Cited by 166Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on BehaviorPain Mechanisms and Treatments

The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.

Understanding How Opioids Contribute to Reward and Analgesia

Fields, Howard L.·2007·Regional Anesthesia and Pain Medicine

DOI 10.1097/00115550-200705000-00012

Open this paper in CoChat — free account

Abstract

Opioids acting at the mu opioid (MOP) receptor produce powerful analgesia. They also produce an intensely rewarding effect that can lead to addiction. The analgesic effect of MOP receptor agonists derives from a direct inhibitory effect on pain transmission at the spinal-cord level and through activation of a descending pain-modulatory pathway. The rewarding effect of MOP agonists is the result of their actions in the mesostriatal dopamine pathway classically associated with both natural and drug rewards. Both the analgesic and rewarding effect of MOP agonists are best understood in the context of decision making under conditions of conflict. Pain is one of many competing motivational states, and endogenous opioids suppress responses to noxious stimuli in the presence of conflicting motivations, such as hunger or a threatening predator. When a food reward is available, MOP agonists microinjected into the mesostriatal circuit promote its consumption, while concomitantly suppressing responses to noxious stimulation. The mesostriatal "reward" circuit, thus, appears to perform a function critical to decision making and can either amplify or suppress responses to noxious stimuli.

Integrity signals

Registry

Crossref · 10.1097/00115550-200705000-00012

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Integrative Action of the Nervous System.
Sherrington, C. (1907) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-190734120-00021 · Cited by 4,136
Molecular mechanisms of nociception
Julius, D., & Basbaum, A. I. (2001) · Nature · doi:10.1038/35093019 · Cited by 2,685
Sensory Mechanisms of the Spinal Cord
Willis, W. D., & Coggeshall, R. E. (1978) · Springer eBooks · doi:10.1007/978-1-4757-1688-7 · Cited by 1,456
THE MECHANISM OF PLACEBO ANALGESIA
Levine, J., Gordon, N., & Fields, H. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92762-9 · Cited by 1,094
Self-citation
Wall and Melzack's Textbook of Pain
McMahon, S. B., & Koltzenburg, M. (2005) · Cited by 1,014
Opiate analgesics inhibit substance P release from rat trigeminal nucleus
Jessell, T. M., & Iversen, L. L. (1977) · Nature · doi:10.1038/268549a0 · Cited by 970
State-dependent opioid control of pain
Fields, H. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1431 · Cited by 946
Self-citation
P AIN M ECHANISMS : Labeled Lines Versus Convergence in Central Processing
Craig, A. D. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131022 · Cited by 765
Central nervous system mechanisms of pain modulation
Fields, H. L., Basbaum, A. I., & Heinricher, M. M. (2006) · Elsevier eBooks · doi:10.1016/b0-443-07287-6/50012-6 · Cited by 761
Self-citation
TREATMENT OF EXCESSIVE AXILLARY SWEATING
Gibbs, J. R. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91979-5 · Cited by 560

