Hyperactive Boys Almost Grown Up: V. Replication of Psychiatric Status

Mannuzza, Salvatore

doi:10.1001/archpsyc.1991.01810250079012

Cited by 549Attention Deficit Hyperactivity DisorderChild and Adolescent Psychosocial and Emotional DevelopmentPsychopathy, Forensic Psychiatry, Sexual Offending

Hyperactive Boys Almost Grown Up: V. Replication of Psychiatric Status

Mannuzza, Salvatore·1991·Archives of General Psychiatry

DOI 10.1001/archpsyc.1991.01810250079012

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Abstract

We previously reported a prospective follow-up study of 101 young adult males whose conditions had been diagnosed as hyperactivity in childhood. Compared with controls, probands had significantly higher rates of attention-deficit, antisocial, and drug use disorders at follow-up (mean age, 18 years). The present study was an attempt to replicate these findings on an independent sample of 94 hyperactive boys who were seen at the same clinic, compared with 78 normal controls. Assessments were made by clinicians who were blind to group membership. Information was obtained for 90% of the original cohort. As in the previous study, significantly more probands than controls were given ongoing diagnoses of attention-deficit disorder (43% vs 4%), antisocial disorders (32% vs 8%), and drug use disorders (10% vs 1%). Furthermore, the absolute rates of these disorders were comparable for corresponding groups across studies, and the adjusted odds ratios did not differ significantly. As previously, there was no increased risk for affective disorders in the grown hyperactive children. The present study provides a powerful replication of the nature of the young adult outcome of childhood hyperactivity.

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Separate categories for Alcohol and Non-Alcohol SUD were included since the authors' late adolescent and adult follow-ups showed that, compared to controls, probands were at significantly increased risk for Non-Alcohol SUD, but not for Alcohol SUD.
“Separate categories for Alcohol and Non-Alcohol SUD were included since our late adolescent and adult follow-ups showed that, compared to controls, probands were at significantly increased risk for Non-Alcohol SUD, but not for Alcohol SUD (3–6).”
From Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. (2008) · cites this paper as [4]
Childhood attention deficit hyperactivity disorder is significantly associated with adolescent and adult substance use disorders.
“Numerous studies have shown that childhood attention deficit hyperactivity disorder (ADHD) is significantly associated with adolescent and adult substance use disorders (SUD) (1–8).”
From Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. (2008) · cites this paper as [4]
Follow-ups of this sample consistently showed substantial comorbidity between SUD and antisocial disorder (3-6).
“It is not surprising that age at initiation was significantly associated with both SUD and antisocial personality disorder since follow-ups of this sample consistently showed substantial comorbidity between SUD and antisocial disorder (3–6).”
From Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. (2008) · cites this paper as [4]

