Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry

Dopamine in motivational control: rewarding, aversive, and alerting

Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.022 · Cited by 2,396 · see citing works

Dissociable Roles of Ventral and Dorsal Striatum in Instrumental Conditioning

O'Doherty, J., Dayan, P., Schultz, J., Deichmann, R., Friston, K., & Dolan, R. J. (2004) · Science · doi:10.1126/science.1094285 · Cited by 2,088 · see citing works

Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex

Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477 · see citing works

Reward representations and reward-related learning in the human brain: Insights from neuroimaging

O’Doherty, J. P. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.10.016 · Cited by 1,426 · see citing works

Characterization of a rat model of incisional pain

Brennan, T. J., Vandermeulen, E., & Gebhart, G. F. (1996) · Pain · doi:10.1016/0304-3959(95)01441-1 · Cited by 1,101 · see citing works

Dopamine and drug addiction: the nucleus accumbens shell connection

Di Chiara, G., Bassareo, V., Fenu, S., De Luca, M. A., Spina, L., Cadoni, C., Acquas, E., Carboni, E., Valentini, V., & Lecca, D. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.032 · Cited by 935 · see citing works

Projections from the Rat Prefrontal Cortex to the Ventral Tegmental Area: Target Specificity in the Synaptic Associations with Mesoaccumbens and Mesocortical Neurons

Carr, D. B., & Sesack, S. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03864.2000 · Cited by 880 · see citing works

Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking

Stuber, G. D., Sparta, D. R., Stamatakis, A. M., van Leeuwen, W. A., Hardjoprajitno, J. E., Cho, S., Tye, K. M., Kempadoo, K. A., Zhang, F., Deisseroth, K., et al. (2011) · Nature · doi:10.1038/nature10194 · Cited by 878 · see citing works

Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli

Brischoux, F., Chakraborty, S., Brierley, D. I., & Ungless, M. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811507106 · Cited by 801 · see citing works

Dopamine signals for reward value and risk: basic and recent data

Schultz, W. (2010) · Behavioral and Brain Functions · doi:10.1186/1744-9081-6-24 · Cited by 653 · see citing works

Ventral Tegmental Area Neurons in Learned Appetitive Behavior and Positive Reinforcement

Fields, H. L., Hjelmstad, G. O., Margolis, E. B., & Nicola, S. M. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094341 · Cited by 611 · see citing works

Pain pathways and parabrachial circuits in the rat.

Gauriau, C., & Bernard, J. (2002) · Experimental Physiology · doi:10.1113/eph8702357 · Cited by 572 · see citing works

Unmasking the tonic-aversive state in neuropathic pain

King, T. E., Vera–Portocarrero, L. P., Gutierrez, T., Vanderah, T. W., Dussor, G. O., Lai, J. Y., Fields, H. L., & Porreca, F. (2009) · Nature Neuroscience · doi:10.1038/nn.2407 · Cited by 570 · see citing works

Risky business: the neuroeconomics of decision making under uncertainty

Platt, M. L., & Huettel, S. A. (2008) · Nature Neuroscience · doi:10.1038/nn2062 · Cited by 556 · see citing works

Predicting Value of Pain and Analgesia: Nucleus Accumbens Response to Noxious Stimuli Changes in the Presence of Chronic Pain

Baliki, M. N., Geha, P., Fields, H. L., & Apkarian, A. V. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.002 · Cited by 549 · see citing works

Reward Circuitry Activation by Noxious Thermal Stimuli

Becerra, L. R., Breiter, H. C., Wise, R. A., González, R., & Borsook, D. (2001) · Neuron · doi:10.1016/s0896-6273(01)00533-5 · Cited by 489 · see citing works

Negative Reward Signals from the Lateral Habenula to Dopamine Neurons Are Mediated by Rostromedial Tegmental Nucleus in Primates

Hong, S., Jhou, T. C., Smith, M., Saleem, K. S., & Hikosaka, O. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1384-11.2011 · Cited by 390 · see citing works

IMAGING VALUATION MODELS IN HUMAN CHOICE

Montague, P. R., King‐Casas, B., & Cohen, J. D. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112903 · Cited by 371 · see citing works

Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli

Roitman, M. F., Wheeler, R. A., Wightman, R. M., & Carelli, R. M. (2008) · Nature Neuroscience · doi:10.1038/nn.2219 · Cited by 343 · see citing works

Neurobiological Mechanisms of Placebo Responses

Zubieta, J., & Stohler, C. S. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04424.x · Cited by 277 · see citing works

Modulation of A10 dopamine neurons by gamma-aminobutyric acid agonists.