Show all 38 references

Sorted by citations

Pain and emotion: a biopsychosocial review of recent research
Lumley, M. A., Cohen, J. L., Borszcz, G. S., Cano, A., Radcliffe, A. M., Porter, L. S., Schubiner, H., & Keefe, F. J. (2011) · Journal of Clinical Psychology · doi:10.1002/jclp.20816 · Cited by 836
A common neurobiology for pain and pleasure
Leknes, S., & Tracey, I. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2333 · Cited by 784
The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses.
Jhou, T. C., Fields, H. L., Baxter, M. G., Saper, C. B., & Holland, P. C. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.001 · Cited by 696
Self-citation
Music and social bonding: â€œself-otherâ€ merging and neurohormonal mechanisms
Tarr, B., Launay, J., & Dunbar, R. I. M. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01096 · Cited by 548
Brain mediators of predictive cue effects on perceived pain
Atlas, L. Y., Bolger, N., Lindquist, M. A., & Wager, T. D. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0057-10.2010 · Cited by 389
Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry
Navratilova, E., Xie, J. Y., Okun, A., Qu, C., Eyde, N., Ci, S., Ossipov, M. H., King, T., Fields, H. L., & Porreca, F. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214605109 · Cited by 313
Self-citation
Common brain mechanisms of chronic pain and addiction
Elman, I., & Borsook, D. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.027 · Cited by 303
Beyond happiness: Building a science of discrete positive emotions.
Shiota, M. N., Campos, B., Oveis, C., Hertenstein, M. J., Simon-Thomas, E. R., & Keltner, D. J. (2017) · American Psychologist · doi:10.1037/a0040456 · Cited by 304
Distinct Brain Systems Mediate the Effects of Nociceptive Input and Self-Regulation on Pain
Woo, C.-W., Roy, M., Buhle, J. T., & Wager, T. D. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002036 · Cited by 263
Pain and suicidality: Insights from reward and addiction neuroscience
Elman, I., Borsook, D., & Volkow, N. D. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.003 · Cited by 226
Cocaine Drives Aversive Conditioning via Delayed Activation of Dopamine-Responsive Habenular and Midbrain Pathways
Jhou, T. C., Good, C. H., Rowley, C. S., Xu, S., Wang, H., Burnham, N. W., Hoffman, A. F., Lupica, C. R., & Ikemoto, S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3634-12.2013 · Cited by 211
The Neurobiology Shaping Affective Touch: Expectation, Motivation, and Meaning in the Multisensory Context
Ellingsen, D., Leknes, S., Løseth, G. E., Wessberg, J., & Olausson, H. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01986 · Cited by 214
Synchrony as an Adaptive Mechanism for Large‐Scale Human Social Bonding
Launay, J., Tarr, B., & Dunbar, R. (2016) · Ethology · doi:10.1111/eth.12528 · Cited by 218
Pain, affective symptoms, and cognitive deficits in patients with cerebral dopamine dysfunction
Jarcho, J. M., Mayer, E. A., Jiang, Z. K., Feier, N. A., & London, E. D. (2012) · Pain · doi:10.1016/j.pain.2012.01.002 · Cited by 160
Evaluation of reward from pain relief
Navratilova, E., Xie, J. Y., King, T. E., & Porreca, F. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12095 · Cited by 152
Calcium-Permeable AMPA Receptors in the Nucleus Accumbens Regulate Depression-Like Behaviors in the Chronic Neuropathic Pain State
Goffer, Y., Xu, D., Eberle, S. E., D’amour, J. A., Lee, M., Tukey, D. S., Froemke, R. C., Ziff, E. B., & Wang, J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2454-13.2013 · Cited by 147
Activation of μ-Opioid Receptors in the Dorsal Striatum is Necessary for Adult Social Attachment in Monogamous Prairie Voles
Burkett, J. P., Spiegel, L. L., Inoue, K., Murphy, A. Z., & Young, L. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.117 · Cited by 133
The Recurrent Pain and Sexual Sequelae of Provoked Vestibulodynia: A Perpetuating Cycle
Basson, R. J. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02803.x · Cited by 123
Lost but making progress—Where will new analgesic drugs come from?
Borsook, D., Hargreaves, R. J., Bountra, C., & Porreca, F. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008320 · Cited by 116
Neuronal Decision-Making Circuits
Kristan, W. B. (2008) · Current Biology · doi:10.1016/j.cub.2008.07.081 · Cited by 109
Placebo improves pleasure and pain through opposite modulation of sensory processing
Ellingsen, D., Wessberg, J., Eikemo, M., Liljencrantz, J., Endestad, T., Olausson, H., & Leknes, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305050110 · Cited by 112
