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Resting-state Network-specific Breakdown of Functional Connectivity during Ketamine Alteration of Consciousness in Volunteers
Open accessAbstract
Background: Consciousness-altering anesthetic agents disturb connectivity between brain regions composing the resting-state consciousness networks (RSNs). The default mode network (DMn), executive control network, salience network (SALn), auditory network, sensorimotor network (SMn), and visual network sustain mentation. Ketamine modifies consciousness differently from other agents, producing psychedelic dreaming and no apparent interaction with the environment. The authors used functional magnetic resonance imaging to explore ketamine-induced changes in RSNs connectivity. Methods: Fourteen healthy volunteers received stepwise intravenous infusions of ketamine up to loss of responsiveness. Because of agitation, data from six subjects were excluded from analysis. RSNs connectivity was compared between absence of ketamine (wake state [W1]), light ketamine sedation, and ketamine-induced unresponsiveness (deep sedation [S2]). Results: Increasing the depth of ketamine sedation from W1 to S2 altered DMn and SALn connectivity and suppressed the anticorrelated activity between DMn and other brain regions. During S2, DMn connectivity, particularly between the medial prefrontal cortex and the remaining network (effect size β [95% CI]: W1 = 0.20 [0.18 to 0.22]; S2 = 0.07 [0.04 to 0.09]), and DMn anticorrelated activity ( e.g. , right sensory cortex: W1 = −0.07 [−0.09 to −0.04]; S2 = 0.04 [0.01 to 0.06]) were broken down. SALn connectivity was nonuniformly suppressed ( e.g. , left parietal operculum: W1 = 0.08 [0.06 to 0.09]; S2 = 0.05 [0.02 to 0.07]). Executive control networks, auditory network, SMn, and visual network were minimally affected. Conclusions: Ketamine induces specific changes in connectivity within and between RSNs. Breakdown of frontoparietal DMn connectivity and DMn anticorrelation and sensory and SMn connectivity preservation are common to ketamine and propofol-induced alterations of consciousness.
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“Based on fMRI, functional disconnections of frontal-parietal networks have been shown during general anesthesia in humans induced by structurally and pharmacologically diverse agents, including the volatile anesthetic sevoflurane [131, 139–141]”
From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [139]
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Metadata
- Authors
- Bonhomme, V., Vanhaudenhuyse, A., Demertzi, A., Bruno, M.-A., Jaquet, O., Bahri, M. A., Plenevaux, A., Boly, M., Boveroux, P., Soddu, A., Brichant, J. F., Maquet, P., & Laureys, S.
- Affiliations
- Western University (CA)
- University of Liège (BE)
- Corresponding author
- Bonhomme, Vincent
- ORCID
- Venue
- Anesthesiology
- Published
- 2016-11
- Volume
- 125
- Issue
- 5
- Pages
- 873-888
- ISSN
- 0003-3022 (ISSN-L)
- OpenAlex
- W2518058704
- Cited by
- 207
- References
- 47
- Citations by year
- 2026: 20 · 2025: 18 · 2024: 23 · 2023: 15 · 2022: 18 · 2021: 24 · 2020: 23 · 2019: 24 · 2018: 22 · 2017: 14 · 2016: 6
- FWCI
- 14.00
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Anesthesiology (publishedVersion)
- PubMed (publishedVersion)
- Scholarship@Western (Western University) (publishedVersion, cc-by-nc-nd)
- Scholarship@Western (Western University) (submittedVersion, cc-by-nc-nd)
- Open Repository and Bibliography (University of Liège) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Keywords
- ketamine, altered states of consciousness, resting-state networks, functional connectivity, default mode network, salience network, frontoparietal network, sensorimotor network, auditory network, visual network, propofol, medial prefrontal cortex, frontoparietal connectivity
- MeSH terms
- Adult, Anesthetics, Dissociative, Brain, Consciousness, Female, Humans, Image Processing, Computer-Assisted, Ketamine, Magnetic Resonance Imaging, Male, Nerve Net, Reference Values, Rest, Young Adult
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