Neurons May Live for Decades with Neurofibrillary Tangles

PE859, a Novel Tau Aggregation Inhibitor, Reduces Aggregated Tau and Prevents Onset and Progression of Neural Dysfunction In Vivo

Okuda, M., Hijikuro, I., Fujita, Y., Wu, X., Nakayama, S., Sakata, Y., Noguchi, Y., Ogo, M., Akasofu, S., Ito, Y., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117511 · Cited by 38

Cell death and survival pathways in Alzheimer's disease: an integrative hypothesis testing approach utilizing -omic data sets

Brokaw, D. L., Piras, I. S., Mastroeni, D., Weisenberger, D. J., Nolz, J., Delvaux, E., Serrano, G. E., Beach, T. G., Huentelman, M. J., & Coleman, P. D. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.06.022 · Cited by 38

Melatonin Mitigates Kainic Acid-Induced Neuronal Tau Hyperphosphorylation and Memory Deficits through Alleviating ER Stress

Shi, C., Zeng, J. Y., Li, Z., Chen, Q., Hang, W., Xia, L., Wu, Y., Chen, J., & Shi, A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00005 · Cited by 37

Causal links among amyloid, tau, and neurodegeneration

Bilgel, M., Wong, D. F., Moghekar, A., Ferrucci, L., Resnick, S. M., & Initiative, T. A. D. N. (2022) · Brain Communications · doi:10.1093/braincomms/fcac193 · Cited by 38

The role of oxidative stress in the pathogenesis of Alzheimer's disease

Filipčík, P., Cente, M., Ferencĭk, M., Hulín, I., & Novak, M. (2006) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/bf03656857 · Cited by 37

Senile Dementia of the Neurofibrillary Tangle Type: A Comparison with Alzheimer’s Disease

Yamada, M., Itoh, Y., Sodeyama, N., Suematsu, N., Otomo, E., Matsushita, M., & Mizusawa, H. (2001) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051245 · Cited by 36

Antioxidants reduce neurodegeneration and accumulation of pathologic Tau proteins in the auditory system after blast exposure

Du, X., West, M., Cai, Q., Cheng, W., Ewert, D. L., Li, W., Floyd, R. A., & Kopke, R. D. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.343 · Cited by 36

Sources of Extracellular Tau and its Signaling

Ávila, J., Simón, D., Díaz-Hernández, M., Pintor, J. J., & Hernández, F. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131832 · Cited by 36

Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast‐Induced Traumatic Brain Injury

Du, X., West, M., Cheng, W., Ewert, D. L., Li, W., Saunders, D., Towner, R. A., Floyd, R. A., & Kopke, R. D. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4159357 · Cited by 36

Neurophysiological assessment of neural network plasticity and connectivity: Progress towards early functional biomarkers for disease interception therapies in Alzheimer’s disease

Walsh, C., Drinkenburg, W. H. I. M., & Ahnaou, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.020 · Cited by 37

Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent

Orr, M. E., Garbarino, V. R., Salinas, A., & Buffenstein, R. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.12.004 · Cited by 34

Why therapies for Alzheimer’s disease do not work: Do we have consensus over the path to follow?

Amtul, Z. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.09.003 · Cited by 35

Clusterin up-regulation following sub-lethal oxidative stress and lipid peroxidation in human neuroblastoma cells

Strocchi, P., Smith, M. A., Perry, G. L., Tamagno, E., Danni, O., Pession, A., Gaiba, A., & Dozza, B. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.019 · Cited by 33

A Novel Perspective on Tau in Alzheimers Disease

Bonda, D., Castellani, R. J., Zhu, X., Nunomura, A., Lee, H., Perry, G. L., & Smith, M. A. (2011) · Current Alzheimer Research · doi:10.2174/156720511796717131 · Cited by 32

Protein Aggregation in Alzheimers Disease and Other Neoropathological Disorders

Dimakopoulos, A. C. (2005) · Current Alzheimer Research · doi:10.2174/1567205052772795 · Cited by 33

Book Review: Is Alzheimer’s Disease a Mitochondrial Disorder?