Behavioral choice by presynaptic inhibition of tactile sensory terminals
Gaudry, Q., & Kristan, W. B. (2009) · Nature Neuroscience · doi:10.1038/nn.2400 · Cited by 108
Pain and the context
Carlino, E., Frisaldi, E., & Benedetti, F. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.17 · Cited by 112
Brain activity of anandamide: a rewarding bliss?
Scherma, M., Masia, P., Satta, V., Fratta, W., Fadda, P., & Tanda, G. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0075-x · Cited by 114
Different contexts, different pains, different experiences
Carlino, E., & Benedetti, F. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.053 · Cited by 115
Cerebral interactions of pain and reward and their relevance for chronic pain
Becker, S., Gandhi, W., & Schweinhardt, P. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.013 · Cited by 103
Brain-Derived Neurotrophic Factor in the Mesolimbic Reward Circuitry Mediates Nociception in Chronic Neuropathic Pain
Zhang, H., Qian, Y., Li, C., Liu, D., Wang, L., Wang, X., Liu, M., Liu, H., Zhang, S., Guo, X.-Y., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.1180 · Cited by 105
Craving of Prescription Opioids in Patients With Chronic Pain: A Longitudinal Outcomes Trial
Wasan, A. D., Ross, E. L., Michna, E., Chibnik, L. B., Greenfield, S. F., Weiss, R. D., & Jamison, R. N. (2012) · Journal of Pain · doi:10.1016/j.jpain.2011.10.010 · Cited by 100
The Conundrum of Opioid Tapering in Long-Term Opioid Therapy for Chronic Pain: A Commentary
Manhapra, A., Arias, A. J., & Ballantyne, J. C. (2018) · Substance Abuse · doi:10.1080/08897077.2017.1381663 · Cited by 98
Sodium channels in pain disorders: pathophysiology and prospects for treatment
Dib‐Hajj, S. D., Geha, P., & Waxman, S. G. (2017) · Pain · doi:10.1097/j.pain.0000000000000854 · Cited by 103
The Positive Consequences of Pain: A Biopsychosocial Approach
Bastian, B., Jetten, J., Hornsey, M. J., & Leknes, S. (2014) · Personality and Social Psychology Review · doi:10.1177/1088868314527831 · Cited by 91
Orbitofrontal cortex mediates pain inhibition by monetary reward
Becker, S., Gandhi, W., Pomares, F. B., Wager, T. D., & Schweinhardt, P. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw173 · Cited by 96
Dynamic brain-to-brain concordance and behavioral mirroring as a mechanism of the patient-clinician interaction
Ellingsen, D., Isenburg, K., Jung, C. J., Lee, J., Gerber, J. A., Mawla, I., Sclocco, R., Jensen, K. B., Edwards, R. R., Kelley, J. M., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc1304 · Cited by 87
Evidence for endogenous opioid release in the amygdala during positive emotion
Koepp, M. J., Hammers, A., LAWRENCE, A., Asselin, M., Grasby, P. M., & Bench, C. J. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.08.032 · Cited by 82
The role of hedonics in the Human Affectome
Becker, S., Bräscher, A., Bannister, S., Bensafi, M., Calma‐Birling, D., Chan, R. C. K., Eerola, T., Ellingsen, D., Ferdenzi, C., Hanson, J. L., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.003 · Cited by 93
Facets and mechanisms of adaptive pain behavior: predictive regulation and action
Morrison, I., Perini, I., & Dunham, J. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00755 · Cited by 80
Integrative Model of Human-Animal Interactions: A One Health–One Welfare Systemic Approach to Studying HAI
Leconstant, C., & Spitz, É. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.656833 · Cited by 72
Temporal mismatch between pain behaviour, skin Nerve Growth Factor and intra-epidermal nerve fibre density in trigeminal neuropathic pain
Evans, L. J., Loescher, A. R., Boissonade, F. M., Whawell, S. A., Robinson, P. P., & Andrew, D. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-1 · Cited by 68
Discovery of a Novel Selective Kappa-Opioid Receptor Agonist Using Crystal Structure-Based Virtual Screening
Negri, A., Rives, M., Caspers, M. J., Prisinzano, T. E., Javitch, J. A., & Filizola, M. (2013) · Journal of Chemical Information and Modeling · doi:10.1021/ci400019t · Cited by 66
Pain in Times of Stress.
Ahmad, A. H., & Zakaria, R. (2015) · Europe PMC (PubMed Central) · Cited by 63
Morphine effects within the rodent anterior cingulate cortex and rostral ventromedial medulla reveal separable modulation of affective and sensory qualities of acute or chronic pain
Gomtsian, L., Bannister, K., Eyde, N., Robles, D., Dickenson, A. H., Porreca, F., & Navratilova, E. (2018) · Pain · doi:10.1097/j.pain.0000000000001355 · Cited by 65
The role of dopamine in the perceptual modulation of nociceptive stimuli by monetary wins or losses
