Are young women with Turner syndrome at greater risk of coronary artery disease?
Abstract
BACKGROUND: Turner syndrome is an X chromosome aberration that affects females. Women with Turner syndrome are exposed to a greater risk of coronary artery disease, arterial hypertension and type 2 diabetes mellitus. DESIGN: The objective of our study was to assess the prevalence of classic risk factors of coronary artery disease in young women with Turner syndrome in comparison to a representative group of Polish young women from the general population. METHODS: The study enrolled 176 women aged 25 years with Turner syndrome from the whole of Poland. The controls were 231 young women selected to be representative, who took part in the NATPOL PLUS study (website: http://www.natpol.pl). RESULTS: Women with Turner syndrome tended to be shorter and lighter than the general population (P < 0.0001), they were also found to present higher values of body mass index and waist-hip ratio (P < 0.0001). Significantly higher values of diastolic blood pressure (P < 0.0001) and levels of total cholesterol and low-density lipoprotein fraction were found in the group of women with Turner syndrome, whereas the high-density lipoprotein fraction level was lower (P < 0.05). Similarly, glucose levels on an empty stomach were significantly higher among women with Turner syndrome (P < 0.0001). CONCLUSION: Women with Turner syndrome constitute a group at higher cardiovascular risk. This group of women requires effective preventative medicine from the earliest age.
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Individuals with TS and comorbidities often exhibit higher total cholesterol, LDL cholesterol, and triglycerides compared to controls, although severe elevations are infrequently reported.
“Individuals with TS and comorbidities often exhibit higher total cholesterol, LDL cholesterol, and triglycerides compared to controls, although severe elevations are infrequently reported.331,476”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [476]
Hypercholesterolemia is prevalent in TS and is influenced by numerous intrinsic factors, including obesity, metabolic syndrome, and type 1 or type 2 diabetes.
“Hypercholesterolemia is prevalent in TS and is influenced by numerous intrinsic factors, including obesity, metabolic syndrome, and type 1 or type 2 diabetes.”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [476]
Cites
Weight, Weight Change, and Coronary Heart Disease in Women: Risk Within the 'Normal' Weight Range
Willett, W. C. (1995) · JAMA · doi:10.1001/jama.1995.03520300035033 · Cited by 924 · see citing works
Evidence-Based Guidelines for Cardiovascular Disease Prevention in Women
Mosca, L. J., Appel, L. J., Benjamin, E. J., Berra, K. A., Chandra‐Strobos, N., Fabunmi, R. P., Grady, D. G., Haan, C. K., Hayes, S. N., Judelson, D. R., et al. (2004) · Circulation · doi:10.1161/01.cir.0000114834.85476.81 · Cited by 917 · see citing works
Rosenfeld, R. G. (1990) · Cited by 505 · see citing works
Turner's Syndrome in Adulthood
Elsheikh, M., Dunger, D. B., Conway, G. S., & Wass, J. A. H. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0457 · Cited by 397 · see citing works
Cardiovascular Malformations and Complications in Turner Syndrome
Sybert, V. P. (1998) · PEDIATRICS · doi:10.1542/peds.101.1.e11 · Cited by 326 · see citing works
Lippe, B. M. (1991) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30284-6 · Cited by 252 · see citing works
Gravholt, C. H., Naeraa, R. W., Nyholm, B., Gerdes, L. U., Christiansen, E., Schmitz, O., & Christiansen, J. S. (1998) · Diabetes Care · doi:10.2337/diacare.21.7.1062 · Cited by 204 · see citing works
Mortality ratios, life expectancy, and causes of death in patients with Turner's syndrome.
Price, W. H., Clayton, J. F., Collyer, S., Mey, R. D., & Wilson, J. (1986) · Journal of Epidemiology & Community Health · doi:10.1136/jech.40.2.97 · Cited by 154 · see citing works
Coronary atherogenic risk factors in women.
Stangl, V., Baumann, G., & Stangl, K. (2002) · European Heart Journal · doi:10.1053/euhj.2002.3329 · Cited by 124 · see citing works
Undiagnosed morbidity in adult women with Turner's syndrome
Garden, A., Diver, M. J., & Fraser, W. D. (1996) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1996.00849.x · Cited by 51 · see citing works
Gravholt, C. H. (2002) · American Journal of Cardiovascular Drugs · doi:10.2165/00129784-200202060-00005 · Cited by 45 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Gravholt, C. H., Andersen, N. H., Conway, G. S., Dekkers, O. M., Geffner, M. E., Klein, K. O., Lin, A. E., Mauras, N., Quigley, C. A., Rubin, K., et al. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0430 · Cited by 1,101 · see citing works
XX sex chromosome complement promotes atherosclerosis in mice
Alsiraj, Y., Chen, X., Thatcher, S. E., Temel, R. E., Cai, L., Blalock, E. M., Katz, W. S., Ali, H., Petriello, M. C., Deng, P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10462-z · Cited by 268 · see citing works
Cardiovascular Phenotype in Turner Syndrome—Integrating Cardiology, Genetics, and Endocrinology
Mortensen, K. H., Andersen, N. H., & Gravholt, C. H. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1059 · Cited by 217 · see citing works
“• Hypertension (81) • Insulin resistance (227) and overt diabetes (1) • Dyslipidemia (228) • Obesity (229) • Estrogen deficiency (229) • GH deficiency (229) • Hypercoagulable clotting system (201)”
BackgroundClinical practice guidelines for the care of girls and women with Turner syndrome.
