Cited by 598Hyperglycemia and glycemic control in critically ill and hospitalized patientsEnhanced Recovery After SurgeryIntensive Care Unit Cognitive Disorders

Importance of Perioperative Glycemic Control in General Surgery: A Report From the Surgical Care and Outcomes Assessment Program

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Kwon, Steve, Thompson, Rachel, Dellinger, Patchen, Yanez, David, Farrohki, Ellen, Flum, David·2013·Annals of Surgery

Abstract

OBJECTIVE: To determine the relationship of perioperative hyperglycemia and insulin administration on outcomes in elective colon/rectal and bariatric operations. BACKGROUND: There is limited evidence to characterize the impact of perioperative hyperglycemia and insulin on adverse outcomes in patients, with and without diabetes, undergoing general surgical procedures. METHODS: The Surgical Care and Outcomes Assessment Program is a Washington State quality improvement benchmarking-based initiative. We evaluated the relationship of perioperative hyperglycemia (>180 mg/dL) and insulin administration on mortality, reoperative interventions, and infections for patients undergoing elective colorectal and bariatric surgery at 47 participating hospitals between fourth quarter of 2005 and fourth quarter of 2010. RESULTS: Of the 11,633 patients (55.4 ± 15.3 years; 65.7% women) with a serum glucose determination on the day of surgery, postoperative day 1, or postoperative day 2, 29.1% of patients were hyperglycemic. After controlling for clinical factors, those with hyperglycemia had a significantly increased risk of infection [odds ratio (OR) 2.0; 95% confidence interval (CI), 1.63-2.44], reoperative interventions (OR, 1.8; 95% CI, 1.41-2.3), and death (OR, 2.71; 95% CI, 1.72-4.28). Increased risk of poor outcomes was observed both for patients with and without diabetes. Those with hyperglycemia on the day of surgery who received insulin had no significant increase in infections (OR, 1.01; 95% CI, 0.72-1.42), reoperative interventions (OR, 1.29; 95% CI, 0.89-1.89), or deaths (OR, 1.21; 95% CI, 0.61-2.42). A dose-effect relationship was found between the effectiveness of insulin-related glucose control (worst 180-250 mg/dL, best <130 mg/dL) and adverse outcomes. CONCLUSIONS: Perioperative hyperglycemia was associated with adverse outcomes in general surgery patients with and without diabetes. However, patients with hyperglycemia who received insulin were at no greater risk than those with normal blood glucoses. Perioperative glucose evaluation and insulin administration in patients with hyperglycemia are important quality targets.

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Authors
Kwon, S., Thompson, R., Dellinger, P., Yanez, D., Farrohki, E., & Flum, D.
Affiliations
  • University of Washington (US)
  • Harborview Medical Center (US)
  • Providence Regional Medical Center Everett (US)
Corresponding author
  • Kwon, Steve
  • Dellinger, Patchen
  • Flum, David
Venue
Annals of Surgery
Published
2013-01
Volume
257
Issue
1
Pages
8-14
ISSN
0003-4932 (ISSN-L)
OpenAlex
W2115757854
Cited by
598
References
50
Citations by year
2026: 45 · 2025: 44 · 2024: 37 · 2023: 50 · 2022: 54 · 2021: 51 · 2020: 49 · 2019: 41 · 2018: 42 · 2017: 54 · 2016: 48 · 2015: 29 · 2014: 32 · 2013: 19 · 2012: 2
FWCI
21.05
Type
journal article
Language
en
Open access
Locations
  • Annals of Surgery (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Agency for Healthcare Research and Quality (R01HS020025, 1 R01 HS 20025-01)
  • National Institute of Diabetes and Digestive and Kidney Diseases (T32DK070555)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Keywords
glycemic control, perioperative hyperglycemia, insulin therapy, colorectal surgery, bariatric surgery, postoperative infection, postoperative mortality, reoperation, diabetes mellitus, dose-response relationship, hospital performance comparison, patient safety
MeSH terms
Adult, Aged, Colectomy, Drug Administration Schedule, Female, Humans, Hyperglycemia, Hypoglycemic Agents, Insulin, Male, Middle Aged, Outcome and Process Assessment, Health Care, Rectum, Reoperation, Retrospective Studies, General Surgery, Surgical Wound Infection, Washington, Cohort Studies, Logistic Models, Elective Surgical Procedures, Perioperative Care, Bariatric Surgery

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