Becker, S., Gandhi, W., Elfassy, N. M., & Schweinhardt, P. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12303 · Cited by 60
Reduced Basal Ganglia μ-Opioid Receptor Availability in Trigeminal Neuropathic Pain: A Pilot Study
DosSantos, M. F. H., Martikainen, I. K., Nascimento, T. D., Love, T., Deboer, M. D., Maslowski, E., Monteiro, A. A., Vincent, M. B., Zubieta, J.-K., & DaSilva, A. F. M. (2012) · Molecular Pain · doi:10.1186/1744-8069-8-74 · Cited by 57
Preemptive Stimulation of AgRP Neurons in Fed Mice Enables Conditioned Food Seeking under Threat
Jikomes, N., Ramesh, R. N., Mandelblat-Cerf, Y., & Andermann, M. L. (2016) · Current Biology · doi:10.1016/j.cub.2016.07.019 · Cited by 58
Mesopontine rostromedial tegmental nucleus neurons projecting to the dorsal raphe and pedunculopontine tegmental nucleus: psychostimulant-elicited Fos expression and collateralization
Lavezzi, H. N., Parsley, K. P., & Zahm, D. S. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0368-z · Cited by 54
Involvement of the nucleus accumbens and dopamine system in chronic pain
Benarroch, E. E. (2016) · Neurology · doi:10.1212/wnl.0000000000003243 · Cited by 52
Pain: A Distributed Brain Information Network?
Mano, H., & Seymour, B. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002037 · Cited by 66
Lysergic Acid Diethylamide and Psilocybin for the Management of Patients with Persistent Pain: a Potential Role?
Whelan, A., & Johnson, M. I. (2018) · Pain Management · doi:10.2217/pmt-2017-0068 · Cited by 51
Persistent pain alters AMPA receptor subunit levels in the nucleus accumbens
Su, C. H., D’amour, J. A., Lee, M. S., Lin, H.-Y., Manders, T. R., Xu, D., Eberle, S. E., Goffer, Y., Zou, A., Rahman, M., et al. (2015) · Molecular Brain · doi:10.1186/s13041-015-0140-z · Cited by 51
Endogenous opiates and behavior: 2007
Bodnar, R. J. (2008) · Peptides · doi:10.1016/j.peptides.2008.09.007 · Cited by 54
Psychological Processes in Chronic Pain: Influences of Reward and Fear Learning as Key Mechanisms – Behavioral Evidence, Neural Circuits, and Maladaptive Changes
Nees, F., & Becker, S. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.051 · Cited by 49
Placebo treatment affects brain systems related to affective and cognitive processes, but not nociceptive pain
Botvinik‐Nezer, R., Petre, B., Čeko, M., Lindquist, M. A., Friedman, N. P., & Wager, T. D. (2024) · Nature Communications · doi:10.1038/s41467-024-50103-8 · Cited by 50
‘Naltrexone Blocks Endorphins Released when Dancing in Synchrony’
Tarr, B., Launay, J., Benson, C., & Dunbar, R. I. M. (2017) · Adaptive Human Behavior and Physiology · doi:10.1007/s40750-017-0067-y · Cited by 48
Altered prefrontal correlates of monetary anticipation and outcome in chronic pain
Martucci, K. T., Borg, N., MacNiven, K. H., Knutson, B. D., & Mackey, S. (2018) · Pain · doi:10.1097/j.pain.0000000000001232 · Cited by 46
Physical Pain as Pleasure: A Theoretical Perspective
Dunkley, C. R., Henshaw, C. D., Henshaw, S. K., & Brotto, L. A. (2019) · The Journal of Sex Research · doi:10.1080/00224499.2019.1605328 · Cited by 47
Methadone Antinociception Is Dependent on Peripheral Opioid Receptors
He, L., Kim, J., Ou, C. J., McFadden, W., van Rijn, R. M., & Whistler, J. L. (2009) · Journal of Pain · doi:10.1016/j.jpain.2008.09.011 · Cited by 42
Mechanisms for the Regulation of State Changes in the Central Nervous System
Pfaff, D. W., Kieffer, B. L., & Swanson, L. W. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.031 · Cited by 40
Behavioral and neurochemical analysis of ongoing bone cancer pain in rats
Remeniuk, B., Sukhtankar, D. D., Okun, A., Navratilova, E., Xie, J. Y., King, T. E., & Porreca, F. (2015) · Pain · doi:10.1097/j.pain.0000000000000218 · Cited by 40
Endogenous opioid modulation of food intake and body weight: Implications for opioid influences upon motivation and addiction
Bodnar, R. J. (2019) · Peptides · doi:10.1016/j.peptides.2019.04.008 · Cited by 40
Prevalence and clinical characteristics of patients with restless legs syndrome with painful symptoms
Cho, Y. W., Song, M. L., Earley, C. J., & Allen, R. P. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2014.12.024 · Cited by 38
Brain substrates of reward processing and the μ-opioid receptor: a pathway into pain?
Nees, F., Becker, S., Millenet, S., Banaschewski, T., Poustka, L., Bokde, A. L. W., Bromberg, U., Büchel, C., Conrod, P., Desrivières, S., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000000720 · Cited by 35
A Novel Role for the Periaqueductal Gray in Consummatory Behavior
