Cited by 659Anesthesia and Pain ManagementPain Management and TreatmentPediatric Pain Management Techniques

Preoperative Anxiety and Catastrophizing: A Systematic Review and Meta-analysis of the Association With Chronic Postsurgical Pain

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Theunissen, Maurice, Peters, Madelon L., Bruce, Julie, Gramke, Hans-Fritz, Marcus, Marco A.·2012·The Clinical Journal of Pain

Abstract

OBJECTIVES: Anxiety and pain catastrophizing predict acute postoperative pain. However, it is not well established whether they also predict chronic postsurgical pain (CPSP). The aim of this systematic review and meta-analysis was to investigate whether high levels of preoperative anxiety or pain catastrophizing are associated with an increased risk of CPSP. METHODS: Electronic search databases included PubMed and PsychINFO. Additional literature was obtained by reference tracking and expert consultation. Studies from 1958 until October 2010, investigating the association between preoperative anxiety or pain catastrophizing and CPSP in adult surgery patients, were assessed. The primary outcome was the presence of pain at least 3 months postoperatively. RESULTS: Twenty-nine studies were included; 14 instruments were used to assess anxiety or pain catastrophizing. Sixteen studies (55%) reported a statistically significant association between anxiety or pain catastrophizing and CPSP. The proportion of studies reporting a statistically significant association was 67% for studies of musculoskeletal surgery and 36% for other types of surgery. There was no association with study quality, but larger studies were more likely to report a statistically significant relationship. The overall pooled odds ratio, on the basis of 15 studies, ranged from 1.55 (95% confidence interval, 1.10-2.20) to 2.10 (95% confidence interval, 1.49-2.95). Pain catastrophizing might be of higher predictive utility compared with general anxiety or more specific pain-related anxiety. DISCUSSION: There is evidence that anxiety and catastrophizing play a role in the development of CPSP. We recommend that anxiety measures should be incorporated in future studies investigating the prediction and transition from acute to chronic postoperative pain.

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  • The most frequent psychological risk factors for CPSP and fatigue include anxiety, such as hypervigilance and pain catastrophizing.

    “The most frequent tap into anxiety, such as hypervigilance and pain catastrophizing [24–28].”

    From Pre- and post-operative psychological interventions to prevent pain and fatigue after breast cancer surgery (PREVENT): Protocol for a randomized controlled trial (2022) · cites this paper as [28]

    The Discussion reports that preoperative anxiety or pain catastrophizing was significantly associated with chronic postsurgical pain in 16 of 29 studies. The paper does not establish that these are the most frequent psychological risk factors, and the cited passages do not address fatigue or identify hypervigilance as a risk factor. (LLM, conf=0.86)

    Experimental — accuracy not yet measured
  • Positive outcome expectancy has been identified as a protective factor in the transition from acute to chronic pain.

    “Positive outcome expectancy has been identified as a protective factorfrom the transition from acute to chronic pain 354–356.”

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Research works printed but not linked: 4

  1. Huber C, Lautenbacher S. The relevance of psychological variables in postoperative pain -Psychological variables and postoperative pain. Anasth Intensivmed. 2008;49:1-16.
  2. Joanna Briggs Institute. Joanna Briggs Insitute Reviewers' Manual: 2008 edition. 2008 ed. Adelaide: The Joanna Briggs Institute; 2008.
  3. Brander VA, Stulberg SD, Adams AD, et al. Predicting total knee replacement pain: a prospective, observational study. Clin Orthop Relat Res. 2003;416:27-36.
  4. Brander V, Gondek S, Martin E, et al. Pain and depression influence outcome 5 years after knee replacement surgery. Clin Orthop Relat Res. 2007;464:21-26.

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Authors
Theunissen, M., Peters, M. L., Bruce, J., Gramke, H.-F., & Marcus, M. A.
Affiliations
  • Maastricht University Medical Centre (NL)
  • Maastricht University (NL)
  • University of Warwick (GB)
Corresponding author
  • Theunissen, Maurice
  • Gramke, Hans-Fritz
  • Marcus, Marco A.
Venue
The Clinical Journal of Pain
Published
2012-11
Volume
28
Issue
9
Pages
819-841
ISSN
0749-8047 (ISSN-L)
OpenAlex
W1974125795
Cited by
659
References
64
Citations by year
2026: 45 · 2025: 31 · 2024: 34 · 2023: 91 · 2022: 50 · 2021: 53 · 2020: 39 · 2019: 111 · 2018: 49 · 2017: 37 · 2016: 33 · 2015: 30 · 2014: 35 · 2013: 20 · 2012: 1
FWCI
5.31
Type
journal article
Language
en
Licence
other-oa
Locations
  • Clinical Journal of Pain (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
Keywords
preoperative anxiety, pain catastrophizing, chronic postoperative pain, postoperative pain, pain-related anxiety, musculoskeletal surgery, risk prediction, acute to chronic pain transition
MeSH terms
Anxiety, Female, Humans, Male, Pain Measurement, Postoperative Pain, Databases, Bibliographic, Catastrophization

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