Kalivas, P. W., Duffy, P., & Eberhardt, H. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13057-7 · Cited by 267 · see citing works

The Ventral Tegmental Area Is Required for the Behavioral and Nucleus Accumbens Neuronal Firing Responses to Incentive Cues

Yun, I. A., Wakabayashi, K. T., Fields, H. L., & Nicola, S. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5282-03.2004 · Cited by 238 · see citing works

The development of a conditioned place preference to morphine: Effects of microinjections into various CNS sites.

Olmstead, M. C., & Franklin, K. B. J. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.6.1324 · Cited by 231 · see citing works

The development of a conditioned place preference to morphine: Effects of microinjections into various CNS sites.

Olmstead, M. C., & Franklin, K. B. J. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.6.1324 · Cited by 216 · see citing works

Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy

Qu, C., King, T. E., Okun, A., Lai, J. Y., Fields, H. L., & Porreca, F. (2011) · Pain · doi:10.1016/j.pain.2011.03.002 · Cited by 214 · see citing works

Baclofen Inhibits Heroin Self-Administration Behavior and Mesolimbic Dopamine Release

Xi, Z.-X., & Stein, E. A. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35044-x · Cited by 177 · see citing works

Understanding How Opioids Contribute to Reward and Analgesia

Fields, H. L. (2007) · Regional Anesthesia & Pain Medicine · doi:10.1016/j.rapm.2007.01.001 · Cited by 166 · see citing works

Understanding how opioids contribute to reward and analgesia

Fields, H. L. (2007) · Regional Anesthesia and Pain Medicine · doi:10.1097/00115550-200705000-00012 · Cited by 166 · see citing works

Signal valence in the nucleus accumbens to pain onset and offset

Becerra, L. R., & Borsook, D. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2007.12.007 · Cited by 137 · see citing works

Afferent drive elicits ongoing pain in a model of advanced osteoarthritis

Okun, A., Liu, P., Davis, P., Ren, J., Remeniuk, B., Brion, T., Ossipov, M. H., Xie, J. Y., Dussor, G. O., King, T. E., et al. (2012) · Pain · doi:10.1016/j.pain.2012.01.022 · Cited by 131 · see citing works

Determination of dopamine, serotonin, and their metabolites in pediatric cerebrospinal fluid by isocratic high performance liquid chromatography coupled with electrochemical detection

Hubbard, K. E., Wells, A., Owens, T. S., Tagen, M., Fraga, C. H., & Stewart, C. F. (2009) · Biomedical Chromatography · doi:10.1002/bmc.1338 · Cited by 118 · see citing works

Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processes

Laviolette, S. R., Nader, K., & van der Kooy, D. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00327-8 · Cited by 105 · see citing works

Ongoing pain in the MIA model of osteoarthritis

Liu, P., Okun, A., Ren, J., Rui-chen, G., Ossipov, M. H., Xie, J. Y., King, T. E., & Porreca, F. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.01.027 · Cited by 100 · see citing works

Transient Inflammation-Induced Ongoing Pain is Driven by TRPV1 Sensitive Afferents

Okun, A., Felice, M. D., Eyde, N., Ren, J., Mercado, R., King, T. E., & Porreca, F. (2011) · Molecular Pain · doi:10.1186/1744-8069-7-4 · Cited by 100 · see citing works

Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity

King, T. E., Qu, C., Okun, A., Mercado, R., Ren, J., Brion, T., Lai, J. Y., & Porreca, F. (2011) · Pain · doi:10.1016/j.pain.2011.04.020 · Cited by 95 · see citing works

Conditioning of Opioid Reinforcement: Neuroanatomical and Neurochemical Substrates

Shippenberg, T. S., Herz, A., Spanagel, R., Bals-Kubik, R., & Stein, C. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb25980.x · Cited by 91 · see citing works

Alterations in immediate-early gene proteins in the rat forebrain induced by acute morphine injection

Garcia, M. M., Brown, H. E., & Harlan, R. E. (1995) · Brain Research · doi:10.1016/0006-8993(95)00625-z · Cited by 81 · see citing works

The parabrachial nucleus is a critical link in the transmission of short latency nociceptive information to midbrain dopaminergic neurons

Coizet, V., Dommett, E. J., Klop, E. M., Redgrave, P., & Overton, P. G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.03.049 · Cited by 80 · see citing works

Dual Role of Medial A10 Dopamine Neurons in Affective Encoding

Liu, Z., Shin, R. S., & Ikemoto, S. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.4 · Cited by 73 · see citing works

Cocaine reward and hyperactivity in the rat: Sites of mu opioid receptor modulation

Soderman, A. R., & Unterwald, E. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.063 · Cited by 71 · see citing works

Effects of reversible inactivation of the ventral tegmental area on the acquisition and expression of morphine-induced conditioned place preference in the rat

Moaddab, M., Haghparast, A., & Hassanpour-Ezatti, M. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.11.030 · Cited by 70 · see citing works

