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Cited by 62Sleep and related disordersStress Responses and CortisolCancer, Stress, Anesthesia, and Immune Response

Association Between Subjective Sleep Quality and Depression on Immunocompetence in Low-Income Women at Risk for Cervical Cancer

Savard, Josee, Miller, Suzanne M., Mills, Megan, O'Leary, Ann, Harding, Heather, Douglas, Steven D., Mangan, Charles E., Belch, Richard +1 more·1999·Psychosomatic Medicine
DOI 10.1097/00006842-199907000-00014
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Abstract

OBJECTIVE: The purpose of this study was to investigate whether subjective sleep quality is more strongly associated with immunocompetence than depression among women at risk for cervical cancer. METHODS: Participants were 91 women referred for colposcopy because of abnormal results on a Pap smear. On the day of the procedure. participants completed the Center for Epidemiological Studies Depression Scale, two indices of subjective sleep quality (ie, satisfaction with sleep obtained and degree of sleep restfulness), and a health behaviors assessment questionnaire. Levels of peripheral blood lymphocyte subpopulations (helper T, cytotoxic/suppressor T, NK, and B cells) were also assessed at this time. Approximately 10 days later, the presence of depressive disorder was assessed using the Structured Clinical Interview for DSM-III-R. RESULTS: Hierarchical regression analyses revealed that satisfaction with the amount of sleep obtained was significantly associated with the circulating number and percentage of helper T cells (T(H)/CD4+) and the percentage of cytotoxic/suppressor T cells (T(C)/CD8+), after controlling for confounder variables (ie, age, smoking status, and drug use). Depression was significantly associated only with the percentage of T(C) cells. Sleep satisfaction remained significantly associated with the number and percentage of T(H) cells and percentage of T(C) cells after controlling for the variance explained by depression. CONCLUSIONS: Results of this study suggest that subjective sleep quality shares a significant and independent portion of the variance with immunity that is not accounted for by depression. Although the long-term impact of these immune alterations on disease progression needs to be directly explored, it may be important to systematically screen for and manage sleep disturbance in women at high risk for cervical cancer.

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Crossref · 10.1097/00006842-199907000-00014

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  • In the same study, individuals with insomnia and healthy sleepers did not differ with respect to PSG-based sleep parameters, contrasting with subjective reports of higher nocturnal wake time and lower sleep efficiency in those with insomnia.

    “individuals with insomnia and healthy sleepers also did not differ with respect to PSG-based sleep parameters (490), contrasting with subjective reports of higher nocturnal wake time and lower sleep efficiency in those with insomnia”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [490]

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Authors
Savard, J., Miller, S. M., Mills, M., O'Leary, A., Harding, H., Douglas, S. D., Mangan, C. E., Belch, R., & Winokur, A.
ORCID
Venue
Psychosomatic Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1999
Volume
61
Issue
4
Pages
496-507
ISSN
0033-3174 (ISSN-L)
DOI
10.1097/00006842-199907000-00014
OpenAlex
W2071822803
Cited by
62
References
129
Citations by year
2026: 2 · 2025: 3 · 2023: 2 · 2022: 2 · 2019: 2 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 3
FWCI
1.18
Type
journal article
Language
en
Open access
closed
Locations
  • Psychosomatic Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ca061280-04, 5r01ca058999-05)
  • National Cancer Institute (CA61280, CA58999, P30CA006927, CA06927)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
Keywords
subjective sleep quality, depression, immunocompetence, cervical cancer risk, lymphocyte subsets, T helper cells, suppressor/cytotoxic T cells, natural killer cells, B cells, sleep satisfaction, sleep disorders, low-income women, colposcopy, abnormal Pap smear
MeSH terms
Adolescent, Adult, Uterine Cervical Neoplasms, Colposcopy, Depressive Disorder, Female, Follow-Up Studies, Humans, Immunocompetence, Middle Aged, Neoplasm Staging, Psychiatric Status Rating Scales, Risk Factors, Sleep, Socioeconomic Factors, T-Lymphocytes, Antigens, CD

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