Tryon, V. L., & Mizumori, S. J. Y. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00178 · Cited by 34
Molecular neurological correlates of endorphinergic/dopaminergic mechanisms in reward circuitry linked to endorphinergic deficiency syndrome (EDS)
Blum, K., Baron, D. A., McLaughlin, T., & Gold, M. S. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.116733 · Cited by 41
Toward Composite Pain Biomarkers of Neuropathic Pain—Focus on Peripheral Neuropathic Pain
Diaz, M. M., Caylor, J. R., Strigo, I. A., Lerman, I. R., Henry, B. L., López, E., Wallace, M. S., Ellis, R. J., Simmons, A. N., & Keltner, J. R. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.869215 · Cited by 38
Cognitive–Affective and Somatic Side Effects of Morphine and Pentazocine: Side-Effect Profiles in Healthy Adults
Riley, J. L., Hastie, B. A., Glover, T. L., Fillingim, R. B., Staud, R. M., & Campbell, C. M. (2009) · Pain Medicine · doi:10.1111/j.1526-4637.2009.00680.x · Cited by 35
Cannabinoids, reward processing, and psychosis
Gunasekera, B., Diederen, K. M. J., & Bhattacharyya, S. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05801-2 · Cited by 35
Pharmacological Manipulation of the Rostromedial Tegmental Nucleus Changes Voluntary and Operant Ethanol Self-Administration in Rats
Fu, R., Zuo, W., Gregor, D. M., Li, J., Grech, D., & Ye, J.-H. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12974 · Cited by 33
Placebo analgesia: cognitive influences on therapeutic outcome
Watson, A., Power, A., Brown, C. A., El‐Deredy, W., & Jones, A. K. P. (2012) · Arthritis Research & Therapy · doi:10.1186/ar3783 · Cited by 36
Neuroanatomical distribution of μ-opioid receptor mRNA and binding in monogamous prairie voles (Microtus ochrogaster) and non-monogamous meadow voles (Microtus pennsylvanicus)
Inoue, K., Burkett, J. P., & Young, L. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.03.035 · Cited by 33
Docking and Free Energy Perturbation Studies of Ligand Binding in the Kappa Opioid Receptor
Goldfeld, D. A., Murphy, R. B., Kim, B., Wang, L., Beuming, T., Abel, R., & Friesner, R. A. (2014) · The Journal of Physical Chemistry B · doi:10.1021/jp5053612 · Cited by 31
Opioid modulation of song in male zebra finches (Taenopygia guttata)
Khurshid, N., Jayaprakash, N., Hameed, L. S., Mohanasundaram, S., & Iyengar, S. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.003 · Cited by 31
Pleasure-Related Analgesia Activates Opioid-Insensitive Circuits
Kut, E., Candia, V., von Overbeck, J., Pok, J., Fink, D., & Folkers, G. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3736-10.2011 · Cited by 30
The central versus peripheral antinociceptive effects of μ-opioid receptor agonists in the new model of rat visceral pain
Al‐Khrasani, M., Lackó, E., Riba, P., Király, K. P., Sobor, M., Tímár, J., Mousa, S. A., Schäfer, M., & Fürst, S. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.10.018 · Cited by 30
Investigational peptide and peptidomimetic μ and δ opioid receptor agonists in the relief of pain
Giri, A. K., & Hruby, V. J. (2013) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2014.856879 · Cited by 28
Paradoxical surrogate markers of dental injury-induced pain in the mouse
Gibbs, J. L., Urban, R., & Basbaum, A. I. (2013) · Pain · doi:10.1016/j.pain.2013.04.018 · Cited by 28
Is Chronic Pain a Disease?
Ballantyne, J. C., & Sullivan, M. D. (2022) · Journal of Pain · doi:10.1016/j.jpain.2022.05.001 · Cited by 25
Glutamate inputs send prediction error of reward, but not negative value of aversive stimuli, to dopamine neurons
Amo, R., Uchida, N., & Watabe‐Uchida, M. (2024) · Neuron · doi:10.1016/j.neuron.2023.12.019 · Cited by 23
AMPAkines Target the Nucleus Accumbens to Relieve Postoperative Pain
Su, C. H., Lin, H. Y., Yang, R., Xu, D., Lee, M., Pawlak, N., Norcini, M., Sideris, A., Recio‐Pinto, E., Huang, D., et al. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001336 · Cited by 24
Biophysical Properties of Somatic and Axonal Voltage-Gated Sodium Channels in Midbrain Dopaminergic Neurons
Yang, J., Xiao, Y., Li, L., He, Q., Li, M., & Shu, Y. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00317 · Cited by 29
Virtual Reality as a Pain Distraction Modality for Experimentally Induced Pain in a Chronic Pain Population: An Exploratory Study
Brown, P., Powell, W. A., Dansey, N., Al‐Abbadey, M., Stevens, B., & Powell, V. (2021) · Cyberpsychology Behavior and Social Networking · doi:10.1089/cyber.2020.0823 · Cited by 23
Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent µ-/δ-opioid receptor antagonist, regulates obese-related factors in mice