How conditioned stimuli acquire the ability to activate VTA dopamine cells: A proposed neurobiological component of reward-related learning

Zellner, M. R., & Ranaldi, R. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.011 · Cited by 68 · see citing works

Role of extracellular signal‐regulated kinase in the ventral tegmental area in the suppression of the morphine‐induced rewarding effect in mice with sciatic nerve ligation

Ozaki, S., Narita, M., Narita, M., Ozaki, M., Khotib, J., & Suzuki, T. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02272.x · Cited by 66 · see citing works

A quantitative study of brainstem projections from lamina I neurons in the cervical and lumbar enlargement of the rat

Polgár, E., Wright, L. L., & Todd, A. J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.10.041 · Cited by 57 · see citing works

High ambient temperature increases 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”)-induced Fos expression in a region-specific manner

Hargreaves, G. A., Hunt, G. E., Cornish, J. L., & McGregor, I. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.023 · Cited by 45 · see citing works

Regional differences in naloxone modulation of Δ9-THC induced Fos expression in rat brain

Allen, K. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(02)00364-7 · Cited by 44 · see citing works

Peripheral nerve injury differentially regulates dopaminergic pathways in the nucleus accumbens of rats with either ‘pain alone’ or ‘pain and disability’

Austin, P. J., Beyer, K., Bembrick, A. L., & Keay, K. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.040 · Cited by 39 · see citing works

Baclofen inhibits opiate-induced conditioned place preference and associated induction of Fos in cortical and limbic regions

Kaplan, G. B., Leite‐Morris, K. A., Joshi, M., Shoeb, M. H., & Carey, R. J. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03218-9 · Cited by 39 · see citing works

Reacquisition of heroin and cocaine place preference involves a memory consolidation process sensitive to systemic and intra-ventral tegmental area naloxone

Sticht, M. A., Mitsubata, J., Tucci, M. C., & Leri, F. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.10.005 · Cited by 23 · see citing works

Acute noxious stimulation modifies morphine effect in serotonergic but not dopaminergic midbrain areas

Bajic, D., & Commons, K. G. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.031 · Cited by 10 · see citing works

Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits

Hashmi, J. A., Baliki, M. N., Huang, L., Baria, A. T., Torbey, S., Hermann, K. M., Schnitzer, T. J., & Apkarian, A. V. (2013) · Brain · doi:10.1093/brain/awt211 · Cited by 762 · see citing works

Neurons for hunger and thirst transmit a negative-valence teaching signal

Betley, J. N., Xu, S., Cao, Z. F. H., Gong, R., Magnus, C. J., Yu, Y., & Sternson, S. M. (2015) · Nature · doi:10.1038/nature14416 · Cited by 704 · see citing works

Endogenous and Exogenous Opioids in Pain

Corder, G. F., Castro, D. C., Bruchas, M. R., & Scherrer, G. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-061522 · Cited by 511 · see citing works

Reward and motivation in pain and pain relief

Navratilova, E., & Porreca, F. (2014) · Nature Neuroscience · doi:10.1038/nn.3811 · Cited by 481 · see citing works

Psychological processing in chronic pain: a neural systems approach

Simons, L. E., Elman, I., & Borsook, D. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.12.006 · Cited by 359 · see citing works

Peripheral input and its importance for central sensitization

Baron, R., Hans, G. H., & Dickenson, A. H. (2013) · Annals of Neurology · doi:10.1002/ana.24017 · Cited by 280 · see citing works

Ventral tegmental area dopamine revisited: effects of acute and repeated stress

Holly, E. N., & Miczek, K. A. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4151-3 · Cited by 265 · see citing works

Distinct Brain Systems Mediate the Effects of Nociceptive Input and Self-Regulation on Pain

Woo, C.-W., Roy, M., Buhle, J. T., & Wager, T. D. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002036 · Cited by 263 · see citing works

The Mesolimbic Dopamine System in Chronic Pain and Associated Affective Comorbidities

Serafini, R. A., Pryce, K. D., & Zachariou, V. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.10.018 · Cited by 237 · see citing works

Predicting transition to chronic pain

Apkarian, A. V., Baliki, M. N., & Farmer, M. A. (2013) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32836336ad · Cited by 232 · see citing works

Mesolimbic dopamine signaling in acute and chronic pain

Taylor, A. M. W., Becker, S., Schweinhardt, P., & Cahill, C. M. (2016) · Pain · doi:10.1097/j.pain.0000000000000494 · Cited by 229 · see citing works

Reward deficiency and anti-reward in pain chronification

Borsook, D., Linnman, C., Faria, V., Strassman, A. M., Becerra, L. R., & Elman, I. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.033 · Cited by 227 · see citing works

Stress-induced plasticity and functioning of ventral tegmental dopamine neurons

Douma, E. H., & de Kloet, E. R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.015 · Cited by 226 · see citing works

