Cited by 393Clinical Nutrition and GastroenterologyRespiratory Support and MechanismsNosocomial Infections in ICU

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Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury*

Singer, Pierre, Theilla, Myriam, Fisher, Haran, Gibstein, Lilly, Grozovski, Elad, Cohen, Jonathan·2006·Critical Care Medicine

DOI 10.1097/01.ccm.0000206111.23629.0a

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Abstract

OBJECTIVE: To explore the effects of an enteral diet enriched with eicosapentaenoic acid (EPA), gamma-linolenic acid (GLA), and antioxidants on the respiratory profile and outcome of patients with acute lung injury. DESIGN: Single-center, prospective, randomized, controlled, unblinded study. SETTING: General intensive care department of a tertiary-care, university-affiliated hospital. PATIENTS: A total of 100 patients with acute lung injury, diagnosed according to the American-European Consensus Conference on ARDS. INTERVENTIONS: Patients were randomized to receive the standard isonitrogenous, isocaloric enteral diet or the standard diet supplemented with EPA and GLA for 14 days. MEASUREMENTS AND MAIN RESULTS: Patient demographics, Acute Physiology and Chronic Health Evaluation II score, and type of admission were noted at admission. Compared with baseline oxygenation (EPA + GLA group vs. control group), by days 4 and 7, patients receiving the EPA + GLA diet showed significant improvement in oxygenation (PaO(2)/FIO(2), 317.3 +/- 99.5 vs. 214.3 +/- 56.4 and 296.5 +/- 165.3 vs. 236.3 +/- 79.8, respectively; p < .05). Compliance was significantly higher in the EPA + GLA group observed at day 7 (55.1 +/- 46.5 vs. 35.2 +/- 20.0 mL/mbar, p < .05). No significant difference was found in nutritional variables. Resting energy expenditure was significantly higher in patients in the EPA + GLA group, but their body mass index was also higher (p < .05). A significant difference was found in length of ventilation (p < .04) in favor of the EPA + GLA group. There was no between-group difference in survival. CONCLUSIONS: In patients with acute lung injury, a diet enriched with EPA + GLA may be beneficial for gas exchange, respiratory dynamics, and requirements for mechanical ventilation.

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Authors: Singer, P., Theilla, M., Fisher, H., Gibstein, L., Grozovski, E., & Cohen, J.
Affiliations: Tel Aviv University (IL)
ORCID: Singer, Pierre
Cohen, Jonathan
Venue: Critical Care Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-04
Volume: 34
Issue: 4
Pages: 1033-1038
ISSN: 0090-3493 (ISSN-L)
DOI: 10.1097/01.ccm.0000206111.23629.0a
OpenAlex: W2096340924
Cited by: 393
References: 20
Citations by year: 2026: 4 · 2025: 9 · 2024: 5 · 2023: 4 · 2022: 2 · 2021: 16 · 2020: 16 · 2019: 17 · 2018: 11 · 2017: 13 · 2016: 16 · 2015: 29 · 2014: 41 · 2013: 28 · 2012: 32
FWCI: 22.86
Type: journal article
Language: en
Open access: closed
Locations: Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Keywords: acute lung injury, acute respiratory distress syndrome, enteral nutrition, eicosapentaenoic acid, gamma-linolenic acid, omega-3 fatty acids, antioxidants, mechanical ventilation, oxygenation, ventilator compliance, resting energy expenditure, mechanical ventilation duration, critically ill patients
MeSH terms: Adult, Enteral Nutrition, Female, Humans, Male, Middle Aged, Prospective Studies, Respiration, Artificial, Respiratory Distress Syndrome, Eicosapentaenoic Acid, Treatment Outcome, gamma-Linolenic Acid

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Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury*

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