Nocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjects
Abstract
Insomnia predicts cardiovascular and non-cardiovascular disease mortality. This study evaluated EEG sleep, nocturnal sympathetic activity, and daytime measures of immune function in subjects with primary insomnia (n = 17) and patients with current major depression (n = 14) as compared to controls (n = 31). Insomniacs showed disordered sleep continuity along with nocturnal increases of average levels of circulating norepinephrine and decreases of natural killer cell responses, whereas depressed patients showed declines of natural killer cell activity, but no differences of EEG sleep or nocturnal catecholamines as compared to controls. Impairments of sleep efficiency correlated with nocturnal elevations of norepinephrine in the insomniacs but not in the depressives or controls. These data indicate that insomnia is associated with nocturnal sympathetic arousal and declines of natural immunity, and further support the role of sleep in the regulation of sympathetic nervous and immune system functioning.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Later studies found that 24-h urinary free cortisol, norepinephrine, and catecholamine metabolites levels were increased in patients with insomnia or were correlated with PSG indices of sleep disturbance in insomnia patients.
“later studies found that 24-h urinary free cortisol, norepinephrine, and catecholamine metabolites levels were increased in patients with insomnia or were correlated with PSG indices of sleep disturbance in insomnia patients(148-151).”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [151]
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772 · see citing works
Biology of Natural Killer Cells
Trinchieri, G. (1989) · Advances in Immunology · doi:10.1016/s0065-2776(08)60664-1 · Cited by 2,902 · see citing works
Mortality Associated With Sleep Duration and Insomnia
Kripke, D. F., Garfinkel, L., Wingard, D. L., Klauber, M. R., & Marler, M. R. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.2.131 · Cited by 1,614 · see citing works
Sleep Complaints Among Elderly Persons: An Epidemiologic Study of Three Communities
Foley, D. J., Monjan, A. A., Brown, S. L., Simonsick, E. M., Wallace, R. B., & Blazer, D. G. (1995) · Sleep · doi:10.1093/sleep/18.6.425 · Cited by 1,610 · see citing works
Sympathetic-Nerve Activity during Sleep in Normal Subjects
Somers, V. K., Dyken, M. E., Mark, A. L., & Abboud, F. M. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302043280502 · Cited by 1,574 · see citing works
Sleep and Psychiatric Disorders: A Meta-analysis
Benca, R. M. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080059010 · Cited by 1,468 · see citing works
Circadian variation and triggers of onset of acute cardiovascular disease.
Muller, J. E., Tofler, G. H., & Stone, P. H. (1989) · Circulation · doi:10.1161/01.cir.79.4.733 · Cited by 1,426 · see citing works
Circadian variation in the frequency of sudden cardiac death.
Muller, J. E., Ludmer, P. L., Willich, S. N., Tofler, G. H., Aylmer, G., Klangos, I., & Stone, P. H. (1987) · Circulation · doi:10.1161/01.cir.75.1.131 · Cited by 1,083 · see citing works
Short and Long Sleep and Sleeping Pills: Is Increased Mortality Associated?
Kripke, D. F. (1979) · Archives of General Psychiatry · doi:10.1001/archpsyc.1979.01780010109014 · Cited by 660 · see citing works
Willich, S. N., Levy, D., Rocco, M. B., Tofler, G. H., Stone, P. H., & Muller, J. E. (1987) · The American Journal of Cardiology · doi:10.1016/0002-9149(87)91027-7 · Cited by 653 · see citing works
Sleep Apnea and Cardiovascular Disease
Leung, R. S. T., & Bradley, T. D. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.12.2107045 · Cited by 645 · see citing works
24-Hour Metabolic Rate in Insomniacs and Matched Normal Sleepers
Bonnet, M. H., & Arand, D. L. (1995) · Sleep · doi:10.1093/sleep/18.7.581 · Cited by 557 · see citing works
Sleep Apnea and Hypertension: A Population-based Study
Hla, K. M., Young, T. B., Bidwell, T., Palta, M., Skatrud, J. B., & Dempsey, J. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-120-5-199403010-00005 · Cited by 551 · see citing works
Morning increase in onset of ischemic stroke.
