ling, E., & Dheen, S. T. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.020 · Cited by 152 · see citing works
O'Sullivan, J. B., Ryan, K. M., Curtin, N. M., Harkin, A., & Connor, T. J. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114570800967x · Cited by 146 · see citing works
What is microglia neurotoxicity (Not)?
Biber, K. P. H., Owens, T., & Boddeke, E. (2014) · Glia · doi:10.1002/glia.22654 · Cited by 141 · see citing works
Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo
Kozina, E. A., Sadasivan, S., Jiao, Y., Dou, Y., Ma, Z., Tan, H., Kodali, K., Shaw, T. I., Peng, J., & Smeyne, R. J. (2018) · Brain · doi:10.1093/brain/awy077 · Cited by 137 · see citing works
Soucy, G., Boivin, G., Labrie, F., & Rivest, S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6391 · Cited by 138 · see citing works
Blandino, P., Barnum, C. J., Solomon, L. G., Larish, Y., Lankow, B. S., & Deak, T. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.04.013 · Cited by 137 · see citing works
Gosselin, D., & Rivest, S. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.12.004 · Cited by 130 · see citing works
Goralski, K. B., Hartmann, G., Piquette‐Miller, M., & Renton, K. W. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705227 · Cited by 130 · see citing works
The brain’s best friend: microglial neurotoxicity revisited
Hellwig, S., Heinrich, A., & Biber, K. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00071 · Cited by 126 · see citing works
Glezer, I., Lapointe, A., & Rivest, S. (2006) · The FASEB Journal · doi:10.1096/fj.05-5234fje · Cited by 126 · see citing works
Maezawa, I., Nivison, M. P., Montine, K. S., Maeda, N., & Montine, T. J. (2006) · The FASEB Journal · doi:10.1096/fj.05-5423fje · Cited by 113 · see citing works
Chugh, D., Nilsson, P. G., Afjei, S. A., Bakochi, A., & Ekdahl, C. T. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.09.005 · Cited by 106 · see citing works
Turrin, N. P., & Rivest, S. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422901003 · Cited by 107 · see citing works
Keene, C. D., Cudaback, E., Li, X., Montine, K. S., & Montine, T. J. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.08.002 · Cited by 103 · see citing works
Sepsis-associated encephalopathy: A review of literature
Fülesdi, B., Molnár, L., Németh, N., & Molnár, C. (2018) · Neurology India · doi:10.4103/0028-3886.227299 · Cited by 101 · see citing works
García-Bueno, B., Madrigal, J. L. M., Pérez-Nievas, B. G., & Leza, J. C. (2008) · Endocrinology · doi:10.1210/en.2007-0482 · Cited by 97 · see citing works
Maatouk, L., Compagnion, A.-C., Sauvage, M.-A. C.-D., Bemelmans, A.-P., Leclere-Turbant, S., Cirotteau, V., Tohme, M., Beke, A., Trichet, M., Bazin, V., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04569-y · Cited by 95 · see citing works
Attenuated microglial activation mediates tolerance to the neurotoxic effects of methamphetamine
Thomas, D. M., & Kuhn, D. M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02906.x · Cited by 95 · see citing works
Immune-To-Brain Signaling: How Important are the Blood–Brain Barrier-independent Pathways?
