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Components of hostility as predictors of sudden death and myocardial infarction in the Multiple Risk Factor Intervention Trial.
Abstract
We tested the hypothesis that hostility is associated with increased relative risk (RR) for coronary death and nonfatal myocardial infarction among participants in the prospective Multiple Risk Factor Intervention Trial (MRFIT). Cases (N = 192) were compared with matched controls (N = 384) on a variety of behavioral characteristics associated with the Type A behavior pattern (TABP), including three different but interrelated components of hostility. Logistic regression analyses revealed that only two of the eight TABP attributes analyzed on the overall sample were significant. Only total Potential for Hostility, when dichotomized into "low" and "high" categories, and the antagonistic interpersonal component of hostility (Stylistic Hostility) had positive unadjusted associations with coronary heart disease (CHD) incidence (RR = 1.7, p = 0.003; and RR = 1.5, p = 0.016, respectively). The global TABP and related paralinguistic attributes were not significantly related to CHD incidence. After adjustment for the traditional risk factors of age, serum cholesterol, blood pressure, and cigarette smoking, only dichotomous Potential for Hostility showed a significant relative risk (RR = 1.5, p = 0.032). Ordinal logistic regression revealed a nonsignificant effect.(ABSTRACT TRUNCATED AT 250 WORDS)
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“However, in the early 1980s investigators began to study hostility in particular [159, 160], concluding that it was the primary “toxic” component of the Type A personality [161, 162].”
From Personality and Longevity: Knowns, Unknowns, and Implications for Public Health and Personalized Medicine (2011) · cites this paper as [162]
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Lau, B., & Knardahl, S. (2008) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0b013e31815c89a1 · Cited by 63
“Some studies have reported that the suspiciousness/cynicism dimension of hostility increases the risk of CHD.(28) It is conceivable that individuals who are suspicious of others, who are not able to trust others, may find job insecurity particularly distressing.”
BackgroundCaska, C. M., Hendrickson, B. E., Wong, M. H., Ali, S., Neylan, T. C., & Whooley, M. A. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31819b6a08 · Cited by 64
Hopelessness, Depressive Symptoms, and Carotid Atherosclerosis in Women
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“, 1993; Suarez and Williams, 1990) and with the development of disease (Dembroski et al., 1989; Matthews et al., 1977; Siegman et al., 1987) than the tendency to simply feel angry.”
BackgroundMethodHostility Predicts Restenosis After Percutaneous Transluminal Coronary Angioplasty
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The Impact of Emotions on Coronary Heart Disease Risk
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History of Treatment for Depression: Risk Factor for Myocardial Infarction in Hypertensive Patients
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Biobehavioral research on coronary heart disease: Where is the person?
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Burns, J. W. (1995) · Journal of Behavioral Medicine · doi:10.1007/bf01857874 · Cited by 53
Hostility, anger-in, and cardiovascular reactivity in White women.
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Psychological factors affecting a medical condition
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Cardiovascular Reactivity and Interpersonal Relations: Psychosomatic Processes in Social Context
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Buselli, E. F., & Stuart‐Shor, E. (1999) · The Journal of Cardiovascular Nursing · doi:10.1097/00005082-199904000-00006 · Cited by 51
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“Also, this findingwas in linewith the general understanding that people with less agreeableness/antagonism, of which cynicism and the type A behaviour pattern of anger/hostility were part, tended to experience cardiovascular reactivity and were at higher risk of developing coronary heart disease (Dembroski and Costa,…”
BackgroundSelf- and spouse ratings of anger and hostility as predictors of coronary heart disease.
Kneip, R. C., Delamater, A. M., Ismond, T., Milford, C., Salvia, L., & Schwartz, D. (1993) · Health Psychology · doi:10.1037//0278-6133.12.4.301 · Cited by 61
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“Hostility is a significant independent predictor of CHD [4,5].”
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“, [20-22], which is a major cause of morbidity and mortality in HD patients [23].”