Marler, J. R., Price, T. R., Clark, G., Muller, J. E., Robertson, T., Mohr, J. P., Hier, D. B., Wolf, P. A., Caplan, L. R., & Foulkes, M. A. (1989) · Stroke · doi:10.1161/01.str.20.4.473 · Cited by 515 · see citing works
Mallon, L., Broman, J. ‐., & Hetta, J. (2002) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2002.00941.x · Cited by 495 · see citing works
Partial night sleep deprivation reduces natural killer and celhdar immune responses in humans
Irwin, M., McClintick, J., Costlow, C., Fortner, M., White, J., & Gillin, J. C. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.5.8621064 · Cited by 480 · see citing works
Self-citationEffects of Insufficient Sleep on Blood Pressure Monitored by a New Multibiomedical Recorder
Tochikubo, O., Ikeda, A., Miyajima, E., & Ishii, M. (1996) · Hypertension · doi:10.1161/01.hyp.27.6.1318 · Cited by 470 · see citing works
Heart Rate Variability in Insomniacs and Matched Normal Sleepers
Bonnet, M. H., & Arand, D. L. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199809000-00017 · Cited by 451 · see citing works
Irwin, M. R., Thompson, J., Miller, C., Gillin, J. C., & Ziegler, M. G. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5788 · Cited by 389 · see citing works
Self-citationRedwine, L. S., Hauger, R. L., Gillin, J. C., & Irwin, M. R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.10.6871 · Cited by 373 · see citing works
Self-citationDinges, D. F., Douglas, S. D., Zaugg, L., Campbell, D. E., McMann, J. M., Whitehouse, W. G., Orne, E. C., Kapoor, S. C., Icaza, E., & Orne, M. T. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117184 · Cited by 361 · see citing works
Sleep problems in the community elderly as predictors of death and nursing home placement
Pollak, C. P., PERLICK, D. A., Linsner, J. P., Wenston, J., & Hsieh, F. (1990) · Journal of Community Health · doi:10.1007/bf01321316 · Cited by 350 · see citing works
Reduction of immune function in life stress and depression
Irwin, M. R., Patterson, T. W., Smith, T. L., Caldwell, C. L., Brown, S. A., Gillin, J. C., & Grant, I. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90016-u · Cited by 345 · see citing works
Self-citationRedwine, L. S. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.10.3597 · Cited by 285 · see citing works
Inflammation, Depressive Symptomatology, and Coronary Artery Disease
Appels, A., Bär, F. W. H. M., Bär, J., Bruggeman, C., & de Baets, A. M. (2000) · Psychosomatic Medicine · doi:10.1097/00006842-200009000-00001 · Cited by 270 · see citing works
Shakhar, G., & Ben‐Eliyahu, S. (1998) · PubMed · Cited by 253 · see citing works
Dodt, C., Breckling, U., Derad, I., Fehm, H. L., & Jan Born, A. (1997) · Hypertension · doi:10.1161/01.hyp.30.1.71 · Cited by 252 · see citing works
Partial sleep deprivation reduces natural killer cell activity in humans.
Irwin, M., Mascovich, A., Gillin, J. C., Willoughby, R., Pike, J., & Smith, T. L. (1994) · Psychosomatic Medicine · doi:10.1097/00006842-199411000-00004 · Cited by 249 · cited 4× · see citing works
“…with experimental evidence that partial night sleep deprivation increases nocturnal levels of norepinephrine and decreases NK cell responses (Irwin et al., 1994; Irwin et al., 1996, 1999), these data implicate sleep continuity in the regulation of the immune and sympathetic nervous systems.”
