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Cited by 410Hepatitis C virus researchHIV, Drug Use, Sexual RiskHepatitis Viruses Studies and Epidemiology

Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours.

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Danta, Mark, Brown, David, Bhagani, Sanjay, Pybus, Oliver G, Sabin, Caroline A, Nelson, Mark, Fisher, Martin, Johnson, Anne M +1 more·2007·AIDS
DOI 10.1097/qad.0b013e3281053a0c
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Abstract

OBJECTIVE: To characterize the mode of hepatitis C virus (HCV) transmission in a recent epidemic of acute HCV in HIV-infected individuals using linked molecular and clinical epidemiological studies. DESIGN: Individuals diagnosed with acute HCV between 1999 and 2005 at three urban HIV units in the UK were enrolled into a phylogenetic and case-control study. Phylogenetic trees were constructed from the amplified sequences of the E1/E2 region of the HCV genome and were used to compare cases with unrelated sequences. A questionnaire-based, case-control study using matched controls recruited from each HIV unit identified putative transmission factors. RESULTS: One hundred and eleven HIV-positive men who have sex with men with acute HCV (genotype 1: 84%) were enrolled. Phylogenetic analysis of 93 E1/E2 sequences revealed seven monophyletic clusters signifying multiple independent HCV lineages co-circulating in the HIV-positive population. Permucosal rather than percutaneous transmission factors were associated with case/control status. Cases (n = 60) had more sexual partners, increased levels of high-risk sexual behaviour and were more likely to have shared drugs via a nasal or anal route in the preceding year in comparison with controls (n = 130). Sex in a group of more than two people was the strongest predictor of case/control status; odds ratios associated with participation in two or at least three types of high-risk sexual behaviour in a group were 9.16 (95% confidence interval, 3.51-23.90) and 23.50 (95% confidence interval, 9.47-58.33), respectively. CONCLUSION: The identified co-circulating HCV lineages belong to different subtypes and genotypes, implying that rather than viral change, the epidemic is due to permucosal transmission factors that should be the focus of public health interventions.

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  • Risk of HCV infection increases commensurate with increasing numbers of sex partners among heterosexual persons and MSM with HIV infection, especially if their partners are also coinfected with HIV.

    “Certain studies have revealed that risk increases commensurate with increasing numbers of sex partners among heterosexual persons (1337,1338,1351–1353) and MSM with HIV infection (1349,1354–1357), especially if their partners are also coinfected with HIV (237,1340,1354–1356,1358).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1356]

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Authors
Danta, M., Brown, D., Bhagani, S., Pybus, O. G., Sabin, C. A., Nelson, M., Fisher, M., Johnson, A. M., & Dusheiko, G. M.
Affiliations
  • University College London (GB)
  • University of Oxford (GB)
  • The Royal Free Hospital (GB)
  • Chelsea and Westminster Hospital (GB)
  • Brighton and Sussex University Hospitals NHS Trust (GB)
Corresponding author
Danta, Mark
ORCID
Venue
AIDS
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-05-11
Volume
21
Issue
8
Pages
983-991
ISSN
0269-9370 (ISSN-L)
DOI
10.1097/qad.0b013e3281053a0c
OpenAlex
W2076559408
Cited by
410
References
31
Citations by year
2026: 3 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 7 · 2020: 13 · 2019: 14 · 2018: 19 · 2017: 24 · 2016: 30 · 2015: 42 · 2014: 29 · 2013: 37 · 2012: 30
FWCI
25.40
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • AIDS (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
  • Health Sciences › Medicine › Hepatology › Hepatitis Viruses Studies and Epidemiology
Keywords
acute hepatitis C, HIV coinfection, men who have sex with men, HCV transmission, sexual risk behavior, group sex, HCV genotype 1, HCV subtypes
MeSH terms
Acute Disease, Adult, Disease Outbreaks, England, Genotype, Hepatitis C, Humans, Male, Middle Aged, Phylogeny, Risk Factors, Risk-Taking, HIV Infections, Case-Control Studies, Hepacivirus, Homosexuality, Male, Substance-Related Disorders, Antiretroviral Therapy, Highly Active

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