Cash, A., Perry, G. L., Ogawa, O., Raina, A. K., Zhu, X., & Smith, M. A. (2002) · The Neuroscientist · doi:10.1177/107385802236968 · Cited by 32

Caspases first

Ávila, J. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.157 · Cited by 33

Gene Therapy Models of Alzheimer’s Disease and Other Dementias

Combs, B., Kneynsberg, A., & Kanaan, N. M. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-3271-9_25 · Cited by 33

Alzheimer Neurofibrillary Degeneration: Therapeutic Targets and High-Throughput Assays

Iqbal, K., Alonso, A. D. C., El-Akkad, E., Gong, C., Haque, N., Khatoon, S., Pei, J.-J., Tanimukai, H., Tsujio, I., Wang, J., et al. (2003) · Journal of Molecular Neuroscience · doi:10.1385/jmn:20:3:425 · Cited by 31

Phosphorylation of Tau Protein Associated as a Protective Mechanism in the Presence of Toxic, C-Terminally Truncated Tau in Alzheimer's Disease

Luna‐Muñoz, J., Charles, R., Claude, M., Flores-Rodríguez, P., Ávila, J., Sergio, R., de la Cruz, F., Mena, R., Meraz‐Ríos, M. A., & Florán, B. (2013) · InTech eBooks · doi:10.5772/54228 · Cited by 43

Risk of Misdiagnosing Chronic Traumatic Encephalopathy in Men With Depression

Iverson, G. L., & Gardner, A. J. (2019) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.19010021 · Cited by 30

Retired National Football League Players are Not at Greater Risk for Suicide

Iverson, G. L. (2019) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acz023 · Cited by 30

Non-Rodent Genetic Animal Models for Studying Tauopathy: Review of Drosophila, Zebrafish, and C. elegans Models

Giong, H.-K., Subramanian, M., Yu, K., & Lee, J.-S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168465 · Cited by 31

A how-to guide for a precision medicine approach to the diagnosis and treatment of Alzheimer's disease

Devi, G. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1213968 · Cited by 29

Use of bomb pulse carbon-14 to age senile plaques and neurofibrillary tangles in Alzheimer’s disease

Lovell, M. A., Robertson, J. D., Buchholz, B. A., Xie, C., & Markesbery, W. R. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00281-0 · Cited by 29

PHF and PHF-like fibrils –cause or consequence?

Ihara, Y. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00200-1 · Cited by 28

Neurofibrillary changes of the Alzheimer type in very elderly individuals: Neither inevitable nor benign

Del Tredici, K., & Braak, H. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.04.016 · Cited by 27

TOC1: A valuable tool in assessing disease progression in the rTg4510 mouse model of tauopathy

Ward, S. M., Himmelstein, D. S., Ren, Y., Fu, Y., Yu, X., Roberts, K. F., Binder, L. I., & Sahara, N. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.03.002 · Cited by 28

Ionizing radiation causes increased tau phosphorylation in primary neurons

Li, L., Wang, W., Welford, S. M., Zhang, T., Wang, X., & Zhu, X. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12769 · Cited by 27

Therapeutic and diagnostic challenges for frontotemporal dementia

Dâ€TMAlton, S., & Lewis, J. M. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00204 · Cited by 26

Risk for Misdiagnosing Chronic Traumatic Encephalopathy in Men With Anger Control Problems

Iverson, G. L., & Gardner, A. J. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00739 · Cited by 25

The Significance of Tau Aggregates in the Human Brain

Castellani, R. J. (2020) · Brain Sciences · doi:10.3390/brainsci10120972 · Cited by 25

The tauopathies

Devi, G. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-323-98817-9.00015-6 · Cited by 27

Caspase-Mediated Truncation of Tau Potentiates Aggregation

Lee, S., & Shea, T. B. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/731063 · Cited by 25

Death or secretion? The demise of a plausible assumption about CSF-tau in Alzheimer Disease?