Gravholt, C. H., Andersen, N. H., Christin-Maitre, S., Davis, S. M., Duijnhouwer, A., Gawlik, A., Maciel-Guerra, A. T., Gutmark-Little, I., Fleischer, K., Hong, D., et al. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae050 · Cited by 224 · see citing works
The changing face of Turner syndrome
Gravholt, C. H., Viuff, M., Just, J., Sandahl, K., Brun, S., van der Velden, J., Andersen, N. H., & Skakkebaek, A. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnac016 · Cited by 149 · see citing works
Turner Syndrome: Updating the Paradigm of Clinical Care
Pinsker, J. E. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1245 · Cited by 123 · see citing works
Freriks, K., Timmermans, J., Beerendonk, C. C. M., Verhaak, C. M., Netea-Maier, R. T., Otten, B. J., Braat, D. D. M., Smeets, D. F. C. M., Kunst, D. H. P. M., Hermus, A. R. M. M., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0346 · Cited by 120 · see citing works
Management of Cardiovascular Risk Factors in Adults With Congenital Heart Disease
Lui, G. K., Fernandes, S. M., & McElhinney, D. B. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.001076 · Cited by 103 · see citing works
Taboada, M., Santen, R., Lima, J., Hossain, J., Singh, R., Klein, K. O., & Mauras, N. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1449 · Cited by 82 · see citing works
“healthy eugonadal controls (27) and vs.”
Hypertension, Obesity, and Coronary Artery Disease in the Survivors of Congenital Heart Disease
Roche, S. L., & Silversides, C. K. (2013) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2013.03.021 · Cited by 77 · see citing works
“It is likely that any increased risk of CAD seen in young women with Turner syndrome is multifactorial related to traditional risk factors and to inherent abnormalities of the coronary vasculature.(80,81) Even after successful coarctation repair, ongoing pathological processes increase in the risk of late cardiovascul…”
BackgroundPirgon, Ö., Atabek, M. E., Oran, B., & Güçlü, R. (2009) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4008/jcrpe.v1i2.9 · Cited by 34 · see citing works
“(27) In a group of women with TS who were tested, hypercholesterolemia was diagnosed in nearly 37% of females, a frequency which was twice as great as in the general population.(28) Analysis of large prospective studies revealed that to assess the risk among women, the HDL-cholesterol level seems to play an essential…”
Imaging of cardiovascular risk in patients with Turner's syndrome
Marin, A., Weir-McCall, J. R., Webb, D. J., van Beek, E. J. R., & Mirsadraee, S. (2015) · Clinical Radiology · doi:10.1016/j.crad.2015.03.009 · Cited by 32 · see citing works
Moving Toward an Understanding of Hormone Replacement Therapy in Adolescent Girls
Davenport, M. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1429.031 · Cited by 27 · see citing works
Cardiovascular risk in Turner syndrome
Donato, B., & Ferreira, M. J. (2018) · Revista Portuguesa de Cardiologia · doi:10.1016/j.repc.2017.08.008 · Cited by 29 · see citing works
Long-term effects of previous oxandrolone treatment in adult women with Turner syndrome
Freriks, K., Sas, T. C. J., Traas, M. A. F., Netea-Maier, R. T., den Heijer, M., Hermus, A. R. M. M., Wit, J. M., van Alfen-van der Velden, J. A. E. M., Otten, B. J., de Muinck Keizer-Schrama, S. M. P. F., et al. (2013) · European Journal of Endocrinology · doi:10.1530/eje-12-0404 · Cited by 24 · see citing works
The influence of hormonal replacement and growth hormone treatment on the lipids in Turner syndrome
Irzyniec, T. J., & Jeż, W. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2013.872236 · Cited by 21 · see citing works
“phenotype, which has been widely described by other authors [2,14].”
BackgroundResultAlsiraj, Y., Thatcher, S. E., Blalock, E. M., Saintilnord, W. N., Daugherty, A., Lu, H. S., Luo, W., Shen, Y. H., LeMaire, S. A., Arnold, A. P., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314407 · Cited by 19 · see citing works
A prospective study of lipids in adult women with Turner syndrome
Sandahl, K. J., Just, J., Erlandsen, M., Mortensen, K. H., Andersen, N. H., & Gravholt, C. H. (2023) · Journal of the Endocrine Society · doi:10.1210/jendso/bvad124 · Cited by 14 · see citing works
“Others have reported normal lipid levels in TS alongside elevations in lipoprotein Lp(a) [10, 16-18].”
