The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury*
Abstract
OBJECTIVE: To explore the effects of an enteral diet enriched with eicosapentaenoic acid (EPA), gamma-linolenic acid (GLA), and antioxidants on the respiratory profile and outcome of patients with acute lung injury. DESIGN: Single-center, prospective, randomized, controlled, unblinded study. SETTING: General intensive care department of a tertiary-care, university-affiliated hospital. PATIENTS: A total of 100 patients with acute lung injury, diagnosed according to the American-European Consensus Conference on ARDS. INTERVENTIONS: Patients were randomized to receive the standard isonitrogenous, isocaloric enteral diet or the standard diet supplemented with EPA and GLA for 14 days. MEASUREMENTS AND MAIN RESULTS: Patient demographics, Acute Physiology and Chronic Health Evaluation II score, and type of admission were noted at admission. Compared with baseline oxygenation (EPA + GLA group vs. control group), by days 4 and 7, patients receiving the EPA + GLA diet showed significant improvement in oxygenation (PaO(2)/FIO(2), 317.3 +/- 99.5 vs. 214.3 +/- 56.4 and 296.5 +/- 165.3 vs. 236.3 +/- 79.8, respectively; p < .05). Compliance was significantly higher in the EPA + GLA group observed at day 7 (55.1 +/- 46.5 vs. 35.2 +/- 20.0 mL/mbar, p < .05). No significant difference was found in nutritional variables. Resting energy expenditure was significantly higher in patients in the EPA + GLA group, but their body mass index was also higher (p < .05). A significant difference was found in length of ventilation (p < .04) in favor of the EPA + GLA group. There was no between-group difference in survival. CONCLUSIONS: In patients with acute lung injury, a diet enriched with EPA + GLA may be beneficial for gas exchange, respiratory dynamics, and requirements for mechanical ventilation.
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“Finally, Stehle et al. (235) in a meta-analysis including only stable patients showed an advantage to administering GLN.”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [235]
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ESPEN guideline on clinical nutrition in the intensive care unit.
Singer, P., Blaser, A. R., Berger, M. M., Alhazzani, W., Calder, P. C., Casaer, M. P., Hiesmayr, M., Mayer, K., Montejo, J. C., Pichard, C., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.08.037 · Cited by 2,904
Self-citationMcClave, S. A., Martindale, R. G., Vanek, V. W., McCarthy, M., Roberts, P., Taylor, B., Ochoa, J. B., Napolitano, L., Cresci, G., the A.S.P.E.N. Board of Directors, et al. (2009) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607109335234 · Cited by 1,873
Metadata
- Authors
- Singer, P., Theilla, M., Fisher, H., Gibstein, L., Grozovski, E., & Cohen, J.
- Affiliations
- Tel Aviv University (IL)
- Venue
- Critical Care Medicine
- Published
- 2006-04
- Volume
- 34
- Issue
- 4
- Pages
- 1033-1038
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2096340924
- Cited by
- 393
- References
- 20
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 5 · 2023: 4 · 2022: 2 · 2021: 16 · 2020: 16 · 2019: 17 · 2018: 11 · 2017: 13 · 2016: 16 · 2015: 29 · 2014: 41 · 2013: 28 · 2012: 32
- FWCI
- 22.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
- Keywords
- acute lung injury, acute respiratory distress syndrome, enteral nutrition, eicosapentaenoic acid, gamma-linolenic acid, omega-3 fatty acids, antioxidants, mechanical ventilation, oxygenation, ventilator compliance, resting energy expenditure, mechanical ventilation duration, critically ill patients
- MeSH terms
- Adult, Enteral Nutrition, Female, Humans, Male, Middle Aged, Prospective Studies, Respiration, Artificial, Respiratory Distress Syndrome, Eicosapentaenoic Acid, Treatment Outcome, gamma-Linolenic Acid
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