Importance of Perioperative Glycemic Control in General Surgery: A Report From the Surgical Care and Outcomes Assessment Program
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OBJECTIVE: To determine the relationship of perioperative hyperglycemia and insulin administration on outcomes in elective colon/rectal and bariatric operations. BACKGROUND: There is limited evidence to characterize the impact of perioperative hyperglycemia and insulin on adverse outcomes in patients, with and without diabetes, undergoing general surgical procedures. METHODS: The Surgical Care and Outcomes Assessment Program is a Washington State quality improvement benchmarking-based initiative. We evaluated the relationship of perioperative hyperglycemia (>180 mg/dL) and insulin administration on mortality, reoperative interventions, and infections for patients undergoing elective colorectal and bariatric surgery at 47 participating hospitals between fourth quarter of 2005 and fourth quarter of 2010. RESULTS: Of the 11,633 patients (55.4 ± 15.3 years; 65.7% women) with a serum glucose determination on the day of surgery, postoperative day 1, or postoperative day 2, 29.1% of patients were hyperglycemic. After controlling for clinical factors, those with hyperglycemia had a significantly increased risk of infection [odds ratio (OR) 2.0; 95% confidence interval (CI), 1.63-2.44], reoperative interventions (OR, 1.8; 95% CI, 1.41-2.3), and death (OR, 2.71; 95% CI, 1.72-4.28). Increased risk of poor outcomes was observed both for patients with and without diabetes. Those with hyperglycemia on the day of surgery who received insulin had no significant increase in infections (OR, 1.01; 95% CI, 0.72-1.42), reoperative interventions (OR, 1.29; 95% CI, 0.89-1.89), or deaths (OR, 1.21; 95% CI, 0.61-2.42). A dose-effect relationship was found between the effectiveness of insulin-related glucose control (worst 180-250 mg/dL, best <130 mg/dL) and adverse outcomes. CONCLUSIONS: Perioperative hyperglycemia was associated with adverse outcomes in general surgery patients with and without diabetes. However, patients with hyperglycemia who received insulin were at no greater risk than those with normal blood glucoses. Perioperative glucose evaluation and insulin administration in patients with hyperglycemia are important quality targets.
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The glycemic threshold for an increase in complications is estimated to be somewhere between 100 and 180 mg/dL in most studies.
“The glycemic threshold for an increase in complications is estimated to be somewhere between 100 and 180 mg/dL (5.5 and 10 mmol/L) in most of these studies (135-138).”
From 16. Diabetes Care in the Hospital: Standards of Care in Diabetes—2026 (2026) · cites this paper as [138]
The Methods (Data Specification; page not available) define hyperglycemia as glucose above 180 mg/dL, and the Results associate it with increased complications. The paper does not estimate a 100–180 mg/dL threshold or say that this range applies in most studies. (LLM, conf=0.83)
Experimental — accuracy not yet measuredPeople who develop stress hyperglycaemia have more adverse peri-operative outcomes than those with diabetes mellitus.
“People who develop stress hyperglycaemia have more adverse peri‐operative outcomes than those with diabetes mellitus [78, 79, 80].”
Postoperative hyperglycemia is a well-established risk factor for postoperative complications.
“Postoperative hyperglycemia is a wellestablished risk factor for postoperative complications.157”
From Guidelines for antenatal and preoperative care in cesarean delivery: Enhanced Recovery After Surgery Society recommendations (part 1)—2025 update (2026) · cites this paper as [157]
CGM, particularly when paired with insulin pumps and HCL systems, can lower hypoglycemia occurrence.
“Also, CGM, especially when connected to insulin pumps and HCL devices, can reduce occurrence of hypoglycemia.1248”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [1248]
The Methods (Data Specification) say the study recorded only the highest glucose level at each time point and had no information on hypoglycemia. The Discussion likewise says hypoglycemia data were unavailable for this analysis. Searches for CGM, insulin pumps, and hybrid closed-loop systems found no passage addressing whether they reduce hypoglycemia. (LLM, conf=0.75)
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Self-citation
- Authors
- Kwon, S., Thompson, R., Dellinger, P., Yanez, D., Farrohki, E., & Flum, D.
- Affiliations
- University of Washington (US)
- Harborview Medical Center (US)
- Providence Regional Medical Center Everett (US)
- Corresponding author
- Kwon, Steve
- Dellinger, Patchen
- Flum, David
- Venue
- Annals of Surgery
- Published
- 2013-01
- Volume
- 257
- Issue
- 1
- Pages
- 8-14
- ISSN
- 0003-4932 (ISSN-L)
- PMC
- PMC4208433
- OpenAlex
- W2115757854
- Semantic Scholar
- dbc7c57ccbc1918481ba8fcdd13b54f442500ff7
- Cited by
- 598
- References
- 50
- Citations by year
- 2026: 45 · 2025: 44 · 2024: 37 · 2023: 50 · 2022: 54 · 2021: 51 · 2020: 49 · 2019: 41 · 2018: 42 · 2017: 54 · 2016: 48 · 2015: 29 · 2014: 32 · 2013: 19 · 2012: 2
- FWCI
- 21.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Surgery (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Agency for Healthcare Research and Quality (R01HS020025, 1 R01 HS 20025-01)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK070555)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Keywords
- glycemic control, perioperative hyperglycemia, insulin therapy, colorectal surgery, bariatric surgery, postoperative infection, postoperative mortality, reoperation, diabetes mellitus, dose-response relationship, hospital performance comparison, patient safety
- MeSH terms
- Adult, Aged, Colectomy, Drug Administration Schedule, Female, Humans, Hyperglycemia, Hypoglycemic Agents, Insulin, Male, Middle Aged, Outcome and Process Assessment, Health Care, Rectum, Reoperation, Retrospective Studies, General Surgery, Surgical Wound Infection, Washington, Cohort Studies, Logistic Models, Elective Surgical Procedures, Perioperative Care, Bariatric Surgery
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