Hall, G. F., & Saman, S. (2012) · Communicative & Integrative Biology · doi:10.4161/cib.21437 · Cited by 26

p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function

Perea, J. R., Bolós, M., Cuadros, R., García, E., García‐Escudero, V., Hernández, F., McManus, R. M., Heneka, M. T., & Ávila, J. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02715-0 · Cited by 24

Chronic Traumatic Encephalopathy: The cellular sequela to repetitive brain injury

Vile, A., & Atkinson, L. (2017) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2017.03.035 · Cited by 24

Differential expression of LMO4 protein in Alzheimer's disease

Leuba, G., Vernay, A., Vu, D., Walzer, C., Belloir, B., Kraftsik, R., Bouras, C., & Savioz, A. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.0305-1846.2003.00511.x · Cited by 23

Pathological Impact of Tau Proteolytical Process on Neuronal and Mitochondrial Function: a Crucial Role in Alzheimer’s Disease

Olesen, M. A., & Quintanilla, R. A. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03434-4 · Cited by 23

Serotonin Receptors as a Potential Target in the Treatment of Alzheimer’s Disease

Eremin, D. V., Kondaurova, E. M., Rodnyy, A. Y., Molobekova, C. A., Kudlay, D. A., & Naumenko, V. S. (2023) · Biochemistry (Moscow) · doi:10.1134/s0006297923120064 · Cited by 23

Alzheimer's disease: Its diagnosis and pathogenesis

Kril, J. J., & Halliday, G. M. (2001) · International review of neurobiology · doi:10.1016/s0074-7742(01)48016-0 · Cited by 22

Hyperphosphorylated Tau Inflicts Intracellular Stress Responses that Are Mitigated by Apomorphine

Song, Z., Wang, K., Hagar, H. C., Chen, H., Kuan, C.-Y., Zhang, K., & Kuo, M. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03689-x · Cited by 23

Selectivity requirements for diagnostic imaging of neurofibrillary lesions in Alzheimer's disease: A simulation study

Schafer, K. N., Kim, S., Anastasios Matzavinos, A., & Kuret, J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.066 · Cited by 21

Epigenetic dysregulation of brainstem nuclei in the pathogenesis of Alzheimer’s disease: looking in the correct place at the right time?

Iatrou, A., Kenis, G., Rutten, B. P. F., Lunnon, K., & van den Hove, D. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2361-4 · Cited by 22

Brain rhythm attractor breakdown in Alzheimer’s disease: Functional and pathologic implications

Karageorgiou, E., & Vossel, K. A. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.02.003 · Cited by 21

Should Alzheimer's disease be equated with human brain ageing?: A maladaptive interaction between brain evolution and senescence

Neill, D. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.06.004 · Cited by 22

Sequence and trajectory of early Alzheimer’s disease-related tau inclusions in the hippocampal formation of cases without amyloid-β deposits

Braak, H., Mayer, B., Feldengut, S., Schön, M., & Tredici, K. D. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02862-x · Cited by 20

Senescence may mediate conversion of tau phosphorylation-induced apoptotic escape to neurodegeneration

Wang, J., & Wang, Z.-H. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.03.007 · Cited by 20

The interplay between tauopathy and aging through interruption of UPR/Nrf2/autophagy crosstalk in the Alzheimer’s disease transgenic experimental models

Amini, J., Sanchooli, N., Milajerdi, M.-H., Baeeri, M., Haddadi, M., & Sanadgol, N. (2023) · International Journal of Neuroscience · doi:10.1080/00207454.2023.2210409 · Cited by 19

Clinicopathological Staging of Dynamics of Neurodegeneration and Neuronal Loss in Alzheimer Disease

Węgiel, J., Flory, M. J., Kuchna, I., Nowicki, K., Ma, S. Y., Wegiel, J., Badmajew, E., de Leon, M. J., Wısnıewskı, T., & Reisberg, ‌. (2020) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaa140 · Cited by 20

Alterations in neurofilaments and the transformation of the cytoskeleton in axons may provide insight into the aberrant neuronal changes of Alzheimer’s disease

Vickers, J. C., Kirkcaldie, M., Phipps, A. J., & King, A. E. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.07.012 · Cited by 18

Multiregional Age-Associated Reduction of Brain Neuronal Reserve Without Association With Neurofibrillary Degeneration or β-Amyloidosis

Węgiel, J., Flory, M. J., Kuchna, I., Nowicki, K., Ma, S. Y., Wegiel, J., Badmajew, E., Silverman, W. P., de Leon, M. J., Reisberg, ‌., et al. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx027 · Cited by 18

The necroptosis pathway and its role in age-related neurodegenerative diseases: will it open up new therapeutic avenues in the next decade?

