Multiple DTI index analysis in normal aging, amnestic MCI and AD. Relationship with neuropsychological performance
Abstract
White matter (WM) damage has been reported in Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) in diffusion tensor imaging (DTI) studies. It is, however, unknown how the investigation of multiple tensor indexes in the same patients, can differentiate them from normal aging or relate to patients cognition. Forty-six individuals (15 healthy, 16 a-MCI and 15 AD) were included. Voxel-based tract based spatial-statistics (TBSS) was used to obtain whole-brain maps of main WM bundles for fractional anisotropy (FA), radial diffusivity (DR), axial diffusivity (DA) and mean diffusivity (MD). FA reductions were evidenced among AD patients with posterior predominance. A-MCI patients displayed reduced mean FA in these critical regions, compared to healthy elders. MD increases were widespread in both groups of patients. Interestingly, a-MCI patients exhibited DR increases in overlapping areas of FA shrinkages in AD, whereas DA increases were only observed in AD. Gray matter atrophy explained most DTI differences, except those regarding MD in both groups as well as DR increases in posterior associative pathways among a-MCI cases. FA values were the only DTI measure significantly related to memory performance among patients. Present findings suggest that most DTI-derived changes in AD and a-MCI are largely secondary to gray matter atrophy. Notably however, specific DR signal increases in posterior parts of the inferior fronto-occipital and longitudinal fasciculi may reflect early WM compromise in preclinical dementia, which is independent of atrophy. Finally, global measures of integrity, particularly orientation coherence (FA) of diffusion, appear to be more closely related to the cognitive profile of our patients than indexes reflecting water movement parallel (DA) and perpendicular (DR) to the primary diffusion direction.
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An increase in axial diffusivity was observed, albeit in a spatially more restricted manner when compared to that of the other DTI indices.
“Consistent with previous studies in mild cognitive impairment (O’Dwyer et al., 2012) and Alzheimer’s disease dementia (Acosta-Cabronero et al., 2010, 2012; Bosch et al., 2012), we observed an increase in axial diffusivity, albeit in a spatially more restricted manner when compared to that of the other DTI indices.”
From White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease (2018) · cites this paper as Bosch et al., 2012
Hyperphosphorylated tau becomes dissociated from microtubules, leading to impairment of axonal transport and appearance of dystrophic axons.
“Hyperphosphorylated tau becomes dissociated from microtubules, leading to impairment of axonal transport and appearance of dystrophic axons 8–11.”
From Amyloid-beta induced retrograde axonal degeneration in a mouse tauopathy model (2019) · cites this paper as [8]
Cites
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630 · see citing works
Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data
Smith, S. M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T. E., Mackay, C., Watkins, K., Ciccarelli, O., Cader, M., Matthews, P., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.024 · Cited by 6,035 · see citing works
MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging
Fazekas, F., Chawluk, J. B., Alavi, A. A., Hurtig, H. I., & Zimmerman, R. A. (1987) · American Journal of Roentgenology · doi:10.2214/ajr.149.2.351 · Cited by 5,327 · see citing works
The basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,653 · see citing works
The Neuropsychological Assessment
