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A study evaluating ceftriaxone as a treatment agent for primary and secondary syphilis in pregnancy.
Abstract
OBJECTIVES: To evaluate the efficacy of ceftriaxone in pregnant women who were diagnosed with early syphilis. STUDY: Eleven women with a history of penicillin allergy, positive skin test, but prior history of safe usage of cephalosporins were included. Ceftriaxone (250 mg) was given intramuscularly once daily for 7 and 10 days to patients with primary and secondary syphilis, respectively. A second course of therapy was provided at 28 weeks' gestation. The rapid plasma reagin test (RPR) was measured before and after therapy. The blood of neonates was also tested at delivery and during the follow-up period. RESULTS: The serum RPR titers of 11 mothers decreased fourfold, 3 months after treatment. Ten patients developed negative RPR results. The serum RPR was negative at delivery or 6 months after delivery in all neonates. CONCLUSIONS: Ceftriaxone may be considered as an alternative for treatment of early syphilis in pregnancy.
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Data are insufficient to recommend ceftriaxone or other cephalosporins for treatment of maternal infection and prevention of congenital syphilis.
“Data are insufficient to recommend ceftriaxone or other cephalosporins for treatment of maternal infection and prevention of congenital syphilis (646,647).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [646]
Citations
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Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 3,018
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Congenital Syphilis Prevention: Strategies, Evidence, and Future Directions
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Metadata
- Authors
- Zhou, P., Gu, Z., Xu, J., Wang, X., & Liao, K.
- Affiliations
- Shanghai Skin Disease Hospital (CN)
- Corresponding author
- Zhou, Pingyu
- Venue
- Sexually Transmitted Diseases
- Published
- 2005-08
- Volume
- 32
- Issue
- 8
- Pages
- 495-498
- ISSN
- 0148-5717 (ISSN-L)
- OpenAlex
- W2029158439
- Cited by
- 49
- References
- 20
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 1
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sexually Transmitted Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Syphilis Diagnosis and Treatment
- Health Sciences › Medicine › Pharmacology (medical) › Historical Medical Research and Treatments
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- ceftriaxone, maternal syphilis, primary syphilis, secondary syphilis, penicillin allergy, cephalosporin therapy, RPR, neonatal syphilis, maternal syphilis treatment
- MeSH terms
- Adult, Anti-Bacterial Agents, Ceftriaxone, Drug Administration Schedule, Female, Humans, Injections, Intramuscular, Pregnancy, Pregnancy Complications, Infectious, Pregnancy Trimesters, Syphilis, Ultrasonography, Prenatal, Treatment Outcome
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