Quan, N. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8026-z · Cited by 94 · see citing works
Hirose, K., Hartsock, J. J., Johnson, S. B., Santi, P. A., & Salt, A. N. (2014) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-014-0476-6 · Cited by 93 · see citing works
Soulet, D., & Rivest, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200301097 · Cited by 93 · see citing works
Hirose, K., Li, S.-Z., Ohlemiller, K. K., & Ransohoff, R. M. (2014) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-014-0458-8 · Cited by 82 · see citing works
Neuroprotective effects of resident microglia following acute brain injury
Simard, A. R., & Rivest, S. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21469 · Cited by 81 · see citing works
Roberts, D. J., & Goralski, K. B. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.10.1245 · Cited by 81 · see citing works
Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice
Maezawa, I., Maeda, N., Montine, T. J., & Montine, K. S. (2006) · Journal of Neuroinflammation · doi:10.1186/1742-2094-3-10 · Cited by 81 · see citing works
Development of a Novel Noncompetitive Antagonist of IL-1 Receptor
Quiniou, C., Sapieha, P. S., Lahaie, I., Hou, X., Brault, S., Beauchamp, M., Leduc, M., Řihakova, L., Joyal, J., Nadeau, S., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.10.6977 · Cited by 79 · see citing works
Glucocorticoids: Protectors of the Brain during Innate Immune Responses
Glezer, I., & Rivest, S. (2004) · The Neuroscientist · doi:10.1177/1073858404263494 · Cited by 79 · see citing works
Ziaja, M. (2013) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-013-0383-y · Cited by 79 · see citing works
Sugama, S., & Kakinuma, Y. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100111 · Cited by 78 · see citing works
Sergerie, Y., Boivin, G., Gosselin, D., & Rivest, S. (2007) · The Journal of Infectious Diseases · doi:10.1086/511987 · Cited by 76 · see citing works
Milatović, D., Zaja‐Milatovic, S., Montine, K. S., Shie, F., & Montine, T. J. (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-20 · Cited by 70 · see citing works
Dual Effect of Catecholamines and Corticosterone Crosstalk on Pineal Gland Melatonin Synthesis
Fernandes, P. A. C. M., Tamura, E. K., D'Argenio-Garcia, L., Muxel, S. M., Cruz‐Machado, S. D. S., Marçola, M., Carvalho‐Sousa, C. E., Cecon, E., Ferreira, Z. S., & Markus, R. P. (2016) · Neuroendocrinology · doi:10.1159/000445189 · Cited by 65 · see citing works
Radler, M. E., Hale, M. W., & Kent, S. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.11.014 · Cited by 64 · see citing works
The neuroendocrine control of the innate immune system in health and brain diseases
Bellavance, M., & Rivest, S. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01129.x · Cited by 60 · see citing works
Impact of aging immune system on neurodegeneration and potential immunotherapies
Liang, Z., Zhao, Y., Ruan, L., Zhu, L., Jin, K., Zhuge, Q., Su, D., & Zhao, Y. L. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.07.006 · Cited by 61 · see citing works
Effects of TNF-α and IFN-γ on Nitric Oxide-Induced Neurotoxicity in the Mouse Brain
Blais, V., & Rivest, S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.7043 · Cited by 55 · see citing works
Feng, P., Zhao, H., Chai, J., Huang, L., & Wang, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043140 · Cited by 51 · see citing works
Steiner, A. A., Doğan, M. D., Ivanov, A. I., Patel, S., Rudaya, A. Y., Jennings, D. H., Orchinik, M., Pace, T. W. W., O’Connor, K., Watkins, L. R., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-2295fje · Cited by 49 · see citing works
Local Corticosterone Infusion Enhances Nocturnal Pineal Melatonin Production In Vivo
Fernandes, P. A. C. M., Bothorel, B., Clesse, D., Monteiro, A. W. A., Calgari, C., Raison, S., Simonneaux, V., & Markus, R. P. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01817.x · Cited by 46 · see citing works
Parkinson’s disease and immune system: is the culprit LRRKing in the periphery?