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Hostility in asymptomatic men with angiogaphically confirmed coronary artery disease
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Mika Kivimaki, B., Vahtera, J., Koskenvuo, M., Uutela, A. K., & Pentti, J. (1998) · Psychological Medicine · doi:10.1017/s003329179800659x · Cited by 48
“It has been reported that hostility contributes to various health problems and diseases (Barefoot et al. 1983, 1989; Shekelle et al. 1983; Smith & Frohm, 1985; Dembroski et al. 1989; Romanov et al. 1994; Miller et al. 1996).”
BackgroundMethodInfluentialCitalopram intervention for hostility: Results of a randomized clinical trial.
Kamarck, T. W., Haskett, R. F., Muldoon, M. F., Flory, J. D., Anderson, B. J., Bies, R. R., Pollock, B. G., & Manuck, S. B. (2009) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0014394 · Cited by 48
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Heck, G. L. V. (1997) · European Journal of Personality · doi:10.1002/(sici)1099-0984(199712)11:5 · Cited by 79
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“, 1985) but failed to predict myocardial infarction (MI) and sudden death (Dembroski et al., 1989).”
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Secondary Prevention of Ischemic Heart Disease
Ketterer, M. W. (1993) · Psychosomatics · doi:10.1016/s0033-3182(93)71821-6 · Cited by 44
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Smith, T. W., Gallo, L. C., & Ruiz, J. M. (2003) · Wiley eBooks · doi:10.1002/9780470753552.ch13 · Cited by 45
Fava, G. A., Sonino, N., & Wise, T. N. (2011) · Advances in psychosomatic medicine · doi:10.1159/isbn.978-3-8055-9854-5 · Cited by 45
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Hypertension and the Reactivity Hypothesis: The Next Generation
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Psychological Risk Factors and Cardiovascular Disease: Is it All in Your Head?
Menezes, A. R., Lavie, C. J., Milani, R. V., O’Keefe, J. H., & Lavie, T. J. (2011) · Postgraduate Medicine · doi:10.3810/pgm.2011.09.2472 · Cited by 45
Genetic Analysis of Anger: Genetic Dominance or Competitive Sibling Interaction
Rebollo, I., & Boomsma, D. I. (2006) · Behavior Genetics · doi:10.1007/s10519-005-9025-8 · Cited by 42
“…10.1007/s10519-005-9025-8 216 0001-8244/06/0300-0216/0 2006 Springer Science+Business Media, Inc. the prediction of CHD incidence; and so the focus of research has changed from TABP to hostility, and to anger (Dembroski et al., 1989; Matthews, 1988; Palmero et al., 2001; Siegman and Smith, 1994).”
BackgroundInfluentialThe relationship between anger-coping styles and lifestyle behaviors in teenagers
Musante, L., & Treiber, F. A. (2000) · Journal of Adolescent Health · doi:10.1016/s1054-139x(99)00098-1 · Cited by 42
Hostility and registered sickness absences: a prospective study of municipal employees
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“There is growing evidence that hostility may contribute to some major health problems and disease endpoints (Smith & Frohm, 1985; Dembroski et al. 1989).”
BackgroundMethodMeta-Analysis of Personality Traits in Alzheimer’s Disease: A Comparison with Healthy Subjects
D’Iorio, A., Garramone, F., Piscopo, F., Baiano, C., Raimo, S., & Santangelo, G. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170901 · Cited by 43
“The authors interpreted their results on the basis of the idea that individuals with low level of Agreeableness tend to be aggressive, antagonistic, and hostile and thus they are at high risk of cardiovascular diseases [50, 51] that, in turn, may contribute to increase the risk of AD.”