Ogden, J. A. (2005) · Oxford University Press eBooks · doi:10.1093/oso/9780195171358.003.0002 · Cited by 4,382 · see citing works
Basser, P. J., & Pierpaoli, C. (1996) · Journal of Magnetic Resonance, Series B · doi:10.1006/jmrb.1996.0086 · Cited by 4,306 · see citing works
Moms, J. C., Heyman, A., Mohs, R. C., Hughes, J. P., van Belle, G., Fillenbaum, G., Mellits, E. D., & Clark, C. (1989) · Neurology · doi:10.1212/wnl.39.9.1159 · Cited by 4,130 · see citing works
Diffusion tensor imaging: Concepts and applications
Le Bihan, D., Mangin, J., Poupon, C., Clark, C. A., Pappata, S., Molko, N., & Chabriat, H. (2001) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1076 · Cited by 3,547 · see citing works
Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859 · see citing works
Diffusion tensor imaging of the brain
Alexander, A. L., Lee, J. E., Lazar, M., & Field, A. S. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.05.011 · Cited by 2,747 · see citing works
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268 · see citing works
Accurate, Robust, and Automated Longitudinal and Cross-Sectional Brain Change Analysis
Smith, S. M., Zhang, Y., Jenkinson, M., Chen, J. M., Matthews, P. M., Federico, A., & Stefano, N. D. (2002) · NeuroImage · doi:10.1006/nimg.2002.1040 · Cited by 2,013 · see citing works
Demyelination increases radial diffusivity in corpus callosum of mouse brain
Song, S.-K., Yoshino, J., Le, T. Q., Lin, S.-J., Sun, S.-W., Cross, A. H., & Armstrong, R. C. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.028 · Cited by 1,658 · see citing works
Alzheimer’s Disease Neuroimaging Initiative
Mueller, S. G., Weiner, M. W., Thal, L. J., Petersen, R. C., Jack, C. R., Jagust, W. J., Trojanowski, J. Q., Toga, A. W., & Beckett, L. A. (2007) · Springer eBooks · doi:10.1007/978-0-387-72076-0_18 · Cited by 1,493 · see citing works
Genuine memory deficits in dementia
Grober, E. H., & Herman Buschke, L. (1987) · Developmental Neuropsychology · doi:10.1080/87565648709540361 · Cited by 1,045 · see citing works
A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study
Brun, A., & Englund, E. (1986) · Annals of Neurology · doi:10.1002/ana.410190306 · Cited by 1,014 · see citing works
Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease
Bartzokis, G. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.03.001 · Cited by 968 · see citing works
Why Voxel-based morphometry should be used
Ashburner, J., & Friston, K. J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0961 · Cited by 842 · see citing works
Smith, S. M., Johansen‐Berg, H., Jenkinson, M., Rueckert, D., Nichols, T. E., Miller, K. L., Robson, M. D., Jones, D. K., Klein, J. C., Bartsch, A. J., et al. (2007) · Nature Protocols · doi:10.1038/nprot.2007.45 · Cited by 578 · see citing works
Bozzali, M. (2002) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.6.742 · Cited by 568 · see citing works
The effect of filter size on VBM analyses of DT-MRI data
Jones, D. K., Symms, M. R., Cercignani, M., & Howard, R. J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.02.013 · Cited by 562 · see citing works
Petrides, M., & Pandya, D. Ν. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902730106 · Cited by 547 · see citing works
Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease
Zhang, Y., Schuff, N. W., Jahng, G., Bayne, W., Mori, S., Schad, L. R., Mueller, S. G., Du, A., Kramer, J. H., Yaffe, K. S., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000250326.77323.01 · Cited by 508 · see citing works
White matter changes in mild cognitive impairment and AD: a diffusion tensor imaging study
Medina, D., deToledo-Morrell, L., Urresta, F., Gabrieli, J. D. E., Moseley, M., Fleischman, D., Bennett, D. A., Leurgans, S., Turner, D. A., & Stebbins, G. T. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.026 · Cited by 492 · see citing works