Quantifying cerebral contributions to pain beyond nociception

Woo, C., Schmidt, L., Krishnan, A., Jepma, M., Roy, M., Lindquist, M. A., Atlas, L. Y., & Wager, T. D. (2017) · Nature Communications · doi:10.1038/ncomms14211 · Cited by 215 · see citing works

Brain Circuits Encoding Reward from Pain Relief

Navratilova, E., Atcherley, C. W., & Porreca, F. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.09.003 · Cited by 202 · see citing works

Reward, motivation, and emotion of pain and its relief

Porreca, F., & Navratilova, E. (2017) · Pain · doi:10.1097/j.pain.0000000000000798 · Cited by 198 · see citing works

A dopaminergic switch for fear to safety transitions

Luo, R., Uematsu, A., Weitemier, A. Z., Aquili, L., Koivumaa, J., McHugh, T. J., & Johansen, J. P. (2018) · Nature Communications · doi:10.1038/s41467-018-04784-7 · Cited by 195 · see citing works

Microglia Disrupt Mesolimbic Reward Circuitry in Chronic Pain

Taylor, A. M. W., Castonguay, A., Taylor, A. J., Murphy, N. P., Ghogha, A., Cook, C. P., Xue, L., Olmstead, M. C., Koninck, Y. D., Evans, C. J., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4036-14.2015 · Cited by 190 · see citing works

Endogenous Opioid Activity in the Anterior Cingulate Cortex Is Required for Relief of Pain

Navratilova, E., Xie, J. Y., Meske, D. S., Qu, C., Morimura, K., Okun, A., Arakawa, N., Ossipov, M. H., Fields, H. L., & Porreca, F. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3862-14.2015 · Cited by 186 · see citing works

Activation of cortical somatostatin interneurons prevents the development of neuropathic pain

Cichon, J., Blanck, T. J. J., Gan, W., & Yang, G. (2017) · Nature Neuroscience · doi:10.1038/nn.4595 · Cited by 163 · see citing works

Modulation of pain, nociception, and analgesia by the brain reward center

Mitsi, V., & Zachariou, V. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.017 · Cited by 168 · see citing works

Pain: A Precision Signal for Reinforcement Learning and Control

Seymour, B. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.055 · Cited by 164 · see citing works

Role of nucleus accumbens in neuropathic pain: Linked multi-scale evidence in the rat transitioning to neuropathic pain

Chang, P.-C., Pollema-Mays, S. L., Centeno, M. V., Procissi, D., Contini, M., Baria, A. T., Martina, M., & Apkarian, A. V. (2014) · Pain · doi:10.1016/j.pain.2014.02.019 · Cited by 161 · see citing works

Studying ongoing and spontaneous pain in rodents – challenges and opportunities

Tappe‐Theodor, A., & Kuner, R. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12643 · Cited by 152 · see citing works

Evaluation of reward from pain relief

Navratilova, E., Xie, J. Y., King, T. E., & Porreca, F. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12095 · Cited by 147 · see citing works

Parceling Human Accumbens into Putative Core and Shell Dissociates Encoding of Values for Reward and Pain

Baliki, M. N., Mansour, A. R., Baria, A. T., Huang, L., Berger, S., Fields, H. L., & Apkarian, A. V. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1731-13.2013 · Cited by 146 · see citing works

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states

Little, J. W., Ford, A., Symons-Liguori, A. M., Chen, Z., Janes, K., Doyle, T. M., Xie, J. Y., Luongo, L., Tosh, D. K., Maione, S., et al. (2014) · Brain · doi:10.1093/brain/awu330 · Cited by 144 · see citing works

Calcium-Permeable AMPA Receptors in the Nucleus Accumbens Regulate Depression-Like Behaviors in the Chronic Neuropathic Pain State

Goffer, Y., Xu, D., Eberle, S. E., D’amour, J. A., Lee, M., Tukey, D. S., Froemke, R. C., Ziff, E. B., & Wang, J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2454-13.2013 · Cited by 142 · see citing works

Pain-relief learning in flies, rats, and man: basic research and applied perspectivesPreprint

Gerber, B., Yarali, A., Diegelmann, S., Wotjak, C. T., Pauli, P., & Fendt, M. (2014) · Learning & Memory · doi:10.1101/lm.032995.113 · Cited by 139 · see citing works

Mapping Cortical Integration of Sensory and Affective Pain Pathways

Singh, A., Patel, D. J., Li, A., Hu, L., Zhang, Q., Liu, Y., Guo, X., Robinson, E. J., Martinez, E., Doan, L., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.02.091 · Cited by 133 · see citing works

Altered periaqueductal gray resting state functional connectivity in migraine and the modulation effect of treatment

