Cited by 370Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Neurons May Live for Decades with Neurofibrillary Tangles

Morsch, Renee, Simon, William, Coleman, Paul D.·1999·Journal of Neuropathology and Experimental Neurology

DOI 10.1097/00005072-199902000-00008

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Abstract

Neurons containing neurofibrillary tangles (NFT) are one of the pathological hallmarks of Alzheimer disease (AD). It is known that this population of neurons express gene products and thus function to some degree, but it is unknown how long these neurons may survive with NFT. It is also thought that the formation of NFT results in the death of neurons. Using quantitative data on neuron loss and NFT formation as a function of disease duration, we have generated a computer program that models both the degeneration of CA1 hippocampal neurons and the formation of NFT in these neurons in AD. Modeling various neuron survival times with NFT and altering selected assumptions upon which the models are based, we arrive at the conclusions that 1) CA1 hippocampal neurons survive with NFT for about 20 years, and 2) NFT may not be obligatory for death of CA1 hippocampal neurons in AD.

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Authors: Morsch, R., Simon, W., & Coleman, P. D.
Affiliations: University of Rochester Medicine (US)
ORCID: Simon, William
Coleman, Paul D.
Venue: Journal of Neuropathology and Experimental Neurology
Publisher: Oxford University Press (OUP)
Published: 1999-02
Volume: 58
Issue: 2
Pages: 188-197
ISSN: 0022-3069 (ISSN-L)
DOI: 10.1097/00005072-199902000-00008
OpenAlex: W2018983416
Cited by: 370
References: 0
Citations by year: 2026: 3 · 2025: 4 · 2024: 12 · 2023: 16 · 2022: 11 · 2021: 9 · 2020: 19 · 2019: 10 · 2018: 15 · 2017: 13 · 2016: 12 · 2015: 18 · 2014: 19 · 2013: 13 · 2012: 15
FWCI: 7.55
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neuropathology & Experimental Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r35ag009016-07, 5r01ag014441-05)
National Institute on Aging (AG 08665, AG09016, R01 AG14441, P30AG008665)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: neurofibrillary tangles, Alzheimer's disease, neuronal survival, CA1 hippocampal neurons, neurodegeneration, neuronal loss, disease duration, computational modeling, neuronal cell death
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Cell Count, Cell Survival, Hippocampus, Humans, Middle Aged, Neurons, Neurofibrillary Tangles, Cellular Senescence, Disease Progression

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Neurons May Live for Decades with Neurofibrillary Tangles

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