InfluentialSelf-citationRio, F. G., Racionero, M. A., Pino, J. M., Martínez, I., Ortuño, F., Villasante, C., & Villamor, J. (2000) · CHEST Journal · doi:10.1378/chest.117.5.1417 · Cited by 249 · see citing works
Sleep deprivation and human immune function
Dinges, D. F., Douglas, S. D., Hamarman, S., Zaugg, L., & Kapoor, S. C. (1995) · Advances in Neuroimmunology · doi:10.1016/0960-5428(95)00002-j · Cited by 234 · see citing works
Shakhar, G., & Ben‐Eliyahu, S. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.7.3251 · Cited by 231 · see citing works
Mallon, L., Broman, J., & Hetta, J. E. (2000) · International Psychogeriatrics · doi:10.1017/s1041610200006414 · Cited by 199 · see citing works
The Effect of Sleep Apnea on Plasma and Urinary Catecholamines
Dimsdale, J. E., Coy, T. V., Ziegler, M. G., Ancoli‐Israel, S., & Clausen, J. L. (1995) · SLEEP · doi:10.1093/sleep/18.5.377 · Cited by 178 · see citing works
Self-citationSleep and Host Defenses: A Review
Benca, R. M., & Quintáns, J. (1997) · SLEEP · doi:10.1093/sleep/20.11.1027 · Cited by 157 · see citing works
Bloom, B. J., Owens, J. A., McGuinn, M., Hart, C. N., Schaeffer, L., & Alario, A. J. (2002) · PubMed · Cited by 152 · see citing works
Abnormal Electroencephalographic Sleep Profiles in Major Depression
Thase, M. E. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830020013003 · Cited by 142 · see citing works
Nocturnal non-dipping: what does it augur?
Pickering, T. G., & Kario, K. (2001) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200109000-00010 · Cited by 128 · see citing works
Neuroimmunologic aspects of sleep and sleep loss
Rogers, N. L., Szuba, M. P., Staab, J. P., Evans, D. L., & Dinges, D. F. (2001) · Seminars in Clinical Neuropsychiatry · doi:10.1053/scnp.2001.27907 · Cited by 116 · see citing works
Irwin, M. R., Smith, T. L., & Gillin, J. C. (1992) · Psychosomatic Medicine · doi:10.1097/00006842-199201000-00002 · Cited by 114 · see citing works
Self-citationPsychotropic Medication and Insomnia Complaints in Two Epidemiological Studies
Ohayon, M. M., & Caulet, M. (1996) · The Canadian Journal of Psychiatry · doi:10.1177/070674379604100711 · Cited by 100 · see citing works
Immunity and depression: Insomnia, Retardation, and reduction of natural killer cell activity
Cover, H., & Irwin, M. (1994) · Journal of Behavioral Medicine · doi:10.1007/bf01858106 · Cited by 97 · see citing works
Self-citationMechanisms Underlying the Morning Increase in Platelet Aggregation: A Flow Cytometry Study
Andrews, N. P., Gralnick, H. R., Merryman, P. K., Vail, M., & Quyyumi, A. A. (1996) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00398-1 · Cited by 92 · see citing works
Sleep deprivation as a probe of homeostatic sleep regulation in primary alcoholics
Irwin, M. R., Gillin, J. C., Dang, J., Weissman, J., Phillips, E., & Ehlers, C. L. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01304-x · Cited by 72 · see citing works
Self-citationThase, M. E., Kupfer, D. J., Fasiczka, A. L., Buysse, D. J., Simons, A. D., & Frank, E. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00259-4 · Cited by 70 · see citing works
Psychosocial stress moderates the relationship of cancer history with natural killer cell activity
VITALIANO, P. P., Scanlan, J. M., Ochs, H. D., Syrjala, K. L., Siegler, I. C., & Snyder, E. A. (1998) · Annals of Behavioral Medicine · doi:10.1007/bf02884961 · Cited by 64 · see citing works
Savard, J., Miller, S. M., Mills, M., O'Leary, A., Harding, H., Douglas, S. D., Mangan, C. E., Belch, R., & Winokur, A. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199907000-00014 · Cited by 62 · see citing works
Sleep physiological characteristics of exhausted men.