Bennett, I. J., Madden, D. J., Vaidya, C. J., Howard, D. V., & Howard, J. H. (2009) · Human Brain Mapping · doi:10.1002/hbm.20872 · Cited by 485 · see citing works
Martino, J., Brogna, C., Robles, S. G., Vergani, F., & Duffau, H. (2010) · Cortex · doi:10.1016/j.cortex.2009.07.015 · Cited by 476 · see citing works
Assessing the effects of age on long white matter tracts using diffusion tensor tractography
Davis, S. W., Dennis, N. A., Buchler, N. G., White, L. E., Madden, D. J., & Cabeza, R. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.01.068 · Cited by 458 · see citing works
Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD
Yoshita, M., Fletcher, E., Harvey, D., Ortega, M., Martinez, O., Mungas, D. M., Reed, B. R., & DeCarli, C. S. (2006) · Neurology · doi:10.1212/01.wnl.0000249119.95747.1f · Cited by 434 · see citing works
Diffusion tensor imaging of the brain: review of clinical applications
Sundgren, P. C., Dong, Q., Gomez‐Hassan, D. M., Mukherji, S. K., Maly, P. V., & Welsh, R. C. (2004) · Neuroradiology · doi:10.1007/s00234-003-1114-x · Cited by 427 · see citing works
Absolute diffusivities define the landscape of white matter degeneration in Alzheimer’s disease
Acosta-Cabronero, J., Williams, G. B., Pengas, G., & Nestor, P. J. (2010) · Brain · doi:10.1093/brain/awp257 · Cited by 393 · see citing works
Jones, D. K., & Leemans, A. (2010) · Methods in molecular biology · doi:10.1007/978-1-61737-992-5_6 · Cited by 391 · see citing works
Solé‐Padullés, C., Bartrés‐Faz, D., Junqué, C., Vendrell, P., Rami, L., Clemente, I. C., Bosch, B., Villar, A., Bargalló, N., Jurado, M. Á., et al. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.10.008 · Cited by 387 · see citing works
Self-citationUngerleider, L. G., Gaffan, D., & Pelak, V. S. (1989) · Experimental Brain Research · doi:10.1007/bf00248903 · Cited by 357 · see citing works
White matter damage on diffusion tensor imaging correlates with age-related cognitive decline
Charlton, R. A., Barrick, T. R., McIntyre, D. J., Shen, Y., O'Sullivan, M., Howe, F. A., Clark, C. A., Morris, R. G., & Markus, H. S. (2006) · Neurology · doi:10.1212/01.wnl.0000194256.15247.83 · Cited by 354 · see citing works
Cognitive aging, executive function, and fractional anisotropy: a diffusion tensor MR imaging study.
Grieve, S. M., Williams, L. M., Paul, R. H., Clark, C. R., & Gordon, E. (2007) · PubMed Central · Cited by 350 · see citing works
Sullivan, E. V., Rohlfing, T., & Pfefferbaum, A. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.04.007 · Cited by 346 · see citing works
Regional white matter volume differences in nondemented aging and Alzheimer's disease
Salat, D. H., Greve, D. N., Pacheco, J., Quinn, B. T., Helmer, K. G., Buckner, R. L., & Fischl, B. R. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.10.030 · Cited by 312 · see citing works
Stricker, N. H., Schweinsburg, B. C., Delano‐Wood, L., Wierenga, C. E., Bangen, K. J., Haaland, K. Y., Frank, L. R., Salmon, D. P., & Bondi, M. W. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.11.027 · Cited by 308 · see citing works
Topography of the uncinate fascicle and adjacent temporal fiber tracts
Ebeling, U., & Cramon, D. V. (1992) · Acta Neurochirurgica · doi:10.1007/bf01406373 · Cited by 300 · see citing works
Mild cognitive impairment and Alzheimer disease: regional diffusivity of water
Kantarci, K., Jack, C. R., Xu, Y. C., Campeau, N. G., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Kokmen, E., Tangalos, E. G., et al. (2001) · Radiology · doi:10.1148/radiology.219.1.r01ap14101 · Cited by 300 · see citing works