The influence of growth hormone therapy on the cardiovascular system in Turner syndrome
Dyrka, K., Rozkiewicz, N., Obara-Moszyńska, M., & Niedziela, M. (2020) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2020-0266 · Cited by 15 · see citing works
Coronary anatomy in Turner syndrome versus patients with isolated bicuspid aortic valves
Koenraadt, W. M. C., Siebelink, H.-M. J., Bartelings, M. M., Schalij, M. J., van der Vlugt, M. J., van den Bosch, A. E., Budde, R. P. J., Roos-Hesselink, J. W., Duijnhouwer, A. L., van den Hoven, A. T., et al. (2019) · Heart · doi:10.1136/heartjnl-2018-313724 · Cited by 10 · see citing works
Sigakis, C. J. G., Browne, L. P., Bang, T., Khanna, A., Pruente, R., & Vargas, D. (2019) · Journal of Thoracic Imaging · doi:10.1097/rti.0000000000000372 · Cited by 8 · see citing works
Carl, A., Good, M., Haag, E., Hutaff-Lee, C. F., Swain, D. M., Tartaglia, N. R., Sakamoto, C., Davis, S., & Thompson, T. (2024) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.63564 · Cited by 7 · see citing works
“…functioning deficits (Green et al., 2015), reduced social cognition (Jordan et al., 2023; Wolstencroft & Skuse, 2019), cardio-vascular disease (Kozlowska-Wojciechowska et al., 2006), dysmorphic features (Kruszka et al., 2020), and infertility (Hewitt et al., 2013 Theme: Opportunities for…”
BackgroundOrwat, S., & Diller, G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa892 · Cited by 8 · see citing works
Kelley, J. C., Gutmark‐Little, I., Backeljauw, P. F., & Bamba, V. (2017) · Hormone Research in Paediatrics · doi:10.1159/000477761 · Cited by 7 · see citing works
Cardiovascular Complications in Patients with Turner’s Syndrome
Kostopoulou, E., Bosdou, J. Κ., Anagnostis, P. G., Stevenson, J. C., & Goulis, D. G. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200531152459 · Cited by 6 · see citing works
The Unique Challenge of Coronary Artery Disease in Adult Patients with Congenital Heart Disease
Borrelli, N., Merola, A., Barracano, R., Palma, M., Altobelli, I., Abbate, M., Papaccioli, G., Ciriello, G. D., Liguori, C., Sorice, D., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13226839 · Cited by 4 · see citing works
Cardiovascular risk in Turner syndrome
Donato, B., & Ferreira, M. J. (2018) · Revista Portuguesa de Cardiologia (English Edition) · doi:10.1016/j.repce.2017.08.008 · Cited by 3 · see citing works
Bai, W., Huang, W., Xu, R., Fu, H., Zou, Q., Chen, L., Xu, H., Wen, L., Xie, L., Wu, J., et al. (2022) · Clinical Endocrinology · doi:10.1111/cen.14866 · Cited by 3 · see citing works
Valencia, E., Serna-Higuita, L. M., Medina, C., & Arango, Á. I. (2011) · Colombia medica · doi:10.25100/cm.v42i1.751 · Cited by 1 · see citing works
Turner syndrome in adulthood. A childhood disease grown up
Freriks, K. (2015) · Radboud Repository (Radboud University)
Cardiovascular Disorders of Turner's Syndrome: A Review
Yuan, S.-M., & Jing, H. (2010) · Balkan Journal of Medical Genetics · doi:10.2478/v10034-010-0011-y
“It has been suspected that TS patients are at greater risk of coronary artery disease due to their significantly higher blood pressure and levels of total cholesterol and low-density lipoprotein fraction as well as of lower high-density lipoprotein fraction compared to controls [44].”
BackgroundOrellano, H. A., Casella, M., & Spina, S. V. (2020) · Revista de ecocardiografía práctica y otras técnicas de imagen cardíaca · doi:10.37615/retic.v3n2a10
The social context of the atypical development of girls and women with Turner syndrome
Dołęga, Z., & Irzyniec, T. J. (2015) · Czasopismo Psychologiczne Psychological Journal · doi:10.14691/cppj.21.1.65
- Authors
- Kozlowska-Wojciechowska, M., Jez, W., Zdrojewski, T., & Chwojnicki, K.
- Affiliations
- Gdańsk Medical University (PL)
- Venue
- European Journal of Cardiovascular Prevention & Rehabilitation
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-06-01
- Volume
- 13
- Issue
- 3
- Pages
- 467-469
- ISSN
- 1741-8267 (ISSN-L)
- 1741-8275
- OpenAlex
- W2003272488
- Cited by
- 33
- References
- 11
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 2 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 2 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Cardiovascular Prevention & Rehabilitation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- Turner syndrome, coronary artery disease, cardiovascular risk factors, young women, hypertension, dyslipidemia, type 2 diabetes, body mass index, waist-to-hip ratio, fasting blood glucose, cardiovascular disease prevention
- MeSH terms
- Adult, Blood Glucose, Blood Pressure, Body Height, Body Weight, Cholesterol, Coronary Artery Disease, Female, Humans, Risk Factors, Turner Syndrome, Body Mass Index, Waist-Hip Ratio
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