van Diest, R., & Appels, W. P. (1994) · Psychosomatic Medicine · doi:10.1097/00006842-199401000-00004 · Cited by 56 · see citing works
Irwin, M. R., & Miller, C. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb02025.x · Cited by 42 · see citing works
Self-citationInsomnia in Diabetic Hemodialysis Patients
Han, S. Y., Yoon, J.-W., Jo, S.-K., Shin, J.-H., Shin, C., Lee, J.-B., Cha, D.-R., Cho, W.-Y., Pyo, H.-J., Kim, H. K., et al. (2002) · The Nephron journals/Nephron journals · doi:10.1159/000064460 · Cited by 36 · see citing works
Diurnal Physiologic Processes and Circadian Variation of Acute Myocardial Infarction
Fenga, D.-L., & Toiler, G. H. (1995) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/174182679500200602 · Cited by 36 · see citing works
Diurnal physiologic processes and circadian variation of acute myocardial infarction
Da-li, F., & Tofler, G. H. (1995) · Journal of Cardiovascular Risk · doi:10.1097/00043798-199512000-00002 · Cited by 27 · see citing works
Relationship Between Sympathetic Nerve Traffic and Plasma Concentrations of Noradrenaline in Man
Wallin, B. G. (1988) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1988.tb02029.x · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
The hyperarousal model of insomnia: A review of the concept and its evidence
Riemann, D., Spiegelhalder, K., Feige, B., Voderholzer, U., Berger, M., Perlis, M., & Nissen, C. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.04.002 · Cited by 1,789 · see citing works
Sleep and mental disorders: a meta-analysis of polysomnographic research
Baglioni, C., Nanovska, S., Regen, W., Spiegelhalder, K., Feige, B., Nissen, C., Reynolds, C. F., & Riemann, D. (2016) · Psychological Bulletin · doi:10.1037/bul0000053 · Cited by 1,074 · see citing works
Hyperarousal and insomnia: state of the science
Bonnet, M. H., & Arand, D. L. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.05.002 · Cited by 914 · see citing works
Insomnia with objective short sleep duration: The most biologically severe phenotype of the disorder
Vgontzas, A. N., Fernandez-Mendoza, J., Liao, D., & Bixler, E. O. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.09.005 · Cited by 776 · see citing works
Insomnia with Objective Short Sleep Duration is Associated with a High Risk for Hypertension
Vgontzas, A. N., Liao, D., Bixler, E. O., Chrousos, G. P., & Vela-Bueno, A. (2009) · Sleep · doi:10.1093/sleep/32.4.491 · Cited by 748 · see citing works
Depressive disorders and immunity: 20 years of progress and discovery
Irwin, M. R., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.01.010 · Cited by 676 · see citing works
Self-citationEffects of sleep and circadian rhythm on the human immune system
Lange, T., Dimitrov, S., & Born, J. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05300.x · Cited by 591 · see citing works
Sick and tired: does sleep have a vital role in the immune system?