Regional rates of neocortical atrophy from normal aging to early Alzheimer disease
McDonald, C. R., McEvoy, L. K., Gharapetian, L., Fennema-Notestine, C., Hagler, D. J., Holland, D., Koyama, A., Brewer, J. B., & Dale, A. M. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b16431 · Cited by 299 · see citing works
Fellgiebel, A., Wille, P., Müller, M. J., Winterer, G., Scheurich, A., Vucurevic, G., Schmidt, L. G., & Stoeter, P. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000077817 · Cited by 298 · see citing works
Harsan, L. A., Poulet, P., Guignard, B., Steibel, J., Parizel, N., de Sousa, P. L., Boehm, N., Grucker, D., & Ghandour, M. S. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20742 · Cited by 284 · see citing works
Gouw, A. A., Seewann, A., Vrenken, H., van der Flier, W. M., Rozemuller, J. M., Barkhof, F., Scheltens, P., & Geurts, J. J. G. (2008) · Brain · doi:10.1093/brain/awn265 · Cited by 281 · see citing works
White matter pathology isolates the hippocampal formation in Alzheimer's disease
Salat, D. H., Tuch, D. S., van der Kouwe, A. J. W., Greve, D. N., Pappu, V., Lee, S. Y., Hevelone, N. D., Zaleta, A. K., Growdon, J. H., Corkin, S., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.03.013 · Cited by 279 · see citing works
Zahr, N. M., Torsten Rohlfing, B., Pfefferbaum, A., & Sullivan, E. V. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.09.046 · Cited by 276 · see citing works
Fellgiebel, A., Müller, M. J., Wille, P. R., Dellani, P. R., Scheurich, A., Schmidt, L., & Stoeter, P. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.11.006 · Cited by 261 · see citing works
Qiu, D., Tan, L., Zhou, K., & Khong, P. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.02.023 · Cited by 250 · see citing works
White matter tract integrity in aging and Alzheimer's disease
Damoiseaux, J. S., Smith, S. M., Witter, M. P., Sanz‐Arigita, E., Barkhof, F., Scheltens, P., Stam, C. J., Zarei, M., & Rombouts, S. A. R. B. (2008) · Human Brain Mapping · doi:10.1002/hbm.20563 · Cited by 249 · see citing works
Liu, Y., Spulber, G., Lehtimäki, K. K., Könönen, M., Hallikainen, I., Gröhn, H., Kivipelto, M., Hallikainen, M., Vanninen, R., & Soininen, H. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.10.006 · Cited by 236 · see citing works
Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer’s disease.
Mielke, M. M., Kozauer, N. A., Chan, K. C. G., George, M., Toroney, J., Zerrate, M., Bandeen-Roche, K., Wang, M.-C., vanZijl, P., & Pekar, J. J. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.01.054 · Cited by 225 · see citing works
Huang, J., Friedland, R. P., & Auchus, A. P. (2007) · American Journal of Neuroradiology · doi:10.3174/ajnr.a0700 · Cited by 220 · see citing works
Neuropathology of white matter changes in Alzheimer’s disease and vascular dementia
Englund, E. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051183 · Cited by 213 · see citing works
Voxel-based detection of white matter abnormalities in mild Alzheimer disease
Xie, S., Xiao, J., Gong, G., Zang, Y., Wang, Y., Wu, H., & Jiang, X. X. (2006) · Neurology · doi:10.1212/01.wnl.0000219625.77625.aa · Cited by 208 · see citing works
Rose, S. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.074336 · Cited by 189 · see citing works
Tyszka, J., Readhead, C., Bearer, E., Pautler, R., & Jacobs, R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.08.037 · Cited by 187 · see citing works
Diffusion-weighted MR imaging of the hippocampus and temporal white matter in Alzheimer's disease
Hanyu, H., Sakurai, H., Iwamoto, T., Takasaki, M., Shindo, H., & Abe, K. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00043-4 · Cited by 175 · see citing works
. Identification of Alzheimer and vascular lesion thresholds for mixed dementia.