Greggio, E., Civiero, L., Bisaglia, M., & Bubacco, L. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-94 · Cited by 42 · see citing works
TLR4-mediated brain inflammation halts neurogenesis: impact of hormonal replacement therapy
Mouihate, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00146 · Cited by 41 · see citing works
Modulation of the Innate Immune Response by NMDA Receptors Has Neuropathological Consequences
Glezer, I., Zekki, H., Scavone, C., & Rivest, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11094.2003 · Cited by 41 · see citing works
Genes Involved in the Balance between Neuronal Survival and Death during Inflammation
Glezer, I., Chernomoretz, A., David, S., Plante, M.-M., & Rivest, S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000310 · Cited by 40 · see citing works
Goralski, K. B., Abdulla, D., Sinal, C. J., Arsenault, A., & Renton, K. W. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00562.2004 · Cited by 38 · see citing works
Maezawa, I., Zaja‐Milatovic, S., Milatović, D., Stephen, C., Sokal, I., Maeda, N., Montine, T. J., & Montine, K. S. (2006) · Journal of Neuroinflammation · doi:10.1186/1742-2094-3-21 · Cited by 38 · see citing works
The immune-pineal axis: the role of pineal and extra-pineal melatonin in modulating inflammation
Markus, R., & Ferreira, Z. (2011) · Advances in Neuroimmune Biology · doi:10.3233/nib-2011-009 · Cited by 29 · see citing works
Abdulla, D., Goralski, K. B., Cano, E. G. D. B., & Renton, K. W. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.105.004564 · Cited by 33 · see citing works
Caspase-1 Activity in Microglia Stimulated by Pro-Inflammagen Nanocrystals
Moquin, A., Hutter, E., Choi, A. O., Khatchadourian, A., Castonguay, A., Winnik, F. M., & Maysinger, D. (2013) · ACS Nano · doi:10.1021/nn404473g · Cited by 31 · see citing works
Do pathogen exposure and innate immunity cause brain diseases?
Simard, A. R., & Rivest, S. (2005) · Neurological Research · doi:10.1179/016164105x49526 · Cited by 30 · see citing works
Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration
Sugama, S., Takenouchi, T., Kitani, H., Fujita, M., & Hashimoto, M. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.01.016 · Cited by 26 · see citing works
Cannabinoids in Microglia: A New Trick for Immune Surveillance and Neuroprotection
Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.004 · Cited by 26 · see citing works
Platelets, Thromboinflammation and Neurovascular Disease
Sun, Y., & Langer, H. F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.843404 · Cited by 25 · see citing works
Melatonin Treatment Entrains the Rest-Activity Circadian Rhythm in Rats With Chronic Inflammation
Laste, G., Vidor, L. P., de Macedo, I. C., Rozisky, J. R., Medeiros, L. F., de Souza, A., Meurer, L., de Souza, I. C. C., Torres, I. L. D. S., & Caumo, W. (2013) · Chronobiology International · doi:10.3109/07420528.2013.800088 · Cited by 25 · see citing works
Goldstein, E. Z., Church, J. S., Pukos, N., Gottipati, M. K., Popovich, P. G., & McTigue, D. M. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.08.015 · Cited by 24 · see citing works
van Strien, M. E., Mercier, D., Drukarch, B., Brevé, J. J. P., Poole, S., Binnekade, R., Bol, J. G. J. M., Blits, B., Verhaagen, J., & van Dam, A.-M. (2010) · Gene Therapy · doi:10.1038/gt.2010.8 · Cited by 21 · see citing works
Sepsis-Associated Encephalopathy (Review)
Nv, B., & Ostrova, I. V. (2017) · General Reanimatology · doi:10.15360/1813-9779-2017-5-121-139 · Cited by 19 · see citing works
Brain inflammation enhances 1-methyl-4-phenylpyridinium-evoked neurotoxicity in rats
Goralski, K. B. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.12.022 · Cited by 20 · see citing works
Chen, T.-J., Shen, S., Lin, H.-Y., Chien, L.-L., & Chen, Y. (2003) · Toxicology Letters · doi:10.1016/j.toxlet.2003.10.012 · Cited by 18 · see citing works