Li, Z., Liu, M., Lan, L., Zeng, F., Makris, N., Liang, Y., Guo, T., Wu, F., Gao, Y., Dong, M., et al. (2016) · Scientific Reports · doi:10.1038/srep20298 · Cited by 127 · see citing works

Acute stress selectively reduces reward sensitivity

Berghorst, L. H., Bogdan, R., Frank, M. J., & Pizzagalli, D. A. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00133 · Cited by 131 · see citing works

Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior

Markovic, T., Pedersen, C. E., Massaly, N., Vachez, Y. M., Ruyle, B. C., Murphy, C. A., Abiraman, K., Shin, J. H., Garcia, J. J., Yoon, H. J., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00924-3 · Cited by 129 · see citing works

Cognition in the Chronic Pain Experience: Preclinical Insights

Phelps, C. E., Navratilova, E., & Porreca, F. (2021) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2021.01.001 · Cited by 120 · see citing works

Current evidence of cannabinoid‐based analgesia obtained in preclinical and human experimental settings

Lötsch, J., Weyer-Menkhoff, I., & Tegeder, I. (2017) · European Journal of Pain · doi:10.1002/ejp.1148 · Cited by 118 · see citing works

Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area μ Opioid Receptors

Hipólito, L., Wilson‐Poe, A. R., Campos‐Jurado, Y., Zhong, E., González-Romero, J. L., Virag, L., Whittington, R. A., Comer, S. D., Carlton, S. M., Walker, B. M., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1053-15.2015 · Cited by 115 · see citing works

Neural mechanisms of pain and alcohol dependence

Apkarian, A. V., Neugebauer, V., Koob, G. F., Edwards, S., Levine, J. D., Ferrari, L. F., Egli, M., & Regunathan, S. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.09.008 · Cited by 114 · see citing works

Pain modulates dopamine neurons via a spinal–parabrachial–mesencephalic circuit

Yang, H., de Jong, J. W., Cerniauskas, I., Peck, J. R., Lim, B. K., Gong, H., Fields, H. L., & Lammel, S. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00903-8 · Cited by 113 · see citing works

Lost but making progress—Where will new analgesic drugs come from?

Borsook, D., Hargreaves, R. J., Bountra, C., & Porreca, F. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008320 · Cited by 112 · see citing works

Development of CGRP-dependent pain and headache related behaviours in a rat model of concussion: Implications for mechanisms of post-traumatic headache

Bree, D., & Levy, D. (2016) · Cephalalgia · doi:10.1177/0333102416681571 · Cited by 112 · see citing works

A functional subdivision within the somatosensory system and its implications for pain research

Ma, Q. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.015 · Cited by 108 · see citing works

Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex

Zhou, H., Zhang, Q., Martinez, E., Dale, J., Hu, S., Zhang, E., Liu, K. G., Huang, D., Yang, G., Chen, Z. S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06295-x · Cited by 111 · see citing works

Evidence and explanation for the involvement of the nucleus accumbens in pain processing

Harris, H. N., & Peng, Y. B. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.266909 · Cited by 108 · see citing works

Neural circuits and motivational processes for hunger

Sternson, S. M., Nicholas Betley, J., & Cao, Z. F. H. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.04.006 · Cited by 108 · see citing works

Rapid treatment-induced brain changes in pediatric CRPS

Erpelding, N., Simons, L., Lebel, A., Serrano, P., Pielech, M., Prabhu, S., Becerra, L., & Borsook, D. (2016) · Brain Structure and Function · doi:10.1007/s00429-014-0957-8 · Cited by 108 · see citing works

Does the kappa opioid receptor system contribute to pain aversion?

Cahill, C. M., Taylor, A. M. W., Cook, C., Ong, E., Morón, J. A., & Evans, C. J. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00253 · Cited by 105 · see citing works

Central Processing of Itch in the Midbrain Reward Center

Su, X., Chen, M., Yuan, Y., Li, Y., Guo, S.-S., Luo, H., Huang, C., Sun, W., Li, Y., Zhu, M. X., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.030 · Cited by 106 · see citing works

Animal models for the study of depressive disorder

Song, J., & Kim, Y. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13622 · Cited by 104 · see citing works

Positive emotions and brain reward circuits in chronic pain

Navratilova, E., Morimura, K., Xie, J. Y., Atcherley, C. W., Ossipov, M. H., & Porreca, F. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.23968 · Cited by 100 · see citing works

Brain-Derived Neurotrophic Factor in the Mesolimbic Reward Circuitry Mediates Nociception in Chronic Neuropathic Pain

Zhang, H., Qian, Y., Li, C., Liu, D., Wang, L., Wang, X., Liu, M., Liu, H., Zhang, S., Guo, X.-Y., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.1180 · Cited by 101 · see citing works