Gold, G., Giannakopoulos, P., Herrmann, F. R., Bouras, C., & Kovari, E. (2007) · Brain · doi:10.1093/brain/awm228 · Cited by 163 · see citing works
Human brain myelination and amyloid beta deposition in Alzheimer's disease
Bartzokis, G., Lu, P. H., & Mintz, J. (2007) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2007.01.019 · Cited by 162 · see citing works
Wang, L., Goldstein, F. C., Veledar, E., Levey, A. I., Lah, J. J., MELTZER, C. C., Holder, C. A., & Mao, H. (2009) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1484 · Cited by 145 · see citing works
Taoka, T., Iwasaki, S., Sakamoto, M., Nakagawa, H., Fukusumi, A., Myochin, K., Hirohashi, S., Hoshida, T., & Kichikawa, K. (2006) · PubMed Central · Cited by 127 · see citing works
Yasmin, H., Nakata, Y., Aoki, S., Abe, O., Sato, N., Nemoto, K., Arima, K., Furuta, N., Uno, M., Hirai, S., et al. (2008) · Neuroradiology · doi:10.1007/s00234-007-0353-7 · Cited by 117 · see citing works
Kiuchi, K., Morikawa, M., Taoka, T., Nagashima, T., Yamauchi, T., Makinodan, M., Norimoto, K., Hashimoto, K., Kosaka, J., Inoue, Y., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.052 · Cited by 116 · see citing works
Duan, J., Wang, H., Xu, J., Lin, X. Z., Chen, S., Kang, Z., & Yao, Z. (2006) · Surgical and Radiologic Anatomy · doi:10.1007/s00276-006-0111-2 · Cited by 115 · see citing works
Huang, J., & Auchus, A. P. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.021 · Cited by 102 · see citing works
Stout, J. C., Jernigan, T. L., Archibald, S. L., & Salmon, D. P. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550080056013 · Cited by 101 · see citing works
Schiavone, F., Charlton, R. A., Barrick, T. R., Morris, R. G., & Markus, H. S. (2008) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21572 · Cited by 98 · see citing works
Decreased myelin lipids in Alzheimer's disease and vascular dementia
Wallin, A., Gottfries, C. G., Karlsson, I., & Svennerholm, L. T. (1989) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1989.tb03886.x · Cited by 97 · see citing works
Walhovd, K. B., Fjell, A. M., Amlien, I. K., Grambaitė, R., Stenset, V. T. V., Bjørnerud, A., Reinvang, I., Gjerstad, L., Cappelen, T., & Due‐Tønnessen, P. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.10.053 · Cited by 96 · see citing works
Functional relevant loss of long association fibre tracts integrity in early Alzheimer's disease
Fellgiebel, A., Schermuly, I., Gerhard, A., Keller, I., Albrecht, J., Weibrich, C., Müller, M. J., & Stoeter, P. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.12.010 · Cited by 85 · see citing works
Zhang, Y., Du, A., Hayasaka, S., Jahng, G., Hlavin, J. A., Zhan, W., Weiner, M. W., & Schuff, N. W. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.10.009 · Cited by 80 · see citing works
Regional distribution of measurement error in diffusion tensor imaging
Marenco, S., Rawlings, R. R., Rohde, G. K., et al. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.01.008 · Cited by 76 · see citing works
Diffusion tensor changes in patients with amnesic mild cognitive impairment and various dementias
Chen, T., Lin, C.-C., Chen, Y., Liu, H., Hua, M., Huang, Y., & Chiu, M. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2008.09.002 · Cited by 75 · see citing works
Evaluation of bilateral cingulum with tractography in patients with Alzheimer’s disease
Xie, S., Xiao, J. X., Wang, Y. H., Wu, H. K., Gong, G. L., & Jiang, X. X. (2005) · NeuroReport · doi:10.1097/01.wnr.0000174061.41897.ee · Cited by 68 · see citing works
