Hepatitis C virus in the semen of men coinfected with HIV-1: prevalence and origin.
Abstract
OBJECTIVE: To compare the prevalence of hepatitis C (HCV) RNA in semen from men infected with HCV and those coinfected with HIV-1/HCV and to study the origin of HCV shed in semen. DESIGN: Two prospective studies (HC EP09 and BINECO) included 120 HCV-positive men, 82 coinfected with HIV-1; all had positive HCV RNA detection in blood. METHODS: Paired blood and semen samples were collected for HCV RNA detection and quantification in seminal plasma and in blood serum; repeated semen samples were obtained for 45 men. HCV RNA was sought in spermatozoa and non-sperm cells. Phylogenetic analysis of the HVR-1 region of HCV compared the quasispecies in blood serum and seminal plasma of two men. RESULTS: HCV RNA was more frequently found in the semen of men coinfected with HIV-1 (37.8%) than in those with only HCV infection (18.4%) (P = 0.033). HCV RNA detection in semen was intermittent and was positive in at least one semen sample of 42.8% of HIV-1/HCV-coinfected men who provided repeated samples. Men with HCV-positive semen had significantly higher HCV load in blood than men with HCV-negative semen (P = 0.038). Phylogenetic comparison of HCV quasispecies in blood and in semen showed no evidence of HCV replication in genital leukocytes; however, a phenetic structure was observed between compartments (P < 0.001). CONCLUSIONS: HCV particles in semen originate from passive passage from blood, with preferential transfer of some variants. Nearly half of HIV-1/HCV-coinfected men may intermittently harbour HCV in their semen. Recommendations of protected sex for HIV-infected individuals should be reinforced.
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Continued unprotected sexual contact between partners with HIV can facilitate spread of HCV infection because the virus can be recovered from the semen of men with HIV infection.
“Continued unprotected sexual contact between partners with HIV can facilitate spread of HCV infection because the virus can be recovered from the semen of men with HIV infection (1349,1381).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1381]
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- Authors
- Briat, A., Dulioust, E., Galimand, J., Fontaine, H., Chaix, M.-L., Letur-Könirsch, H., Pol, S., Jouannet, P., Rouzioux, C., & Leruez-Ville, M.
- Affiliations
- Université Paris Descartes (FR)
- Hôpital Necker-Enfants Malades (FR)
- Venue
- AIDS
- Published
- 2005-11-04
- Volume
- 19
- Issue
- 16
- Pages
- 1827-1835
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W1972301325
- Cited by
- 97
- References
- 29
- Citations by year
- 2024: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2018: 5 · 2017: 5 · 2016: 10 · 2015: 9 · 2014: 8 · 2013: 5 · 2012: 4
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- AIDS (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Styrelsen för Internationellt Utvecklingssamarbete
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- hepatitis C virus, HIV-1/HCV coinfection, semen, HCV RNA, seminal plasma, HCV quasispecies, HCV transmission
- MeSH terms
- Adult, Humans, Male, Prospective Studies, RNA, Viral, Semen, HIV-1, HIV Infections, Hepacivirus, Hepatitis C, Chronic
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