Effect of Subanesthetic Ketamine on Intrinsic Functional Brain Connectivity: A Placebo-controlled Functional Magnetic Resonance Imaging Study in Healthy Male Volunteers
Open accessAbstract
Background: The influence of psychoactive drugs on the central nervous system has been investigated with positron emission tomography and task-related functional magnetic resonance imaging. However, it is not known how these drugs affect the intrinsic large-scale interactions of the brain (resting-state functional magnetic resonance imaging connectivity). In this study, the effect of low-dose S(+)-ketamine on intrinsic brain connectivity was investigated. Methods: Twelve healthy, male volunteers received a 2-h intravenous S(+)-ketamine infusion (first hour 20 mg/70 kg, second hour 40 mg/70 kg). Before, during, and after S(+)-ketamine administration, resting-state brain connectivity was measured. In addition, heat pain tests were performed between imaging sessions to determine ketamine-induced analgesia. A mixed-effects general linear model was used to determine drug and pain effects on resting-state brain connectivity. Results: Ketamine increased the connectivity most importantly in the cerebellum and visual cortex in relation to the medial visual network. A decrease in connectivity was observed in the auditory and somatosensory network in relation to regions responsible for pain sensing and the affective processing of pain, which included the amygdala, insula, and anterior cingulate cortex. Connectivity variations related to fluctuations in pain scores were observed in the anterior cingulate cortex, insula, orbitofrontal cortex, and the brainstem, regions involved in descending inhibition of pain. Conclusions: Changes in connectivity were observed in the areas that explain ketamine's pharmacodynamic profile with respect to analgesia and psychedelic and other side effects. In addition, pain and ketamine changed brain connectivity in areas involved in endogenous pain modulation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Ketamine counters the hyper-excitatory state in ascending pain circuitry through NMDAR inhibition while also enhancing activity in brain regions involved in top-down pain inhibition, such as the prefrontal cortex and brainstem.
“ketamine counters the hyper-excitatory state present in ascending pain circuitry through NMDAR inhibition while also enhancing the activity of brain regions involved in top-down inhibition of pain centers such as the PFC and brainstem (Niesters et al., 2012).”
From Mechanisms of ketamine and its metabolites as antidepressants (2022) · cites this paper as Niesters et al., 2012
The PAIN MEDICINE section identifies ketamine as an NMDA receptor antagonist and links pain relief to increased connectivity in the orbitofrontal cortex and brainstem, regions involved in descending pain inhibition. The RSN Connectivity on Pain Processing section attributes that connectivity change to variation in pain scores, not simply to a drug-induced increase in activity. The paper does not establish that ketamine counters a hyper-excitatory state in ascending pain circuitry through NMDA receptor inhibition. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630 · see citing works
SMITH, S., & NICHOLS, T. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.061 · Cited by 5,250 · see citing works
Correspondence of the brain's functional architecture during activation and rest
Smith, S. M., Fox, P. T., Miller, K. L., Glahn, D. C., Fox, P. M., Mackay, C. E., Filippini, N., Watkins, K. E., Toro, R., Laird, A. R., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905267106 · Cited by 5,150 · see citing works
Consistent resting-state networks across healthy subjects
Damoiseaux, J. S., Rombouts, S. A. R. B., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., & Beckmann, C. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601417103 · Cited by 4,326 · see citing works
Self-citationInvestigations into resting-state connectivity using independent component analysis
Beckmann, C. F., DeLuca, M., Devlin, J. T., & Smith, S. M. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1634 · Cited by 3,398 · see citing works
Mesulam, M. (1998) · Brain · doi:10.1093/brain/121.6.1013 · Cited by 3,072 · see citing works
Toward discovery science of human brain function
Biswal, B. B., Mennes, M., Zuo, X.-N., Gohel, S., Kelly, C., Smith, S. M., Beckmann, C. F., Adelstein, J. S., Buckner, R. L., Colcombe, S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911855107 · Cited by 2,970 · see citing works
Self-citationNeural correlates of the psychedelic state as determined by fMRI studies with psilocybin
Carhart-Harris, R. L., Erritzoe, D., Williams, T., Stone, J. M., Reed, L. J., Colasanti, A., Tyacke, R. J., Leech, R., Malizia, A. L., Murphy, K., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119598109 · Cited by 1,172 · see citing works
Ossipov, M. H., Dussor, G. O., & Porreca, F. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43766 · Cited by 1,165 · see citing works
Activation of the Opioidergic Descending Pain Control System Underlies Placebo Analgesia
Eippert, F., Bingel, U., Schoell, E. D., Yacubian, J., Klinger, R., Lorenz, J., & Büchel, C. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.014 · Cited by 839 · see citing works
Boveroux, P., Vanhaudenhuyse, A., Bruno, M.-A., Noirhomme, Q., Lauwick, S., Luxen, A., Degueldre, C., Plenevaux, A., Schnakers, C., Phillips, C., et al. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181f697f5 · Cited by 630 · see citing works
Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network
Bingel, U., Lorenz, J., Schoell, E., Weiller, C., & Büchel, C. (2006) · Pain · doi:10.1016/j.pain.2005.08.027 · Cited by 567 · see citing works
General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis
Brown, E. N., Purdon, P. L., & Dort, C. J. V. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153200 · Cited by 551 · see citing works
Sigtermans, M. J., van Hilten, J. J., Bauer, M. C. R., Arbous, M. S., Marinus, J., Sarton, E. Y., & Dahan, A. (2009) · Pain · doi:10.1016/j.pain.2009.06.023 · Cited by 468 · see citing works
Self-citationPsychedelic Effects of Ketamine in Healthy Volunteers
Bowdle, A. T., Radant, A. D., Cowley, D. S., Kharasch, E. D., Strassman, R. J., & Roy‐Byrne, P. (1998) · Anesthesiology · doi:10.1097/00000542-199801000-00015 · Cited by 370 · see citing works
Adverse events associated with ketamine for procedural sedation in adults
Strayer, R. J., & Nelson, L. S. (2008) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2007.12.005 · Cited by 325 · see citing works
Deakin, J. F. W., Lees, J., McKie, S., Hallak, J. E. C., Williams, S. R., & Dursun, S. M. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.37 · Cited by 311 · see citing works
Prestimulus functional connectivity determines pain perception in humans
Ploner, M., Lee, M., Wiech, K., Bingel, U., & Tracey, I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906186106 · Cited by 297 · see citing works
King, C. D., Wong, F., Currie, T., Mauderli, A. P., Fillingim, R. B., & Riley, J. L. (2009) · Pain · doi:10.1016/j.pain.2008.12.027 · Cited by 284 · see citing works
Långsjö, J., Kaisti, K. K., Aalto, S., Hinkka‐Yli‐Salomäki, S., Aantaa, R., Oikonen, V., Sipilä, H. T., Kurki, T. J. I., Silvanto, M., & Scheinin, H. (2003) · Anesthesiology · doi:10.1097/00000542-200309000-00016 · Cited by 238 · see citing works
Brain functional integration decreases during propofol-induced loss of consciousness
Schrouff, J., Perlbarg, V., Boly, M., Marrelec, G., Boveroux, P., Vanhaudenhuyse, A., Bruno, M., Laureys, S., Phillips, C. L. M., Pélégrini‐Issac, M., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.04.020 · Cited by 228 · see citing works
Evaluating the Affective Component of the Cerebellar Cognitive Affective Syndrome
Wolf, U., Rapoport, M. J., & Schweizer, T. A. (2009) · Journal of Neuropsychiatry · doi:10.1176/jnp.2009.21.3.245 · Cited by 195 · see citing works
S -Ketamine Anesthesia Increases Cerebral Blood Flow in Excess of the Metabolic Needs in Humans
Långsjö, J., Maksimow, A. T., Salmi, E., Kaisti, K. K., Aalto, S., Oikonen, V., Hinkka‐Yli‐Salomäki, S., Aantaa, R., Sipilä, H. T., Viljanen, T., et al. (2005) · Anesthesiology · doi:10.1097/00000542-200508000-00008 · Cited by 160 · see citing works
Eikermann, M., Grosse-Sundrup, M., Zaremba, S., Henry, M., Bittner, E. A., Hoffmann, U., & Chamberlin, N. L. (2011) · Anesthesiology · doi:10.1097/aln.0b013e31823d010a · Cited by 152 · see citing works
S(+)-ketamine Effect on Experimental Pain and Cardiac Output
Sigtermans, M. J., Dahan, A., Mooren, R. A. G., Bauer, M., Kest, B., Sarton, E. Y., & Olofsen, E. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181b437b1 · Cited by 151 · see citing works
Self-citationEffect of intrapulmonary tetrahydrocannabinol administration in humans
Zuurman, L., Roy, C., Schoemaker, R. C., Hazekamp, A., den Hartigh, J., Bender, J., Verpoorte, R., Pinquier, J. L., Cohen, A., & van Gerven, J. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108089581 · Cited by 139 · see citing works
Rogers, R., Wise, R. G., Painter, D., Longe, S., & Tracey, I. (2004) · Anesthesiology · doi:10.1097/00000542-200402000-00018 · Cited by 132 · see citing works
Effects of Subanesthetic Ketamine on Regional Cerebral Glucose Metabolism in Humans
Långsjö, J. W., Salmi, E., Kaisti, K. K., Aalto, S., Hinkka, S., Aantaa, R., Oikonen, V., Viljanen, T., Kurki, T., Silvanto, M., et al. (2004) · Anesthesiology · doi:10.1097/00000542-200405000-00006 · Cited by 123 · see citing works
Ketamine for the treatment of chronic non-cancer pain
Noppers, I. M., Niesters, M., Aarts, L. P. H. J., Smith, T., Sarton, E. Y., & Dahan, A. (2010) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2010.515978 · Cited by 120 · see citing works
Self-citationNeuroimaging: visualising the brain in pain
May, A. (2007) · Neurological Sciences · doi:10.1007/s10072-007-0760-x · Cited by 118 · see citing works
Khalili‐Mahani, N., Zoethout, R. M. W., Beckmann, C. F., Baerends, E., de Kam, M. L., Soeter, R. P., Dahan, A., van Buchem, M. A., van Gerven, J. M. A., & Rombouts, S. A. R. B. (2012) · Human Brain Mapping · doi:10.1002/hbm.21265 · Cited by 114 · see citing works
Self-citationRespiratory Interactions of Ketamine and Morphine
Bourke, D. L., Malit, L. A., & Smith, T. C. (1987) · Anesthesiology · doi:10.1097/00000542-198702000-00008 · Cited by 110 · see citing works
Ketamine alters neural processing of facial emotion recognition in healthy men: an fMRI study
Abel, K. M., Allin, M. P. G., Kucharska‐Pietura, K., David, A. S., Andrew, C., Williams, S., Brammer, M. J., & Phillips, M. L. (2003) · Neuroreport · doi:10.1097/00001756-200303030-00018 · Cited by 109 · see citing works
Derbyshire, S. W. G., & Osborn, J. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.04.032 · Cited by 107 · see citing works
Temporal changes in cortical activation during conditioned pain modulation (CPM), a LORETA study
Moont, R., Crispel, Y., Lev, R., Pud, D., & Yarnitsky, D. (2011) · Pain · doi:10.1016/j.pain.2011.01.036 · Cited by 106 · see citing works
Offset Analgesia in Neuropathic Pain Patients and Effect of Treatment with Morphine and Ketamine
Niesters, M., Hoitsma, E., Sarton, E. Y., Aarts, L. P. H. J., & Dahan, A. (2011) · Anesthesiology · doi:10.1097/aln.0b013e31822fd03a · Cited by 104 · see citing works
Self-citationEffect of ketamine on endogenous pain modulation in healthy volunteers
Niesters, M., Dahan, A., Swartjes, M., Noppers, I. M., Fillingim, R. B., Aarts, L. P. H. J., & Sarton, E. Y. (2011) · Pain · doi:10.1016/j.pain.2010.12.015 · Cited by 92 · see citing works
Self-citationRigby, M., Bourdellès, B. L., HEAVENS, R. P., Kelly, S., Smith, D. W., Butler, A., Hammans, R., Hills, R., Xuereb, J. H., Hill, R., et al. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00089-9 · Cited by 92 · see citing works
Benarroch, E. E. (2011) · Neurology · doi:10.1212/wnl.0b013e31821b7cc9 · Cited by 90 · see citing works
Ketamine effects on brain function — Simultaneous fMRI/EEG during a visual oddball task
Musso, F., Brinkmeyer, J., Ecker, D., London, M. K., Thieme, G., Warbrick, T., Wittsack, H., Saleh, A., Greb, W., de Boer, P., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.045 · Cited by 80 · see citing works
Imaging Pain Modulation by Subanesthetic S-(+)-Ketamine
Sprenger, T., Valet, M., Woltmann, R., Zimmer, C., Freynhagen, R., Kochs, E. F., ̈lle, T. R. T., & Wagner, K. J. (2006) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000231635.14872.40 · Cited by 78 · see citing works
Swartjes, M., Morariu, A. M., Niesters, M., Aarts, L. P. H. J., & Dahan, A. (2011) · Anesthesiology · doi:10.1097/aln.0b013e31821bdb9b · Cited by 57 · see citing works
Self-citationFu, C. H. Y., Abel, K. M., Allin, M. P. G., Gasston, D., Costafreda, S. G., John Suckling, A., Williams, S., & McGuire, P. K. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0154-9 · Cited by 52 · see citing works
Hong-luan, Y., Li, Q., Wang, D., Shi, L., Lü, G., Sun, L., Wang, L., Zhu, W. H., Mak, Y. T., Wong, N.-K., et al. (2011) · NeuroToxicology · doi:10.1016/j.neuro.2011.11.001 · Cited by 52 · see citing works
BOLD fMRI mapping of brain responses to nociceptive stimuli in rats under ketamine anesthesia
Shih, Y. I., Chang, C., Chen, J., & Jaw, F.-S. (2008) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2007.12.004 · Cited by 37 · see citing works
Neural correlates of S-ketamine induced psychosis during overt continuous verbal fluency
Nagels, A., Kirner-Veselinovic, A., Krach, S., & Kircher, T. T. J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.021 · Cited by 35 · see citing works
Effects of ketamine-induced psychopathological symptoms on continuous overt rhyme fluency
Nagels, A., Kirner-Veselinovic, A., Wiese, R., Paulus, F. M., Kircher, T. T. J., & Krach, S. (2011) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-011-0281-8 · Cited by 24 · see citing works
Chamberlin, N. L., & Eikermann, M. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181f69825 · Cited by 21 · see citing works
Ketamine-Induced Disruption of Verbal Self-Monitoring Linked to Superior Temporal Activation
Stone, J. M., Abel, K. M., Allen, M. P. G., van Haren, N. E. M., Matsumoto, K., McGuire, P. K., & Fu, C. H. Y. (2010) · Pharmacopsychiatry · doi:10.1055/s-0030-1267942 · Cited by 18 · see citing works
Flagged first, then by citations
1 of the 50 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Schwenk, E. S., Viscusi, E. R., Buvanendran, A., Hurley, R. W., Wasan, A. D., Narouze, S., Bhatia, A., Davis, F. N., Hooten, W. M., & Cohen, S. P. (2018) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0000000000000806 · Cited by 628 · see citing works
Ketamine for chronic pain: risks and benefits
Niesters, M., Martini, C. H., & Dahan, A. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12094 · Cited by 514 · see citing works
Self-citationResting-State Functional MR Imaging: A New Window to the Brain
Barkhof, F., Haller, S., & Rombouts, S. A. R. B. (2014) · Radiology · doi:10.1148/radiol.14132388 · Cited by 383 · see citing works
Self-citationReviewing the ketamine model for schizophrenia
Frohlich, J., & Van Horn, J. D. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881113512909 · Cited by 303 · see citing works
Ketamine use in current clinical practice
Gao, M., Rejaei, D., & Liu, H. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.5 · Cited by 286 · see citing works
Muthukumaraswamy, S. D., Shaw, A. D., Jackson, L. E., Hall, J., Moran, R., & Saxena, N. K. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0903-15.2015 · Cited by 230 · see citing works
Bonhomme, V., Vanhaudenhuyse, A., Demertzi, A., Bruno, M.-A., Jaquet, O., Bahri, M. A., Plenevaux, A., Boly, M., Boveroux, P., Soddu, A., et al. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001275 · Cited by 207 · see citing works
Mechanisms of ketamine and its metabolites as antidepressants
Hess, E. M., Riggs, L. M., Michaelides, M., & Gould, T. D. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114892 · Cited by 169 · see citing works
Maher, D. P., Chen, L. L., & Mao, J. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001787 · Cited by 166 · see citing works
Ketamine for the treatment of addiction: evidence and potential mechanisms
Ivan Ezquerra-Romano, I., Lawn, W., Krupitsky, E., & Morgan, C. J. A. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.017 · Cited by 163 · see citing works
Role of Ketamine in Acute Postoperative Pain Management: A Narrative Review
Radvansky, B. M., Shah, K., Parikh, A., Sifonios, A. N., Le, V., & Eloy, J. D. (2015) · BioMed Research International · doi:10.1155/2015/749837 · Cited by 132 · see citing works
Ketamine applications beyond anesthesia – A literature review
Nowacka, A., & Borczyk, M. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172547 · Cited by 129 · see citing works
Persson, J. (2013) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12111 · Cited by 125 · see citing works
DeLorenzo, C., DellaGioia, N., Bloch, M. H., Sanacora, G., Nabulsi, N., Abdallah, C. G., Yang, J., Wen, R., Mann, J. J., Krystal, J. H., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.024 · Cited by 105 · see citing works
Gass, N., Schwarz, A. J., Sartorius, A., Schenker, E., Risterucci, C., Spedding, M., Zheng, L., Meyer‐Lindenberg, A., & Weber‐Fahr, W. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.290 · Cited by 104 · see citing works
Kraguljac, N. V., Frölich, M. A., Tran, S., White, D. M., Nichols, N., Barton-McArdle, A., Reid, M. A., Bolding, M., & Lahti, A. C. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.122 · Cited by 101 · see citing works
Niesters, M., Aarts, L. P. H. J., Sarton, E. Y., & Dahan, A. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aes578 · Cited by 99 · see citing works
Self-citationKetamine-Associated Brain Changes: A Review of the Neuroimaging Literature
Ionescu, D. F., Felicione, J. M., Gosai, A., Cusin, C., Shin, P., Shapero, B. G., & Deckersbach, T. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000179 · Cited by 91 · see citing works
Shahbabaie, A., Ebrahimpoor, M., Hariri, A., Nitsche, M. A., Hatami, J., Fatemizadeh, E., Oghabian, M. A., & Ekhtiari, H. (2018) · Brain and Behavior · doi:10.1002/brb3.922 · Cited by 80 · see citing works
Fomberstein, K., Qadri, S., & Ramani, R. (2013) · Current Opinion in Anaesthesiology · doi:10.1097/01.aco.0000433060.59939.fe · Cited by 77 · see citing works
Single-dose serotonergic stimulation shows widespread effects on functional brain connectivity
Klaassens, B. L., van Gorsel, H. C., Khalili-Mahani, N., van der Grond, J., Wyman, B. T., Whitcher, B., Rombouts, S. A. R. B., & van Gerven, J. M. A. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.08.012 · Cited by 76 · see citing works
Self-citationJoules, R., Doyle, O., Schwarz, A. J., O’Daly, O., Brammer, M. J., Williams, S., & Mehta, M. A. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3951-9 · Cited by 76 · see citing works
Chen, X., Spaeth, R. B., Freeman, S. G., Scarborough, D. M., Hashmi, J. A., Wey, H., Egorova, N., Vangel, M. G., Mao, J., Wasan, A. D., et al. (2015) · Molecular Pain · doi:10.1186/s12990-015-0071-9 · Cited by 76 · see citing works
Shimonovich, S., Gigi, R., Shapira, A., Sarig‐Meth, T., Nadav, D., Rozenek, M., West, D., & Halpern, P. (2016) · BMC Emergency Medicine · doi:10.1186/s12873-016-0107-0 · Cited by 75 · see citing works
Comorbidities and the Complexities of Chronic Pain
Dahan, A., van Velzen, M., & Niesters, M. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000402 · Cited by 73 · see citing works
Self-citationNarrative Review: Low-Dose Ketamine for Pain Management
Riccardi, A., Guarino, M., Serra, S., Spampinato, M. D., Vanni, S., Shiffer, D., Voza, A., Fabbri, A., & Iaco, F. D. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12093256 · Cited by 74 · see citing works
Kamp, J., van Velzen, M., Olofsen, E., Boon, M., Dahan, A., & Niesters, M. (2019) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2019.1689958 · Cited by 70 · see citing works
Self-citationKhalili‐Mahani, N., Rombouts, S. A. R. B., van Osch, M. J. P., Duff, E. P., Carbonell, F., Nickerson, L. D. H., Becerra, L. R., Dahan, A., Evans, A. C., Soucy, J., et al. (2017) · Human Brain Mapping · doi:10.1002/hbm.23516 · Cited by 61 · see citing works
Self-citationEffect of subanaesthetic ketamine on plasma and saliva cortisol secretion
Khalili‐Mahani, N., Martini, C. H., Olofsen, E., Dahan, A., & Niesters, M. (2015) · British Journal of Anaesthesia · doi:10.1093/bja/aev135 · Cited by 66 · see citing works
Self-citationMüller, F., Musso, F., London, M. K., de Boer, P., Zacharias, N., & Winterer, G. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.05.037 · Cited by 64 · see citing works
Jonkman, K., Dahan, A., van de Donk, T., Aarts, L. P. H. J., Niesters, M., & van Velzen, M. (2017) · F1000Research · doi:10.12688/f1000research.11372.1 · Cited by 63 · see citing works
Self-citationChronic administration of ketamine induces cognitive deterioration by restraining synaptic signaling
Luo, Y., Yang, Y., Zhang, M., He, H., & Fan, N. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0793-6 · Cited by 61 · see citing works
Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives
Pallavicini, C., Vilas, M. G., Villarreal, M. F., Zamberlán, F., Muthukumaraswamy, S. D., Nutt, D., Carhart-Harris, R. L., & Tagliazucchi, E. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.06.053 · Cited by 55 · see citing works
Humo, M., Ayazgök, B., Becker, L. J., Waltisperger, E., Rantamäki, T., & Yalçın, İ. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109898 · Cited by 54 · see citing works
Anesthesia, brain changes, and behavior: Insights from neural systems biology
Colon, É., Bittner, E. A., Kussman, B. D., McCann, M. E., Soriano, S. G., & Borsook, D. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.01.005 · Cited by 57 · see citing works
Ketamine and esketamine in suicidal thoughts and behaviors: a systematic review
Jollant, F., Colle, R., Nguyen, T. M. L., Corruble, E., Gardier, A. M., Walter, M., Abbar, M., & Wagner, G. (2023) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253231151327 · Cited by 56 · see citing works
Resting state functional connectivity: Its physiological basis and application in neuropharmacology
Lu, H., & Stein, E. A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.023 · Cited by 54 · see citing works
The Pharmacology of Visual Hallucinations in Synucleinopathies
Russo, M., Carrarini, C., Dono, F., Rispoli, M. G., Pietro, M. D., Stefano, V. D., Ferri, L., Bonanni, L., Sensi, S. L., & ONOFRJ, M. C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01379 · Cited by 56 · see citing works
The neurophysiology of ketamine: an integrative review
McMillan, R. L., & Muthukumaraswamy, S. D. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2019-0090 · Cited by 49 · see citing works
Klaassens, B. L., van Gerven, J., Klaassen, E. S., van der Grond, J., & Rombouts, S. A. R. B. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.05.044 · Cited by 52 · see citing works
Self-citationDoss, M. K., May, D. G., Johnson, M. W., Clifton, J. M., Hedrick, S. L., Prisinzano, T. E., Griffiths, R. R., & Barrett, F. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-73216-8 · Cited by 52 · see citing works
Application of Ketamine in Pain Management and the Underlying Mechanism
Ma, X., Yan, J., & Jiang, H. (2023) · Pain Research and Management · doi:10.1155/2023/1928969 · Cited by 51 · see citing works
Khalili‐Mahani, N., Niesters, M., van Osch, M. J. P., Oitzl, M. S., Veer, I. M., de Rooij, M., van Gerven, J., van Buchem, M. A., Beckmann, C. F., Rombouts, S. A. R. B., et al. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.12.050 · Cited by 50 · see citing works
Self-citationMultistage drug effects of ketamine in the treatment of major depression
Walter, M., Li, S., & Demenescu, L. R. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0535-3 · Cited by 47 · see citing works
Schwertner, A., Zortéa, M., Torres, F. V., & Caumo, W. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00070 · Cited by 47 · see citing works
Nugent, A. C., Robinson, S. E., Coppola, R., & Zarate, C. A. (2016) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2016.06.006 · Cited by 42 · see citing works
Liebe, T., Li, M., Čolić, L., Munk, M. H. J., Sweeney‐Reed, C. M., Woelfer, M., Kretzschmar, M., Steiner, J. H., von Düring, F., Behnisch, G., et al. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.09.001 · Cited by 45 · see citing works
Tajerian, M., Leu, D., Yang, P., Huang, T., Kingery, W. S., & Clark, J. D. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000889 · Cited by 41 · see citing works
Ketamine—A Narrative Review of Its Uses in Medicine
Radvansky, B. M., Puri, S., Sifonios, A. N., Eloy, J. D., & Le, V. (2015) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000000257 · Cited by 41 · see citing works
Disrupted offset analgesia distinguishes patients with chronic pain from healthy controls
Kobinata, H., Ikeda, E., Zhang, S., Li, T., Makita, K., & Kurata, J. (2017) · Pain · doi:10.1097/j.pain.0000000000000989 · Cited by 39 · see citing works
Dawson, N., McDonald, M., Higham, D. J., MORRIS, B. J., & Pratt, J. A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.26 · Cited by 37 · see citing works
Magnetic resonance imaging for chronic pain: diagnosis, manipulation, and biomarkers
Tu, Y., Cao, J., Bi, Y., & Hu, L. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1822-4 · Cited by 37 · see citing works
Klaassens, B. L., Rombouts, S. A. R. B., Winkler, A. M., van Gorsel, H. C., van der Grond, J., & van Gerven, J. (2016) · Human Brain Mapping · doi:10.1002/hbm.23362 · Cited by 35 · see citing works
Self-citationvan Velzen, M., Dahan, J. D. C., van Dorp, E. L. A., Mogil, J. S., Hooijmans, C. R., & Dahan, A. (2021) · Pain · doi:10.1097/j.pain.0000000000002231 · Cited by 34 · see citing works
Self-citationDistinct effects of ketamine and acetyl l-carnitine on the dopamine system in zebrafish
Robinson, B. L., Dumas, M., Cuevas, E., Gu, Q., Paule, M. G., Ali, S. F., & Kanungo, J. (2016) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2016.02.004 · Cited by 30 · see citing works
The Effect of Ketamine on Electrophysiological Connectivity in Major Depressive Disorder
Nugent, A. C., Ballard, E. D., Gilbert, J. R., Tewarie, P. K. B., Brookes, M. J., & Zarate, C. A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00519 · Cited by 30 · see citing works
Tricklebank, M. D., Robbins, T. W., Simmons, C., & Wong, E. H. F. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05787-x · Cited by 30 · see citing works
Motoyama, Y., Oshiro, Y., Takao, Y., Sato, H., Obata, N., Izuta, S., Mizobuchi, S., & Kan, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-49360-1 · Cited by 26 · see citing works
Neuropsychopharmacological effects of midazolam on the human brain
Wang, J., Sun, P., & Liang, P. (2020) · Brain Informatics · doi:10.1186/s40708-020-00116-y · Cited by 28 · see citing works
Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
Moujaes, F., Ji, J. L., Rahmati, M., Burt, J. B., Schleifer, C. H., Adkinson, B. D., Savić, A., Santamauro, N. P., Tamayo, Z., Diehl, C., et al. (2024) · eLife · doi:10.7554/elife.84173 · Cited by 27 · see citing works
Li, D., Vlisides, P. E., & Mashour, G. A. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.118891 · Cited by 24 · see citing works
Stone, J. M., Kotoula, V., Dietrich, C., Simoni, S. D., Krystal, J. H., & Mehta, M. A. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115592337 · Cited by 24 · see citing works
Adhikari, B. M., Dukart, J., Hipp, J. F., Forsyth, A., McMillan, R. L., Muthukumaraswamy, S. D., Ryan, M. C., Hong, L. E., Eickhoff, S. B., Jahandshad, N., et al. (2019) · Human Brain Mapping · doi:10.1002/hbm.24838 · Cited by 23 · see citing works
Effects of ketamine on brain function during smooth pursuit eye movements
Steffens, M., Becker, B., Neumann, C., Kasparbauer, A., Meyhöfer, I., Weber, B., Mehta, M. A., Hurlemann, R., & Ettinger, U. (2016) · Human Brain Mapping · doi:10.1002/hbm.23294 · Cited by 24 · see citing works
An Update on the Basic and Clinical Science of Ketamine Analgesia
Doan, L., & Wang, J. (2018) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000635 · Cited by 25 · see citing works
Kotoula, V., Webster, T., Stone, J. M., & Mehta, M. A. (2021) · Brain and Neuroscience Advances · doi:10.1177/23982128211055426 · Cited by 22 · see citing works
Adžić, M., Lukić, I., Mitić, M., Glavonic, E., Dragicevic-Curic, N., & Ivković, S. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121803 · Cited by 21 · see citing works
Kleinloog, D., den Boogaard, A. U., Dahan, A., Mooren, R. A. G., Klaassen, E. S., Stevens, J., Freijer, J. I., & van Gerven, J. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115570082 · Cited by 22 · see citing works
Self-citationFan, N., Luo, Y., Xu, K., Zhang, M., Ke, X., Huang, X., Ding, Y., Wang, D., Ning, Y., Deng, X., et al. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.11.006 · Cited by 22 · see citing works
Spies, M., Klöbl, M., Höflich, A. S., Hummer, A., Vanicek, T., Michenthaler, P., Kranz, G. S., Hahn, A., Winkler, D., Windischberger, C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-46702-x · Cited by 22 · see citing works
Archibald, J., MacMillan, E. L., Enzler, A., Jutzeler, C. R., Schweinhardt, P., & Kramer, J. L. K. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116794 · Cited by 20 · see citing works
Opposing effects of ketamine and acetyl l-carnitine on the serotonergic system of zebrafish
Robinson, B. L., Dumas, M., Paule, M. G., Ali, S. F., & Kanungo, J. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.09.006 · Cited by 19 · see citing works
Peng, F., Fan, J., Ge, T., Liu, Q. Q., & Li, B. J. (2020) · Cell Proliferation · doi:10.1111/cpr.12804 · Cited by 18 · see citing works
(2020) · Advances in Pharmacology · doi:10.1016/bs.apha.2020.04.003 · Cited by 18 · see citing works
Vogt, K. M., Ibinson, J. W., Smith, C., Citro, A. T., Norton, C. M., Karim, H. T., Popov, V., Mahajan, A., Aizenstein, H. J., Reder, L. M., et al. (2021) · Anesthesiology · doi:10.1097/aln.0000000000003774 · Cited by 18 · see citing works
Akintunde, S. B., Obayopo, S. O., Adekunle, A. S., Obisesan, O. R., & Olaoye, O. S. (2021) · Energy Reports · doi:10.1016/j.egyr.2021.06.070 · Cited by 18 · see citing works
Dose‐dependent effects of esketamine on brain activity in awake mice: A BOLD phMRI study
Kawazoe, K., McGlynn, R. P., Felix, W., Sevilla, R. S., Liao, S., Kulkarni, P., & Ferris, C. F. (2022) · Pharmacology Research & Perspectives · doi:10.1002/prp2.1035 · Cited by 18 · see citing works
Applications of Resting State Functional MR Imaging to Neuropsychiatric Diseases
Pearlson, G. D. (2017) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2017.06.005 · Cited by 18 · see citing works
Forsyth, A., McMillan, R. L., Campbell, D. A., Malpas, G. A., Maxwell, E., SLEIGH, J. W., Dukart, J., Hipp, J. F., & Muthukumaraswamy, S. D. (2019) · Human Brain Mapping · doi:10.1002/hbm.24889 · Cited by 17 · see citing works
Anesthesia and the neurobiology of fear and posttraumatic stress disorder
Vogt, K. M., & Pryor, K. O. (2022) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000001176 · Cited by 17 · see citing works
Thomas, J., Sharma, D., Mohanta, S., & Jain, N. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117694 · Cited by 17 · see citing works
Chang, Y. F., Li, J.-Y., Jayakumar, T., Hung, S.-H., Lee, W.-C., Manubolu, M., Sheu, J., & Hsu, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122545 · Cited by 16 · see citing works
Kleinloog, D., Rombouts, S. A. R. B., Zoethout, R., Klumpers, L. E., Niesters, M., Khalili‐Mahani, N., Dahan, A., & van Gerven, J. (2015) · Brain Connectivity · doi:10.1089/brain.2014.0314 · Cited by 16 · see citing works
Self-citationThe Emerging Role of Ketamine in Acute Postoperative Pain Management
Edinoff, A. N., Askins, D. H., Bobo, E., White, K. L., Eswani, Z., Jackson, E. D., Wenger, D. M., Kaye, A. J., Cornett, E. M., Kaye, A. M., et al. (2023) · Current Pain and Headache Reports · doi:10.1007/s11916-023-01134-1 · Cited by 15 · see citing works
Pain Management - Practices, Novel Therapies and Bioactives
Waisundara, V. Y., Banjari, I., & Balkić, J. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.87267 · Cited by 14 · see citing works
Zang, Z., Geiger, L. S., Braun, U., Cao, H., Zangl, M., Schäfer, A., Moessnang, C., Ruf, M., Reis, J., Schweiger, J. I., et al. (2018) · Network Neuroscience · doi:10.1162/netn_a_00045 · Cited by 15 · see citing works
Niesters, M., Sitsen, E., Oudejans, L. C. J., Vuyk, J., Aarts, L. P. H. J., Rombouts, S. A. R. B., de Rover, M., Khalili‐Mahani, N., & Dahan, A. (2014) · Brain Connectivity · doi:10.1089/brain.2014.0247 · Cited by 14 · see citing works
Self-citationChronic Opioid Therapy Modifies QST Changes After Ketamine Infusion in Chronic Pain Patients
Maher, D. P., Zhang, Y., Ahmed, S. U., Doshi, T. L., Malarick, C., Stabach, K., Mao, J., & Chen, L. L. (2017) · Journal of Pain · doi:10.1016/j.jpain.2017.07.008 · Cited by 14 · see citing works
Effects of ketamine on brain function during response inhibition
Steffens, M., Neumann, C., Kasparbauer, A., Becker, B., Weber, B., Mehta, M. A., Hurlemann, R., & Ettinger, U. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5081-7 · Cited by 12 · see citing works
Icaza, E. E., & Mashour, G. A. (2013) · Anesthesiology · doi:10.1097/01.anes.0000435635.42332.ee · Cited by 11 · see citing works
Amygdala activity associated with social choice in mice
Mihara, T., Mensah-Brown, K. G., Sobota, R., Lin, R., Featherstone, R. E., & Siegel, S. J. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.04.040 · Cited by 11 · see citing works
Ketamine normalizes high-gamma power in the anterior cingulate cortex in a rat chronic pain model
Friesner, I. D., Martinez, E., Zhou, H., Gould, J. D., Li, A., Chen, Z. S., Zhang, Q., & Wang, J. (2020) · Molecular Brain · doi:10.1186/s13041-020-00670-w · Cited by 11 · see citing works
Objective markers of the analgesic response to morphine in experimental pain research
Brokjær, A., Olesen, A. E., Kreilgaard, M., Graversen, C., Gram, M., Christrup, L. L., Dahan, A., & Drewes, A. M. (2015) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2015.01.005 · Cited by 10 · see citing works
Self-citationRegion- and time- specific effects of ketamine on cerebral blood flow: a randomized controlled trial
Gärtner, M., Weigand, A., Meiering, M. S., Weigner, D., Carstens, L., Keicher, C., Hertrampf, R., Beckmann, C. F., Mennes, M., Wunder, A., et al. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01605-4 · Cited by 9 · see citing works
Discriminative Structured Feature Engineering for Macroscale Brain Connectomes
Pu, J., Wang, J., Yu, W., Shen, Z., Lv, Q., Zeljic, K., Zhang, C., Sun, B., Liu, G., & Wang, Z. (2015) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2015.2431294 · Cited by 9 · see citing works
de la Salle, S., Choueiry, J., Shah, D. K., Bowers, H., McIntosh, J. F., Ilivitsky, V., Carroll, B., & Knott, V. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.173092 · Cited by 9 · see citing works
Ionescu, T. M., Grohs, G., & Hengerer, B. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1177428 · Cited by 7 · see citing works
Ketamine and other NMDA receptor antagonists for chronic pain
Ferraro, M. C., Cashin, A. G., O'Connell, N. E., Visser, E., Shaheed, C. A., Wewege, M. A., Gustin, S. M., & McAuley, J. H. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd015373 · Cited by 7 · see citing works
Ketamine infusion therapy for chronic pain management in South Korea
Castañeda, A. M., Choi, J. K., Lee, C.-S., Oh, E., Kim, Y., Moon, J. Y., Lee, P. B., & Kim, Y. C. (2018) · Medicine · doi:10.1097/md.0000000000011709 · Cited by 7 · see citing works
Wahdan, A. S., Mohamed, M. M., Helmy, N. Y., Shehata, G. M., & Salama, A. K. (2020) · Türk anesteziyoloji ve reanimasyon derneği dergisi · doi:10.5152/tjar.2020.787 · Cited by 6 · see citing works
- Authors
- Niesters, M., Khalili-Mahani, N., Martini, C., Aarts, L., van Gerven, J., van Buchem, M. A., Dahan, A., & Rombouts, S.
- Affiliations
- PhD Student.
- Senior Research Associate.
- PhD Student, Resident.
- Leiden University Medical Center (NL)
- Professor, Department of Neurology, Leiden University Medical Center, and Center for Human Drug Research, Leiden, The Netherlands.
- Professor, Leiden Institute for Brain and Cognition (LIBC) and Department of Radiology, Leiden University Medical Center.
- Leiden University (NL)
- Venue
- Anesthesiology
- Published
- 2012-10-01
- Volume
- 117
- Issue
- 4
- Pages
- 868-877
- ISSN
- 0003-3022 (ISSN-L)
- OpenAlex
- W2056836466
- Cited by
- 147
- References
- 50
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 6 · 2023: 9 · 2022: 4 · 2021: 12 · 2020: 17 · 2019: 14 · 2018: 12 · 2017: 11 · 2016: 13 · 2015: 18 · 2014: 10 · 2013: 10
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Anesthesiology (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Keywords
- subanesthetic ketamine, resting-state functional connectivity, intrinsic brain connectivity, ketamine analgesia, pain modulation, cerebellum, visual cortex, anterior cingulate cortex, insula, amygdala, descending pain inhibition, psychedelic effects, ketamine side effects
- MeSH terms
- Adult, Anesthetics, Dissociative, Brain, Data Interpretation, Statistical, Hallucinogens, Hot Temperature, Humans, Image Processing, Computer-Assisted, Injections, Intravenous, Ketamine, Magnetic Resonance Imaging, Male, Nerve Net, Pain, Pain Measurement, Linear Models, Single-Blind Method, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