BackgroundThe Current Status of the Coronary Prone Behaviour Pattern
Johnston, D. W. (1993) · Journal of the Royal Society of Medicine · doi:10.1177/014107689308600712 · Cited by 42
Building a theory of adaptive neuroticismPreprint
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Steca, P., D’Αddario, M., Magrin, M. E., Miglioretti, M., Monzani, D., Pancani, L., Sarini, M., Scrignaro, M., Vecchio, L. P., Fattirolli, F., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161840 · Cited by 45
Assessing Alexithymia and Type A Behavior in Coronary Heart Disease Patients: A Multimethod Approach
Beresnevaitė, M., Taylor, G. J., & Bagby, R. M. (2007) · Psychotherapy and Psychosomatics · doi:10.1159/000099846 · Cited by 41
Hostility, Sodium Consumption, and Cardiovascular Response to Interpersonal Stress
Miller, S. B., Friese, M., Dolgoy, L., Sita, A., Lavoie, K., & Campbell, T. S. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199801000-00016 · Cited by 39
“INTRODUCTION Epidemiological studies have linked hostility to coronary heart disease (1-5), coronary artery disease severity (6—10), the progression of atherosclerosis (11), and hypertension (1, 12, 13).”
BackgroundMethodInfluentialBurell, G. K., Öhman, A., Sundin, STRÖM, G., Ramund, B., Cullhed, I., & Thoresen, C. E. (1994) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm0101_3 · Cited by 45
Gidron, Y., Davidson, K. W., & Ilia, R. (2001) · Journal of Behavioral Medicine · doi:10.1023/a:1005631819744 · Cited by 39
“, 1985), to be higher in patients with CHD or unstable angina than in healthy or noncardiac patient controls (Meesters and Smulders, 1994; Mendes de Leon, 1992), and to be prospectively related to CHD and mortality independent of other CHD risk factors (e.g., Barefoot et al., 1989; Barefoot et al., 1995; Dembroski et…”
BackgroundInfluentialThe Relationship between Hostility and Behavioral Risk Factors for Poor Health in Women Veterans
Calhoun, P. S., Bosworth, H. B., Siegler, I. C., & Bastian, L. A. (2001) · Preventive Medicine · doi:10.1006/pmed.2001.0921 · Cited by 39
Follick, M. J., Ahern, D. K., Gorkin, L., NIAURA, R. S., Herd, J. A., Ewart, C. K., SCHRON, E. B., Kornfeld, D. S., Capone, R. J., & The CAPS Investigators (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90737-l · Cited by 39
Bearing grudges and physical health: relationship to smoking, cardiovascular health and ulcers
Messias, E., Saini, A., Sinato, P., et al. (2009) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-009-0054-0 · Cited by 38
“Given that hostility seems to remain the most reliable risk factor for heart disease, as opposed to the broad concept of type-A personality [5, 17] it was not surprising we found an association between bearing grudges and three cardiovascular outcomes.”
BackgroundPersonality and diabetes mellitus incidence in a national sample
Čukić, I., & Weiß, A. (2014) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2014.07.004 · Cited by 37
Serum lipid concentrations, hostility and cardiovascular reactions to mental stress
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Maruta, T., Hamburgen, M. E., JENNINGS, C. A., Offord, K. P., Colligan, R. C., Frye, R. L., & Malinchoc, M. (1993) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)60156-6 · Cited by 37
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Is aspirin, as used for antithrombosis, an emotion-modulating agent?
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Emotional (Non-)Expression and Health: Data, Questions, and Challenges
ek, I. N., Vingerhoets, A. J. J. M., & Denollet, J. (2002) · Psychology and Health · doi:10.1080/08870440290025740 · Cited by 39
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Prevalence of Type A behavior in untreated hypertensive individuals.