Balthazar, M. L. F., Yasuda, C. L., Pereira, F., Pedro, T., Damasceno, B. P., & Cendes, F. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02408.x · Cited by 60 · see citing works
Abnormal integrity of association fiber tracts in amnestic mild cognitive impairment
Bai, F., Zhang, Z., Watson, D. R., Yu, H., Shi, Y., Yuan, Y., Qian, Y., & Jia, J. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.12.009 · Cited by 59 · see citing works
Nakata, Y., Sato, N., Nemoto, K., Abe, O., Shikakura, S., Arima, K., Furuta, N., Uno, M., Hirai, S., Masutani, Y., et al. (2008) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2008.07.013 · Cited by 59 · see citing works
Contributors to white matter damage in the frontal lobe in Alzheimer's disease
Chalmers, K. A., Wilcock, G., & Love, S. (2005) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2005.00678.x · Cited by 56 · see citing works
Rami, L., Gómez‐Ansón, B., Sánchez‐Valle, R., Bosch, B., Monté, G. C., Lladó, A., & Molinuevo, J. L. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000109750 · Cited by 50 · see citing works
Self-citationWhite Matter Hyperintensities and Cognitive Dysfunction in Alzheimer Disease
Heo, J., Lee, S., Chu, K., Park, H.-J., Shim, J.-Y., & Kim, M. (2009) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988709335800 · Cited by 43 · see citing works
Regional white matter decreases in alzheimer's disease using optimized voxel-based morphometry
Li, S., Pu, F., Shi, F., Xie, S., Wang, Y., & Jiang, T. (2008) · Acta Radiologica · doi:10.1080/02841850701627181 · Cited by 38 · see citing works
Yoshiura, T., Mihara, F., Koga, H., Ohyagi, Y., Noguchi, T., Togao, O., Ogomori, K., Miyoshi, K., Yamasaki, T., Kaneko, K., et al. (2006) · Academic Radiology · doi:10.1016/j.acra.2006.09.042 · Cited by 19 · see citing works
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Mechanisms of white matter changes induced by meditation
Tang, Y.-Y., Lu, Q., Fan, M., Yang, Y., & Posner, M. I. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207817109 · Cited by 335 · see citing works
Fibre-specific white matter reductions in Alzheimer’s disease and mild cognitive impairment
Mito, R., Raffelt, D., Dhollander, T., Vaughan, D. N., Tournier, J.-D., Salvado, O., Brodtmann, A., Rowe, C. C., Villemagne, V. L., & Connelly, A. (2018) · Brain · doi:10.1093/brain/awx355 · Cited by 309 · see citing works
Jacobs, H. I. L., Van Boxtel, M. P. J., Jolles, J., Verhey, F. R. J., & Uylings, H. B. M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.06.009 · Cited by 293 · see citing works
White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease
Araque Caballero, M. Á., Suárez-Calvet, M., Duering, M., Franzmeier, N., Benzinger, T., Fagan, A. M., Bateman, R. J., Jack, C. R., Levin, J., Dichgans, M., et al. (2018) · Brain · doi:10.1093/brain/awy229 · Cited by 179 · see citing works
“, 2012) and Alzheimer’s disease dementia (Acosta-Cabronero et al., 2010, 2012; Bosch et al., 2012), we observed an increase in axial diffusivity, albeit in a spatially more restricted manner when compared to that of the other DTI indices.”
ResultGold, B. T., Johnson, N. F., Powell, D. K., & Smith, C. D. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.07.009 · Cited by 170 · see citing works
Bartzokis, G., Lu, P. H., Heydari, P., Couvrette, A., Lee, G. J., Kalashyan, G., Freeman, F., Grinstead, J. W., Villablanca, P., Finn, J. P., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.010 · Cited by 152 · see citing works
Is Alzheimer’s a disease of the white matter?
