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Can patients with oral allergy syndrome be at risk of anaphylaxis?
Abstract
Purpose of review: Oral allergy syndrome, also known as pollen-food syndrome (PFS), is a condition usually associated with adults and characterized by mild transient oropharyngeal symptoms. The purpose of this review is to determine whether systemic or anaphylactic reactions do occur and if so, who is affected and what are the triggers. Recent findings: An increasing number of studies demonstrate that PFS occurs all age groups, and a significant number of affected adults do experience systemic and anaphylactic reactions. The upsurge in the adoption of vegan lifestyles, increase in consumption of fruits and vegetables including smoothies and juices, and use of plant foods in nutritional or body-building supplements, could exacerbate this. Changes in pollen and pollution levels, cofactors and sensitization to other plant food allergens may also be involved. Summary: While the majority of those with PFS will continue to experience mild symptoms, all individuals should be properly advised regarding the dangers of concentrated or unusual forms of plant food allergens such as smoothies, juices, soy/nut milks and nutritional supplements. Further well characterized studies are needed to determine risk factors for severe reactions, and sensitization patterns to pollens and plant food allergens.
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“Although most cases involve mild symptoms localized to the oral cavity, severe systemic reactions, including anaphylaxis, are reported in a small but significant subset of patients [62,63], underscoring the importance of early diagnosis and management.”
From Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges (2024) · cites this paper as [62]
In the citing paper
“Systemic reactions are estimated to occur in approximately 2-10% of PFAS cases, with severe outcomes such as hypotension and respiratory distress being extremely rare (1-2%) [54,57,62,63].”
From Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges (2024) · cites this paper as [62]
In the citing paper
“Systemic reactions are estimated to occur in approximately 2-10% of PFAS cases, with severe outcomes such as hypotension and respiratory distress being extremely rare (1-2%) [54,57,62,63].”
From Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges (2024) · cites this paper as [62]
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Food-Induced Anaphylaxis: Role of Hidden Allergens and Cofactors
Skypala, I. J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00673 · Cited by 96
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Cited by
Sorted by citations
Kato, Y., Morikawa, T., & Fujieda, S. (2025) · Allergology International · doi:10.1016/j.alit.2024.08.007 · Cited by 45
Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges
Haidar, L., Bănărescu, C. F., Uța, C., Moldovan, S. I., Zimbru, E.-L., Zimbru, R.-I., Ciurariu, E., Georgescu, M., & Panaitescu, C. (2024) · Applied Sciences · doi:10.3390/app15010066 · Cited by 21
Metadata
- Authors
- Skypala, I. J.
- Affiliations
- Royal Brompton & Harefield NHS Foundation Trust
- Venue
- Current Opinion in Allergy & Clinical Immunology
- Published
- 2020-07-28
- Volume
- 20
- Issue
- 5
- Pages
- 459-464
- ISSN
- 1528-4050
- 1473-6322
- Cited by
- 30
- References
- 1
- Language
- en
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