Capturing the aversive state of cephalic pain preclinically

Felice, M. D., Eyde, N., Dodick, D. W., Dussor, G. O., Ossipov, M. H., Fields, H. L., & Porreca, F. (2013) · Annals of Neurology · doi:10.1002/ana.23922 · Cited by 99 · see citing works

Analogous responses in the nucleus accumbens and cingulate cortex to pain onset (aversion) and offset (relief) in rats and humans

Becerra, L. R., Navratilova, E., Porreca, F., & Borsook, D. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00284.2013 · Cited by 99 · see citing works

Chronic pain induces generalized enhancement of aversion

Zhang, Q., Manders, T. R., Tong, A. P., Yang, R., Garg, A., Martinez, E., Zhou, H., Dale, J., Goyal, A., Urien, L., et al. (2017) · eLife · doi:10.7554/elife.25302 · Cited by 98 · see citing works

Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain

Bannister, K., Qu, C., Navratilova, E., Oyarzo, J. N., Xie, J. Y., King, T. E., Dickenson, A. H., & Porreca, F. (2017) · Pain · doi:10.1097/j.pain.0000000000001040 · Cited by 97 · see citing works

Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain

Makary, M. M., Polosecki, P. I., Cecchi, G., DeAraujo, I. E., Barron, D. S., Constable, R. T., Whang, P. G., Thomas, D.-A. M., Mowafi, H. O., Small, D. M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918682117 · Cited by 90 · see citing works

Monoamines as Drug Targets in Chronic Pain: Focusing on Neuropathic Pain

Bravo, L., Llorca-Torralba, M., Berrocoso, E., & Micó, J. A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01268 · Cited by 89 · see citing works

Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids

Leitl, M. D., Onvani, S., Bowers, M. S., Cheng, K., Rice, K. C., Carlezon, W. A., Banks, M. L., & Negus, S. S. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.236 · Cited by 87 · see citing works

Scaling Up Cortical Control Inhibits Pain

Dale, J., Zhou, H., Zhang, Q., Martinez, E., Hu, S., Liu, K., Urien, L., Chen, Z. S., & Wang, J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.139 · Cited by 87 · see citing works

A neurobehavioral approach to addiction: implications for the opioid epidemic and the psychology of addiction

Bechara, A., Berridge, K. C., Bickel, W. K., Morón, J. A., Williams, S. B., & Stein, J. S. (2019) · Psychological Science in the Public Interest · doi:10.1177/1529100619860513 · Cited by 82 · see citing works

Neuroinflammation—a co-occurring phenomenon linking chronic pain and opioid dependence

Cahill, C. M., & Taylor, A. M. W. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.12.003 · Cited by 82 · see citing works

Brain-derived neurotrophic factor–mediated projection-specific regulation of depressive-like and nociceptive behaviors in the mesolimbic reward circuitry

Liu, D., Tang, Q., Cui, Y., Song, Y., Liu, Y., Yang, J., Liu, H., Zhang, Y., Wu, S., Song, Y., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000001083 · Cited by 79 · see citing works

The Roles of Phasic and Tonic Dopamine in Tic Learning and Expression

Maia, T. V., & Conceição, V. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.025 · Cited by 76 · see citing works

Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: A potential biomarker of efficacy

Xie, J. Y., Qu, C., Patwardhan, A. M., Ossipov, M. H., Navratilova, E., Becerra, L. R., Borsook, D., & Porreca, F. (2014) · Pain · doi:10.1016/j.pain.2014.05.018 · Cited by 76 · see citing works

Cues conditioned to withdrawal and negative reinforcement: Neglected but key motivational elements driving opioid addiction

Pantazis, C. B., Gonzalez, L. A., Tunstall, B. J., Carmack, S. A., Koob, G. F., & Vendruscolo, L. F. (2021) · Science Advances · doi:10.1126/sciadv.abf0364 · Cited by 73 · see citing works

Dopamine: from prediction error to psychotherapy

Papalini, S., Beckers, T., & Vervliet, B. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0814-x · Cited by 75 · see citing works

John J. Bonica Award Lecture: Peripheral neuronal hyperexcitability: the “low-hanging” target for safe therapeutic strategies in neuropathic pain

Raja, S. N., Ringkamp, M., Guan, Y., & Campbell, J. N. (2020) · Pain · doi:10.1097/j.pain.0000000000001838 · Cited by 71 · see citing works

Synapse-specific opioid modulation of thalamo-cortico-striatal circuits

Birdsong, W. T., Jongbloets, B. C., Engeln, K. A., Wang, D., Scherrer, G., & Mao, T. (2019) · eLife · doi:10.7554/elife.45146 · Cited by 70 · see citing works

BDNF as a biomarker for neuropathic pain: Consideration of mechanisms of action and associated measurement challenges

Thakkar, B., & Acevedo, E. O. (2023) · Brain and Behavior · doi:10.1002/brb3.2903 · Cited by 69 · see citing works