Irvine, J., Garner, D. M., Craig, H. M., et al. (1991) · Hypertension · doi:10.1161/01.hyp.18.1.72 · Cited by 35
�hman, A., Burell, G. K., Ramund, B., & Fleischman, N. (1992) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/bf00960090 · Cited by 35
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“…Barefoot et al., 1995 [52] 730 27 MMPI, Ho, SS Kawachi et al., 1996 [36] 1305 7 MMPI-2, anger SS CAD patients Hecker et al., 1988 [40] 250 8.5 SI Dembroski et al., 1989 [41] 192 7.1 SI DeLeon et al., 1996 [53] 149 1.5 State trait anger sc Ho, hostility; MI, myocardial infarction; MMPI,…”
InfluentialKetterer, M. W., Denollet, J., Goldberg, A. D., McCullough, P. A., John, S. P., Farha, A., Clark, V., Keteyian, S. J., Chapp, J., Thayer, B., et al. (2002) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/174182670200900106 · Cited by 34
Hostility, aggression and the risk of nonfatal myocardial infarction in postmenopausal women
Lahad, A., Heckbert, S. R., Koepsell, T. D., Psaty, B. M., & Patrick, D. L. (1997) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(96)00369-8 · Cited by 33
Cynical hostility in adult male twins.
Smith, T. W., McGonigle, M. M., Turner, C. W., Ford, M. H., & Slattery, M. L. (1991) · Psychosomatic Medicine · doi:10.1097/00006842-199111000-00008 · Cited by 31
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Biobehavioral factors in the context of ischemic cardiovascular diseases
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Observed Hostility and the Risk of Incident Ischemic Heart Disease
Newman, J. D., Davidson, K. W., Shaffer, J. A., Schwartz, J. E., Chaplin, W. F., Kirkland, S., & Shimbo, D. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.04.044 · Cited by 32
“the Expanded Structured Interview (ESI) is one of the most commonly used interview-based measures of hostility (10,11).”
Lavie, C. J., & Milani, R. V. (1999) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)63992-x · Cited by 32
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Socioeconomic Status and Coronary Heart Disease Risk: The Role of Social Cognitive Factors
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“Hostility, a disposition reflecting anger proneness and a distrustful view of others (Barefoot, Dodge, Peterson, Dahlstrom, & Williams, 1989), is predictive of CHD (Barefoot et al., 1983; Dembroski et al., 1989) and has been inversely related to SES (Barefoot, Peterson, Dahlström, & Williams, 1991; Scherwitz, Perkins,…”
BackgroundDivergent Influence of Different Type A Dimensions on Job Strain and Effort-Reward Imbalance
Hintsa, T., Hintsanen, M., Jokela, M. M., Pulkki-Råbäck, L., & Keltikangas‐Järvinen, L. (2010) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0b013e3181c559ea · Cited by 33
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Denial of Depression as an Independent Correlate of Coronary Artery Disease
Ketterer, M. W., Kenyon, L., Foley, B. A., Brymer, J. F., Rhoads, K., Kraft, P. L., & Lovallo, W. R. (1996) · Journal of Health Psychology · doi:10.1177/135910539600100108 · Cited by 31
“Conceivably, anger/hostility is not a correlate of atherosclerosis, but still is a predictor of acute cardiac events and specifically sudden cardiac death (Allan & Scheidt, 1990; Brackett & Powell, 1988; Dembroski et al., 1989; DeSilva, 1986; Greene et al., 1972).”
BackgroundMethodGrynberg, D., Gidron, Y., Denollet, J., & Luminet, O. (2011) · Journal of Behavioral Medicine · doi:10.1007/s10865-011-9351-7 · Cited by 57
Christenfeld, N. J. S., Phillips, D. P., & Glynn, L. M. (1999) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(99)00035-5 · Cited by 30
“Because attitudes can affect morbidity and mortality [10–13, 32–34] it is conceivable that “positive” and “negative” initials may do so as well, if these initials influence self-regard.”
BackgroundResultPersonality profiles among normal aged individuals as measured by the NEO-PI-R
Roepke, S., McAdams, L. A., Lindamer, L. A., Patterson, T. L., & Jeste, D. V. (2001) · Aging & Mental Health · doi:10.1080/13607860120038339 · Cited by 30
“An overtly hostile interpersonal style (a facet of Agreeableness) has been shown to be related to arterial stenosis, myocardial infarction, and coronary death (Dembroski et al., 1989; Siegman et al., 1987).”
