Cited by 175Pain Mechanisms and TreatmentsNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

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Oxytocin and Pain: A Systematic Review and Synthesis of Findings

Rash, Joshua A., Aguirre-Camacho, Aldo, Campbell, Tavis S.·2014·The Clinical Journal of Pain

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Abstract

OBJECTIVES: A review of the literature was conducted to assess the association between oxytocin (OT) and pain. METHODS: PsychInfo, PubMed, and Medline (EBSCO) research databases were searched for peer-reviewed articles written between 1950 and 2012. Of a total of 1166 articles returned, 50 (9 human, 33 animal, and 8 spinal cord samples) met full inclusion criteria and were included in the review. RESULTS: OT had a reliable effect as defined by increasing pain tolerance in 29 of 33 animal studies reviewed. This effect persisted across central and peripheral modes of administration and type of noxious stimulus used (eg, heat, electric). The results suggest that OT acts as an analgesic for acute pain in animals. Preliminary research with humans offers consistent evidence to suggest that OT decreases pain sensitivity, though the reliability and stability of such effects cannot yet be determined. Although the findings are encouraging, there is a need for methodologically rigorous work in humans where OT is administered centrally. DISCUSSION: Further research seems to be warranted as the existence of biologically and psychologically plausible mechanisms linking OT and pain have been well supported using animal models with limited but encouraging human research. Implications and recommendations are discussed. Findings from this research may inform therapeutic methods for the management of pain.

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Self-citation
How does maternal oxytocin influence children's mental health problem and maternal mental health problem?
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Self-citation

Authors: Rash, J. A., Aguirre-Camacho, A., & Campbell, T. S.
Affiliations: University of Calgary (CA)
ORCID: Rash, Joshua A.
Campbell, Tavis S.
Venue: The Clinical Journal of Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2014-05
Volume: 30
Issue: 5
Pages: 453-462
ISSN: 0749-8047 (ISSN-L)
DOI: 10.1097/ajp.0b013e31829f57df
OpenAlex: W2015140100
Cited by: 175
References: 37
Citations by year: 2026: 8 · 2025: 19 · 2024: 13 · 2023: 14 · 2022: 10 · 2021: 22 · 2020: 14 · 2019: 9 · 2018: 15 · 2017: 12 · 2016: 14 · 2015: 9 · 2014: 14
FWCI: 1.40
Type: journal article
Language: en
Open access: closed
Locations: Clinical Journal of Pain (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, pain, analgesia, pain tolerance, acute pain, noxious stimuli, thermal pain, animal models, human subjects research, pain management, centralized management
MeSH terms: Analgesics, Animals, Disease Models, Animal, Humans, Oxytocin, Pain, Spinal Cord, Databases, Factual

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Oxytocin and Pain: A Systematic Review and Synthesis of Findings

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