Evaluation of bilateral cingulum with tractography in patients with Alzheimer’s disease
Abstract
A fiber-tracking algorithm was used to extract fractional anisotropy of bilateral cingulum bundles in patients with probable Alzheimer's disease and normal aging controls. In addition, their hippocampal volumes were measured manually. Relative to normal controls, Alzheimer's disease patients showed a significant reduction of fractional anisotropy and hippocampal volumes. Significant correlation was observed between fractional anisotropy values and volumes of hippocampi and mini-mental state examination scores. This study suggests that lower anisotropy of cingulum bundles is associated with cognitive dysfunction and atrophy of the limbic system.
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Initial DTI tractography studies portrayed the cingulum as a unitary bundle.
“Initial DTI tractography studies portrayed the cingulum as a unitary bundle (e.g., Catani et al., 2002; Xie et al., 2005; see Fig. 6A).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Xie et al., 2005
Cites
The basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,653 · see citing works
Diffusion tensor MR imaging of the human brain
Pierpaoli, C., Jezzard, P., Basser, P. J., Barnett, A., & Di Chiro, G. (1996) · Radiology · doi:10.1148/radiology.201.3.8939209 · Cited by 2,664 · see citing works
Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment
Jack, C. R., Petersen, R. C., Xu, Y. C., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Waring, S. C., Tangalos, E. G., & Kokmen, E. (1999) · Neurology · doi:10.1212/wnl.52.7.1397 · Cited by 1,404 · see citing works
Fox, N. C., Crum, W. R., Scahill, R. I., Stevens, J. M., Janssen, J. C., & Rossor, M. N. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05408-3 · Cited by 455 · see citing works
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The cingulum bundle: Anatomy, function, and dysfunction
Bubb, E. J., Metzler-Baddeley, C., & Aggleton, J. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.008 · Cited by 740 · see citing works
A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease
Sexton, C. E., Kalu, U. G., Filippini, N., Mackay, C. E., & Ebmeier, K. P. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.019 · Cited by 410 · see citing works
Villain, N., Desgranges, B., Viader, F., de la Sayette, V., Mezenge, F., Landeau, B., Baron, J.-C., Eustache, F., & Chetelat, G. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1392-08.2008 · Cited by 366 · see citing works
van den Heuvel, M., Mandl, R., Luigjes, J., & Hulshoff Pol, H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2964-08.2008 · Cited by 349 · see citing works
White matter damage in Alzheimer disease and its relationship to gray matter atrophy
Agosta, F., Pievani, M., Sala, S., Geroldi, C., Galluzzi, S., Frisoni, G. B., & Filippi, M. (2011) · Radiology · doi:10.1148/radiol.10101284 · Cited by 288 · see citing works
Bosch, B., Arenaza-Urquijo, E. M., Rami, L., Sala-Llonch, R., Junqué, C., Solé-Padullés, C., Peña-Gómez, C., Bargalló, N., Molinuevo, J. L., & Bartrés-Faz, D. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.02.004 · Cited by 272 · see citing works
Is Alzheimer’s a disease of the white matter?
Sachdev, P. S., Zhuang, L., Braidy, N., & Wen, W. (2013) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32835ed6e8 · Cited by 137 · see citing works
Suridjan, I., Pollock, B. G., Verhoeff, N. P. L. G., Voineskos, A. N., Chow, T., Rusjan, P. M., Lobaugh, N. J., Houle, S., Mulsant, B. H., & Mizrahi, R. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.1 · Cited by 132 · see citing works
Bozzali, M., Giulietti, G., Basile, B., Serra, L., Spanò, B., Perri, R., Giubilei, F., Marra, C., Caltagirone, C., & Cercignani, M. (2012) · Human Brain Mapping · doi:10.1002/hbm.21287 · Cited by 107 · see citing works
White matter microstructural damage in Alzheimer's disease at different ages of onset
Canu, E., Agosta, F., Spinelli, E. G., Magnani, G., Marcone, A., Scola, E., Falautano, M., Comi, G., Falini, A., & Filippi, M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.026 · Cited by 42 · see citing works
Automated tractography of the cingulate bundle in Alzheimer's disease: a multicenter DTI study
Fischer, F. U., Scheurich, A., Wegrzyn, M., Schermuly, I., Bokde, A. L. W., Klöppel, S., Pouwels, P. J. W., Teipel, S., Yakushev, I., & Fellgiebel, A. (2012) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.23621 · Cited by 34 · see citing works
Wang, Z., Dai, Z., Shu, H., Liu, D., Guo, Q., He, Y., & Zhang, Z. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160724 · Cited by 26 · see citing works
- Authors
- Xie, S., Xiao, J. X., Wang, Y. H., Wu, H. K., Gong, G. L., & Jiang, X. X.
- Affiliations
- Peking University First Hospital (CN)
- Chinese Academy of Sciences (CN)
- Venue
- NeuroReport
- Published
- 2005-08-22
- Volume
- 16
- Issue
- 12
- Pages
- 1275-1278
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W1976676059
- Cited by
- 68
- References
- 4
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 7 · 2013: 7 · 2012: 9
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, cingulum, fractional anisotropy, diffusion tractography, hippocampal volume, cognitive impairment, white matter integrity, Mini-Mental State Examination
- MeSH terms
- Aged, Aged, 80 and over, Algorithms, Alzheimer Disease, Atrophy, Female, Gyrus Cinguli, Hippocampus, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Mental Status Schedule, Middle Aged, Statistics as Topic, Anisotropy
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