Marczak, E. D., Jinsmaa, Y., Myers, P. H., Blankenship, T., Wilson, R., Balboni, G., Salvadori, S., & Lazarus, L. H. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.06.041 · Cited by 22
Apparent Effects of Opioid Use on Neural Responses to Reward in Chronic Pain
Martucci, K. T., MacNiven, K. H., Borg, N., Knutson, B. D., & Mackey, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-45961-y · Cited by 20
Decision Points: The Factors Influencing the Decision to Feed in the Medicinal Leech
Gaudry, Q., & Kristan, W. B. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00101 · Cited by 22
Distraction from pain depends on task demands and motivation
Vogel, T. A., Falk, C. F., Otto, A. R., & Roy, M. (2022) · PAIN Reports · doi:10.1097/pr9.0000000000001041 · Cited by 21
Variation in the μ-opioid receptor gene (OPRM1) and experiences of felt security in response to a romantic partner’s quarrelsome behavior
Tchalova, K., Sadikaj, G., Moskowitz, D. S., Zuroff, D. C., & Bartz, J. A. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0600-4 · Cited by 22
Pain in an era of armed conflicts: prevention and treatment for warfighters and civilian casualties
George, E., Elman, I., Becerra, L., Berg, S., & Borsook, D. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.002 · Cited by 18
Endogenous opioids and feeding behavior: A decade of further progress (2004–2014). A Festschrift to Dr. Abba Kastin
Bodnar, R. J. (2015) · Peptides · doi:10.1016/j.peptides.2015.03.019 · Cited by 18
Evidence for dopaminergic involvement in endogenous modulation of pain relief
Desch, S., Schweinhardt, P., Seymour, B., Flor, H., & Becker, S. (2023) · eLife · doi:10.7554/elife.81436 · Cited by 19
Efeitos da estimulação cerebral profunda bilateral do núcleo subtalâmico sobre a sensibilidade e a dor em indivíduos com doença de Parkinson idiopática
Cury, R. G. (2015) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2015.tde-26102015-150231 · Cited by 18
Doubling Your Payoff: Winning Pain Relief Engages Endogenous Pain Inhibition
Becker, S., Gandhi, W., Kwan, S., Ahmed, A., & Schweinhardt, P. (2015) · eNeuro · doi:10.1523/eneuro.0029-15.2015 · Cited by 19
Opioid modulation of cell proliferation in the ventricular zone of adult zebra finches (Taenopygia guttata)
Khurshid, N., Hameed, L. S., Mohanasundaram, S., & Iyengar, S. (2010) · The FASEB Journal · doi:10.1096/fj.09-146746 · Cited by 16
Altered Neural Correlates of Emotion Associated Pain Processing in Persistent Somatoform Pain Disorder: An fMRI Study
Luo, Y., Yan, C., Huang, T., Fan, M., Liu, L., Zhao, Z., Ni, K., Jiang, H., Huang, X., Lu, Z., et al. (2016) · Pain Practice · doi:10.1111/papr.12358 · Cited by 19
Suicide and the opioid overdose crisis among American Indian and Alaska Natives: a storm on two fronts demanding swift action
Ivanich, J., Weckstein, J., Nestadt, P. S., Cwik, M. F., Walls, M. L., Haroz, E. E., O’Keefe, V. M., Goklish, N. A., & Barlow, A. (2021) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2021.1955895 · Cited by 18
The brain in pain.
Ahmad, A. H., & Aziz, C. B. A. (2014) · Europe PMC (PubMed Central) · Cited by 16
Screening for Addictive Disorders Within a Workers’ Compensation Clinic: An Exploratory Study
Parhami, I., Hyman, M. H., Siani, A., Lin, S., Collard, M., Garcia, J., Casaus, L. R., TSUANG, J. W., & FONG, T. W. (2011) · Substance Use & Misuse · doi:10.3109/10826084.2011.629705 · Cited by 14
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
DaSilva, A. F. M., Nascimento, T. D., Love, T., DosSantos, M. F. H., Martikainen, I. K., Kaplan, C. M., Deboer, M. D., Lucas, S. R., Bender, M. A., Koeppe, R. A., et al. (2014) · Journal of Visualized Experiments · doi:10.3791/50682 · Cited by 14
Opioid receptor blockade inhibits self-disclosure during a closeness-building social interaction
Tchalova, K., & MacDonald, G. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104559 · Cited by 12
COMT Val158Met Affects the Analgesic Response to Acupuncture Among Cancer Survivors With Chronic Pain
Yang, M., Baser, R. E., Khanin, R., Autuori, I., Li, Q. S., Panageas, K. S., Orlow, I., & Mao, J. J. J. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.05.005 · Cited by 14
How Accurate Appraisal of Behavioral Costs and Benefits Guides Adaptive Pain Coping
Gandhi, W., Morrison, I., & Schweinhardt, P. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00103 · Cited by 14
Pain in critically ill patients with substance use disorder or long-term opioid use for chronic pain.
Drew, D. J., & Marie, B. S. (2011) · AACN Advanced Critical Care · doi:10.1097/nci.0b013e318220c504 · Cited by 12