Acute stress-induced cortisol elevations mediate reward system activity during subconscious processing of sexual stimuli

Oei, N. Y. L., Both, S., van Heemst, D., & van der Grond, J. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.10.005 · Cited by 70 · see citing works

Impaired mesocorticolimbic connectivity underlies increased pain sensitivity in chronic low back pain

Yu, S., Li, W., Shen, W., Edwards, R. R., Gollub, R. L., Wilson, G., Park, J., Ortiz, A., Cao, J., Gerber, J. A., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116969 · Cited by 67 · see citing works

Acupuncture Treatment Modulates the Connectivity of Key Regions of the Descending Pain Modulation and Reward Systems in Patients with Chronic Low Back Pain

Yu, S., Ortiz, A., Gollub, R. L., Wilson, G., Gerber, J. A., Park, J., Huang, Y., Shen, W., Chan, S., Wasan, A. D., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061719 · Cited by 69 · see citing works

Stress relief as a natural resilience mechanism against depression-like behaviors

Dong, Y., Li, Y., Xiang, X., Xiao, Z.-C., Hu, J., Li, Y., Li, H., & Hu, H. (2023) · Neuron · doi:10.1016/j.neuron.2023.09.004 · Cited by 69 · see citing works

The altered right frontoparietal network functional connectivity in migraine and the modulation effect of treatment

Li, Z., Lan, L., Zeng, F., Makris, N., Hwang, J., Guo, T., Wu, F., Gao, Y., Dong, M., Liu, M., et al. (2016) · Cephalalgia · doi:10.1177/0333102416641665 · Cited by 67 · see citing works

Inhibition of the Prefrontal Projection to the Nucleus Accumbens Enhances Pain Sensitivity and Affect

Zhou, H., Martinez, E., Lin, H. H., Yang, R., Dale, J., Liu, K., Huang, D., & Wang, J. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00240 · Cited by 67 · see citing works

The Role of Dopamine in Associative Learning in Drosophila: An Updated Unified Model

Adel, M., & Griffith, L. C. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00665-0 · Cited by 64 · see citing works

Decreased dopaminergic inhibition of pyramidal neurons in anterior cingulate cortex maintains chronic neuropathic pain

Lançon, K., Qu, C., Navratilova, E., Porreca, F., & Séguéla, P. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109933 · Cited by 59 · see citing works

Closed-loop stimulation using a multiregion brain-machine interface has analgesic effects in rodents

Sun, G., Zeng, F., McCartin, M., Zhang, Q., Xu, H., Liu, Y., Chen, Z. S., & Wang, J. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abm5868 · Cited by 61 · see citing works

Re-examining the Mysterious Role of the Cerebellum in Pain

Li, C. N., Keay, K. A., Henderson, L. A., & Mychasiuk, R. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1538-23.2024 · Cited by 63 · see citing works

From Pleasure to Pain, and Back Again: The Intricate Relationship Between Alcohol and Nociception

Robins, M. T., Heinricher, M. M., & Ryabinin, A. E. (2019) · Alcohol and Alcoholism · doi:10.1093/alcalc/agz067 · Cited by 61 · see citing works

A trigger for opioid misuse: chronic pain and stress dysregulate the mesolimbic pathway and kappa opioid system

Massaly, N., Morón, J. A., & Al-Hasani, R. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00480 · Cited by 59 · see citing works

A new aspect of chronic pain as a lifestyle-related disease

Senba, E., & Kami, K. (2017) · Neurobiology of Pain · doi:10.1016/j.ynpai.2017.04.003 · Cited by 57 · see citing works

Top-Down Cortical Control of Acute and Chronic Pain

Urien, L., & Wang, J. (2019) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000744 · Cited by 55 · see citing works

Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons

Hsu, T. M., McCutcheon, J. E., & Roitman, M. F. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00410 · Cited by 57 · see citing works

Emotional and Motivational Pain Processing: Current State of Knowledge and Perspectives in Translational Research

Becker, S., Navratilova, E., Nees, F., & Damme, S. V. (2018) · Pain Research and Management · doi:10.1155/2018/5457870 · Cited by 57 · see citing works

Inhibition of TRPV1 by SHP-1 in nociceptive primary sensory neurons is critical in PD-L1 analgesia

Liu, B., Cao, Q.-L., Zhao, X., Liu, H.-Z., & Zhang, Y. (2020) · JCI Insight · doi:10.1172/jci.insight.137386 · Cited by 55 · see citing works

Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats

Genaro, K., Fabris, D., Arantes, A. L. F., Zuardi, A. W., Crippa, J. A. S., & Prado, W. A. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00391 · Cited by 54 · see citing works

Aversive Motivation and Cognitive ControlPreprint

Yee, D. M., Leng, X., Shenhav, A., & Braver, T. S. (2021) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.12.016 · Cited by 57 · see citing works

Lysergic Acid Diethylamide and Psilocybin for the Management of Patients with Persistent Pain: a Potential Role?

