Cited by 458Treatment of Major DepressionBipolar Disorder and TreatmentMental Health Treatment and Access

Does Incomplete Recovery From First Lifetime Major Depressive Episode Herald a Chronic Course of Illness?

Judd, Lewis L., Paulus, Martin J., Schettler, Pamela J., Akiskal, Hagop S., Endicott, Jean, Leon, Andrew C., Maser, Jack D., Mueller, Timothy +2 more·2000·American Journal of Psychiatry

Abstract

OBJECTIVE: This study investigated the influence of incomplete recovery from first lifetime major depressive episodes on long-term outcome. METHOD: After their first lifetime major depressive episode, patients were divided into asymptomatic (N=70) and residual subthreshold depressive symptom (N=26) recovery groups and compared on longitudinal course during up to 12 years of prospective naturalistic follow-up. RESULTS: Patients with residual subthreshold depressive symptoms during recovery had significantly more severe and chronic future courses. Those with residual symptoms relapsed to major and minor depressive episodes faster and had more recurrences, shorter well intervals, and fewer symptom-free weeks during follow-up than asymptomatic patients. CONCLUSIONS: Resolution of major depressive episodes with residual subthreshold depressive symptoms, even the first lifetime episode, appears to be the first step of a more severe, relapsing, and chronic future course. When ongoing subthreshold symptoms continue after major depressive episodes, the illness is still active, and continued treatment is strongly recommended.

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Crossref · 10.1176/appi.ajp.157.9.1501

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7 of 7 references verified0 citation errors · 0 not checkable

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Authors
Judd, L. L., Paulus, M. J., Schettler, P. J., Akiskal, H. S., Endicott, J., Leon, A. C., Maser, J. D., Mueller, T., Solomon, D. A., & Keller, M. B.
Affiliations
University of California San Diego (US)
Venue
American Journal of Psychiatry
Published
2000-09-01
Volume
157
Issue
9
Pages
1501-1504
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
OpenAlex
W2167845443
Cited by
458
References
7
Citations by year
2025: 2 · 2024: 7 · 2023: 9 · 2022: 12 · 2021: 7 · 2020: 5 · 2019: 11 · 2018: 16 · 2017: 15 · 2016: 14 · 2015: 23 · 2014: 18 · 2013: 31 · 2012: 29
FWCI
7.55
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R01MH025478)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords
major depressive episode, incomplete recovery, relapse, recurrence, long-term outcomes, naturalistic follow-up
MeSH terms
Antidepressive Agents, Chronic Disease, Depressive Disorder, Follow-Up Studies, Hospitalization, Humans, Longitudinal Studies, Prospective Studies, Recurrence, Severity of Illness Index, Comorbidity, Survival Analysis, Outcome Assessment, Health Care, Dysthymic Disorder

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