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“Although psychiatric comorbidity with bipolar or juvenile conduct disorder clearly increases that risk [11,24–26], ADHD itself appears to be a risk factor for later SUD [23].”
Background
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“For example, Lahey and Loeber cite two studies that do not support the hypothesis that children with ADHD in the absence of CD are at risk for later developing antisocial behavior (Loeber, 1988; Magnusson & Bergman, 1990) and three studies that did (Gittelman, Mannuzza, Shenker, & Bonagura, 1985; Lambert, 1988; Mannuz…”
Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood.
Mannuzza, S., Klein, R. G., Truong, N. L., Moulton, J. L., Roizen, E. R., Howell, K. H., & Castellanos, F. X. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07091465 · Cited by 263 · see citing works
Self-citation
Response Inhibition in Adolescents Diagnosed With Attention Deficit Hyperactivity Disorder During Childhood: An Event-Related fMRI Study
Schulz, K. P., Fan, J., Tang, C. Y., Newcorn, J. H., Buchsbaum, M. S., Cheung, A. M., & Halperin, J. M. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.9.1650 · Cited by 262 · see citing works
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Patterns of Psychiatric Comorbidity with Attention-Deficit/Hyperactivity Disorder
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Accuracy of Adult Recall of Childhood Attention Deficit Hyperactivity Disorder
Mannuzza, S., KLEIN, R. G., Klein, D. F., BESSLER, A., & Shrout, P. E. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1882 · Cited by 238 · see citing works
Self-citation
Adolescent Outcomes of Childhood Attention-Deficit/Hyperactivity Disorder in a Diverse Community Sample
Bussing, R., Mason, D. M., Bell, L., Porter, P., & GARVAN, C. W. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.03.006 · Cited by 240 · see citing works
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“Furthermore, studies indicate that problems due to ADHD are not just transient childhood phenomena, but can adversely a ect the developmental path of a ected young- sters, resulting in eventual impaired adult pro- ductivity and well-being (Mannuzza et al., 1991, 1993).”
Background
Conduct Disorder in Girls: A Review of the Literature
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The Prospective Relation Between Dimensions of Anxiety and the Initiation of Adolescent Alcohol Use
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Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center
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“axis-I disorders is highly prevalent, especially with mood disorders and substance use-related disorders [12, 22, 32, 46], (2) the”
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A New Self-Report Scale for Assessment of Adolescent Psychopathology: Factor Structure, Reliability, Validity, and Diagnostic Sensitivity
Conners, C., Wells, K. C., Parker, J., Sitarenios, G., Diamond, J. M., & Powell, J. W. (1997) · Journal of Abnormal Child Psychology · doi:10.1023/a:1022637815797 · Cited by 237 · see citing works
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Six-week, double-blind, placebo-controlled study of desipramine for adult attention deficit hyperactivity disorder
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Abikoff, H., & Klein, R. G. (1992) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.60.6.881 · Cited by 226 · see citing works
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Developmental aspects of delinquency and internalizing problems and their association with persistent juvenile substance use between ages 7 and 18
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Efficacy of the Incredible Years Basic parent training programme as an early intervention for children with conduct problems and ADHD.
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“Children with ADHD are also at a heightened risk of developing conduct problems, substance abuse, and interpersonal and occupational difficulties that can persist into adulthood (Manuzza et al. 1991; Taylor et al. 1996).”
Background
Attentional difficulties in middle childhood and psychosocial outcomes in young adulthood.
Fergusson, D. M., Lynskey, M. T., & Horwood, L. (1997) · Journal of Child Psychology and Psychiatry and Allied Disciplines · doi:10.1111/j.1469-7610.1997.tb01690.x · Cited by 214 · see citing works
ADHD in adults: A study of clinical characteristics, impairment and comorbidity
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“adulthood in as much as 30 /60% of the cases (2, 3).”
Background
Preliminary Normative Data on <i>DSM-IV</i> Attention Deficit Hyperactivity Disorder in College Students
Heiligenstein, E., Conyers, L. M., Berns, A. R., & Smith, M. A. (1998) · Journal of American College Health · doi:10.1080/07448489809595609 · Cited by 209 · see citing works
Treatment of Attention-Deficit–Hyperactivity Disorder
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Brain gray matter deficits at 33-year follow-up in adults with attention-deficit/hyperactivity disorder established in childhood
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“Although we cannot rule out instrument-related error (see the supplementary Instrument available on the authors’ Web site), the use of similar approaches did not yield high rates of ADHD symptoms in comparison participants in 2 previous blinded assessments.(21,23) Nevertheless, analyses excluding ADHDNOS did not alter…”
MethodResult
Does ADHD Affect the Course of Substance Abuse? Findings From a Sample of Adults With and Without ADHD
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Few Preschool Boys and Girls with ADHD are Well-Adjusted During Adolescence
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“Third, internalizing behavior has been inconsistently linked with ADHD (Fischer et al. 2002; Mannuzza et al. 1991), but the clinical significance of mood disturbance (particularly depression) in adolescence necessitates its inclusion in any definition of being well-adjusted (Lewinsohn et al.”
Background
Prevalence of Attention-Deficit/Hyperactivity Disorder Symptoms in 4- to 17-Year-Old Children in the General Population
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Reliabilität und Validität der Wender-Utah-Rating-Scale-Kurzform: Retrospektive Erfassung von Symptomen aus dem Spektrum der Aufmerksamkeitsdefizit/Hyperaktivitätsstörung
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Prevalence of adult attention-deficit hyperactivity disorder among cocaine abusers seeking treatment.
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Authors: Mannuzza, S.
Affiliations: Long Island Jewish Medical Center (US)
Corresponding author: Mannuzza, Salvatore
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 1991-01-01
Volume: 48
Issue: 1
Pages: 77
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.1991.01810250079012
OpenAlex: W2108483316
Cited by: 549
References: 0
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 12 · 2014: 16 · 2013: 18 · 2012: 21
FWCI: 14.99
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH-18579, R01MH018579, MH30906)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords: hyperactive children, adult outcomes, attention deficit disorder, antisocial personality disorder, drug use disorders, mood disorders, replication study, young men, long-term follow-up
MeSH terms: Adolescent, Age Factors, Alcoholism, Antisocial Personality Disorder, Attention Deficit Disorder with Hyperactivity, Mental Disorders, Child, Child Behavior Disorders, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Male, Psychiatric Status Rating Scales, Psychometrics, Regression Analysis, Comorbidity, Prevalence, Substance-Related Disorders

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Hyperactive Boys Almost Grown Up: V. Replication of Psychiatric Status

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