BackgroundHospitalization cost offset of a hostility intervention for coronary heart disease patients.
Davidson, K. W., Gidron, Y., Mostofsky, E., & Trudeau, K. J. (2007) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.75.4.657 · Cited by 31
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“…factors including depression and hopelessness (e.g., Everson et al., 1996; Frasure-Smith et al., 1999), hostility (e.g., Barefoot et al., 1995; Dembroski et al., 1989; Ironson et al., 1992; Siegman et al., 2000), vital ex- haustion (VE; Appels and Mulder, 1988), and the combination of…”
BackgroundRole of hostility in women's health during midlife: A longitudinal study.
Adams, S. H. (1994) · Health Psychology · doi:10.1037//0278-6133.13.6.488 · Cited by 30
Hostility and myocardial infraction in men
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Psychosocial Predictors of Death for Low-Risk Patients After a First Myocardial Infarction
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Empirical basis for cardiac psychology.
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Personality Characteristics, Reactivity, and Cardiovascular Disease
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Experimental stress and cardiac function
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Hostility and Platelet Reactivity in Individuals Without a History of Cardiovascular Disease Events
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“First, antagonism is composed partly of cynicism and the type A behavior pattern of anger/hostility which have been associated with cardiovascular reactivity and the increased risk of developing coronary heart disease [85-90].”
BackgroundSiegman, A. W., Malkin, A. R., Boyle, S., Vaitkus, M. A., Barko, W. F., & Franco, E. (2002) · Journal of Behavioral Medicine · doi:10.1023/a:1013558000465 · Cited by 24
“…been identified as risk factors for CHD, such as trait anger (Siegman et al., 1998; Williams et al., 2000), the outward expression of anger (e.g., Dembroski et al., 1989; Kawachi et al., 1996; Mittleman et al., 1995; Siegman et al., 1987, 1998), and poor anger control (Siegman et al., 1998), are…”
BackgroundHughes, J. W., Sherwood, A., Blumenthal, J. A., Suarez, E. C., & Hinderliter, A. L. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000041546.04128.43 · Cited by 24
“For women, the equation containing these variables accounted for 23% of the variance in CD25 [F(4,60) 5.”
BackgroundAnger and cardiovascular health.
Siegel, J. M. (1992) · American Psychological Association eBooks · doi:10.1037/10105-003 · Cited by 24
The relation between defense use and adaptive behavior
Davidson, K. W., MacGregor, M. W., Johnson, E. A., et al. (2003) · Journal of Research in Personality · doi:10.1016/s0092-6566(03)00054-0 · Cited by 23
Factores de riesgo e intervenciones psicológicas eficaces en los trastornos cardiovasculares
Fernández-Abascal, E. G., Díaz, M. D. M., & Sánchez, F. J. D. (2003) · Psicothema · Cited by 23
Assessment of Personality in Psychosomatic Medicine: Current Concepts
Cosci, F. (2011) · Advances in psychosomatic medicine · doi:10.1159/000330014 · Cited by 23
Metadata
- Authors
- Dembroski, T. M., MacDougall, J. M., Costa, P. T., & Grandits, G. A.
- Affiliations
- University of Maryland, Baltimore (US)
- Venue
- Psychosomatic Medicine
- Published
- 1989-09
- Volume
- 51
- Issue
- 5
- Pages
- 514-522
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2085057750
- Cited by
- 377
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 7 · 2012: 4
- FWCI
- 14.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-36027)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- hostility, Type A behavior pattern, myocardial infarction, sudden cardiac death, coronary artery disease, Multiple Risk Factor Intervention Trial, cardiovascular risk factors, serum cholesterol, blood pressure, cigarette smoking
- MeSH terms
- Adult, Coronary Disease, Death, Sudden, Hostility, Humans, Male, Middle Aged, Myocardial Infarction, Personality Tests, Risk Factors, Type A Personality, United States, Survival Rate, Case-Control Studies, Randomized Controlled Trials as Topic
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