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Cited by 210Hepatitis C virus researchHIV, Drug Use, Sexual RiskHIV/AIDS Research and Interventions

Unsafe sex and increased incidence of hepatitis C virus infection among HIV-infected men who have sex with men: the Swiss HIV Cohort Study.

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Rauch, A., Martin, M., Weber, R., Hirschel, B., Tarr, P. E., Bucher, H. C., Vernazza, P., Bernasconi, E. +4 more·2005·Clinical Infectious Diseases
DOI 10.1086/431486
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Abstract

BACKGROUND: Data on the incidence of hepatitis C virus (HCV) infection among human immunodeficiency virus (HIV)-infected persons are sparse. It is controversial whether and how frequently HCV is transmitted by unprotected sexual intercourse. METHODS: We assessed the HCV seroprevalence and incidence of HCV infection in the Swiss HIV Cohort Study between 1988 and 2004. We investigated the association of HCV seroconversion with mode of HIV acquisition, sex, injection drug use (IDU), and constancy of condom use. Data on condom use or unsafe sexual behavior were prospectively collected between 2000 and 2004. RESULTS: The overall seroprevalence of HCV infection was 33% among a total of 7899 eligible participants and 90% among persons reporting IDU. We observed 104 HCV seroconversions among 3327 participants during a total follow-up time of 16,305 person-years, corresponding to an incidence of 0.64 cases per 100 person-years. The incidence among participants with a history of IDU was 7.4 cases per 100 person-years, compared with 0.23 cases per 100 person-years in patients without such a history (P<.001). In men who had sex with men (MSM) without a history of IDU who reported unsafe sex, the incidence was 0.7 cases per 100 person-years, compared with 0.2 cases per 100 person-years in those not reporting unsafe sex (P=.02), corresponding to an incidence rate ratio of 3.5 (95% confidence interval, 1.2-10.0). The hazard of acquiring HCV infection was elevated among younger participants who were MSM. CONCLUSIONS: HCV infection incidence in the Swiss HIV Cohort Study was mainly associated with IDU. In HIV-infected MSM, HCV infection was associated with unsafe sex.

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  • Risk of HCV infection increases commensurate with increasing numbers of sex partners among heterosexual persons and MSM with HIV infection, especially if their partners are also coinfected with HIV.

    “Certain studies have revealed that risk increases commensurate with increasing numbers of sex partners among heterosexual persons (1337,1338,1351–1353) and MSM with HIV infection (1349,1354–1357), especially if their partners are also coinfected with HIV (237,1340,1354–1356,1358).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1354]

    The Abstract reports higher HCV incidence among HIV-infected MSM who reported unsafe sex. The Discussion says some studies associated HCV prevalence with more sexual partners, especially among MSM, but also notes conflicting findings. This paper does not establish that HCV risk rises commensurately with partner count in HIV-infected MSM, or that risk is especially high when partners are HIV-coinfected. (LLM, conf=0.86)

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  1. Glass TR, Young J, Vernazza PL, et al. Is unsafe sexual behavior in- creasing among HIV-infected individuals? AIDS 2004; 18:1707-14.

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Authors
Rauch, A., Martin, M., Weber, R., Hirschel, B., Tarr, P. E., Bucher, H. C., Vernazza, P., Bernasconi, E., Zinkernagel, A. S., Evison, J., Furrer, H., & Study, S. H. C.
Affiliations
  • University of Bern (CH)
  • Swiss HIV Cohort Study (CH)
  • Kantonsspital St. Gallen (CH)
  • Ospedale regionale di Lugano (CH)
Corresponding author
Furrer, H.
ORCID
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2005-08-01
Volume
41
Issue
3
Pages
395-402
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/431486
OpenAlex
W2171773735
Cited by
210
References
41
Citations by year
2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 16 · 2015: 16 · 2014: 14 · 2013: 18 · 2012: 21
FWCI
7.75
Type
journal article
Language
en
Open access
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • SERVAL (Université de Lausanne) (publishedVersion, other-oa)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
  • reroDoc Digital Library (submittedVersion)
  • IRIS (submittedVersion)
  • Bern Open Repository and Information System (University of Bern) (submittedVersion, other-oa)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
  • Zurich Open Repository and Archive (University of Zurich)
Funders
  • National Science Foundation
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords
hepatitis C virus, HIV infection, men who have sex with men, unprotected sex, condom use, intravenous drug use, HCV seroconversion, HCV incidence, HCV seroprevalence, sexual transmission, Swiss HIV Cohort Study
MeSH terms
Adult, Female, Hepatitis C, Humans, Male, Risk Factors, Switzerland, Cohort Studies, HIV Infections, Incidence, Prevalence, Proportional Hazards Models, Homosexuality, Male, Unsafe Sex

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