Bryant, P. A., Trinder, J., & Curtis, N. (2004) · Nature Reviews Immunology · doi:10.1038/nri1369 · Cited by 551 · see citing works
Insomnia With Objective Short Sleep Duration and Incident Hypertension: The Penn State Cohort
Fernandez-Mendoza, J., Vgontzas, A. N., Liao, D., Shaffer, M. L., Vela-Bueno, A., Basta, M., & Bixler, E. O. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.193268 · Cited by 425 · see citing works
Sleep changes in the disorder of insomnia: a meta-analysis of polysomnographic studies
Baglioni, C., Regen, W., Teghen, A., Spiegelhalder, K., Feige, B., Nissen, C., & Riemann, D. (2014) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2013.04.001 · Cited by 386 · see citing works
Irwin, M. R., Olmstead, R., Carrillo, C., Sadeghi, N., Breen, E. C., Witarama, T., Yokomizo, M., Lavretsky, H., Carroll, J. E., Motivala, S. J., et al. (2014) · Sleep · doi:10.5665/sleep.4008 · Cited by 303 · see citing works
Self-citationPrevalence and Polysomnographic Correlates of Insomnia Comorbid with Medical Disorders
Budhiraja, R., Roth, T., Hudgel, D. W., Budhiraja, P., & Drake, C. L. (2011) · Sleep · doi:10.5665/sleep.1114 · Cited by 255 · see citing works
Fernandez-Mendoza, J., Calhoun, S. L., Bixler, E. O., Karataraki, M., Liao, D., Vela-Bueno, A., Jose Ramos-Platon, M., Sauder, K. A., Basta, M., & Vgontzas, A. N. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181fe365a · Cited by 261 · see citing works
Chronic sleep loss during pregnancy as a determinant of stress: impact on pregnancy outcome
Palagini, L., Gemignani, A., Banti, S., Manconi, M., Mauri, M., & Riemann, D. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2014.02.013 · Cited by 220 · see citing works
Increased nocturnal interleukin-6 excretion in patients with primary insomnia: A pilot study
Burgos, I., Richter, L., Klein, T., Fiebich, B., Feige, B., Lieb, K., Voderholzer, U., & Riemann, D. (2006) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.06.007 · Cited by 198 · see citing works
Lanfranchi, P. A., Pennestri, M.-H., Fradette, L., Dumont, M., Morin, C. M., & Montplaisir, J. (2009) · Sleep · doi:10.1093/sleep/32.6.760 · Cited by 198 · see citing works
Sleep: important considerations for the prevention of cardiovascular disease
Grandner, M. A., Alfonso-Miller, P., Fernandez-Mendoza, J., Shetty, S., Shenoy, S., & Combs, D. (2016) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000324 · Cited by 166 · see citing works
Hall, M. H., Smagula, S. F., Boudreau, R. M., Ayonayon, H. N., Goldman, S. E., Harris, T. B., Naydeck, B. L., Rubin, S. M., Samuelsson, L., Satterfield, S., et al. (2015) · Sleep · doi:10.5665/sleep.4394 · Cited by 155 · see citing works
Fernandez-Mendoza, J., Baker, J. H., Vgontzas, A. N., Gaines, J., Liao, D., & Bixler, E. O. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.12.026 · Cited by 155 · see citing works
Carroll, J. E., Cole, S. W., Seeman, T. E., Breen, E. C., Witarama, T., Arevalo, J. M. G., Ma, J., & Irwin, M. R. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.08.024 · Cited by 129 · see citing works
Self-citationBenedict, C., Brytting, M., Markström, A., Broman, J.-E., & Schiöth, H. B. (2012) · BMC Immunology · doi:10.1186/1471-2172-13-1 · Cited by 119 · see citing works
Smagula, S. F., Stone, K. L., Redline, S., Ancoli-Israel, S., Barrett-Connor, E., Lane, N. E., Orwoll, E. S., & Cauley, J. A. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000312 · Cited by 116 · see citing works
Connecting insufficient sleep and insomnia with metabolic dysfunction
Duan, D., Kim, L. J., Jun, J. C., & Polotsky, V. Y. (2023) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14926 · Cited by 110 · see citing works
Nocturnal levels of ghrelin and leptin and sleep in chronic insomnia
Motivala, S. J., Tomiyama, A. J., Ziegler, M., Khandrika, S., & Irwin, M. R. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.016 · Cited by 105 · see citing works
Self-citationSleep characteristics as predictor variables of stress systems markers in insomnia disorder
Floam, S., Simpson, N., Nemeth, E., Scott‐Sutherland, J., Gautam, S., & Haack, M. (2015) · Journal of Sleep Research · doi:10.1111/jsr.12259 · Cited by 103 · see citing works
Prather, A. A., Epel, E. S., Cohen, B. E., Neylan, T. C., & Whooley, M. A. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.004 · Cited by 100 · see citing works
Okun, M. L., Luther, J. F., Wisniewski, S. R., & Wisner, K. L. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31829cc3e7 · Cited by 94 · see citing works
Prather, A. A., Gurfein, B., Moran, P., Daubenmier, J., Acree, M., Bacchetti, P., Sinclair, E., Lin, J., Blackburn, E., Hecht, F. M., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.12.011 · Cited by 79 · see citing works
Is Insomnia a Risk Factor for Decreased Influenza Vaccine Response?