Chen, R., Weitzner, A. S., McKennon, L. A., & Fonken, L. K. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100337 · Cited by 16 · see citing works
Rôle de la réponse immunitaire innée dans le cerveau
Blais, V., & Rivest, S. (2003) · médecine/sciences · doi:10.1051/medsci/20031910981 · Cited by 16 · see citing works
Lin, H., Baby, N., Lu, J., Kaur, C., Zhang, C., Xu, J., Ling, E., & Dheen, S. T. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-13 · Cited by 16 · see citing works
Toll-Like Receptor 2-Independent and MyD88-Dependent Gene Expression in the Mouse Brain
Naert, G., Laflamme, N., & Rivest, S. (2009) · Journal of Innate Immunity · doi:10.1159/000225990 · Cited by 15 · see citing works
Cosyntropin Attenuates Neuroinflammation in a Mouse Model of Traumatic Brain Injury
Siebold, L., Krueger, A. C., Abdala, J. A., Figueroa, J. D., Bartnik‐Olson, B., Holshouser, B. A., Wilson, C. G., & Ashwal, S. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00109 · Cited by 10 · see citing works
Cost-Reducing Traits for Agonistic Head Collisions: A Case for Neurophysiology
Tobiansky, D. J., Long, K. M., Hamden, J. E., Brawn, J. D., & Fuxjager, M. J. (2021) · Integrative and Comparative Biology · doi:10.1093/icb/icab034 · Cited by 9 · see citing works
Influence of CD14 polymorphism on CD14 expression in patients with extensive burns
Lin, J., Yao, Y.-M., Dong, N., Chai, J., Yu, Y. H., Hou, X., Zhu, J.-M., & Sheng, Z.-Y. (2008) · Burns · doi:10.1016/j.burns.2008.07.014 · Cited by 6 · see citing works
Regulação da produção hormonal da glândula pineal de ratos por moduladores do processo inflamatório.
Paulo, S. (2009) · Cited by 2 · see citing works
Role of Polyamines in the Control of the Immune Response in the Brain
Soulet, D., & Rivest, S. (2006) · Humana Press eBooks · doi:10.1007/978-1-59745-145-1_16 · Cited by 1 · see citing works
Herber, D. L. (2004) · Digital Commons - University of South Florida (University of South Florida)
Antagonist of IL-1 Receptor Development of a Novel Noncompetitive
Chemtob, S., Miller, G., Pshezhetsky, A. V., Heveker, N., Lubell, W. D., Sennlaub, F., Řihakova, L., Joyal, J., Nadeau, S., Brault, S., et al. (2013)
Le virus herpes simplex de type 1 : résistance aux antiviraux et réponse inflammatoire cérébrale
Sergerie, Y. (2007) · Corpus Université Laval (Université Laval)
Signalisation par les récepteurs toll-like dans un contexte d'excitotoxicité
Larochelle, A. (2014) · Corpus Université Laval (Université Laval)
Laste, G. (2013) · Americanae (AECID Library)
Étude moléculaire de l'inflammation chronique dans la maladie de Parkinson
Compagnion, A. (2019) · theses.fr (ABES) · doi:10.70675/04ca138dz3131z4e24z884czbba2f7954a99
The Effect of Different Microglial Activation States on the Survival of Retinal Ganglion Cells
Siddiqui, A. M. (2013) · MacSphere (McMaster University) · doi:10.71548/21084
- Authors
- Nadeau, S., & Rivest, S.
- Affiliations
- Centre hospitalier de l'Université Laval (CA)
- ORCID
- Rivest, Serge
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-09
- Volume
- 169
- Issue
- 6
- Pages
- 3370-3381
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2105582142
- Cited by
- 94
- References
- 27
- Citations by year
- 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 7 · 2013: 9 · 2012: 6
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Illinois at Urbana-Champaign
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- endotoxemia, lipopolysaccharide, CD14, glucocorticoids, corticosterone, microglia, TNF-α, NF-κB signaling, IκBα, MCP-1, anti-CD14 antibody, RU486, systemic inflammation, striatum, neurodegeneration
- MeSH terms
- Animals, Basal Ganglia, Brain, Gene Expression Regulation, Glucocorticoids, Immune Sera, Immunity, Innate, Inflammation, Injections, Intraperitoneal, Injections, Intraventricular, Lipopolysaccharides, Male, Rats, Sprague-Dawley, Lipopolysaccharide Receptors, Endotoxemia, Neutrophil Infiltration, Rats
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