Salvadores, N., & Court, F. A. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1758668 · Cited by 18

The Key Role of Oxidative Stress in Alzheimer's Disease

Moreira, P. I., Nunomura, A., Honda, K., Aliev, G. M., Casadesús, G., Zhu, X., Smith, M. A., & Perry, G. L. (2007) · Elsevier eBooks · doi:10.1016/b978-044452809-4/50153-8 · Cited by 18

Mitotic Epitopes are Incorporated into Age‐dependent Neurofibrillary Tangles in Niemann–Pick Disease Type C

Zhang, M., Wang, X., Jiang, F., Wang, W., Vincent, I. J., & Bu, B. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00286.x · Cited by 18

Untangling Tau: Molecular Insights into Neuroinflammation, Pathophysiology, and Emerging Immunotherapies

Davidson, R., Krider, R. I., Borsellino, P., Noorda, K., Alhwayek, G., & Vida, T. A. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45110553 · Cited by 17

Tau Pathology Generated by Overexpression of Tau

Grundke, I., & Iqbal, K. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65494-6 · Cited by 17

Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau.

Zhang, X., Zhang, Y., Liu, S., Bulloj, A., Tong, G., Zhang, Z., Liao, F., & Xu, H. (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-7 · Cited by 17

Retromer dysfunction at the nexus of tauopathies

Carosi, J. M., Denton, D., Kumar, S., & Sargeant, T. J. (2021) · Cell Death & Differentiation · doi:10.1038/s41418-020-00727-2 · Cited by 16

Novel therapies for combating chronic neuropathological sequelae of TBI

Ikonomović, M. D., Abrahamson, E. E., Carlson, S. W., Graham, S. H., & Dixon, C. E. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.06.021 · Cited by 16

Role of the p62 Protein in the Formation of Neuropathological Cytoplasmic Inclusions

Kuusisto, E. (2004) · Cited by 16

Road to Alzheimer’s Disease: The Pathomechanism Underlying

Anand, R., Kaushal, A., Wani, W. Y., & Gill, K. D. (2011) · Pathobiology · doi:10.1159/000332218 · Cited by 16

Inflammation and Programmed Cell Death in Alzheimer’s Disease: Comparison of the Central Nervous System and Peripheral Blood

Macchi, B., Marino‐Merlo, F., Frezza, C., Cuzzocrea, S., & Mastino, A. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8641-9 · Cited by 15

Should development of Alzheimer¿s disease-specific intravenous immunoglobulin be considered?

Loeffler, D. A. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0198-z · Cited by 15

Pharmacological targets to inhibit alzheimer neurofibrillary degeneration

Iqbal, K., del Alonso, A. C., El-Akkad, E., Gong, C., Haque, N., Khatoon, S., Tsujio, I., & Grundke, I. (2002) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6139-5_29 · Cited by 15

A computational model of Alzheimer's disease at the nano, micro, and macroscales

Chamberland, É., Moravveji, S., Doyon, N., & Duchesne, S. (2024) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2024.1348113 · Cited by 15

Cortical and Hippocampal Neurons from Truncated Tau Transgenic Rat Express Multiple Markers of Neurodegeneration

Filipčík, P., Cente, M., Krajciova, G., Vanický, I., & Novák, M. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9372-8 · Cited by 14

The therapeutic effects of dopamine replacement therapy and its psychiatric side effects are mediated by pineal function

Willis, G. L. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.11.030 · Cited by 14

Probiotic supplement as a promising strategy in early tau pathology prevention: Focusing on GSK-3β?

Flynn, C. M., & Yuan, Q. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1159314 · Cited by 15

Aluminum-induced dendritic pathology revisited: cytochemical and electron microscopic studies of rabbit cortical pyramidal neurons.