Taylor, D. J., Kelly, K., Kohut, M. L., & Song, K.-S. (2017) · Behavioral Sleep Medicine · doi:10.1080/15402002.2015.1126596 · Cited by 69 · see citing works
Disturbed Sleep, a Novel Risk Factor for Preterm Birth?
Okun, M. L., Luther, J. F., Wisniewski, S. R., Sit, D., Prairie, B. A., & Wisner, K. L. (2012) · Journal of Women's Health · doi:10.1089/jwh.2010.2670 · Cited by 61 · see citing works
Acute and Chronic Insomnia: What Has Time and/or Hyperarousal Got to Do with It?
Vargas, I., Nguyen, A. M., Muench, A., Bastien, C. H., Ellis, J. G., & Perlis, M. L. (2020) · Brain Sciences · doi:10.3390/brainsci10020071 · Cited by 58 · see citing works
Apneic Sleep, Insufficient Sleep, and Hypertension
Mansukhani, M. P., Covassin, N., & Somers, V. K. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.11780 · Cited by 52 · see citing works
Sleep and Immunity: Cytokine Pathways Linking Sleep and Health Outcomes
Motivala, S. J., & Irwin, M. R. (2007) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2007.00468.x · Cited by 49 · see citing works
Self-citationSun, J., Wang, W., Zhang, R., Duan, H., Tian, X., Xu, C., Li, X., & Zhang, D. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02074-x · Cited by 18 · see citing works
- Authors
- Irwin, M., Clark, C., Kennedy, B., Christian Gillin, J., & Ziegler, M.
- Affiliations
- University of California, Los Angeles (US)
- University of California San Diego (US)
- Corresponding author
- Irwin, Michael
- Venue
- Brain Behavior and Immunity
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 17
- Issue
- 5
- Pages
- 365-372
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2071697888
- Cited by
- 268
- References
- 53
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 22 · 2021: 15 · 2020: 7 · 2019: 7 · 2018: 9 · 2017: 9 · 2016: 16 · 2015: 9 · 2014: 17 · 2013: 19 · 2012: 12
- FWCI
- 15.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01aa010215-02)
- National Institute on Alcohol Abuse and Alcoholism (AA13239, AA10215, R01AA013239)
- National Institute on Aging (AG 18367, R01AG018367)
- National Institute of Mental Health (MH-55253, R01MH055253, T32MH018399)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR/AG41867)
- National Center for Research Resources (M01RR000827)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- insomnia, major depressive disorder, norepinephrine, sympathetic nervous system arousal, natural killer cells, immune function, sleep continuity, sleep efficiency, sleep EEG, sleep-immune interaction
- MeSH terms
- Analysis of Variance, Circadian Rhythm, Major Depressive Disorder, Electroencephalography, Epinephrine, Humans, Sleep Initiation and Maintenance Disorders, Interleukin-2, Killer Cells, Natural, Lymphocyte Activation, Male, Norepinephrine, Reference Values, Sleep, Sympathetic Nervous System, Case-Control Studies, Polysomnography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
