Posttraumatic stress disorder, alone or additively with early life adversity, is associated with obesity and cardiometabolic risk
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Background and aims There is some evidence that posttraumatic stress disorder (PTSD) and early life adversity may influence metabolic outcomes such as obesity, diabetes, and cardiovascular disease. However, whether and how these interact is not clear.Methods We analyzed data from a cross-sectional and longitudinal study to determine how PTSD severity influences obesity, insulin sensitivity, and key measures and biomarkers of cardiovascular risk. We then looked at how PTSD and early life adversity may interact to impact these same outcomes.Results PTSD severity is associated with increasing risk of obesity, diabetes, and cardiovascular disease, with higher symptoms correlating with higher values of BMI, leptin, fibrinogen, and blood pressure, and lower values of insulin sensitivity. PTSD and early life adversity have an additive effect on these metabolic outcomes. The longitudinal study confirmed findings from the cross sectional study and showed that fat mass, leptin, CRP, sICAM-1, and sTNFRII were significantly increased with higher PTSD severity during a 2.5 year follow-up period.Conclusions Individuals with early life adversity and PTSD are at high risk and should be monitored carefully for obesity, insulin resistance, and cardiometabolic risk.
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For some individuals, a history of early life adversity (ELA), including physical and emotional abuse, trauma, neglect and family discord, can increase the risk of developing obesity in adulthood through mechanisms associated with stress, inflammation, emotional perturbations, maladaptive coping, metabolic disturbances and food addiction.
“For some individuals, a history of early life adversity (ELA), including physical and emotional abuse, trauma, neglect and family discord, can increase the risk of developing obesity in adulthood through mechanisms associated with stress, inflammation, emotional perturbations, maladaptive coping, metabolic disturbances and food addiction 3, 4.”
From History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity (2019) · cites this paper as [3]
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Do measures of healthy eating differ in survivors of early adversity?
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Novel pathogenesis of post-traumatic stress disorder studied in transgenic mice
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Early-Life Home Environment and Obesity in a Mexican American Birth Cohort: The CHAMACOS Study
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Investigating the association between diabetes and mental health: A train-and-test approach
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MEDICINE AND PSYCHOLOGY: MODERN PROBLEMS, NEW TECHNOLOGIES AND WAYS OF DEVELOPING OUTDATED THEORIES
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Central Neurobiological Mechanisms of Stress Resistance in Post-Traumatic Stress States
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- Authors
- Farr, O. M., Ko, B.-J., Joung, K. E., Zaichenko, L., Usher, N., Tsoukas, M., Thakkar, B., Davis, C. R., Crowell, J. A., & Mantzoros, C. S.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Boston Children's Hospital (US)
- Judge Baker Children's Center (US)
- Boston University (US)
- Corresponding author
- Farr, O.M.
- Venue
- Nutrition, Metabolism and Cardiovascular Diseases
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 25
- Issue
- 5
- Pages
- 479-488
- ISSN
- 0939-4753 (ISSN-L)
- PMC
- PMC4404181
- OpenAlex
- W2013756862
- Cited by
- 93
- References
- 31
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 8 · 2021: 11 · 2020: 11 · 2019: 7 · 2018: 8 · 2017: 11 · 2016: 10 · 2015: 3
- FWCI
- 13.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nutrition Metabolism and Cardiovascular Diseases (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (RO1-AG032030)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK81913)
- Clinical Science Research and Development Service of the VA Office of Research and Development (1I01CX000422-01A1)
- Harvard Clinical and Translational Science Center (UL1 RR025758)
- NICHD (5T32HD052961)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- post-traumatic stress disorder, childhood adversity, obesity, cardiometabolic risk, insulin resistance, leptin, fibrinogen, C-reactive protein, sICAM-1, blood pressure, diabetes mellitus, cardiovascular disease, additive effects
- MeSH terms
- Adult, Boston, Cardiovascular Diseases, Child, Child Development, Cross-Sectional Studies, Diabetes Mellitus, Female, Humans, Insulin Resistance, Life Change Events, Longitudinal Studies, Male, Middle Aged, Obesity, Risk Factors, Severity of Illness Index, Stress Disorders, Post-Traumatic, Biomarkers, Comorbidity, Body Mass Index, Metabolic Syndrome, Diabetes Complications
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