Sachdev, P. S., Zhuang, L., Braidy, N., & Wen, W. (2013) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32835ed6e8 · Cited by 137 · see citing works
DTI analyses and clinical applications in Alzheimer’s disease
Oishi, K., Mielke, M. M., Albert, M., Lyketsos, C. G., & Mori, S. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-0007 · Cited by 134 · see citing works
Clerx, L., Visser, P. J., Verhey, F., & Aalten, P. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110797 · Cited by 132 · see citing works
O'Dwyer, L., Lamberton, F., Bokde, A. L. W., Ewers, M., Faluyi, Y. O., Tanner, C., Mazoyer, B., O'Neill, D., Bartley, M., Collins, D. R., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021745 · Cited by 119 · see citing works
O'Dwyer, L., Lamberton, F., Bokde, A. L. W., Ewers, M., Faluyi, Y. O., Tanner, C., Mazoyer, B., O'Neill, D., Bartley, M., Collins, D. R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032441 · Cited by 117 · see citing works
Gold, B. T., Powell, D. K., Andersen, A. H., & Smith, C. D. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.05.036 · Cited by 112 · see citing works
Hahn, C., Lim, H.-K., Won, W. Y., Ahn, K. J., Jung, W.-S., & Lee, C. U. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053493 · Cited by 76 · see citing works
Diminution of context association memory structure in subjects with subjective cognitive decline
Fan, L., Lai, Y., Chen, T., Hsu, Y., Chen, P., Huang, K., Cheng, T., Tseng, W. I., Hua, M., Chen, Y., et al. (2018) · Human Brain Mapping · doi:10.1002/hbm.24022 · Cited by 40 · see citing works
White matter microstructural damage in Alzheimer's disease at different ages of onset
Canu, E., Agosta, F., Spinelli, E. G., Magnani, G., Marcone, A., Scola, E., Falautano, M., Comi, G., Falini, A., & Filippi, M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.026 · Cited by 42 · see citing works
O'Dwyer, L., Lamberton, F., Matura, S., Scheibe, M., Miller, J., Rujescu, D., Prvulovic, D., & Hampel, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036024 · Cited by 34 · see citing works
Amyloid-beta induced retrograde axonal degeneration in a mouse tauopathy model
Nishioka, C., Liang, H.-F., Barsamian, B., & Sun, S.-W. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.01.007 · Cited by 30 · see citing works
Dong, G., Li, H., & Potenza, M. N. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00372 · Cited by 27 · see citing works
Scrascia, F., Curcio, G., Ursini, F., Trotta, L., Quintiliani, L., Migliore, S., Altamura, C., Pitocco, F., Altavilla, R., Melgari, J.-M., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130788 · Cited by 22 · see citing works
- Authors
- Bosch, B., Arenaza-Urquijo, E. M., Rami, L., Sala-Llonch, R., Junqué, C., Solé-Padullés, C., Peña-Gómez, C., Bargalló, N., Molinuevo, J. L., & Bartrés-Faz, D.
- Affiliations
- Hospital Clínic de Barcelona (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 33
- Issue
- 1
- Pages
- 61-74
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2002665706
- Cited by
- 272
- References
- 82
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 7 · 2023: 12 · 2022: 10 · 2021: 11 · 2020: 7 · 2019: 16 · 2018: 19 · 2017: 18 · 2016: 21 · 2015: 26 · 2014: 19 · 2013: 38 · 2012: 23
- FWCI
- 18.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Spanish Ministerio de Educación y Ciencia research project award (SAF2007-66,270)
- Spanish Ministerio de Ciencia e Innovación (SAF2009-07,489)
- Generalitat de Catalunya to the Neuropsychology Research Group (2009SGR941)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, amnestic mild cognitive impairment, normal aging, white matter integrity, fractional anisotropy, radial diffusivity, axial diffusivity, mean diffusivity, gray matter atrophy, memory performance, tract-based spatial statistics, inferior fronto-occipital fasciculus, longitudinal fasciculus, preclinical dementia, white matter microstructure
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alzheimer Disease, Atrophy, Brain Mapping, Cerebral Cortex, Cognition, Female, Humans, Male, Memory, Neuropsychological Tests, Prospective Studies, Anisotropy, Diffusion Tensor Imaging, Cognitive Dysfunction
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