The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Does Prolonged Therapy With a Long-Acting Stimulant Suppress Growth in Children With ADHD?
Abstract
Objective To investigate whether prolonged therapy with a long-acting stimulant affects growth in children with attention-deficit/hyperactivity disorder (ADHD).Method One hundred seventy-eight children ages 6 to 13 years received OROS methylphenidate (OROS MPH, CONCERTA) for at least 21 months. Height and weight were measured monthly during the first year and every 3 months thereafter.Results At baseline, subjects were approximately the expected height for their age and somewhat heavier than expected. Subjects gained height steadily throughout the study and were on average 0.23 cm less than expected at month 21. Weight did not increase and BMI decreased slightly in the first 4 months. Thereafter, weight Z score and BMI Z score remained relatively constant and children were on average 1.23 kg less than expected at month 21. Previous stimulant therapy tended to be associated with a smaller decrease in Z score during the study compared with no previous stimulant therapy. Drug holidays did not significantly affect growth.Conclusions The effects of prolonged OROS MPH therapy on growth were clinically insignificant and limited to slight decreases in weight during the first months of therapy. Drug holidays did not reduce any impact on growth and are thus of questionable utility for limiting potential effects of treatment on growth.
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In the citing paper
“Significant effects on weight and height may require average doses of methylphenidate exceeding 1.5 mg/kg per day which are given continuously [28, 132].”
From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [132]
In the citing paper
“In two recent studies (Pliszka et al., 2006;Spencer et al., 2006) in which drug holidays were allowed but were not systematically varied, stimulantrelated reductions in growth rates were not documented.”
From Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up (2007) · cites this paper as Spencer et al., 2006
In the citing paper
“In two other recent chart-review studies, no evidence was found to support the hypothesis that clinical treatment with stimulant medications reduced the growth rates of children with ADHD (Pliszka et al., 2006;Spencer et al., 2006).”
From Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up (2007) · cites this paper as Spencer et al., 2006
In the citing paper
“but not with two others (Pliszka et al., 2006;Spencer et al., 2006)”
From Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up (2007) · cites this paper as Spencer et al., 2006
Citations
Cites
BARKLEY, R. A., FISCHER, M., EDELBROCK, C. S., & SMALLISH, L. (1990) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199007000-00007 · Cited by 1,507
Classification and definition of protein-calorie malnutrition.
Waterlow, J. C. (1972) · BMJ · doi:10.1136/bmj.3.5826.566 · Cited by 999
Greenhill, L. L., Pliszka, S., & Dulcan, M. K. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200202001-00003 · Cited by 927
Adult psychiatric status of hyperactive boys grown up
Mannuzza, S., Klein, R. G., Bessler, A., Malloy, P., & LaPadula, M. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.4.493 · Cited by 769
Attention-Deficit, S. O., & Disorder, H. (2001) · Pediatrics · doi:10.1542/peds.108.4.1033 · Cited by 636
Hyperactive Boys Almost Grown Up: V. Replication of Psychiatric Status
Mannuzza, S. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810250079012 · Cited by 549
BIEDERMAN, J., FARAONE, S., MILBERGER, S., CURTIS, S., CHEN, L., MARRS, A., OUELLETTE, C., MOORE, P., & SPENCER, T. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199603000-00016 · Cited by 510
Self-citationWolraich, M. L., Greenhill, L. L., Pelham, W., Swanson, J., Wilens, T., Palumbo, D., Atkins, M., McBurnett, K., Bukstein, O., August, G., et al. (2001) · Pediatrics · doi:10.1542/peds.108.4.883 · Cited by 502
(2001) · Europe PMC (PubMed Central) · Cited by 393
MTA Cooperative Group (2004) · PEDIATRICS · doi:10.1542/peds.113.4.762 · Cited by 384
Research works printed but not linked: 2
- Baren, 2000, Lack of effect of different breakfast conditions on the pharmacokinetics and efficacy of OROS methylphenidate HCl extended-release tablets in children with ADHD, Pediatr Res, 47, 23A
- Swanson, 2000, Initiating CONCERTA (OROS methylphenidate HCI) qd in children with attention-deficit hyperactivity disorder, J Clin Res, 3, 59
Cited by
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European guidelines on managing adverse effects of medication for ADHD
(for the European Guidelines Group), Graham, J., Banaschewski, T., Buitelaar, J., Coghill, D., Danckaerts, M., Dittmann, R. W., Döpfner, M., Hamilton, R., Hollis, C., et al. (2011) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-010-0140-6 · Cited by 374
Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up
SWANSON, J. M., ELLIOTT, G. R., GREENHILL, L. L., WIGAL, T., ARNOLD, L. E., VITIELLO, B., HECHTMAN, L., EPSTEIN, J. N., PELHAM, W. E., ABIKOFF, H. B., et al. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3180686d7e · Cited by 323
Storebø, O. J., Pedersen, N., Ramstad, E., Kielsholm, M. L., Nielsen, S. S., Krogh, H. B., Moreira-Maia, C. R., Magnusson, F. L., Holmskov, M., Gerner, T., et al. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012069.pub2 · Cited by 321
Attention-Deficit/Hyperactivity Disorder (ADHD) and Obesity: A Systematic Review of the Literature
Cortese, S., Angriman, M., Maffeis, C., Isnard, P., Konofal, É., Lecendreux, M., Purper‐Ouakil, D., Vincenzi, B., Bernardina, B. D., & Mouren, M. (2008) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390701540124 · Cited by 271
Biederman, J., Melmed, R. D., Patel, A., McBurnett, K., Donahue, J., & Lyne, A. (2008) · CNS Spectrums · doi:10.1017/s1092852900017107 · Cited by 270
Self-citation
Metadata
- Authors
- SPENCER, T. J., FARAONE, S. V., BIEDERMAN, J., LERNER, M., COOPER, K. M., & ZIMMERMAN, B.
- Affiliations
- SUNY Upstate Medical University (US)
- Corresponding author
- SPENCER, THOMAS J.
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 45
- Issue
- 5
- Pages
- 527-537
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W2077454035
- Cited by
- 125
- References
- 41
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 3 · 2016: 2 · 2015: 9 · 2014: 12 · 2013: 2 · 2012: 6
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Keywords
- attention deficit hyperactivity disorder, long-acting stimulants, OROS methylphenidate, growth inhibition, height, weight, body mass index, drug holidays, children
- MeSH terms
- Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Body Height, Body Weight, Child, Clinical Trials as Topic, Delayed-Action Preparations, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Humans, Long-Term Care, Male, Methylphenidate, Body Mass Index
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