Forbes, M. S., Ghribi, O., Herman, M. M., & Savory, J. (2002) · PubMed · Cited by 14

The role of wild-type tau in Alzheimer’s disease and related tauopathies

Lo, C. H., & Sachs, J. N. (2020) · JoLS Journal of Life Sciences · doi:10.36069/jols/20201201 · Cited by 15

Therapeutic potential of oxidant mechanisms in Alzheimer’s disease

Moreira, P. I., Smith, M. A., Zhu, X., Santos, M. S., Oliveira, C. R., & Perry, G. L. (2004) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.4.6.995 · Cited by 14

Tau Loss of Function, by Deletion or Aggregation, Contributes to Peripheral Insulin Resistance

Al‐Lahham, R., & Méndez, N. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230392 · Cited by 13

Environmental reduplicative paramnesia in a case of atypical Alzheimer’s disease

von Gunten, A., Miklossy, J., Suvà, M.-L., Hof, P. R., & Glannakopoulos, P. (2005) · Neurocase · doi:10.1080/13554790590944825 · Cited by 13

Tau modifiers as therapeutic targets for Alzheimer's disease

Liu, Q., Lee, H., Honda, K., Siedlak, S. L., Harris, P. L. R., Cash, A., Zhu, X., Ávila, J., Nunomura, A., Takeda, A., et al. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.06.021 · Cited by 14

Regional quantitative study of formation process of neurofibrillary tangles in the hippocampus of non-demented elderly brains: Comparison with late-onset Alzheimer's disease brains

Takayama, N., Iseki, E., Yamamoto, T., & Kosaka, K. (2002) · Neuropathology · doi:10.1046/j.1440-1789.2002.t01-1-00433.x · Cited by 13

Cytoplasmic cytochrome c immunolabelling in dystrophic neurites in Alzheimer’s disease

Woodhouse, A., Vickers, J. C., & Dickson, T. C. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0107-3 · Cited by 13

Neuropathology in Alzheimer's Disease: Awaking from a Hundred-Year-Old Dream

Nunomura, A., Castellani, R. J., Lee, H., Moreira, P. I., Zhu, X., Perry, G. L., & Smith, M. A. (2006) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2006.8.pe10 · Cited by 13

Sequence of Molecular Events in the Development of Alzheimer’s Disease: Cascade Interactions from Beta-Amyloid to Other Involved Proteins

Bagheri, S., Saboury, A. A., & Saso, L. (2024) · Cells · doi:10.3390/cells13151293 · Cited by 12

Oligomeric Amyloid-β and Tau Alter Cell Adhesion Properties and Induce Inflammatory Responses in Cerebral Endothelial Cells Through the RhoA/ROCK Pathway

Hossen, F., Geng, X. H., Sun, G. Y., Yao, X., & Lee, J. C. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04138-z · Cited by 13

Neuronal loss and inflammation preceding fibrillary tau pathology in a rat model with early human-like tauopathy

Emmerson, J. T., Malcolm, J. C., Carmo, S. D., Nguyen, P., Breuillaud, L., Martínez-Trujillo, J., & Cuello, A. C. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106317 · Cited by 11

Untangling the role of tau in Alzheimer’s disease: A unifying hypothesis

Bhatia, N. S., & Hall, G. F. (2013) · Translational Neuroscience · doi:10.2478/s13380-013-0114-5 · Cited by 11

Alzheimer’s Disease and Its Possible Evolutionary Origin: Hypothesis

Whitfield, J. F., Rennie, K., & Chakravarthy, B. (2023) · Cells · doi:10.3390/cells12121618 · Cited by 11

Does Alzheimer's Disease Result from Attempts at Repair or Protection After Transient Stress?

Bissette, G. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1171 · Cited by 11

Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy

Köhler, C. N., Bista, P., Götz, J., & Schröder, H. C. (2010) · Brain Research · doi:10.1016/j.brainres.2010.05.076 · Cited by 11

Impact of α-Synuclein Pathology on Aging

Parkkinen, L. (2005) · Cited by 11

Molecular and cellular events of dopamine D1 receptor‐mediated tau phosphorylation in SK‐N‐MC cells

Lebel, M., & Cyr, M. (2010) · Synapse · doi:10.1002/syn.20818 · Cited by 10

Top-Down Projections Direct the Gradual Progression of Alzheimer-Related Tau Pathology Throughout the Neocortex

Braak, H., & Tredici, K. D. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9358-8_22 · Cited by 11

DNA Damage does not Correlate with Amyloid-ß-Plaques and Neurofibrillary Tangles in Familial Alzheimer's Disease Presenilin-1 [E280A] Mutation*