Authors: Fields, H. L.
Affiliations: University of California, San Francisco (US)
Corresponding author: Fields, Howard L.
ORCID: Fields, Howard L.
Venue: Regional Anesthesia and Pain Medicine
Publisher: BMJ
Published: 2007-05
Volume: 32
Issue: 3
Pages: 242-246
ISSN: 1098-7339 (ISSN-L)
DOI: 10.1097/00115550-200705000-00012
OpenAlex: W2057241840
Cited by: 166
References: 38
Citations by year: 2026: 4 · 2025: 9 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 9 · 2018: 7 · 2017: 11 · 2016: 19 · 2015: 14 · 2014: 14 · 2013: 16 · 2012: 11
FWCI: 2.63
Type: journal article
Language: en
Open access: closed
Locations: Regional Anesthesia & Pain Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords: opioids, mu-opioid receptor, analgesia, reward, descending pain modulation, opioid use disorder, decision-making, motivational conflict, food reward, endogenous opioids, noxious stimuli
MeSH terms: Analgesics, Opioid, Animals, Conflict, Psychological, Decision Making, Dopamine, Escape Reaction, Feeding Behavior, Humans, Medulla Oblongata, Motivation, Narcotic Antagonists, Opioid-Related Disorders, Nucleus Accumbens, Pain, Periaqueductal Gray, Reward, Spinal Cord, Behavior, Addictive, Receptors, Opioid, mu, Opioid Peptides

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Understanding How Opioids Contribute to Reward and Analgesia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks