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Perioperative Hyperglycemia Management: An Update
Open accessAbstract
An association between perioperative hyperglycemia and adverse outcomes has been established in surgical patients, (1-3) with morbidity being reduced in those treated with insulin.(5-6) A practical treatment algorithm and literature summary is provided for surgical patients with diabetes and hyperglycemia.
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“In individuals undergoing noncardiac general surgery, basal insulin plus premeal short-or rapid-acting insulin (basal-bolus) coverage has been associated with improved glycemic outcomes and lower rates of perioperative complications compared with the reactive, correction-only short-or rapid-acting insulin coverage alone with no basal insulin dosing (74,145).”
From 16. Diabetes Care in the Hospital: Standards of Care in Diabetes—2026 (2026) · cites this paper as [145]
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Intensive versus Conventional Glucose Control in Critically Ill Patients
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Intensive insulin therapy and pentastarch resuscitation in severe sepsis
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Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes
Umpierrez, G. E., Isaacs, S. D., Bazargan, N., You, X., Thaler, L. M., & Kitabchi, A. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8341 · Cited by 2,195
Self-citationEsposito, K., Nappo, F., Marfella, R., Giugliano, G., Giugliano, F., Ciotola, M., Quagliaro, L., Ceriello, A., & Giugliano, D. (2002) · Circulation · doi:10.1161/01.cir.0000034509.14906.ae · Cited by 1,961 · cited 1×
“73 The majority of patients with an insulin pump have type 1 diabetes, but use is growing in type 2 diabetics.”
BackgroundMechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539
Umpierrez, G. E., Smiley, D., Zisman, A., Prieto, L. M., Palacio, A., Ceron, M., Puig, A., & Mejia, R. (2007) · Diabetes Care · doi:10.2337/dc07-0295 · Cited by 671
Self-citationHandelsman, Y., Henry, R. R., Bloomgarden, Z. T., Dagogo-Jack, S., DeFronzo, R. A., Einhorn, D., Ferrannini, E., Fonseca, V. A., Garber, A. J., Grunberger, G., et al. (2016) · Endocrine Practice · doi:10.4158/ep161292.ps · Cited by 358
Self-citationUmpierrez, G., Cardona, S., Pasquel, F., Jacobs, S., Peng, L., Unigwe, M., Newton, C. A., Smiley-Byrd, D., Vellanki, P., Halkos, M., et al. (2015) · Diabetes Care · doi:10.2337/dc15-0303 · Cited by 281
Self-citationUmpierrez, G. E., Smiley, D., Hermayer, K., Khan, A., Olson, D. E., Newton, C., Jacobs, S., Rizzo, M., Peng, L., Reyes, D., et al. (2013) · Diabetes Care · doi:10.2337/dc12-1988 · Cited by 222
Self-citationBellido, V., Suarez, L., Rodriguez, M. G., Sanchez, C., Dieguez, M., Riestra, M., Casal, F., Delgado, E., Menendez, E., & Umpierrez, G. E. (2015) · Diabetes Care · doi:10.2337/dc15-0160 · Cited by 118
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Cited by
Sorted by citations
Perioperative management of hyperglycemia and diabetes in cardiac surgery patients
Galindo, R. J., Fayfman, M., & Umpierrez, G. E. (2018) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2017.10.005 · Cited by 95
Self-citation16. Diabetes Care in the Hospital: Standards of Care in Diabetes—2026
American Diabetes Association Professional Practice Committee for Diabetes*, Bajaj, M., McCoy, R. G., Balapattabi, K., Bannuru, R. R., Bellini, N. J., Bennett, A. K., Beverly, E. A., Briggs Early, K., ChallaSivaKanaka, S., et al. (2026) · Diabetes Care · doi:10.2337/dc26-s016 · Cited by 80
Hulst, A. H., Visscher, M. J., Godfried, M. B., Thiel, B., Gerritse, B. M., Scohy, T. V., Bouwman, R. A., Willemsen, M. G. A., Hollmann, M. W., Preckel, B., et al. (2020) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13927 · Cited by 75
Inpatient hyperglycemia and transitions of care: A systematic review
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Metadata
- Authors
- Duggan, E. W., Carlson, K., & Umpierrez, G. E.
- Affiliations
- Emory University (US)
- Corresponding author
- Duggan, Elizabeth W.
- Venue
- Anesthesiology
- Published
- 2017-03
- Volume
- 126
- Issue
- 3
- Pages
- 547-560
- ISSN
- 0003-3022 (ISSN-L)
- PMC
- PMC5309204
- OpenAlex
- W2582059990
- Cited by
- 402
- References
- 10
- Citations by year
- 2026: 45 · 2025: 49 · 2024: 56 · 2023: 48 · 2022: 53 · 2021: 57 · 2020: 35 · 2019: 37 · 2018: 16 · 2017: 5
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Update notices
- erratum (2018-11-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Anesthesiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000454, UL1TR002378)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK111024)
- National Center for Research Resources (UL1RR025008, M01RR000039)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- perioperative hyperglycemia, diabetes mellitus, insulin therapy, treatment algorithm, surgical patients, adverse outcomes, glycemic control
- MeSH terms
- Humans, Hyperglycemia, Hypoglycemic Agents, Insulin, Perioperative Care
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