Velez‐Pardo, C., Lopera, F. J., & Jiménez-Del-Río, M. (2000) · Journal of Alzheimer s Disease · doi:10.3233/jad-2000-2106 · Cited by 10

Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3β

Engel, T., Goñi‐Oliver, P., Gómez‐Ramos, P., Morán, M. A., Lucas, J. J., Ávila, J., & Hernández, F. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.09.047 · Cited by 10

Plasticity and the Spread of Alzheimer's Disease-Like Changes

Ohm, T. G., Glöckner, F., Distl, R., Treiber‐Held, S., Meske, V., & Schönheit, B. (2003) · Neurochemical Research · doi:10.1023/a:1026017206925 · Cited by 10

Neurofibrillary Tangles

Braak, H., & Tredici, K. D. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374105-9.00269-0 · Cited by 10

Biochemical approaches to assess the impact of post-translational modifications on pathogenic tau conformations using recombinant protein

Alhadidy, M. M., & Kanaan, N. M. (2024) · Biochemical Society Transactions · doi:10.1042/bst20230596 · Cited by 10

Tau Protein

Kanaan, N. M., Himmelstein, D. S., Ward, S., Combs, B., & Binder, L. I. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405195-9.00056-1 · Cited by 9

Focusing on oligomeric tau as a therapeutic target in Alzheimer’s disease and other tauopathies

Rayman, J. B. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2206561 · Cited by 11

Specific serum antibody binding to phosphorylated and non-phosphorylated tau in non-cognitively impaired, mildly cognitively impaired, and Alzheimer’s disease subjects: an exploratory study

Klaver, A. C., Coffey, M. P., Bennett, D. A., & Loeffler, D. A. (2017) · Translational Neurodegeneration · doi:10.1186/s40035-017-0100-x · Cited by 9

Advances in our Understanding of Neurodegeneration

Jellinger, K. A. (2007) · Elsevier eBooks · doi:10.1016/b978-044452809-4/50142-3 · Cited by 9

Cell redistribution of G quadruplex‐structured DNA is associated with morphological changes of nuclei and nucleoli in neurons during tau pathology progression

Comptdaer, T., Tardivel, M., Schirmer, C., Buée, L., & Galas, M. (2024) · Brain Pathology · doi:10.1111/bpa.13262 · Cited by 8

Cellular model of Alzheimer's disease — Relevance to therapeutic testing

Marwarha, G., & Ghribi, O. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.11.011 · Cited by 8

The Role of Aβ and Tau Oligomers in the Pathogenesis of Alzheimer’s Disease

Bhaskar, K., & Lamb, B. T. (2011) · Springer eBooks · doi:10.1007/978-94-007-2774-8_5 · Cited by 8

Duration of neurofibrillary changes in the hippocampal pyramidal neurons

Bobinski, M., Węgiel, J., Tarnawski, M. J., Bobinski, M., de Leon, M. J., Reisberg, ‌., Miller, D. C., & Wı́sniewski, H. M. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00441-7 · Cited by 38

Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation

Kril, J., Patel, S., Harding, A., & Halliday, G. (2002) · Acta Neuropathologica · doi:10.1007/s00401-001-0477-5 · Cited by 190

On the survival time of a tangled neuron in the hippocampal CA4 region in parkinsonism dementia complex of Guam

Schwab, C., Schulzer, M., Steele, J. C., & McGeer, P. L. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00005-6 · Cited by 24

Stereologic Evidence for Persistence of Viable Neurons in Layer II of the Entorhinal Cortex and the CA1 Field in Alzheimer Disease

Hof, P. R., Bussière, T., Gold, G., Kövari, E., Giannakopoulos, P., Bouras, C., Perl, D. P., & Morrison, J. H. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.1.55 · Cited by 85

Neuronal loss and neurofibrillary degeneration in the hippocampal cortex in late-onset sporadic Alzheimer’s disease

Fukutani, Y., Cairns, N. J., Shiozawa, M., Sasaki, K., Sudo, S., Isaki, K., & Lantos, P. L. (2000) · Psychiatry and Clinical Neurosciences · doi:10.1046/j.1440-1819.2000.00747.x · Cited by 70