Whelan, A., & Johnson, M. I. (2018) · Pain Management · doi:10.2217/pmt-2017-0068 · Cited by 51 · see citing works

Persistent pain alters AMPA receptor subunit levels in the nucleus accumbens

Su, C. H., D’amour, J. A., Lee, M. S., Lin, H.-Y., Manders, T. R., Xu, D., Eberle, S. E., Goffer, Y., Zou, A., Rahman, M., et al. (2015) · Molecular Brain · doi:10.1186/s13041-015-0140-z · Cited by 51 · see citing works

The dynamic interaction between pain and opioid misuse

Wilson‐Poe, A. R., & Morón, J. A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13873 · Cited by 48 · see citing works

CRMP2 and voltage-gated ion channels: potential roles in neuropathic pain

Chew, L. A., & Khanna, R. (2018) · Neuronal Signaling · doi:10.1042/ns20170220 · Cited by 50 · see citing works

Pain relief induces dopamine release in the rat nucleus accumbens during the early but not late phase of neuropathic pain

Kato, T., Ide, S., & Minami, M. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.06.060 · Cited by 49 · see citing works

Psychological Processes in Chronic Pain: Influences of Reward and Fear Learning as Key Mechanisms – Behavioral Evidence, Neural Circuits, and Maladaptive Changes

Nees, F., & Becker, S. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.051 · Cited by 49 · see citing works

Understanding the role of dopamine in conditioned and unconditioned fear

Brandão, M. L., & Coimbra, N. C. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0023 · Cited by 49 · see citing works

Temporal pain processing in the primary somatosensory cortex and anterior cingulate cortex

Sun, G., McCartin, M., Liu, W., Zhang, Q., Kenefati, G., Chen, Z. S., & Wang, J. (2023) · Molecular Brain · doi:10.1186/s13041-022-00991-y · Cited by 47 · see citing works

Downregulation of M-channels in lateral habenula mediates hyperalgesia during alcohol withdrawal in rats

Kang, S., Li, J., Zuo, W., Chen, P., Gregor, D., Fu, R., Han, X., Bekker, A., & Ye, J.-H. (2019) · Scientific Reports · doi:10.1038/s41598-018-38393-7 · Cited by 47 · see citing works

Ghrelin attenuated hyperalgesia induced by chronic nitroglycerin: CGRP and TRPV1 as targets for migraine management

Farajdokht, F., Mohaddes, G., Shanehbandi, D., Karimi, P., & Babri, S. (2017) · Cephalalgia · doi:10.1177/0333102417748563 · Cited by 47 · see citing works

Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing

Li, H., Pullmann, D., Cho, J. Y., Eid, M., & Jhou, T. C. (2019) · eLife · doi:10.7554/elife.41542 · Cited by 47 · see citing works

Selective modulation of tonic aversive qualities of neuropathic pain by morphine in the central nucleus of the amygdala requires endogenous opioid signaling in the anterior cingulate cortex

Navratilova, E., Nation, K., Remeniuk, B., Neugebauer, V., Bannister, K., Dickenson, A. H., & Porreca, F. (2019) · Pain · doi:10.1097/j.pain.0000000000001748 · Cited by 46 · see citing works

Corticostriatal circuits in the transition to chronic back pain: The predictive role of reward learning

Löffler, M., Levine, S. M., Usai, K., Desch, S., Mišić, M., Nees, F., & Flor, H. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100677 · Cited by 45 · see citing works

Pain relief activates the mesolimbic dopamine reward pathway

Navratilova, E., Xie, J. Y., Okun, A., Eyde, N., Ci, S., Ossipov, M. H., Deeny, T. K., & Porreca, F. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.662.14

Brain Circuits Encoding Reward from Pain Relief

Navratilova, E., Atcherley, C. W., & Porreca, F. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.09.003 · Cited by 202 · see citing works

Dopamine receptor D2, but not D1, mediates the reward circuit from the ventral tegmental area to the central amygdala, which is involved in pain relief

Huang, M., Wang, G., Lin, Y., Guo, Y., Jin, H., Ren, X., Cao, J., Cao, J., Weidong, Z., & Li, Z. (2022) · Molecular Pain · doi:10.1177/17448069221145096 · Cited by 19 · see citing works

PS136. Time-dependent alteration of reward-induced dopamine release in the nucleus accumbens of the neuropathic pain model rats.

Ido, A., Ide, S., Kato, T., & Minami, M. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw043.136

Activision of Reward Pathway by Pain Relief

Ci, S. (2011) · UA Campus Repository (The University of Arizona)